Mechanism and Role of SOX2 Repression in Seminoma: Relevance to Human Germline Specification by Ritu Kushwaha, Nirmala Jagadish, Manjunath Kustagi, Geetu Mendiratta, Marco Seandel, Rekha Soni, James E. Korkola, Venkata Thodima, Andrea Califano, George J. Bosl, R.S.K. Chaganti

“…Human male germ cell tumors (GCTs) are derived from primordial germ cells (PGCs). …”
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Molecular mechanisms of oogenesis by V. G. Zenkina, O. A. Solodkova, G. G. Bozhko, A. A. Agibalova, I. S. Zenkin

“…Apoptosis causes degeneration of most of the germ cells formed during oogenesis. The molecular mechanisms and factors involved in this process are numerous.Pathways mediated by mitochondria of germ cells and external pathways mediated by receptors of the cell surface were described. …”
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The simultaneous administration of microplastics and cadmium alters rat testicular activity and changes the expression of PTMA, DAAM1 and PREP by Massimo Venditti, Majida Ben Hadj Hassine, Imed Messaoudi, Sergio Minucci

“…We also demonstrated, for the first time, that both MP and Cd can affect the protein level of PTMA, a small peptide that regulates germ cell proliferation and differentiation. Interestingly, the cytoarchitecture of testicular cells was also altered by the treatments, as evidenced by the impaired expression and localization of DAAM1 and PREP, two proteins involved in actin- and microtubule-associated processes, respectively, during germ cells differentiation into spermatozoa, impairing normal spermatogenesis. …”
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Does the LHPP gene share a common biological function in pancancer progression? by Kai Guo, Wei Tian, Hongtao Wang, Dongmin Chang, Yawei Dou, Jinyan Yuan, Yaohua Chen, Bin Hou

“…Cancer-associated fibroblast infiltration was also observed in head and neck squamous cell carcinoma, stomach adenocarcinoma and testicular germ cell tumors. In summary, our pancancer analysis among various tumor types could provide a comprehensive understanding of LHPP biological function in the progression of malignant diseases and promote the development of novel therapeutic targets.…”
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Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity by Yuting Li, Ziqiong Yang, Xiangfen Li, Yang Yu, Xiaofeng Li, Peng Chen, Bing Li, Xiaoxiao Wang, Shou-Dong Ye

“…Summary: Prdm14 plays an important role in the maintenance of mouse embryonic stem cell (mESC) pluripotency and the specification of primordial germ cells (PGCs). However, the mechanism downstream of Prdm14 is still not fully understood. …”
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Deletion of <i>Hn</i><i>rnpk</i> Gene Causes Infertility in Male Mice by Disrupting Spermatogenesis by Haixia Xu, Jiahua Guo, Wei Wu, Qiu Han, Yueru Huang, Yaling Wang, Cencen Li, Xiaofang Cheng, Pengpeng Zhang, Yongjie Xu

“…The initiation of meiosis of following spermatogenesis was not affected in <i>Hnrnpk</i> cKO mice, while most germ cells were arrested at the pachytene stage of the meiosis and no mature sperm were detected in epididymides. …”
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Differentiation of Human Wharton\'s jelly Mesenchymal Stem Cells into Oocyte-like Cells by Follicular Fluid by Mona Zolfaghar, Rouhollah Fathi, Tahereh Naji

“…Wharton's jelly mesenchymal stem cells (WJ-MSCs) have a same differentiation origin with primordial germ cells, therefore, WJ-MSCs could differentiate into oocyte-like cells (OLCs) in the presence of appropriate factors. …”
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miR-301a-5p Regulates <i>TGFB2</i> during Chicken Spermatogenesis by Qixin Guo, Yong Jiang, Hao Bai, Guohong Chen, Guobin Chang

“…Next-generation sequencing was conducted to determine miRNA expression profiles in five cell types: primordial germ cells (PGCs), spermatogonial stem cells (SSCs), spermatogonia (Spa), and chicken sperm. …”
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Spermatogenesis in the giant anteater (Myrmecophaga tridactyla) by Lilja Fromme, Débora Regina Yogui, Mario Henrique Alves, Arnaud Léonard Jean Desbiez, Marion Langeheine, André Luis Quagliatto Santos, Ursula Siebert, Ralph Brehm

“…Nevertheless, little is known on reproductive features in male giant anteaters and, in this regard, microscopic testis morphology and spermatogenesis were studied in roadkill specimens in Brazil. Characteristics of germ cell populations resembled descriptions in other eutherian mammals including other xenarthran species. …”
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Multiple roles of apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B) in human tumors: a pan-cancer analysis by Jiacheng Wu, Ni Li, Linwen Zhu, Dawei Zhen, Mengqi Li, Hang Chen, Mengmeng Ye, Yiqin Wei, Guofeng Shao

