Promoter hypermethylation of PIWI/piRNA pathway genes associated with diminished pachytene piRNA production in bovine hybrid male sterility by Gong-Wei Zhang, Ling Wang, Huiyou Chen, Jiuqiang Guan, Yuhui Wu, Jianjun Zhao, Zonggang Luo, Wenming Huang, Fuyuan Zuo

“…DNA hypermethylation and disruption of piRNA production contributed to unsuccessful germ cell development that may drive bovine HMS.…”
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GSG2 facilitates the progression of human breast cancer through MDM2-mediated ubiquitination of E2F1 by Yu Tang, Gaosai Dai, Yupeng Yang, Huantao Liu

“…Previous evidence demonstrated that germ cell-specific gene 2 (GSG2) was involved in the regulation of multiple cancers. …”
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Evaluation of an Algorithm for Testis-Sparing Surgery in Boys with Testicular Tumors: A Retrospective Cohort Study by Cezanne D. Kooij, Caroline C.C. Hulsker, Mariëtte E.G. Kranendonk, József Zsiros, Annemieke S. Littooij, Leendert H.J. Looijenga, Aart J. Klijn, Annelies M.C. Mavinkurve-Groothuis

“…Results: We identified 31 boys (median age = 5.5 years) with a testicular tumor, 26 germ cell tumors (GCTs), four sex cord-stromal tumors, and one gonadoblastoma. …”
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Anti-Ma2 Antibody-Associated Paraneoplastic Neurological Syndromes: A Pilot Study by Yi Guo, Meng-Ting Cai, Qi-Lun Lai, Yang Zheng, Chun-Hong Shen, Yin-Xi Zhang

“…Two patients with LE were found to have a testicular germ-cell tumor and a thymoma, respectively. In addition, a patient who developed chronic SMN was diagnosed with multiple myeloma (MM) involving multiple organs. …”
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Epidemiological and pathohistological characteristics of testicular neoplasms in the Zenica-Doboj Canton, Bosnia and Herzegovina: a three-year monocentric study by Emir Begagić, Alma Mekić-Abazović, Hakija Bečilić, Alma Efendić, Edin Selimović, Zlatan Memić, Lejla Mujbegović, Fatima Juković-Bihorac

“…Most diagnosed neoplasms (48.6%) were the myxoid type germ cell originating tumors. Conclusion: The incidence of testicular neoplasms in the ZDC was 4.2/100,000 persons in 2019, 3.08/100,000 persons in 2020, and 3.10/100,000 persons in 2021.…”
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Imaging plant germline differentiation within Arabidopsis flowers by light sheet microscopy by Sona Valuchova, Pavlina Mikulkova, Jana Pecinkova, Jana Klimova, Michal Krumnikl, Petr Bainar, Stefan Heckmann, Pavel Tomancak, Karel Riha

“…To overcome this limitation, we have developed a methodology for live imaging of the germ cell lineage within floral organs of Arabidopsis using light sheet fluorescence microscopy. …”
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BRG1 Is Dispensable for Sertoli Cell Development and Functions in Mice by Shuai Wang, Pengxiang Wang, Dongli Liang, Yuan Wang

“…Sertoli cells are somatic supporting cells in spermatogenic niche and play critical roles in germ cell development, but it is yet to be understood how epigenetic modifiers regulate Sertoli cell development and contribution to spermatogenesis. …”
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<i>Mlig-SKP1</i> Gene Is Required for Spermatogenesis in the Flatworm <i>Macrostomum lignano</i> by Mikhail Biryukov, Anastasia Dmitrieva, Valeriya Vavilova, Kirill Ustyantsev, Erzhena Bazarova, Igor Sukhikh, Eugene Berezikov, Alexandr Blinov

“…Our findings reinforce the role of ubiquitination pathways in germ cell regulation and demonstrate the conserved role of <i>SKP1</i> in spermatogenesis.…”
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Teratoma Growth Retardation by HDACi Treatment of the Tumor Embryonal Source by Jure Krasic, Lucija Skara, Monika Ulamec, Ana Katusic Bojanac, Sanja Dabelic, Floriana Bulic-Jakus, Davor Jezek, Nino Sincic

“…Among testicular germ cell tumors, teratomas may often be very aggressive and therapy-resistant. …”
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Gaining Insight into Mitochondrial Genetic Variation and Downstream Pathophysiology: What Can i(PSCs) Do? by Jesse D. Moreira, Deepa M. Gopal, Darrell N. Kotton, Jessica L. Fetterman

