Chemical peritonitis resulting from spontaneous rupture of a mature ovarian cystic teratoma: a case report by Diana Bužinskienė, Matas Mongirdas, Saulius Mikėnas, Gražina Drąsutienė, Linas Andreika, Indrė Sakalauskaitė

“…Mature cystic teratomas (dermoid cysts) are the most common germ cell tumours with 10–25% incidence of adult and 50% of paediatric ovarian tumours. …”
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Identification of cell-type specific alternative transcripts in the multicellular alga Volvox carteri by Ravi Nicholas Balasubramanian, Minglu Gao, James Umen

“…Finally, we interrogated cell type expression patterns of 126 V. carteri predicted RNA binding protein (RBP) encoding genes and found 40 that showed either somatic or germ cell expression bias. These RBPs are potential mediators of CTSAI in V. carteri and suggest possible pre-adaptation for cell type specific RNA processing and a potential path for generating CTSAI in the early ancestors of metazoans and plants. …”
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The First Report on the Transovarial Transmission of Microsporidian <i>Nosema bombycis</i> in Lepidopteran Crop Pests <i>Spodoptera litura</i> and <i>Helicoverpa armigera</i> by Boyan Pei, Chunxia Wang, Bin Yu, Dan Xia, Tian Li, Zeyang Zhou

“…IHA of both eggs manifested numerous spores and proliferative pathogens in the oocyte, confirming that <i>N. bombycis</i> can invade into the female germ cell from the parent body. After hatching of the infected eggs, we detected the infection in offspring larvae and found large quantities of proliferative pathogens, confirming that <i>N. bombycis</i> can transovarially transmit in <i>S. litura</i> and <i>H. armigera</i>, and probably persists in both pest populations via congenital infection. …”
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Rethinking fish biology and biotechnologies in the challenge era for burgeoning genome resources and strengthening food security by Jian-Fang Gui, Li Zhou, Xi-Yin Li

“…Moreover, five precision breeding biotechniques are examined and discussed in detail including gene editing for the introgression or removal of beneficial or detrimental alleles, use of sex-specific markers for the production of mono-sex populations, controllable primordial germ cell on-off strategy for producing sterile offspring, surrogate broodstock-based strategies to accelerate breeding, and genome incorporation and sexual reproduction regain-based approach to create synthetic polyploids. …”
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A Therapeutic Vaccine Targeting Rat BORIS (CTCFL) for the Treatment of Rat Breast Cancer Tumors by Dmitri Loukinov, Amanda Laust Anderson, Mikayel Mkrtichyan, Anahit Ghochikyan, Samuel Rivero-Hinojosa, Jo Tucker, Victor Lobanenkov, Michael G. Agadjanyan, Edward L. Nelson

“…We previously showed that an immunotherapeutic vaccine targeting the germ cell-specific transcription factor BORIS (CTCFL) was highly effective in treating aggressive breast cancer in the 4T1 mouse model. …”
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Progressive Resistance Training and Cancer Testis (PROTRACT) - Efficacy of resistance training on muscle function, morphology and inflammatory profile in testicular cancer patients... by Mackey Abigail L, Lindegaard Birgitte, Adamsen Lis, Andersen Jesper L, Christensen Jesper F, Nielsen Rie H, Rørth Mikael, Daugaard Gedske

“…<p>Abstract</p> <p>Background</p> <p>Standard treatment for patients with disseminated germ cell tumors is combination chemotherapy with bleomycin, etoposide and cisplatin (BEP). …”
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Biomaterials for Testicular Bioengineering: How far have we come and where do we have to go? by Bianca de Oliveira Horvath-Pereira, Gustavo Henrique Doná Rodrigues Almeida, Leandro Norberto da Silva Júnior, Pedro Gabriel do Nascimento, Bárbara de Oliveira Horvath Pereira, João Victor Barbosa Tenório Fireman, Maria Laura dos Reis Ferre Pereira, Ana Claudia Oliveira Carreira, Ana Claudia Oliveira Carreira, Maria Angelica Miglino