“…The high-frequency APOBEC3B changes were principally mutations and amplifications in some tumors, such as uterine corpus endometrial carcinomas or cutaneous melanomas. In testicular germ cell tumors and invasive breast carcinomas, APOBEC3B expression and CD8+ T lymphocyte counts were correlated. …”
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Abdominal tumors in children: A comprehensive study on the diagnosis, management, and clinical outcome of pediatric patients with lymphoma in Kashmir by Zahida Akhtar, Zahid Kaleem, Showkat Majeed Kakroo

“…There are several types of abdominal tumors in pediatric age group which include neuroblastoma, Wilm’s tumor, hepatoblastoma, lymphomas, soft-tissue sarcomas, and germ cell tumors. Aims and Objectives: The present study was objectively conducted to identify Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) tumors among all patients presented with abdominal tumors. …”
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The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots by Shenli Yuan, Tao Huang, Ziyou Bao, Shiyu Wang, Xinyue Wu, Jiang Liu, Hongbin Liu, Zi-Jiang Chen

“…Interestingly, ectopic expression of the germ-cell-specific protein ZCWPW1 in human somatic cells enhances double-strand break repair via homologous recombination. …”
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Single‐cell mRNA sequencing of giant panda (Ailuropoda melanoleuca) seminoma reveals the cellular and molecular characteristics of tumour cells by Chen Yijiao, An Junhui, Hou Rong, Liu Yuliang, Wang Donghui, Liu Songrui, Feng Tongying

“…Single‐cell mRNA sequence was applied to characterise cellular states and molecular circuitries of giant panda testicular seminoma. Only germ cell markers expressed in nearly all tumour cells, and the tumour cells appeared to be the same subtype of seminoma cells. …”
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Rat Tumour Histopathology Associated with Experimental Chronic Dietary Exposure to Ochratoxin A in Prediction of the Mycotoxin’s Risk for Human Cancers by Diana Herman, Peter Mantle

“…Suggestion that OTA could cause human testicular cancer has also been challenged as unsupported by any experimental findings in rats, where the Leydig cell tumour immune profile does not match that of human germ cell neoplasms.…”
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Alkaline phosphatase in clinical practice in childhood: Focus on rickets by Giuseppe Cannalire, Simone Pilloni, Susanna Esposito, Giacomo Biasucci, Giacomo Biasucci, Anna Di Franco, Maria Elisabeth Street

“…ALP includes four isoenzymes depending on the site of tissue expression: intestinal ALP, placental ALP, germ cell ALP and tissue nonspecific ALP or liver/bone/kidney ALP. …”
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Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability by Ziqian Min, Huan Xin, Xiaowen Liu, Jingyu Wan, Ziling Fan, Xinxu Rao, Jiahui Fan, Lifang Yang, Dan Li

“…However, its role in male germ cell development has not been elucidated. Here, we confirm that CHD2 expression is enriched in the male germline. …”
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Epidemiology of thymomas and thymic carcinomas in the United States and Germany, 1999-2019 by Tiemo Sven Gerber, Stephanie Strobl, Alexander Marx, Wilfried Roth, Stefan Porubsky

“…For patients &lt;20 years, predominant tumors included germ cell tumors (42%/14%), lymphomas (38%/53%), and TETs (10%/27%). …”
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BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. by Daniel Nettersheim, Sina Jostes, Rakesh Sharma, Simon Schneider, Andrea Hofmann, Humberto J Ferreira, Per Hoffmann, Glen Kristiansen, Manel B Esteller, Hubert Schorle

“…Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. …”
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Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells by Tomlinson Craig R, Deng Dexin, White Kristina A, Heim Kelly C, Moore Jason H, Freemantle Sarah J, Spinella Michael J

“…We had previously shown that RIP140 limits RA induced tumor cell differentiation of embryonal carcinoma; the pluriopotent stem cells of testicular germ cell tumors. This implies that RIP140 represses key genes required for RA-mediated tumor cell differentiation. …”
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Isochromosome 12p Formation Regulates Vitamin D Metabolism in Testicular Cancer by Peter Törzsök, Jasper Van Goubergen, Martin Pichler, Renate Pichler, Frédéric R. Santer

“…RNAseq analysis of Vitamin D receptor (VDR) genes from the TCGA cohort revealed that clustering of VDR expression signatures could differentiate between pure seminomas and non-seminomatous germ cell tumors (NSGCT). Using TCGA mRNA expression of anabolic (CYP2R1, CYP27A1 and CYP27B1) and catabolic (CYP24A1) Vitamin D enzymes, positive (PTHLH, IFNG, and TNF) and negative (FGF23) feedback regulators could also clearly distinguish between pure seminomas and NSGCT. …”
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