Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background by Tüdös Zbyněk, Szász Paulína, Veverková Lucia, Hruška František, Hartmann Igor, Škarda Jozef, Thomas Rohit Philip

“…We believe that the cause of retroperitoneal spleno-visceral fusions is the anomalous migration of splenic cells along the dorsal mesentery to the urogenital ridge, together with primitive germ cells, at the end of the fifth week and during the sixth week of embryonic age. …”
Get full text

Automatic Evaluation for Bioengineering of Human Artificial Ovary: A Model for Fertility Preservation for Prepubertal Female Patients with a Malignant Tumor by Wanxue Wang, Cheng Pei, Evgenia Isachenko, Yang Zhou, Mengying Wang, Gohar Rahimi, Wensheng Liu, Peter Mallmann, Vladimir Isachenko

“…The use of a fibrin scaffold as a carrier preserves the developmental potential of primordial germ cells and is a potentially effective method for preserving fertility in prepubertal girls.…”
Get full text

Melatonin Supplementation during <i>In Vitro</i> Maturation of Porcine Oocytes Alleviates Oxidative Stress and Endoplasmic Reticulum Stress Induced by Imidacloprid Exposure by Jing Wang, Xin-Qin Wang, Rong-Ping Liu, Ying-Hua Li, Xue-Rui Yao, Nam-Hyung Kim, Yong-Nan Xu

“…Studies have shown that it has a variety of physiological functions and plays a crucial role in the development of animal germ cells and embryos. The potential protective effects of MT against oocyte damage caused by neonicotinoid pesticide toxicity remain unclear. …”
Get full text

Ldha-Dependent Metabolic Programs in Sertoli Cells Regulate Spermiogenesis in Mouse Testis by Xiao-Na Zhang, Hai-Ping Tao, Shuang Li, Yu-Jun Wang, Shi-Xin Wu, Bo Pan, Qi-En Yang

“…Sertoli cells play indispensable roles in spermatogenesis by providing the advanced germ cells with structural, nutritional, and regulatory support. …”
Get full text

Antioxidants as alleviating agents of in-vitro embryo production oxidative stress by Areeg Almubarak, Il-Jeoung Yu, Yubyeol Jeon

“…Nevertheless, various methods for determining the level of ROS in germ cells have been briefly described. Still, it is crucial to develop standardized antioxidant supplement systems to improve overall IVP success. …”
Get full text

Exenatide and Dapagliflozin Combination Enhances Sertoli Cell Secretion of Key Metabolites for Spermatogenesis by João C. Ribeiro, Ana D. Martins, Ivana Jarak, Rui A. Carvalho, Marco G. Alves, Pedro F. Oliveira

“…Spermatogenesis is highly dependent on the metabolic cooperation established between Sertoli cells (SCs) and developing germ cells. To study the effects of dapagliflozin and exenatide on SC metabolism, mouse SCs were treated in the presence of sub-pharmacologic, pharmacologic, and supra-pharmacologic concentrations of dapagliflozin (50, 500, 5000 nM, respectively) and/or exenatide (2.5, 25, 250 pM, respectively). …”
Get full text

Effects of Dexmedetomidine on the Localization of α2A-Adrenergic and Imidazoline Receptors in Mouse Testis by Hayato Nomura, Hayato Terayama, Daisuke Kiyoshima, Ning Qu, Kosuke Shirose, Shuhei Tetsu, Shogo Hayashi, Kou Sakabe, Takeshi Suzuki

“…In the testis, α2A-adrenergic receptors were observed in the cytoplasm of Leydig cells, while imidazoline receptors were observed in germ cells and Leydig cell cytoplasm. The levels of luteinizing hormone and follicle-stimulating hormone mRNA in the pituitary gland significantly temporarily decreased. …”
Get full text

Subfamily hypostominae: similarities and differences in testicular structure of amazonian fish by Ivana Kerly S. Viana, Gicelle M. F. S., Juliana C. D. Pantoja, Renata S. Oliveira, Yanne A. Mendes, José Leocyvan G. Nunes, Maria Auxiliadora P. Ferreira, Rossineide M. Rocha

“…Conclusions On the basis testicular structure and ultrastructural characteristics of the germ cells, there was a greater relationship between B. xanthelus and P. oligospila, while H. zebra had particular characteristics. …”
Get full text

Androgen/Androgen Receptor Signaling in Ovarian Cancer: Molecular Regulation and Therapeutic Potentials by Wei-Min Chung, Lumin Chen, Wei-Chun Chang, Sheng-Yuan Su, Yao-Ching Hung, Wen-Lung Ma

“…Ovarian cancer (OVCA) arises from three cellular origins, namely surface epithelial cells, germ cells, and stromal cells. More than 85% of OVCAs are EOCs (epithelial ovarian carcinomas), which are the most lethal gynecological malignancies. …”
Get full text

Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans by Ian F Price, Hannah L Hertz, Benjamin Pastore, Jillian Wagner, Wen Tang

“…The germ line produces gametes that transmit genetic and epigenetic information to the next generation. Maintenance of germ cells and development of gametes require germ granules—well-conserved membraneless and RNA-rich organelles. …”
Get full text

