Calling the question: what is mammalian transgenerational epigenetic inheritance? by Hasan Khatib, Jessica Townsend, Melissa A. Konkel, Gabi Conidi, Julia A. Hasselkus

“…Two waves of epigenetic reprogramming occur: in the primordial germ cells and the developing embryo after fertilization, characterized by global erasure of DNA methylation and remodelling of histone modifications. …”
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Prediction model construction of mouse stem cell pluripotency using CpG and non-CpG DNA methylation markers by Soobok Joe, Hojung Nam

“…Differentiating into embryonic somatic and germ cells, ESCs exhibit varying degrees of pluripotency, and epigenetic changes occurring in this process have emerged as important factors explaining stem cell pluripotency. …”
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Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice by Hegazy Eman M, Girgis Shenouda M, Ezz El-Arab Aly M, Abd El-Khalek Azzat B

“…Oral administration of aflatoxins (mixture of B₁, B₂, G₁ and G₂) and Ochratoxin A. induced structural and numerical chromosomal aberrations in bone marrow and germ cells of male mice, whereas, honey treatment reduced the genotoxicity of mycotoxins. …”
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Expression profile of amh/Amh during bi-directional sex change in the protogynous orange-spotted grouper Epinephelus coioides. by Guan-Chung Wu, Hau-Wen Li, Wei-Guan Tey, Chien-Ju Lin, Ching-Fong Chang

“…A dormant gonad (a low proliferation rate of early germ cells and no characteristics of both sexes) was found during the transient phase of reversible male-to-female sex change after the withdrawal of chemical administration. …”
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Mll5 is required for normal spermatogenesis. by Damian B Yap, David C Walker, Leah M Prentice, Steven McKinney, Gulisa Turashvili, Katrin Mooslehner-Allen, Teresa Ruiz de Algara, John Fee, Xavier d'Anglemont de Tassigny, William H Colledge, Samuel Aparicio

“…Here we show using RNA in-situ hybridization that Mll5 is expressed in the germ cells of the testes of wild type mice. Consistent with the expression of Mll5, we demonstrate by electron microscopy, video microscopy and in vitro fertilisation techniques that Mll5 deficient mice have defects in terminal maturation and packaging of sperm. …”
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Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice. by Alejo Torres-Cano, Rosa Portella-Fortuny, Claudia Müller-Sánchez, Sonia Porras-Marfil, Marina Ramiro-Pareta, You-Ying Chau, Manuel Reina, Francesc X Soriano, Ofelia M Martínez-Estrada

“…The gonads of Wt1LoxP/GFP;Wt1Cre mice showed a lack of production of Sertoli and pre-granulosa cells and a reduced number of germ cells. NR5A1 and the steroidogenic genes expression was modulated differently in XY and XX Wt1LoxP/GFP;Wt1Cre gonads, explaining the mutant phenotypes. …”
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Maternal H3K36 and H3K27 HMTs protect germline development via regulation of the transcription factor LIN-15B by Chad Steven Cockrum, Susan Strome

“…How maternal MES-4 protects the germline is not well understood, but its role in H3K36 methylation hinted that it may regulate gene expression in primordial germ cells (PGCs). We tested this hypothesis by profiling transcripts from nascent germlines (PGCs and their descendants) dissected from wild-type and mes-4 mutant (lacking maternal and zygotic MES-4) larvae. mes-4 nascent germlines displayed downregulation of some germline genes, upregulation of some somatic genes, and dramatic upregulation of hundreds of genes on the X chromosome. …”
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Reinterpretation of evidence advanced for <it>neo-</it>oogenesis in mammals, in terms of a finite oocyte reserve by Notarianni Elena

“…Specifically, DNA synthesis in germ cells in the postnatal mouse ovary is attributed to mitochondrial genome replication, and to DNA repair in oocytes lagging in meiotic progression. …”
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Histomorphometric changes in testis following administration of tenofovir nanoparticles in an animal model by Edwin Coleridge Naidu, Samuel Oluwaseun Olojede, Sodiq Kolawole Lawal, Onyemaechi Okpara Azu

“…Sperm abnormalities such as distorted basement membranes, loss of germ cells, hypocellular interstitium, and loss of spermatogenic series were increased in the TDF and TDF-N groups. …”
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Chromosomes and speciation in tuco-tuco (Ctenomys, Hystricognathi, Rodentia) by A. A. Torgasheva, E. A. Basheva, M. J. Gomez Fernandez, P. Mirol, P. M. Borodin

