RWP-RK Domain 3 (OsRKD3) induces somatic embryogenesis in black rice by Purwestri, Yekti Asih, Lee, Yang‑Seok, Meehan, Cathal, Mose, Windi, Susanto, Febri Adi, Wijayanti, Putri, Fauzia, Anisa Nazera, Nuringtyas, Tri Rini, Hussain, Nosheen, Putra, Hadi Lanang, Gutierrez-Marcos, Jose

“…Recent studies have revealed that a discrete group of RWP-RK DOMAIN-CONTAINING PROTEIN (RKD) transcription factors act as key regulators of germ cell differentiation and embryo development in land plants. …”
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The role of SNPs in the management of cancer in the broader population by Kitchen-Smith, I

“…</p> <p>In Chapter Two, we experimentally model a SNP found in a p53 response element which associates with Testicular Germ Cell Tumours with one of the highest odds ratios identified for a cancer-risk SNP to date. …”

Essays on Developmental Biology. by Wassarman, Paul M., editor

Characterization and expression analysis of gonad specific igf3 in the medaka ovary by Jiale Xie, Ying Zhong, Yuli Zhao, Wenjie Xie, Jing Guo, Lang Gui, Mingyou Li

“…Collectively, we demonstrated that gonad specific igf3 could mark medaka ovarian somatic cells and germ cells. These findings highlight the importance of igf3 during ovarian development.…”
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A Negative Body Image among Adolescent and Young Adult (AYA) Cancer Survivors: Results from the Population-Based SURVAYA Study by Laura M. H. Saris, Carla Vlooswijk, Suzanne E. J. Kaal, Janine Nuver, Rhodé M. Bijlsma, Tom van der Hulle, Mathilde C. M. Kouwenhoven, Jacqueline M. Tromp, Roy I. Lalisang, Monique E. M. M. Bos, Winette T. A. van der Graaf, Olga Husson

“…Specifically, AYAs who are female, have a higher Body Mass Index (BMI) or tumor stage, diagnosed with breast cancer, cancer of the female genitalia, or germ cell tumors, treated with chemotherapy, using more maladaptive coping strategies, feeling sexually unattractive, and having lower scores of health-related Quality of Life (HRQoL), were more likely to experience a negative body image. …”
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Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers by Fatima Domenica Elisa De Palma, Vincent Carbonnier, Francesco Salvatore, Guido Kroemer, Jonathan G. Pol, Maria Chiara Maiuri

“…By contrast, LINC01087 displayed downregulation in testicular germ cell tumors (TGCT). ROC curve analyses identified LINC01087 as a potential diagnostic indicator in BC, ESCA, OV, STAD, and TGCT. …”
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BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis by Xiaorong Wang, Mengmeng Sang, Shengnan Gong, Zhichuan Chen, Xi Zhao, Guishuan Wang, Zhiran Li, Yingying Huang, Shitao Chen, Gangcai Xie, Enkui Duan, Fei Sun

“…In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice could lead to germ cell defects and a decrease of sperm motility, moreover, this effect is reversible. …”
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miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA–miRNA Network Analysis by Rajakumar Anbazhagan, Raghuveer Kavarthapu, Ryan Dale, Kiersten Campbell, Fabio R. Faucz, Maria L. Dufau

“…Post-transcriptional and translational regulation of some of these germ-cell-specific mRNAs by miRNA-regulated translation arrest and/or decay may lead to spermatogenic arrest in KO and KI mice. …”
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Profile of HER2/neu Expression in Surface Epithelial Ovarian Tumours: A Clinicomorphological Study by Abbirami Rajarajan, Kalaivani Amitkumar, Muthu Sudalaimuthu

“…Results: Out of total sample, SEOT was the most common (n=184, 76.98%) tumour cases, followed by germ cell tumours (n=42, 17.57%) cases and least common was sex cord stromal tumour (n=13, 5.43%). …”
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Pan-cancer analysis of plasmacytoma variant translocation 1 and MYC gene expression pattern and survival prediction by MA Xuefei, WANG Xuefeng, WANG Kankan

“…Finally, survival analysis showed that relatively high expression of PVT1 was significantly associated with shorter overall survival in bladder urothelial carcinoma, breast invasive carcinoma, adrenocortical carcinoma, renal clear cell carcinoma, renal papillary cell carcinoma, lower grade glioma, prostate adenocarcinoma, testicular germ cell tumors and uveal melanoma (log-rank P&lt;0.05). …”
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Towards a More Comprehensive Picture of the MicroRNA-23a/b-3p Impact on Impaired Male Fertility by Lea Simone Becker, Mohammad A. Al Smadi, Hanna Koch, Hashim Abdul-Khaliq, Eckart Meese, Masood Abu-Halima

“…While certain genes are essential for spermatogenesis and male germ cell function, the regulation of their expression remains unclear. …”
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Could MicroRNAs Be Useful Tools to Improve the Diagnosis and Treatment of Rare Gynecological Cancers? A Brief Overview by Riccardo Di Fiore, Sherif Suleiman, Francesca Pentimalli, Sharon A. O’Toole, John J. O’Leary, Mark P. Ward, Neil T. Conlon, Maja Sabol, Petar Ozretić, Ayse Elif Erson-Bensan, Nicholas Reed, Antonio Giordano, C. Simon Herrington, Jean Calleja-Agius