New Screening Test for Male Germline Chimeric Chickens by Polymerase Chain Reaction Using Shingle Nucleotide Polymorphism Detection Primers by Akiko Sano, Takashi Harumi, Shozo Hanzawa, Takaharu Kawashima, Hiroyuki Nakamichi, Yuko Matsubara, Mitsuru Naito

“…Putative germline chimeric chickens were produced by the transfer of stage X blastodermal cells or circulating primordial germ cells from Barred Plymouth Rocks (BPR) to White Leghorns (WL). …”
Get full text

Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8 by Youngyong Park, Samuel O’Rourke, Faten A. Taki, Mohammad A. Alfhili, Mohammad A. Alfhili, Myon Hee Lee

“…Biochemical and reporter analyses showed that PUF-8 specifically binds to a PBE in gld-2 3′ UTR and represses a GFP reporter gene carrying gld-2 3′ UTR in the C. elegans mitotic germ cells. GLD-2 enhances meiotic entry at least in part by activating GLD-1 (a KH motif-containing RNA-binding protein). …”
Get full text

Interspecific hybridization of sturgeon species affects differently their gonadal development by Zuzana Linhartová, Miloš Havelka, Martin Pšenička, Martin Flajšhans

“…Testes contained single spermatogonia along with Sertoli cells and spaces lacking germ cells. The obtained results showed that gonad development was influenced by genetic origin and ploidy of the sturgeon hybrids and were consistent with full fertility of hybrids with even ploidy. …”
Get full text

Bi-Allelic Mutations in Zebrafish <i>pank2</i> Gene Lead to Testicular Atrophy and Perturbed Behavior without Signs of Neurodegeneration by Luca Mignani, Daniela Zizioli, Deepak Khatri, Nicola Facchinello, Marco Schiavone, Giuseppe De Palma, Dario Finazzi

“…The phenotypic characterization of <i>pank2</i>-mutant embryos revealed anomalies in the development of venous vascular structures and germ cells. Adult fish showed testicular atrophy and altered behavioral response in an anxiety test but no evident signs of neurodegeneration. …”
Get full text

Sub-chronic exposure to EOMABRS leachate induces germinal epithelial cell lesions, sperm abnormalities and oxidative damage in rats by J.K. Akintunde, G. Oboh, A.A. Akindahunsi

“…Considerable necrosis of leydig cells and loss of germ cells in the seminiferous tubules with the clumping of interstitial space were seen in EOMABRSL-treated rats. …”
Get full text

Transcriptional Dynamics of Genes Purportedly Involved in the Control of Meiosis, Carbohydrate, and Secondary Metabolism during Sporulation in <i>Ganoderma lucidum</i> by Manjun Cai, Xiaowei Liang, Yuanchao Liu, Huiping Hu, Yizhen Xie, Shaodan Chen, Xiong Gao, Xiangmin Li, Chun Xiao, Diling Chen, Qingping Wu

“…<i>Ganoderma lucidum</i> spores (GLS), the mature germ cells ejected from the abaxial side of the pileus, have diverse pharmacological effects. …”
Get full text

Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions by Xiangyan Dai, Ajay Pradhan, Jiao Liu, Ruolan Liu, Gang Zhai, Linyan Zhou, Jiyan Dai, Feng Shao, Zhiyong Yuan, Zhijian Wang, Zhan Yin

“…However, the associations among the brain, gonad, and sexual behavior in teleosts are still unclear. Here, we utilized germ cells-free tdrd12 knockout (KO) zebrafish, and steroid synthesis enzyme cyp17a1-deficient zebrafish to investigate the differences and interplays in the brain–gonad–behavior axis, and the molecular control of brain dimorphism and male mating behaviors. …”
Get full text

Rotenone causes mitochondrial dysfunction and prevents maturation in porcine oocytes. by Geun Heo, Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Jing Guo, Dongjie Zhou, Xiang-Shun Cui

“…Previous studies have found that rotenone induces the production of reactive oxygen species (ROS) by inhibiting electron transport in the mitochondria of somatic and germ cells. However, there is little precise information on the effects of rotenone exposure in porcine oocytes during in vitro maturation, and the mechanisms underlying these effects have not been determined. …”
Get full text

The impact of adding melatonin and other antioxidants on post-thaw human sperm quality during cryopreservation by Riyam Hussein, Lina Hasan Abbas, Suhaila Rayhaan, Hawraa Abbas Fadhil, Zainab R AL-Mousawi

“…Cryopreservation involves exposing germ cells to substances that prevent freezing, cooling them to below-freezing temperatures, storing, melting, and then removing the anti-freezing material when it has been used. …”
Get full text

Imaging Plate Autoradiography for Ingested Anthropogenic Cesium-137 in Butterfly Bodies: Implications for the Biological Impacts of the Fukushima Nuclear Accident by Ko Sakauchi, Joji M. Otaki

“…These results suggest that ¹³⁷Cs accumulation in reproductive organs may cause adverse transgenerational or maternal effects mediated by reactive oxygen species (ROS) on germ cells. ¹³⁷Cs accumulation was detected in field individuals collected in September 2011 and September 2016 but not in May 2011, which is consistent with the abnormality dynamics known from previous studies. …”
Get full text