“…The classic version of this hypothesis emphasizes the sterility of the hybrids, due to incorrect or incomplete chromosome synapsis in heterozygotes for rearrangements, germ cells death, chromosome nondisjunction and the generation of unbalanced gametes. …”
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The Roles of Luteinizing Hormone, Follicle-Stimulating Hormone and Testosterone in Spermatogenesis and Folliculogenesis Revisited by Olayiwola O. Oduwole, Ilpo T. Huhtaniemi, Micheline Misrahi

“…FSH regulates the proliferation and maturation of germ cells independently and in combination with LH. …”
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Transcriptomics analysis of ethanol treatment of male Aedes aegypti reveals a small set of putative radioprotective genes by Matthew Pinch, Harley Bendzus-Mendoza, Immo A. Hansen, Immo A. Hansen

“…Since irradiation can cause damage to both, somatic and germ cells, and can severely reduce the competitiveness of sterilized males relative to wild males, means to minimize the detrimental effects of radiation are required to produce sterile, competitive males for release. …”
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Normal spermatogenesis in Fank1 (fibronectin type 3 and ankyrin repeat domains 1) mutant mice by Jintao Zhang, Xin Zhang, Yue Zhang, Wentao Zeng, Shuqin Zhao, Mingxi Liu

“…Short-hairpin RNA (shRNA)-based knockdown transgenic mice have oligospermia caused by an increase in apoptotic germ cells. In this study, we investigated the in vivo function of Fank1. …”
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The investigation of hydroalcholic extract of Ducrosia anethifolia boiss on the testis tissue and testosterone hormone by N Rahimi, E Samani Jahromi, S Zolghadri Jahromi

“…Conclusion: According to the results of this study, the Ducrosia anethifolia extract reduces the number of germ cells, the level of testosterone and spermatogenesis in male Wistar rats.…”
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The impact of nano zinc oxide particles on the histology of the male reproductive system of adult male rabbits by Atheer N. Taha, Hana Kh. Ismail

“…These changes are characterized by thickening of tunica albuginea of testis, degenerative and necrotic changes of germ cells lining the seminiferous tubules, arrest of spermatogenesis, giant cell formation, degeneration, and necrosis of epithelial cells lining epididymis canals. …”
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Reduced immunogenicity of induced pluripotent stem cells derived from Sertoli cells. by Xiaoying Wang, Jie Qin, Robert Chunhua Zhao, Martin Zenke

“…Sertoli cells constitute the structural framework in testis and provide an immune-privileged environment for germ cells. Induced pluripotent stem cells (iPS cells) resemble embryonic stem cells (ES cells) and are generated from somatic cells by expression of specific reprogramming transcription factors. …”
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Influence of prepubertal aflatoxicosis on pubertal reproductive activity in male rats by Hussein H. Al-Hichamy, Jabber A. Al-Saaidi

“…Histological sections of the testicles of treated males showed atrophy of some seminiferous tubules, empty lumen, and massive vacuolization and exfoliation of the germ cells. The histological results of the epididymis showed obliteration of the lumen, necrosis of the epithelial layer, deformed cavities, a climbing epithelial layer, and epithelium hyperplasia compared to the control group. …”
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Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosis by Anna O Sedova, Maria I Shtaut, Elizaveta E Bragina, Tatyana M Sorokina, Galina V Shmarina, Marina V Andreeva, Lyubov F Kurilo, Stanislav A Krasovskiy, Aleksander V Polyakov, Vyacheslav B Chernykh

“…Complex semen examination was performed, including standard semen analysis, quantitative karyological analysis (QKA) of immature germ cells (IGCs), transmission electronic microscopy (TEM), biochemical analysis, and sperm DNA fragmentation by terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling (TUNEL) assay. …”
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Evaluation of the Protective Effect of Human Platelet-Rich Plasma on Spermatogenesis and Sperm Chromatin Condensation Following Ischemia-Reperfusion Injury Due to Spermatic Cord To... by Mahya Ramesh, Farnaz Khadivi

“…Introduction: Torsion of spermatic cord induces ischemic-reperfusion injury which leads to testicular dysfunction, apoptosis of germ cells, ROS generation and infertility. Platelet-rich plasma (PRP) is a rich source of growth factors and anti-inflammatory cytokines. …”
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The role of the pAbp gene encoding the cytoplasmic poly(A)-binding protein in spermatogenesis of Drosophila melanogaster by E. U. Bolobolova, E. M. Baricheva, N. V. Dorogova

“…Thus our data show a significant role of PABP in structural transformations of male germ cells during entire spermato-genesis.…”
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