Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis by Mingyao Yang, Francisco Diaz, Ana Rita T. Krause, Yuguo Lei, Wan-Sheng Liu

“…Conversely, dKO males showed an 18% frequency of SCO tubules, increased apoptotic germ cells, and decreased undifferentiated spermatogonia compared to sKO and WT testes. …”
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Transcriptomic analysis of the differentiating ovary of the protogynous ricefield eel Monopterus albus by Jinfeng Cai, Wei Yang, Dong Chen, Yize Zhang, Zhi He, Weimin Zhang, Lihong Zhang

“…Conclusions The present study depicted the first large-scale RNA sequencing of the gonad of ricefield eel larvae, and identified many important functional genes, GO terms and KEGG pathways involved in gonadal development and germ cell meiosis. Results of the present study will facilitate future study on the ovarian differentiation of ricefield eels and other teleosts as well.…”
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Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors by Eirini Christodoulou, Venkata Yellapantula, Katrina O’Halloran, Liya Xu, Jesse L. Berry, Jennifer A. Cotter, Anya Zdanowicz, Leo Mascarenhas, James F. Amatruda, Dejerianne Ostrow, Moiz Bootwalla, Xiaowu Gai, Fariba Navid, Jaclyn A. Biegel

“…A total of 143 plasma samples were analyzed from 19 controls and 73 patients, including 44 bone or soft-tissue sarcomas and 12 renal, 10 germ cell, five hepatic, and two thyroid tumors. cfDNA was isolated from plasma collected at diagnosis, during and after therapy, and/or at relapse. …”
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Successful resection of growing teratoma syndrome in the abdominal wall with reconstruction using tensor fascia lata muscle flap: A case report and literature review by Miho Iwai, Kaori Yoriki, Kohei Aoyama, Yosuke Tarumi, Hisashi Kataoka, Tetsuya Kokabu, Toshiaki Numajiri, Taisuke Mori

“…While cancer cure is the primary goal, fertility preservation is also a cornerstone of the underlying principle of treatment for ovarian germ cell tumors. Growing teratoma syndrome (GTS) presents with growth of mature teratomas during or after chemotherapy. …”
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Repositioning Linagliptin for the Mitigation of Cadmium-Induced Testicular Dysfunction in Rats: Targeting HMGB1/TLR4/NLRP3 Axis and Autophagy by Hany H. Arab, Alzahraa A. Elhemiely, Azza A. K. El-Sheikh, Hana J. Al Khabbaz, El-Shaimaa A. Arafa, Ahmed M. Ashour, Ahmed M. Kabel, Ahmed H. Eid

“…The present findings revealed that linagliptin improved the histopathological lesions, including spermatogenesis impairment and germ cell loss. Moreover, it improved sperm count/motility and serum testosterone. …”
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Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy by Lingna Yi, Xue-Jun Shang, Linglu Lv, Yixiang Wang, Jingjing Zhang, Chao Quan, Yuqin Shi, Yunhao Liu, Ling Zhang

“…Cadmium causes damage to the male reproductive system via induction of germ-cell apoptosis; however, the underlying mechanism of cadmium-induced reproductive toxicity in Leydig cells remains unclear. …”
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The Fight Just Born—Neonatal Cancer: Rare Occurrence with a Favorable Outcome but Challenging Management by Maria Antonietta De Ioris, Francesco Fabozzi, Mariachiara Lodi, Giulia Vitali, Maria Debora De Pasquale, Giada Del Baldo, Rachid Abbas, Emanuele Agolini, Alessandro Crocoli, Chiara Iacusso, Giuseppe Maria Milano, Annalisa Serra, Angela Mastronuzzi

“…We describe the first Italian series over a 15-year period of patients affected by both benign and malignant neoplastic diseases diagnosed within the first 28 days of life; 74 newborns were diagnosed with neonatal tumors, representing 1.5% of the cancer population in the same period, and a prevalence of germ cell tumors (55%) and neuroblastoma (16%) was observed. …”
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Mutation of S461, in the GOLGA3 phosphorylation site, does not affect mouse spermatogenesis by Changtong Xu, Mingcong Zhu, Shuqin Zhao, Xin Zhang, Ying Wang, Mingxi Liu

