Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on <i>Caenorhabditis elegans</i> by Chengcheng Pei, Lingyan Sun, Yanan Zhao, Shenyao Ni, Yaguang Nie, Lijun Wu, An Xu

“…In this study, we explored the joint toxicity of concurrent exposure to Cd and different As species at low concentrations on <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) in comparison to single exposures. Endpoints such as germ cell apoptosis, the number of oocytes, brood size, and the life span were employed to evaluate the combined effects of Cd and As on exposed <i>C. elegans</i> from L3 or L4 stages. …”
Get full text

Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation by Tomonori KAMEDA, Hideyuki NAKASHIMA, Takumi TAKIZAWA, Fumihito MIURA, Takashi ITO, Kinichi NAKASHIMA, Takuya IMAMURA

“…Since the different requirements of DNMTs for germ cell and embryonic development are known, our findings also have considerable implications for future studies on epigenomics in the field of reproductive biology.…”
Get full text

AN ASSESSMENT STUDY OF GROWTH PERFORMANCE AND GONADS DEVELOPMENT OF MONO SEX NILE TILAPIA IN DIFFERENT AGE STAGES DURING THE PRODUCTION PERIOD by Sara El-Nahal, M. Amer, M. Osman, T. Ali

“…As fish reached 4-5 months, male start to recover their testes normal structures and at age of 5.5-6 months, testicular sections appeared normally as pointed out by firmed testicular lobules, existence of all germ cell types and the intensively stored spermatozoa in testicular lumen and testicular ducts, confirming the full maturity of males. …”
Get full text

Subclinical Arteriosclerosis is Associated with Common Vascular Risk Factors in Long-Term Survivors of Testicular Cancer by Javier Espíldora-Hernández, Tania Díaz-Antonio, Javier Baena-Espinar, Inmaculada Alonso-Calderón, José Rioja, Emilio Alba-Conejo, Pedro Valdivielso, Miguel-Ángel Sánchez-Chaparro

“…This was a cross-sectional, observational, case–control study including 50 survivors of Germ Cell Tumor (GCT) (14 years of follow-up) and 53 age-matched controls with no cancer. …”
Get full text

Late presentation of Swyer syndrome: A case report by Swasti Pathak, MD, Gaurav Raj, MD, Rishabh Pratap, MD, Shivam Singh, MD

“…Early diagnosis is crucial in these patients since prophylactic gonadectomy reduces the risk of developing germ cell tumor.…”
Get full text

Establishment of an oligoasthenospermia mouse model based on TAp73 gene suppression by Hong‐Juan Liu, Meng‐Yun Deng, Yan‐Yan Zhu, De‐Ling Wu, Xiao‐Hui Tong, Li Li, Lei Wang, Fei Xu, Tong‐Sheng Wang

“…TAp73 is a critical regulator of the adhesin of germ cell; thus, we sought to explore a novel oligoasthenospermia model based on TAp73 gene suppression. …”
Get full text

A comparative evaluation of semen parameters in pre- and post-Hurricane Katrina human population by Caner Baran, Wayne J Hellstrom, Suresh C Sikka

“…There were significant differences in motility, morphology, number of white blood cell, immature germ cell count, pH and presence of sperm agglutination, but surprisingly there were no significant differences in sperm count between the two populations. …”
Get full text

The effect of hydroalcoholic extract of Cichorium intybus leaf on aryl hydrocarbon receptor expression in the testis of Wistar rats exposed to cigarette smoke by Maryam Hashemi, Mahnaz Azarnia, Zahra Hajebrahimi, Samad Nejad Ebrahimi

“…Oxidative stress caused by excessive ROS eventually leads to germ cell apoptosis and male infertility. The leaves of Cichorium intybus (chicory) are rich in natural antioxidants, but their protective effects on the adverse effects of CS on testicular tissue have not been studied.Materials and Methods: 24 Wistar rats were classified into four groups: control, extract: treatment with chicory extract (200 mg/kg body weight/day) for 13 weeks, smoke: exposed to CS for 13 weeks, and smoke + extract: exposed to CS and treated with the C. intybus extract. …”
Get full text

Cumulus cells steroidogenesis is influenced by the degree of oocyte maturation by Barboni Barbara, Turriani Maura, Bernabò Nicola, Lucidi Pia, Mattioli Mauro

“…<p>Abstract</p> <p>Background</p> <p>The possibility to predict the ability of a germ cell to properly sustain embryo development in vitro or in vivo as early as possible is undoubtedly the main problem of reproductive technologies. …”
Get full text

Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway by Qihui Luo, Yifan Li, Chao Huang, Dongjing Cheng, Wenjing Ma, Yu Xia, Wentao Liu, Zhengli Chen

“…Here, our research shows that obesity resulted in spermatogenic degeneration, imbalance of reproductive hormone, testicular oxidative stress and germ cell apoptosis, whereas evidently recovery effects were observed at 150 and 450 mg/kg SIF. …”
Get full text

Signaling pathways in brain tumors and therapeutic interventions by Shenglan Li, Can Wang, Jinyi Chen, Yanjie Lan, Weichunbai Zhang, Zhuang Kang, Yi Zheng, Rong Zhang, Jianyu Yu, Wenbin Li

