Evaluation of safety, feasibility and efficacy of intra-ovarian transplantation of autologous adipose derived mesenchymal stromal cells in idiopathic premature ovarian failure pati... by M. Mashayekhi, E. Mirzadeh, Z. Chekini, F. Ahmadi, P. Eftekhari-Yazdi, S. Vesali, T. Madani, N. Aghdami

“…Stem cell therapy has the capability to create a regenerative microenvironment and is a proposed treatment for POF-related infertility due to the presence of renewal folliculogenesis and germ cells in the adult ovaries. In this study, we assessed the safety, feasibility, efficacy and dose adjustment of autologous adipose-derived stromal cells (ADSCs) and their ability to improve ovarian function in POF patients. …”
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RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism by Weihao Sun, Xinhui Zhang, Lei Wang, Guanyu Ren, Shuguang Piao, Chenghua Yang, Chenghua Yang, Zhiyong Liu, Zhiyong Liu

“…As the period of cryptorchidism in the cryptorchid testis extended, the seminiferous tubules significantly atrophy, the number of spermatogenic cells declines, and the amount of interstitial fibrous tissue increases in comparison to normal tissues. The number of germ cells per cross-section of seminiferous tubules was significantly lower in cryptorchidism than in normal testicular tissues, according to immunofluorescence staining, but the number of Sertoli cells remained stable. …”
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Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development by Ya Zheng, Bin Mao, Qian Wang, Xin Duan, Meng-Yan Chen, Wei Shen, Chao Li, Yu-Feng Wang

“…In our previous studies, we have found that knockdown of ocnus (ocn), a testis-specific gene, resulted in much smaller testis with no germ cells in Drosophila melanogaster. However, the molecular consequences of ocn knockdown in fly testes are unknown. …”
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Effects of sublethal exposure of diuron on adults of Javanese medaka (Oryzias javanicus, Bleeker 1854) using histopathology and immunochemistry techniques by Kamarudin, Nur Amiera

“…In addition, Diuron caused the decreasing in gonadal staging and maturity of germ cells in oogenesis and spermatogenesis of female and male Javanese medaka. …”
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Fathers’ preconception smoking and offspring DNA methylation by Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I. Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Sarah H. Watkins, Matthew Suderman, Francisco Gómez-Real, Vivi Schlünssen, Cecilie Svanes, John W. Holloway

“…Abstract Background Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. …”
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Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction by Fernanda Sales Coelho, Fernanda Sales Coelho, Sandra Grossi Gava, Luiza Freire Andrade, Juliana Assis Geraldo, Naiara Clemente Tavares, Felipe Miguel Nery Lunkes, Renata Heisler Neves, José Roberto Machado-Silva, Raymond J. Pierce, Guilherme Oliveira, Guilherme Oliveira, Marina Moraes Mourão

“…Smprmt1 is also enriched in S1 and late female germ cells from adult worms. After dsRNA exposure in vitro, we observed a Smcarm1 knockdown in schistosomula and adult worms, 83 and 69%, respectively. …”
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Treating Cancer by Targeting Telomeres and Telomerase by Marko Ivancich, Zachary Schrank, Luke Wojdyla, Brandon Leviskas, Adijan Kuckovic, Ankita Sanjali, Neelu Puri

“…In humans, telomerase activity is typically restricted to renewing tissues, such as germ cells and stem cells, and is generally absent in normal cells. …”
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Spatial positioning of preimplantation mouse embryo cells is regulated by mTORC1 and m7G-cap-dependent translation at the 8- to 16-cell transition by Lenka Gahurova, Jana Tomankova, Pavlina Cerna, Pablo Bora, Michaela Kubickova, Giorgio Virnicchi, Kristina Kovacovicova, David Potesil, Pavel Hruska, Zbynek Zdrahal, Martin Anger, Andrej Susor, Alexander W. Bruce

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Study of Sertoli cells and spermatogenic cells in rats with experimentally induced metabolic syndrome and after balneophysiotherapy by O. L. Kolomiets, E. E. Bragina, A. A. Kashintsova, V. E. Spangenberg, L. A. Nikulina, Yu. N. Korolev, L. V. Mikhailik

“…It is assumed that the activation of autophagy is an important factor in supporting the viability of Sertoli cells and supporting the viability of germ cells in stressful situations, including MS. Apparently, autophagy is an adaptive mechanism that removes the remnants of apoptotic spermatogenic cells that are selected as a result of MS development.…”
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Expression of Melanoma Antigen Genes A11 and A12 in Non-Small Cell Lung Cancer by Gondo Mastutik, Alphania Rahniayu, Isnin Anang Marhana, Mochamad Amin, Heru Fajar Trianto, Reny I’tishom

“…Abstract The melanoma antigen gene (MAGE) belongs to the group of cancer-testis antigens that are exclusively expressed in germ cells but may be re-expressed in cancer cells. …”
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Ecotoxicity assesment of antifouling biocide, zinc pyrithione on the Javanese medaka (Oryzias javanicus, Bleeker 1854) by Abdul Aziz, Fatin Zahidah

“…Therefore, results from the present study prove that relatively higher concentrations of ZnPT could cause in an increased apoptosis of hepatocytes in the liver, tubular in kidney gonadal germ cells in the testis and ovarian follicles of gonads in Oryzias javanicus. …”
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Comparative toxicological-hygienic assessment, structural-morphological, physicochemical characteristics, and virucidal properties of new nanopowder materials TiO2 and TiO2@Ag by O.P. Yavorovsky, V.M. Riabovol, T.O. Zinchenko, M.M. Zahornyi, A.V. Ragulya, N.I. Tyschenko, O.Yu. Povnitsa, L.O. Artiukh, S.D. Zahorodnia, D.D. Ostapiv

“…In the study of the impact of nanomaterials on murine germ cells, it has been established that they affect the activity of mitochondrial enzymes and exert a damaging effect on mitochondrial membranes and overall cell integrity. …”
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