“…Traditional therapeutic interventions aim to restore male fertile potential or preserve sperm viability in severe cases, such as semen cryopreservation, testicular tissue, germ cell transplantation and testicular graft. However, these techniques demonstrate several methodological, clinical, and biological limitations, that impact in their results. …”
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Inherited Chromosomally Integrated Human Herpesvirus 6: Laboratory and Clinical Features by Liliana Gabrielli, Alice Balboni, Eva Caterina Borgatti, Giulio Virgili, Evangelia Petrisli, Alessia Cantiani, Matteo Pavoni, Federico Baiesi Pillastrini, Simona Venturoli, Giulia Piccirilli, Tiziana Lazzarotto

“…Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the chromosomes of the host germ cell and is vertically transmitted. The aims of this study were to identify iciHHV-6 prevalence in hospitalized patients and clinical features in individuals carrying this integration. …”
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<i>DAZL</i> Knockout Pigs as Recipients for Spermatogonial Stem Cell Transplantation by Nathalia L. M. Lara, Taylor Goldsmith, Paula Rodriguez-Villamil, Felipe Ongaratto, Staci Solin, Dennis Webster, Uyanga Ganbaatar, Shane Hodgson, Stanislas M. A. S. Corbière, Alla Bondareva, Daniel F. Carlson, Ina Dobrinski

“…Spermatogonial stem cell (SSC) transplantation into the testis of a germ cell (GC)-depleted surrogate allows transmission of donor genotype via donor-derived sperm produced by the recipient. …”
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Human obstructive (postvasectomy) and nonobstructive azoospermia – Insights from scRNA-Seq and transcriptome analysis by Shitao Chen, Geng An, Hanshu Wang, Xiaolong Wu, Ping Ping, Longfei Hu, Yunmei Chen, Jue Fan, C. Yan Cheng, Fei Sun

“…We found only somatic cells in the NOA samples and explored the transcriptional changes in Sertoli cells in response to a loss of interactions with germ cells. Moreover, we observed a germ cell population discrepancy between an OA (postvasectomy) patient and a healthy individual. …”
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Relapsed and refractory yolk sac tumor of the peritoneum (mesentery): A case report and literature review by Xue Zhou, Lanbo Zhao, Xue Feng, Zhenni Pan, Yadi Bin, Siyi Zhang, Min Li, Miao Guo, Huilian Hou, Qiling Li

“…Second-line therapy regimens and above, including VIP and TIP, improve the prognosis of recurrent germ cell tumors. This relapsed and refractory patient with peritoneal YST benefits from the secondary BEP´ chemotherapy.…”
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Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca by Maria Margareta Cosnarovici, Andra Piciu, Eduard-Alexandru Bonci, Marius-Ioan Bădan, Claudiu-Iulian Bădulescu, Andreea-Ioana Stefan, Alexandru Mester, Rodica Cosnarovici, Maria-Iulia Larg

“…The evaluated tumors included medulloblastomas (47 patients), astrocytomas (44 patients), ependymomas (22 patients), gliomas (20 patients), germ cell tumors (12 patients), primitive neuroectodermal tumors (4 patients), as well as other types of tumors (15 patients); in 20 of the cases, biopsy could not be performed. …”
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Retrospective Analysis of Postchemotheraphy Retroperitoneal Lymph Node Dissection (PC-RPLND) Results in Patients with Non-Seminomatous Testicular Cancers by Hasan Soydan, Ercan Malkoç, Sezgin Okçelik, Ömer Yılmaz, Ferhat Ateş, Furkan Dursun, Kenan Karademir, Temuçin Şenkul1

“…Materials and Methods Patients with advanced staged tumors and Non-seminomatous germ cells and having residual mass after chemotherapy whose tumor markers returned to normal were selected in the study. …”
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TBC1D21 Potentially Interacts with and Regulates Rap1 during Murine Spermatogenesis by Chih-Chun Ke, Ying-Hung Lin, Ya-Yun Wang, Ying-Yu Wu, Mei-Feng Chen, Wei-Chi Ku, Han-Sun Chiang, Tsung-Hsuan Lai

