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2461
Chlorocholine chloride exposure induced spermatogenic dysfunction via iron overload caused by AhR/PERK axis-dependent ferritinophagy activation
Published 2024-04-01“…In vivo, pubertal CCC exposure led to decreased testicular weight, decreased testicular germ cells and poor sperm quality. This effect worsened after cessation of CCC exposure for the next 30 days. …”
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2462
Type I Diabetes in Zebrafish Reduces Sperm Quality and Increases Insulin and Glucose Transporter Transcripts
Published 2023-04-01“…Therefore, our study validates the zebrafish model for type I diabetes research in germ cells.…”
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2463
Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis
Published 2018“…We conclude that the premeiotic transitions are coordinated by RA from Sertoli (somatic) cells. Once germ cells enter meiosis, pachytene spermatocytes produce RA to coordinate the two postmeiotic transitions. …”
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2464
Molecular genetic and clinical aspects of socially relevant viruses underlying congenital diseases
Published 2021-09-01“…The herpesvirus type 6 has been proven to integrate into germ cells with potential for subsequent vertical transmission of chromosomally integrated virus to the offspring and its further intergeneration inheritance. …”
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2465
Spermatogenesis is normal in Tex33 knockout mice
Published 2020-07-01“…TUNEL assay also indicates the germ cells apoptosis ratio was not significantly changed in adult Tex33-/- adult male mouse testis (N = 3), compared with adult Tex33+/+ male (N = 3). …”
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2466
Conserved Transcriptome Features Define Prepubertal Primate Spermatogonial Stem Cells as A<sub>dark</sub> Spermatogonia and Identify Unique Regulators
Published 2023-03-01“…A cross-species analysis revealed cell types analogous to human SSCs in baboon and rhesus germ cells, but a comparison with mouse SSCs revealed significant differences with primate SSCs. …”
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2467
Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome
Published 2005-05-01“…</p> <p>Conclusion</p> <p>We have studied five clusters of genes specifically expressed in female, some of them being also expressed in male germ-cells. Moreover, contrarily to non-clustered oocyte-specific genes, those that are organized in clusters tend to map near chromosome ends, suggesting that this specific near-telomere position of oocyte-clusters in rodents could constitute an evolutionary advantage. …”
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2468
Catalase T-Deficient Fission Yeast Meiocytes Show Resistance to Ionizing Radiation
Published 2020-09-01“…DNA damage and its faulty repair can lead to cell death or promote cancer through the accumulation of mutations. Misrepair in germ cells is particularly dangerous as it may lead to alterations in developmental programs and genetic disease in the offspring. …”
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2469
Maternal exposure to genistein during pregnancy and oxidative DNA damage in testes of male mouse offspring
Published 2022-07-01“…Therefore, high intake of genistein during pregnancy may have adverse effects on the genetic integrity of testes and germ cells of male offspring. In this study, we examined whether maternal exposure to genistein during pregnancy induced oxidative DNA damage in the male germline at adolescence.MethodsAtm-ΔSRI mice have lower glucose-6-phosphate dehydrogenase (G6PDH) activity, which is important for maintaining levels of reduced glutathione and therefore these mice have an increased susceptibility to oxidative stress. …”
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2470
Glutamine supplementation attenuates bisphenol a-induced testicular toxicity in rats
Published 2022-01-01“…The testes of BPA-treated rats showed sloughing and coalescence of germ cells. However, Gln supplementation prevents BPA-induced testicular toxicity. …”
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2471
Research Note: Injection of adenoviral CRISPR/Cas9 system targeting melanophilin gene into different sites of embryos induced regional feather color changes in posthatch quail
Published 2023-11-01“…Injection of adenovirus containing the CRISPR/Cas9 system into avian blastoderm induced genome editing in blastodermal cells randomly, including primordial germ cells, which results in generation of whole-body knockout in the offspring of the virus-injected quail. …”
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2472
Seasonal expression of androgen receptor, aromatase, and estrogen receptor alpha and beta in the testis of the wild ground squirrel (Citellus dauricus Brandt)
Published 2015-02-01“…AR was present in Leydig cells, peritubular myoid cells and Sertoli cells in the breeding season and pre-hibernation with more intense staining in the breeding season, whereas AR was only found in Leydig cells in the nonbreeding season; P450arom was expressed in Leydig cells, Sertoli cells and germ cells during the breeding season, whereas P450arom was found in Leydig cells and Sertoli cells during pre-hibernation, but P450arom was not present in the nonbreeding season; stronger immunohistochemical signal for ERα was present in Sertoli cells and Leydig cells during the breeding season; ERβ was only expressed in Leydig cells of the breeding season. …”
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2473
Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities
Published 2023-01-01“…Loss of ACC function induced spindle abnormalities in cell lines and in germ cells of the Drosophila germarium, and palmitic acid (PA) rescued the spindle defects in the cell line treated transiently with the ACC inhibitor, TOFA. …”
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2474
L-Carnitine and Male Fertility: Is Supplementation Beneficial?
Published 2023-09-01“…In vitro studies suggest that L-Carnitine has a direct influence on somatic Sertoli cells, improving the development of germ cells. Overall, evidence supports that L-Carnitine can positively impact male fertility, even at a relatively low dose of 2 g/day. …”
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2475
Quantitative analysis of CRISPR/Cas9-mediated provirus deletion in blue egg layer chicken PGCs by digital PCR
Published 2022-09-01“…Abstract Primordial germ cells (PGCs), the precursors of sperm and oocytes, pass on the genetic material to the next generation. …”
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2476
Ovarian teratoma in routine biopsy material during a five-year period
Published 2016-01-01“…Teratomas are tumors derived from germ cells, most frequently arising in the gonads. The aim of this study was to determine the number of ovarian teratomas diagnosed in the routine biopsy material at Ljudevit Jurak Clinical Department of Pathology, Sestre milosrdnice University Hospital Center during a 5-year period, as well as their clinical, gross and microscopic characteristics. …”
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2477
Conservation of teleost fishes: Application of reproductive technologies
Published 2024-01-01“…The ability to establish cryo-banks for the full range of fish germplasm, including sperm, oocytes, embryos and germ cells represents a powerful tool for use in the conservation of threatened fish species. …”
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2478
Protective effect of ligustrazine on oxidative stress and apoptosis following testicular torsion in rats
Published 2023-11-01“…The apoptotic index of germ cells in the TMP group (13.05 ± 4.41) was lower than the T/D group (30.23 ± 11.31) (P < 0.05) and higher (P < 0.05) than the Sham group (0.56 ± 0.29). …”
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2479
Ameliorating effect of blueberry consumption on energy drink-induced testicular damage in rats: histological and immunohistochemical study
Published 2023-03-01“…A low dose of Code Red led to sporadic and scattered appearance of seminiferous tubules with loss of spermatogenic germ cells and marked degeneration of interstitial cells. …”
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2480
<i>Vasa</i>, <i>Piwi</i>, and <i>Pl10</i> Expression during Sexual Maturation and Asexual Reproduction in the Annelid <i>Pristina longiseta</i>
Published 2023-08-01“…In this paper, we showed, for the first time, the expression of <i>Vasa</i>, <i>Piwi</i>, and <i>Pl10</i> homologs in mature <i>Pristina longiseta</i> worms with well-developed reproductive system structures and germ cells. Although the animals have been propagated asexually by paratomic fission for over 20 years in our lab, some individuals become sexualized under standard conditions for our laboratory culture and demonstrate various stages of maturation. …”
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