“…Nonetheless, the reduced response rates and unavoidable drug resistance of currently available treatment approaches have become a barrier to further improvement in brain tumor (glioma, meningioma, CNS germ cell tumors, and CNS lymphoma) treatment. Previous literature data revealed that several different signaling pathways are dysregulated in brain tumor. …”
Get full text

Wnt signaling blockade is essential for maintaining the pluripotency of chicken embryonic stem cells by Ryota Kajihara, Ryo Ezaki, Kennosuke Ichikawa, Tenkai Watanabe, Takumi Terada, Mei Matsuzaki, Hiroyuki Horiuchi

“…When the glycogen synthase kinase-3 β inhibitor CHIR99021—which activates Wnt signaling—was added to chESC cultures, the colony shape flattened, and the expression levels of pluripotency-related (NANOG, SOX2, SOX3, OCT4, LIN28A, DNMT3B, and PRDM14) and germ cell (CVH and DAZL) markers showed a decreasing trend, and the growth of chESCs was inhibited after approximately 7 d. …”
Get full text

Clinical significance of assessing autoantibody level in diagnostics of early and late fetal growth retardation by I. V. Ignatko, D. I. Yakubova, A. D. Megrabyan, E. V. Timokhina

“…All patients underwent venous blood sampling to determine the serum autoimmune AB level against 12 human self-antigens using the ELI-P-Test: for human chorionic gonadotropin antigen (hCG), DNA, β2-glycoprotein (β2-GP), collagen, fragment crystallizable of immunoglobulin G (Fc-IgG), insulin, thyroglobulin, S100 protein, surface antigen of germ cell and prostate (Spr), thrombocyte membrane protein (TrM), antineutrophil cytoplasmic antibodies (ANCA), and membrane antigen of glomerular cells (KiMS). …”
Get full text

Generation and Utilization of a Monoclonal Antibody against Hepatitis B Virus Core Protein for a Comprehensive Interactome Analysis by Yusuke Nakai, Kei Miyakawa, Yutaro Yamaoka, Yasuyoshi Hatayama, Mayuko Nishi, Hidefumi Suzuki, Hirokazu Kimura, Hidehisa Takahashi, Yayoi Kimura, Akihide Ryo

“…HBc antigen was produced with a wheat germ cell-free protein synthesis system and used to immunize mice. …”
Get full text

The Embryonic Key Pluripotent Factor NANOG Mediates Glioblastoma Cell Migration via the SDF1/CXCR4 Pathway by Ana Virginia Sánchez-Sánchez, Antonio García-España, Pilar Sánchez-Gómez, Jaime Font-de-Mora, Marián Merino, José Luis Mullor

“…We previously showed in medaka fish that Nanog regulates primordial germ cell migration through Cxcr4b, a chemokine receptor known for its ability to promote migration and metastasis in human cancers. …”
Get full text

FABP9 Mutations Are Not Detected in Cases of Infertility due to Sperm Morphological Defects in Iranian Men by Javad Jamshidi, Farkhondeh Pouresmaeili, Hossein Darvish, Mir Davood Omrani, Eznollah Azargashb, Mohammad Reza Sadeghi, Niknam Lakpour

“…FABP9/PERF15 (Perforatorial15) is the male germ cell-specific fatty acid-binding pro- tein. It was first identified as the major constituent of the murine sperm perforatorium and perinuclear theca. …”
Get full text

Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny by David G. Valcarce, Marta F. Riesco, Leyre Cuesta-Martín, Anna Esteve-Codina, Juan Manuel Martínez-Vázquez, Vanesa Robles

“…Histological analysis of the testicle did not show significant differences in terms of the relative proportions of each germ-cell type; however, the quality of sperm from stressed males was compromised in terms of motility. …”
Get full text

Clinical outcomes and genotype-phenotype correlations in patients with complete and partial androgen insensitivity syndromes by Nae-yun Lee, Ja Hye Kim, Ji-Hee Yoon, Soojin Hwang, Gu-Hwan Kim, Han-Wook Yoo, Jin-Ho Choi

“…One patient with CAIS manifested a mixed germ cell tumor at the age of 30 years. Molecular analysis of AR identified 19 sequence variants; 12 (63%) were previously reported, and the remaining 7 (37%) were novel. …”
Get full text

Extracellular Localisation of the C-Terminus of DDX4 Confirmed by Immunocytochemistry and Fluorescence-Activated Cell Sorting by Yvonne L. Clarkson, Emma Weatherall, Martin Waterfall, Marie McLaughlin, Haojiang Lu, Paul A. Skehel, Richard A. Anderson, Evelyn E. Telfer

“…DDX4 has been reported to be germ cell specific within the gonads and localised intracellularly. …”
Get full text

The consequences of tetraploidy on Caenorhabditis elegans physiology and sensitivity to chemotherapeutics by Kelly R. Misare, Elizabeth A. Ampolini, Hyland C. Gonzalez, Kaitlan A. Sullivan, Xin Li, Camille Miller, Bintou Sosseh, Jaclyn B. Dunne, Christina Voelkel-Johnson, Kacy L. Gordon, Jessica H. Hartman

“…We investigated the reproductive defect further, determining that tetraploid worms have a shorter overall germline length, a higher rate of germ cell apoptosis, more aneuploidy in oocytes and offspring, and larger oocytes and embryos. …”
Get full text