“…Histological and immunofluorescence staining were used to analyze testis and epididymis phenotypes and TUNEL assays were used to measure germ cell apoptosis in spermatogenic tubules. Results Immunofluorescence co-localization showed reduced Golgi localization of GOLGA3S465L with some protein scattered in the cytoplasm of HeLa cells .In addition, protein dephosphorylation experiments indicated a reduced band shift of the dephosphorylated GOLGA3S465L, confirming S461 as the phosphorylation site. …”
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Epigenetic Factors and ncRNAs in Testicular Cancer by David Nuñez-Corona, Estefania Contreras-Sanzón, Jonathan Puente-Rivera, Rodrigo Arreola, Minerva Camacho-Nuez, José Cruz Santiago, Edgar Antonio Estrella-Parra, Julio César Torres-Romero, César López-Camarillo, María Elizbeth Alvarez-Sánchez

“…Epigenetics may also offer critical insights for prognostic evaluation and targeted therapies in patients with testicular germ cell tumors (TGCT). This comprehensive review aims to present the latest discoveries regarding the involvement of some proteins and ncRNAs, mainly miRNAs and lncRNA, in the epigenetic aspect of testicular cancer, emphasizing their relevance in pathogenesis and their potential, given the fact that their specific expression holds promise for prognostic evaluation and targeted therapies.…”
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Cloning and Expression Profiling of the Gene <i>vasa</i> during First Annual Gonadal Development of Cobia (<i>Rachycentron canadum</i>) by Qian Ma, Jiehua Kuang, Gang Chen, Jiandong Zhang, Jiansheng Huang, Feifan Mao, Qiling Zhou

“…The <i>vasa</i> gene is essential for germ cell development and gametogenesis both in vertebrates and in invertebrates. …”
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دور المستويات المصلية لـ CA125 في التمييز بين أورام المبيض السليمة والخبيثة by ميسون ديوب

“…. • The commonest tumors were epithelial in origin followed by the germ cell tumors followed by sex cord stromal tumors and metastatic tumors. • In benign tumorsCa125≥35u/ml was more frequently with endometriosis followed by serous tumors . and in malignant tumors was more frequently with serous tumors followed by mucinous tumors. • The highest sensitivity of ca125 level was in prediction postmenopausal benign tumors but with low specificity followed by prediction postmenopausal malignant tumors with high specificity. • The quality of the test was higher in postmenopausal benign/ malignant tumors compared to premenopausal tumors. …”
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Management of Dermoid Cysts in Pregnancy at a Tertiary Care Centre: A Retrospective Observational Study by Tamma Anusha Reddy, SL Arathy RaJ, Minakshi Kumari, Swati Rathore, K Beena

“…Dermoid cysts are the most common type of ovarian germ cell tumour in pregnancy. Most of them are asymptomatic and are incidental findings. …”
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Establishment of a <i>Coilia nasus</i> Gonadal Somatic Cell Line Capable of Sperm Induction <i>In Vitro</i> by Yuting Kan, Ying Zhong, Muhammad Jawad, Xiao Chen, Dong Liu, Mingchun Ren, Gangchun Xu, Lang Gui, Mingyou Li

“…RT-PCR results revealed that the CnGSC expressed some somatic cell markers such as <i>clu</i>, <i>fshr</i>, <i>hsd3β,</i> and <i>sox9b</i> instead of germ cell markers like <i>dazl</i>, <i>piwi,</i> and <i>vasa</i>. …”
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دور المستويات المصلية لـ CA125 في التمييز بين أورام المبيض السليمة والخبيثة by ميسون ديوب