“…<i>TBC1D21</i> genes (also known as male germ cell RAB GTPase-activating protein MGCRABGAP) are related to sterility, as determined through cDNA microarray testing of human testicular tissues exhibiting spermatogenic defects. …”
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Analysis of gene expression levels and their impact on survival in 31 cancer-types patients identifies novel prognostic markers and suggests unexplored immunotherapy treatment opti... by Claudia Giampietri, Francesca Scatozza, Elena Crecca, Virginia Vigiano Benedetti, Pier Giorgio Natali, Antonio Facchiano

“…A 7-molecules profile was found to specifically discriminate melanoma patients from controls, while two different 6-molecules profiles discriminate pancreatic cancer patients and Testicular Germ Cell Tumors from matched controls. Highly significant survival improvement was found to be related to the expression levels of all nine ICRs in a wide spectrum of malignancies. …”
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Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics by Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton

“…Subsequent pairing of the heavy chain with a germline human kappa light chain serves to facilitate bispecific antibody production by increasing the efficiency of correct pairing.Abbreviations: AID: activation-induced cytidine deaminase; bsAb: bispecific antibody; CDR: complementarity-determining region; CL: light chain constant region; CmLC: common light chain; D: diversity region; ELISA: enzyme-linked immunosorbent assay; FACS: fluorescence-activated cell sorting; Fc: fragment crystallizable; FcRn: neonatal Fc receptor; FR: framework region; GEM: gel-encapsulated microenvironment; Ig: immunoglobulin; IMGT: the international ImMunoGeneTics information system®; J: joining region; KO: knockout; mAb: monoclonal antibody; NGS: next-generation sequencing; PBS: phosphate-buffered saline; PCR: polymerase chain reaction; PGC: primordial germ cell; PGRN: progranulin; TCR: T cell receptor; V: variable region; VK: kappa light chain variable region; VL: light chain variable region; VH: heavy chain variable region…”
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Effect of Malignancy on Semen Parameters by Guy Shrem, Liat Azani, Ido Feferkorn, Tamar Listovsky, Sofia Hussaini, Benjamin Farber, Michael H. Dahan, Mali Salmon-Divon

“…Linear regression models comparing the PG-Tx and ARL groups revealed that the maximum reduction in total motility and concentration was in men with germ-cell tumors, whereas the minimum reduction was in hematological tumors. …”
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Pregnant Women With Malignant Ovarian Tumors: A Case Series by Helena Azimi, Seyyed Rasoul Sajjadi, Shohreh Saeed, Maryam Nakhaee, Amir Hosein Jafarian, Behroouz Davachi, Arezoo Naderi Moghaddam, Toktam Dehghani, Zohreh Yousefi

“…According to the data analysis reports, subtype epithelial tumor and germ cell pathology were equally 45.4%. However, sex-cord tumors were observed in a smaller percentage of cases (9.1%). …”
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FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice by Rheannon O. Blücher, Rachel S. Lim, Ellen G. Jarred, Matthew E. Ritchie, Patrick S. Western

“…Results pERK1/2 was detected in Sertoli cells and inhibition of MEK1/2 reduced Sertoli cell proliferation and organisation and resulted in some germ cells localised outside of the testis cords. While pERK1/2 was not detected in germ cells, inhibition of MEK1/2 after somatic sex determination profoundly disrupted germ cell mitotic arrest, dysregulated a broad range of male germline development genes and prevented the upregulation of key male germline markers, DPPA4 and DNMT3L. …”
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A Novel in vitro Co-culture Systems on Differentiation of Embryonic Stem Cells into Oocyte-like Cells in an in vivo Manner by Ali Delbari, Maryam Nazm Bojnordi, Sina Mojaverrostami, Hatef Ghasemi Hamidabadi, Zahra Bagheri‑Hosseinabadi, Nourollah Rezaei

“…Co-culturing of EBs with our mentioned protocol increased germ cell markers (Stella and Mvh) and increased Oocyte-specific markers (ZP1, Figα and GDF9). …”
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