Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare... by M. Helbig, M. Steinmann, S. Jaschinski, M.J. Seckl, W. Meier, T. Fehm, A.K. Volkmer

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DUSP5 and PHLDA1 mutations in mature cystic teratomas of the ovary identified on whole-exome sequencing may explain teratoma characteristics by Wen-Chung Wang, Yen-Chein Lai

“…Abstract Background Mature cystic teratomas of the ovary are the most common type of germ cell tumor, comprising 33% of ovarian tumors. …”
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Update on fertility restoration from prepubertal spermatogonial stem cells: How far are we from clinical practice? by Maria Grazia Giudice, Francesca de Michele, Jonathan Poels, Maxime Vermeulen, Christine Wyns

“…Different approaches to in vivo or in vitro mature spermatogonial stem cells (SSCs) contained in ITT have been studied: autografting of testicular tissue pieces, transplantation of one's own purified germ cell suspensions, and in vitro maturation (IVM) for subsequent use of sperm for intra cytoplasmic sperm injection (ICSI). …”
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Leiomyosarcoma presenting as unilateral painless testicular mass in a septuagenarian: a case report with review of the literature by Brijmohan Joshi, Ritesh Goel, Anant Kumar, Ruchir Maheshwari, Samit Chaturvedi, Satish Kumar Ranjan

“…The patient underwent a high inguinal orchiectomy due to a suspicion of germ cell tumor, and histopathology and immunohistochemistry confirmed the diagnosis of leiomyosarcoma. …”
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Red Out: Bleeding During Robotic Retroperitoneal Lymph Node Dissection and Strategies To Manage It by Fairleigh Reeves, Natalie George, Ben Challacombe

“…Robotic retroperitoneal lymph node dissection is emerging as an attractive minimally invasive technique to remove residual and recurrent retroperitoneal masses in patients with germ cell malignancies. It has huge potential benefits for patients in terms of lower rates of blood loss, ileus, postoperative pain, and scarring, and faster return to full activity. …”
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Ovarian aging: mechanisms and intervention strategies by Zhu Zhengmao, Xu Wanxue, Liu Lin

“…In this review, we highlight some of critical factors that impact oocyte quantity and quality during aging. Germ cell and follicle reserve at birth determines reproductive lifespan and timing the menopause in female mammals. …”
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Sequence variation in the human transcription factor gene <it>POU5F1</it> by Hastings Noel C, Bertucci Caterina, Sequerra Reynaldo, Hussain Shehnaz K, Rieder Mark, Schwartz Stephen M

“…<p>Abstract</p> <p>Background</p> <p>POU5F1 expression is required to maintain stem cell pluripotency and for primordial germ cells to retain proliferative capability in embryonic development. …”
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METTL21A, a Non-Histone Methyltransferase, Is Dispensable for Spermatogenesis and Male Fertility in Mice by Jinmei Li, Shenglei Feng, Xixiang Ma, Shuiqiao Yuan, Xiaoli Wang

“…Unexpectedly, our results showed that knockout males are fertile without apparent defects in the processes of male germ cell development, including spermatogonial differentiation, meiosis, and sperm maturation. …”
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The role of tumor necrosis factor-alpha and interleukin-1 in the mammalian testis and their involvement in testicular torsion and autoimmune orchitis by Lysiak Jeffrey J

“…IL-1 alpha has been reported to be produced by Sertoli cells, testicular macrophages, and possibly postmeiotic germ cells. IL-1 receptors have been reported on Sertoli cells, Leydig cells, testicular macrophages, and germ cells suggesting both autocrine and paracrine functions. …”
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Efficient dispersal and substrate acquisition traits in a marine invasive species via transient chimerism and colony mobility by Andrew E. Fidler, Aurelie Bacq-Labreuil, Elad Rachmilovitz, Baruch Rinkevich

“…Thus, movements of D. vexillum colony ramets from initial fusion zones lead to progressive segregation of genotypes probably minimizing potential somatic/germ-cell competition/parasitism. We speculate that relatively fast (≤10 mm/day) movement of D. vexillum colonies on substrates along with frequent, and perhaps unrestrained, transient allogeneic fusions play significant roles in this species’ striking invasiveness and capacity to colonize new substrates.…”
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Comparative diagnostic accuracy of frozen sections and scrape cytology in ovarian neoplasms by Swati Bhardwaj, Charanjeet Ahluwalia, Amit Kumar Yadav, Sufian Zaheer, Sachin Kolte, Rashmi Arora

