Personal experience in intramedullary lesions, in adults by G. Iacob

“…Several histologic entities were recorded: ependymomas - 12 cases, astrocytomas - 8 cases, hemangioblastomas - 3 cases, cavernomas - 6 cases, metastases - 2 cases, germ cell tumour - 1 case, malignant peripheral nerve sheath tumour - 1 case. …”
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Differential Proliferation Effects After Short-Term Cultivation Of Mouse Spermatogonial Stem Cells On Different Feeder Layers by Hossein Azizi, Hatef Ghasemi Hamidabadi, Thomas Skutella

“…The mRNA expression of germ cells and somatic cells were analyzed. Results In our study, we observed a significant difference in the proliferation rates and colony size of SSCs among the groups, especially for MEFs (P<0.05). …”
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Achievement of complete in vitro spermatogenesis in testicular tissues from prepubertal mice exposed to mono- or polychemotherapy by Marion Delessard, Laura Stalin, Aurélie Rives-Feraille, Laura Moutard, Justine Saulnier, Ludovic Dumont, Nathalie Rives, Christine Rondanino

“…These alterations were also found in the testicular tissues of polychemotherapy-treated mice after 30 days of organotypic culture and were associated with a reduction in the germ cell/Sertoli cell ratio. The different treatments neither altered the ability of spermatogonia to differentiate in vitro into spermatozoa nor the yield of in vitro spermatogenesis. …”
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Propolis Protects GC-1spg Spermatogonial Cells against Tert-Butyl Hydroperoxide-Induced Oxidative Damage by Filipa Duarte, Mariana Feijó, Ângelo Luís, Sílvia Socorro, Cláudio J. Maia, Sara Correia

“…Oxidative stress disrupts germ cell development and sperm function, with demonstrated harmful effects on male reproduction. …”
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Myoid gonadal stromal tumor of the testis—the novel subtype of testicular gonadal stromal tumors: a case report and review of the literature by Klaus-Peter Dieckmann, Lars Tharun, Markus Angerer, Alexander Harms, Christian Wülfing

“…Myoid gonadal stromal tumor is not much different from other subtypes of gonadal stromal tumors nor from testicular gem cell tumors regarding age and laterality; however, tumor size is smaller in myoid gonadal stromal tumors than in germ cell tumors. Although rarely performed so far, testis-sparing surgery probably constitutes an appropriate treatment of this neoplasm. …”
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Markers of stem cells in human ovarian granulosa cells: is there a clinical significance in ART? by Varras Michail, Griva Theodora, Kalles Vasileios, Akrivis Christodoulos, Paparisteidis Nikolaos

“…</p> <p>Conclusions</p> <p>Expression of OCT-4 mRNA, which is a typical stem cell marker and absence of expression of DAZL mRNA, which is a typical germ cell marker, suggest that a subpopulation of luteinized granulosa cells in healthy ovarian follicles (47.6%) consists of stem cells, which are not originated from primordial germ cells. …”
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Personal experience in intramedullary lesions, in adults by G. Iacob

“…Several histologic entities were recorded: ependymomas - 12 cases, astrocytomas - 8 cases, hemangioblastomas - 3 cases, cavernomas - 6 cases, metastases - 2 cases, germ cell tumour - 1 case, malignant peripheral nerve sheath tumour - 1 case. …”
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Single-course bleomycin, etoposide, and cisplatin (1xBEP) as adjuvant treatment in testicular nonseminoma clinical stage 1: outcome, safety, and risk factors for relapse in a popul... by Klaus-Peter Dieckmann, Tomas Pokrivcak, Lajos Geczi, David Niehaus, Inken Dralle-Filiz, Cord Matthies, Tamas Dienes, Stefanie Zschäbitz, Pia Paffenholz, Tanja Gschliesser, Renate Pichler, Michal Mego, Pia Bader, Friedemann Zengerling, Julia Heinzelbecker, Philipp Krausewitz, Susanne Krege, Gaetano Aurilio, Cem Aksoy, Marcus Hentrich, Christoph Seidel, Péter Törzsök, Tim Nestler, Matthaeus Majewski, Andreas Hiester, Tomas Buchler, Sonia Vallet, Hana Studentova, Sandra Schönburg, Dora Niedersüß-Beke, Julia Ring, Emanuela Trenti, Axel Heidenreich, Christian Wülfing, Hendrik Isbarn, Uwe Pichlmeier, Martin Pichler

“…Introduction: Clinical stage 1 (CS1) nonseminomatous (NS) germ cell tumors involve a 30% probability of relapse upon surveillance. …”
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Profiling mitochondria-polyribosome lncRNAs associated with pluripotency by Lei Zhou, Hui Li, Tingge Sun, Xue Wen, Chao Niu, Min Li, Wei Li, Miguel A. Esteban, Andrew R. Hoffman, Ji-Fan Hu, Jiuwei Cui

“…In conjunction with the total RNA-seq data, this dataset provides a valuable resource to examine the role of lncRNAs in pluripotency, particularly for studies investigating the inter-organelle crosstalk network involved in germ cell development and human reproduction.…”
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DEAD-Box Helicase 4 (Ddx4)⁺ Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers by Stella D’Oronzo, Erica Silvestris, Domenica Lovero, Paola Cafforio, Loren Duda, Gennaro Cormio, Angelo Paradiso, Raffaele Palmirotta, Franco Silvestris