“…Heteroplasmic variants can also segregate during germ cell formation, underlying the inheritance of some mitochondrial mutations. …”
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Rhox6 regulates the expression of distinct target genes to mediate mouse PGCLC formation and ESC self-renewal by Xiaofeng Li, Peng Chen, Junxiang Ji, Quanchao Duan, Jianjian Cao, Ru Huang, Shou-Dong Ye

“…Abstract Background Mouse embryonic stem cells (mESCs) not only retain the property of self-renewal but also have the ability to develop into primordial germ cell-like cells (PGCLCs). However, knowledge about the mechanisms of transcriptional regulation is still limited. …”
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Malignant transformation of mature cystic teratoma - an enigmatic finding in a reproductive woman by Subhransu Kumar Hota, Nikhil Sharma, Pranati Mishra, Ranjana Giri, Kanak Lata Das, Urmila Senapati

“…In the reproductive age group among all ovarian germ cell tumors mature cystic teratoma (MCT) is the most common one. …”
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<i>RpS3</i> Is Required for Spermatogenesis of <i>Drosophila melanogaster</i> by Yang Fang, Fengchao Zhang, Yunhui Zhan, Meina Lu, Di Xu, Jiajia Wang, Qiujun Li, Long Zhao, Ying Su

“…Immunofluorescence staining showed that <i>RpS3</i> knockdown had little effect on early germ cell differentiation, but strongly disrupted the spermatid elongation and individualization processes. …”
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Microcystin-LR induces lactate production disruption via altering the m6A modification in Sertoli cells by Xiannan Meng, Wenju Li, Qingxuan Wu, Yue Gao, Ling Zhang

“…We found an increase in germ cell apoptosis in the seminiferous tubules and low-quality sperm in the epididymis. …”
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Analysis of the transmembrane potential of embryos exposed to action of nickel, cobalt, tin and zinc by G. V. Galyk, Z. Y. Fedorovych, E. I. Lychkovsky, D. I. Sanagursky

“…Germ cells of aquatic organisms are complex systems whose growth and development depends on many factors, one of which is the composition of the aquatic environment. …”
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E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice by Rong-Ge Yan, Qi-Lin Yang, Qi-En Yang

“…Further analyses revealed that meiosis progression and spermiogenesis were normal, however, Sertoli cell proliferation was impaired and germ cell apoptosis was elevated in the testis of <i>E4f1</i> conditional knockout mice. …”
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Seminoma primário do mediastino by Cleverson Winston de Liz Medeiros, Cesar Giovani Conte, Gilberto Tokunaga, Ivo Batista Júnior, Lúcia Noronha, Calixto Antônio Hakim Neto

“…Os autores fazem uma revisão da incidência, patogênese, diagnóstico e formas atuais de tratamento do seminoma de mediastino, além da classificação prognóstica proposta pelo International Germ Cell Cancer Collaborative Group.…”
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Breaking the Mold: Epigenetics and Genomics Approaches Addressing Novel Treatments and Chemoresponse in TGCT Patients by Berenice Cuevas-Estrada, Michel Montalvo-Casimiro, Paulina Munguia-Garza, Juan Alberto Ríos-Rodríguez, Rodrigo González-Barrios, Luis A. Herrera

“…Testicular germ-cell tumors (TGCT) have been widely recognized for their outstanding survival rates, commonly attributed to their high sensitivity to cisplatin-based therapies. …”
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The exceptional stem cell system of <it>Macrostomum lignano</it>: Screening for gene expression and studying cell proliferation by hydroxyurea treatment and irradiation by Eichberger Paul, Hrouda Martina, Kuales Georg, Philipp Isabelle, De Mulder Katrien, Pfister Daniela, Borgonie Gaetan, Hartenstein Volker, Ladurner Peter

“…These stem cells (neoblasts) can give rise to all cell types including germ cells and power the exceptional regenerative capacity of many flatworm species. …”
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Giant Mature Ovarian Cystic Teratoma in a Pediatric Patient: Case Report and Literature Review by Adolfo Eduard Barragán-Curiel, Carlos Murillo-Zepeda, Karla Fernanda Castro-Perez, Francisco Omar Alcalá-Aguirre, Lilian Sabinne Díaz-Montoya, Omar Alfonso Ruiz-Félix, José Antonio Acevedo-Delgado, Moyra Velasco-Preciado

“…Mature cystic teratomas, also called dermoid cysts, are the most common germ-cell ovarian neoplasms in children. On average, ovarian dermoid cysts are slow-growing neoplasms with a mean size between 6.4 and 7.0 cm that enlarge at a rate of 1.8 mm/year; however, these can reach large dimensions. …”
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