“…Gynecological cancers such as malignant germ-cell tumors, sex-cord-stromal tumors, uterine sarcomas and carcinosarcomas, gestational trophoblastic neoplasia, vulvar carcinoma and melanoma of the female genital tract, are defined as rare with an annual incidence of <6 per 100,000 women. …”
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The follicle-stimulating hormone triggers rapid changes in mitochondrial structure and function in porcine cumulus cells by Amel Lounas, Yann Breton, Ariane Lebrun, Isabelle Laflamme, Nathalie Vernoux, Julie Savage, Marie-Ève Tremblay, Martin Pelletier, Marc Germain, François J. Richard

“…Abstract Oocyte maturation is a key process during which the female germ cell undergoes resumption of meiosis and completes its preparation for embryonic development including cytoplasmic and epigenetic maturation. …”
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Expression of Phospholipase D Family Member 6 in Bovine Testes and Its Molecular Characteristics by Rui Yang, Boyang Zhang, Wenqian Zhu, Chunling Zhu, Lanxin Chen, Yansen Zhao, Yueqi Wang, Yan Zhang, Amjad Riaz, Bo Tang, Xueming Zhang

“…Immunofluorescent staining further verified the expression of PLD6 protein in bovine spermatogenic cells like germ cell marker DEAD box helicase 4 (DDX4, also known as VASA). …”
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A Human Homozygous <i>HELQ</i> Missense Variant Does Not Cause Premature Ovarian Insufficiency in a Mouse Model by Shabnam Bakhshalizadeh, Anthony D. Bird, Rajini Sreenivasan, Katrina M. Bell, Gorjana Robevska, Jocelyn van den Bergen, Mohammad Asghari-Jafarabadi, Andrew J. Kueh, Philippe Touraine, Anna Lokchine, Sylvie Jaillard, Katie L. Ayers, Dagmar Wilhelm, Andrew H. Sinclair, Elena J. Tucker

“…HELQ, an enzyme involved in DNA repair, plays a crucial role in repairing DNA cross-links and has been linked to germ cell maintenance, fertility, and tumour suppression in mice. …”
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Autologous and Allogeneic Hematopoetic Stem Cell Transplantation for Solid Tumors in Iran by Ardeshir Ghavamzadeh, Roshanak Derakhshandeh, Arash Jalali, Ali Jafarpour, Kamran Alimoghaddam, AmirAli Hamidieh, Babak Bahar, Masoud Iravani, Seied Asadollah Mousavi, Mohammad Jahani

“…The most common transplant diseases were Neuroblastoma (18, 25.7%), Germ Cell Tumors (13, 18.6%) and Breast Cancer (11, 15.7%). 67 patients (95.7%) received peripheral blood and the 3 other ones (4.3%) received bone marrow as a source of SCT. …”
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Germline Variants in Phosphodiesterase Genes and Genetic Predisposition to Pediatric Adrenocortical Tumors by Emilia Modolo Pinto, Fabio R. Faucz, Luana Z. Paza, Gang Wu, Elizabeth S. Fernandes, Jerome Bertherat, Constantine A. Stratakis, Enzo Lalli, Raul C. Ribeiro, Carlos Rodriguez-Galindo, Bonald C. Figueiredo, Gerard P. Zambetti

“…Germline variants in PDEs have been associated with benign cortisol-secreting adrenocortical adenomas and testicular germ cell cancer but not adrenocortical carcinoma. …”
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Single-cell RNA sequencing reveals cell landscape following antimony exposure during spermatogenesis in Drosophila testes by Jun Yu, Yangbo Fu, Zhiran Li, Qiuru Huang, Juan Tang, Chi Sun, Peiyao Zhou, Lei He, Feiteng Sun, Xinmeng Cheng, Li Ji, Hao Yu, Yi Shi, Zhifeng Gu, Fei Sun, Xinyuan Zhao

“…Pseudotime trajectory analysis revealed three novel states for the complexity of germ cell differentiation, and many novel genes (e.g., Dup98B) were found to be expressed in state-biased manners during spermatogenesis. …”
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HMGA1-Regulating microRNAs Let-7a and miR-26a are Downregulated in Human Seminomas by Marco De Martino, Francesco Esposito, Simona Pellecchia, Ricardo Cortez Cardoso Penha, Gerardo Botti, Alfredo Fusco, Paolo Chieffi

“…Background: Recent studies have underlined HMGA protein’s key role in the onset of testicular germ cell tumors, where HMGA1 is differently expressed with respect to the state of differentiation, suggesting its fine regulation as master regulator in testicular tumorigenesis. …”
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Characterization of Two Gonadal Genes, zar1 and wt1b, in Hermaphroditic Fish Asian Seabass (<i>Lates calcarifer</i>) by Han Cui, Haoyu Zhu, Wenzhuo Ban, Yulin Li, Ruyi Chen, Lingli Li, Xiaoling Zhang, Kaili Chen, Hongyan Xu

“…Therefore, the findings of this study will provide a basis for clarifying the mechanism of <i>Lczar1</i> and <i>Lcwt1b</i> in regulating germ cell development and the sex reversal of Asian seabass and even other hermaphroditic species.…”
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