“…. • The commonest tumors were epithelial in origin followed by the germ cell tumors followed by sex cord stromal tumors and metastatic tumors. • In benign tumorsCa125≥35u/ml was more frequently with endometriosis followed by serous tumors . and in malignant tumors was more frequently with serous tumors followed by mucinous tumors. • The highest sensitivity of ca125 level was in prediction postmenopausal benign tumors but with low specificity followed by prediction postmenopausal malignant tumors with high specificity. • The quality of the test was higher in postmenopausal benign/ malignant tumors compared to premenopausal tumors. …”
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Characterization and expression analysis of sox3 in medaka gonads by Quan Pu, Yuan Ma, Ying Zhong, Jing Guo, Lang Gui, Mingyou Li

“…In this study, medaka sox3 was isolated and its expression patterns were compared with germ cell gene vasa in adult gonads. By reverse transcription-polymerase chain reaction (RT-PCR) analysis, sox3 RNA expression was detected in the brain, eyes and gonads. …”
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The transcriptome of Icerya aegyptiaca (Hemiptera: Monophlebidae) and comparison with neococcoids reveal genetic clues of evolution in the scale insects by Xue-Fei Tang, Yu-Hao Huang, Yi-Fei Sun, Pei-Fang Zhang, Li-Zhi Huo, Hao-Sen Li, Hong Pang

“…Meanwhile, genes related to DNA repair, mitosis, spindle, cytokinesis and oogenesis, were included in the selected genes in I. aegyptiaca, which is possibly associated with cell division and germ cell formation of the hermaphrodite system. Chromatin-related process were enriched from selected genes in neococcoids, along with some mitosis-related genes also detected, which may be related to their unique PGE system. …”
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Evolutionary and Expression Analysis of <i>MOV10</i> and <i>MOV10L1</i> Reveals Their Origin, Duplication and Divergence by Shuaiqi Yang, Xiangmin Zhang, Xianpeng Li, Xiu Yin, Lei Teng, Guangdong Ji, Hongyan Li

“…In mammals, MOV10 and MOV10L1 participate in various kinds of biological contexts, such as defense of RNA virus invasion, neuron system, germ cell and early development. However, <i>mov10</i> and <i>mov10l1</i> in zebrafish are obscure and the evolutionary relationships of <i>mov10</i> among different species remain unclear. …”
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Investigating the molecular mechanism of sterility in female triploid Pacific oyster (Crassostrea gigas) by Enshuo Zhang, Zan Li, Bin Li, Jingjing Fu, Yanwei Feng, Guohua Sun, Xiaohui Xu, Cuiju Cui, Weijun Wang, Jianmin Yang

“…The main cause of sterility is the suppression of the expression of genes that control the process of germ cell proliferation, the failure of the mitotic cycle to proceed smoothly, and the inability to produce an oogonium. …”
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Characterization of a Preclinical In Vitro Model Derived from a SMARCA4-Mutated Sinonasal Teratocarcinosarcoma by Sara Lucila Lorenzo-Guerra, Helena Codina-Martínez, Laura Suárez-Fernández, Virginia N. Cabal, Rocío García-Marín, Cristina Riobello, Blanca Vivanco, Verónica Blanco-Lorenzo, Paula Sánchez-Fernández, Fernando López, Jóse Luis Llorente, Mario A. Hermsen

“…Sinonasal teratocarcinosarcoma (TCS) is a rare tumor that displays a variable histology with admixtures of epithelial, mesenchymal, neuroendocrine and germ cell elements. Facing a very poor prognosis, patients with TCS are in need of new options for treatment. …”
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The CDK Inhibitor Dinaciclib Improves Cisplatin Response in Nonseminomatous Testicular Cancer: A Preclinical Study by Elisa Rossini, Mariangela Tamburello, Andrea Abate, Silvia Zini, Giovanni Ribaudo, Alessandra Gianoncelli, Stefano Calza, Francesca Valcamonico, Nazareno R. Suardi, Giuseppe Mirabella, Alfredo Berruti, Sandra Sigala

“…Background: Most patients with testicular germ cell tumors (GCTs) are treated with cisplatin (CP)-based chemotherapy. …”
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