“…This effect was primarily induced by ML-cells deriving from advanced NS-EOC, suggesting that a tumor-conditioned germ cell niche inhabits its microenvironment and is able to modulate, in a paracrine manner, tumor cell behavior through transcriptome modulation.…”
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Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy by Anke Tropitzsch, Marcus Müller, François Paquet-Durand, Frank Mayer, Hans-Georg Kopp, Andre Schrattenholz, Andrea Müller, Hubert Löwenheim

“…In some scenarios, such as treatment of germ cell tumors or adjuvant therapy of non-small cell lung cancer, cisplatin cannot be replaced without undue loss of efficacy. …”
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Evaluation of the protective effect of Omega-7 against Methotrexate Genotoxicity in bone marrow Cells of Mice by Zahraa Hasani, Ali F. Hassan

“…In contrast, damage to a germ cell (germline mutation) may result in a heritable changed characteristic.Omega-7 is a non-essential monounsaturated free fatty acid with anti-inflammatory, anti-obesity, and antidiabetic effects. …”
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Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification by Sivakamasundari Vijayakumar, Roberta Sala, Gugene Kang, Angela Chen, Michelle Ann Pablo, Abidemi Ismail Adebayo, Andrea Cipriano, Jonas L. Fowler, Danielle L. Gomes, Lay Teng Ang, Kyle M. Loh, Vittorio Sebastiano

“…Abstract Generating primordial germ cell-like cells (PGCLCs) from human pluripotent stem cells (hPSCs) advances studies of human reproduction and development of infertility treatments, but often entails complex 3D aggregates. …”
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Molecular characterization and expression of the feminization-1c (fem-1c) in the freshwater mussel (Hyriopsis cumingii) by Yayu Wang, Congdi Wu, Pengfei Guo, Guiling Wang, Jiale Li

“…During early development of the gonads, Hcfem-1c transcripts were significantly increased in the primordial germ cell differentiation stage (5 months old). We hypothesized that Hcfem-1c probably regulates female gonad differentiation. …”
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The Effect of miR-106b-5p Expression in The Production of iPS-Like Cells from Mice SSCs during The Formation of Teratoma and The Three Embryonic Layers by Amir Hossein Hasani Fard, Fatemeh Kamalipour, Zohreh Mazaheri, Seyed Jalil Hosseini

“…Although these iPS-like cells are pluripotent, they cannot form palpable tumors in vivo.Conclusion: These results demonstrate that infection of hsa-mir-106b-5p into SSCs can reprogram them into iPSCsand advanced germ cell lineages without tumorigenicity. Also, a novel approach for studying the generation of iPSCsand the application of iPS or iPS-like cells in regenerative medicine is presented.…”
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Reproductive Cycle and Sexual Group Maturity of <i>Buccinum osagawai</i> (Neogastropoda: Buccinidae) by Jung Jun Park, Hyeon Jin Kim, So Ryung Shin, Young Guk Jin, Jae Won Kim, Jung Sick Lee

“…The spermatocyte development pattern was group-synchronous, in which multiple stages of germ cell populations were simultaneously identified within the same spermatogenic acinus. …”
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Presentation and treatment of two cases of malignant struma ovarii by Rawan A. Obeidat, Sakhr Alshwayyat, Tala Abdulsalam Alshwayyat, Anwar Rjoop, Qosay Mahmoud Sharqiah

“…Abstract Background Malignant Struma Ovarii (MSO) is a rare type of germ cell tumour which is diagnosed postoperatively on surgical pathology specimens by the presence of differentiated thyroid cancer in mature cystic teratomas in the ovaries. …”
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High prevalence of p16 staining in malignant tumors. by Noémi De Wispelaere, Sebastian Dwertmann Rico, Marcus Bauer, Andreas M Luebke, Martina Kluth, Franziska Büscheck, Claudia Hube-Magg, Doris Höflmayer, Natalia Gorbokon, Sören Weidemann, Katharina Möller, Christoph Fraune, Christian Bernreuther, Ronald Simon, Christian Kähler, Anne Menz, Andrea Hinsch, Frank Jacobsen, Patrick Lebok, Till Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Stefan Steurer, Eike Burandt, Rainer Krech, David Dum, Till Krech, Andreas Marx, Sarah Minner

“…Comparison with clinico-pathological data in 128 vulvar, 149 endometrial, 295 serous ovarian, 396 pancreatic, 1365 colorectal, 284 gastric, and 1245 urinary bladder cancers, 910 breast carcinomas, 620 clear cell renal cell carcinomas, and 414 testicular germ cell tumors revealed only few statistically significant associations. …”
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Cancer incidence among patients attending a tertiary care cancer hospital in central India – A retrospective study by Kunal Peepre, Haritha VS, Yogesh Tiwari

“…Less commonly reported cancers were that of urethral, adrenal, germ cell tumors, and choriocarcinoma followed by that of eye and ear. …”
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The Safety of Chemotherapy for Ovarian Malignancy during Pregnancy by Naidong Xing, Lihui Wang, Xinlei Sui, Chunru Zhao, Yan Huang, Jin Peng

“…Results: In total, 100 pregnant patients complicated with ovarian malignancy were investigated and classified into three groups: 34 cases in the epithelial ovarian cancer (EOC) group, 38 cases in the germ cell tumors (GCTs) group and 28 cases in the sex cord-stromal tumors (SCSTs) group. …”
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