“…In 93% of cases, scrape cytology enabled correct categorization of the tumor as surface epithelial, germ-cell tumor, sex cord-stromal, or others. Conclusion: Scrape cytology is an adjunct to frozen section for providing an intraoperative diagnosis; however, in resource-poor settings, it can be used as a stand-alone method for aiding intraoperative decision-making.…”
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Transient scrotal hyperthermia induces lipid droplet accumulation and reveals a different ADFP expression pattern between the testes and liver in mice. by Mingxi Liu, Lin Qi, Yan Zeng, Yang Yang, Ye Bi, Xiaodan Shi, Hui Zhu, Zuomin Zhou, Jiahao Sha

“…Previously, we focused on the molecular mechanism of germ cell apoptosis and anti-apoptotic factors induced by heat treatment in humans and mice. …”
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Paratesticular cellular angiofibroma: a case report by Takaya Murashima, Kazutaka Kida, Toshihiro Gi, Takuya Hida, Masato Fujii, Takahiro Nagai, Hiroki Takamori, Shoichiro Mukai, Yuichiro Sato, Toshiyuki Kamoto

“…Although testicular germ cell tumor was ruled out clinically, the possibility of malignant potential remained for the tumor. …”
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Role of Human Endogenous Retroviral Long Terminal Repeats (LTRs) in Maintaining the Integrity of the Human Germ Line by Meihong Liu, Maribeth V. Eiden

“…Occasionally, exogenous retroviruses infect germ cells and when this happens a profound shift in the virus host dynamic occurs. …”
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Clinicopathological analysis of ovarian tumours: experience of 3 years in a cancer hospital by Varsha Deshmukh, Afsha Suboohi

“…Serous tumors were the commonest tumors (42%) followed by germ cell tumors. Serous cystadenoma (33.3%) was the commonest non-neoplastic lesion. …”
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BRAF Controls the Effects of Metformin on Neuroblast Cell Divisions in <i>C. elegans</i> by Zhi Qu, Shaoping Ji, Shanqing Zheng

“…Our results showed that the mTOR pathway indeed played a role in controlling germ cell proliferation, but it was not involved in the neuronal Q-cell divisions occurring in L1-arrested worms. …”
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Enhanced Enrichment of Medaka Ovarian Germline Stem Cells by a Combination of Density Gradient Centrifugation and Differential Plating by Jun Hyung Ryu, Seung Pyo Gong

“…Based on cell morphology and gene expression of germ cell-specific <i>Vasa</i> and OGSC-specific <i>Nanos2</i>, we demonstrated that of seven density fractions obtained following PDGC, the 30–35% density fraction contained the highest proportion of OGSCs, and that Matrigel was the most effective biomolecule for the enrichment of <i>Oryzias latipes</i> OGSCs by DP in comparison to laminin, fibronectin, gelatin, and poly-<span style="font-variant: small-caps;">l</span>-lysine. …”
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An insight into metastatic Leydig cell tumors: A case report by Jerel David, Vaibhav Chumbalkar, Juskaran Chadha

“…Sex cord-stromal tumors comprise approximately 5% of all testicular tumors, while the remainder are of germ cell origin. Leydig cell tumors are the most common subtype of testicular sex cord-stromal tumors and account for 1%–2% of all testicular tumors. …”
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Sequence-dependent heterochromatin formation in the human malaria parasite Plasmodium falciparum by Toshiyuki Mori, Mai Nakashima

“…The human malaria parasite Plasmodium falciparum represses transcription of the gene encoding AP2-G, which is the master regulator of germ cell differentiation, via heterochromatin condensation following histone H3 lysine 9 trimethylation (H3K9me3). …”
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<i>Wolbachia</i> Induces Structural Defects Harmful to <i>Drosophila simulans</i> Riverside Spermiogenesis by Maria Giovanna Riparbelli, Ambra Pratelli, Giuliano Callaini

“…Although the molecular mechanisms responsible for this reproductive alteration are beginning to be understood, the effects of <i>Wolbachia</i> on germ cell structure and dynamics have not yet been fully investigated. …”
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