Altered resting state functional brain network topology in chemotherapy-treated breast cancer survivors by Jennifer Bruno, S.M. Hadi Hosseini, Shelli Kesler

“…Compared to healthy females, the breast cancer group displayed altered global brain network organization characterized by significantly decreased global clustering as well as disrupted regional network characteristics in frontal, striatal and temporal areas. …”
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A fatal adverse effect of cefazolin administration: severe brain edema in a patient with multiple meningiomas by Tribuddharat S, Sathitkarnmanee T, Kitkhuandee A, Theerapongpakdee S, Ngamsaengsirisup K, Chanthawong S

“…A computed tomography scan revealed global brain edema with herniation. She was admitted to the intensive care unit for symptomatic treatment and died 10 days after surgery from multiorgan failure. …”
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Arterial stiffness and its influence on cerebral morphology and cognitive function by Melanie Haidegger, Simon Lindenbeck, Edith Hofer, Christina Rodler, Robert Zweiker, Sabine Perl, Lukas Pirpamer, Markus Kneihsl, Simon Fandler-Höfler, Thomas Gattringer, Christian Enzinger, Reinhold Schmidt

“…Only night-time PWV values were associated with global brain atrophy ( p  = 0.005). Conclusions: This study shows a relationship of arterial stiffness and reduced total brain volume. …”
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The neural mechanisms underlying the acute effect of cigarette smoking on chronic smokers. by Kangcheng Wang, Junyi Yang, Songyan Zhang, Dongtao Wei, Xin Hao, Shen Tu, Jiang Qiu

“…Voxel-wise group comparisons of newly developed global brain connectivity (GBC) showed that smokers in the SOA condition had higher GBC in the insula and superior frontal gyrus compared with non-smokers. …”
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Reversible Inactivation of Different Millimeter-Scale Regions of Primate IT Results in Different Patterns of Core Object Recognition Deficits by Rajalingham, Rishi, DiCarlo, James

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Are people ready for personalized brain health? Perspectives of research participants in the Lifebrain consortium by Friedman, BB, Suri, S, Solé-Padullés, C, Düzel, S, Drevon, CA, Baaré, WFC, Bartrés-Faz, D, Fjell, AM, Johansen-Berg, H, Madsen, KS, Nyberg, L, Penninx, BWJH, Sexton, C, Walhovd, KB, Zsoldos, E, Budin-Ljøsne, I

“…Based on our findings, we have launched an ongoing global brain health survey to acquire more extensive, quantitative, and representative data on public perception of personalized brain health.…”

Whole-brain multimodal neuroimaging model using serotonin receptor maps explains non-linear functional effects of LSD by Deco, G, Cruzat, J, Cabral, J, Knudsen, G, Carhart-Harris, R, Whybrow, P, Logothetis, N, Kringelbach, M

“…Taking neuromodulatory activity into account when modeling global brain dynamics will lead to novel insights into human brain function in health and disease and opens exciting possibilities for drug discovery and design in neuropsychiatric disorders.…”

SARS-CoV-2 is associated with changes in brain structure in UK Biobank by Douaud, G, Lee, S, Alfaro-Almagro, F, Arthofer, C, Wang, C, McCarthy, P, Lange, F, Andersson, JLR, Griffanti, L, Duff, E, Jbabdi, S, Taschler, B, Keating, P, Winkler, AM, Collins, R, Matthews, PM, Allen, N, Miller, KL, Nichols, TE, Smith, SM

“…We identified significant longitudinal effects when comparing the two groups, including: (i) greater reduction in grey matter thickness and tissue-contrast in the orbitofrontal cortex and parahippocampal gyrus, (ii) greater changes in markers of tissue damage in regions functionally-connected to the primary olfactory cortex, and (iii) greater reduction in global brain size. The infected participants also showed on average larger cognitive decline between the two timepoints. …”

Comparison of quality control methods for automated diffusion tensor imaging analysis pipelines. by Seyyed M H Haddad, Christopher J M Scott, Miracle Ozzoude, Melissa F Holmes, Stephen R Arnott, Nuwan D Nanayakkara, Joel Ramirez, Sandra E Black, Dar Dowlatshahi, Stephen C Strother, Richard H Swartz, Sean Symons, Manuel Montero-Odasso, ONDRI Investigators, Robert Bartha

“…The mean fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated in global brain grey matter (GM) and white matter (WM) regions. …”
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The yearly rate of Relative Thalamic Atrophy (yrRTA): a simple 2D/3D method for estimating deep gray matter atrophy in Multiple Sclerosis by Manuel eMenéndez-González, Manuel eMenéndez-González, Manuel eMenéndez-González, Jose M Salas-Pacheco, Oscar eArias-Carrión, Oscar eArias-Carrión

“…In particular, we propose to compare the extent of thalamus atrophy (TA) with the extent of unspecific, global brain atrophy, represented by ventricular enlargement. …”
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A Comparative Study of Standardized Infinity Reference and Average Reference for EEG of Three Typical Brain States by Gaoxing Zheng, Xiaoying Qi, Yuzhu Li, Wei Zhang, Yuguo Yu

“…The analysis results revealed the following observations: (1) there is no significant difference in the alpha-wave-blocking effect during the eyes-open state compared with the eyes-closed state for both REST and AR references; (2) there was clear frontal EEG asymmetry during the resting state, and the degree of lateralization under REST was higher than that under AR; (3) the global brain functional connectivity density (FCD) and local FCD have higher values for REST than for AR under different behavior states; and (4) the value of the small-world network characteristic in the eyes-closed state is significantly (in full, alpha, beta and gamma frequency bands) higher than that in the eyes-open state, and the small-world effect under the REST reference is higher than that under AR. …”
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Decision-making, human cognition, and equanimity of mind by Sisir Roy

“…The ability to predict the outcome of future events is, arguably, the most universal and significant of all global brain functions. The ability to anticipate the outcome of a given action depends on sensory stimuli from the outside world and previously learned experience and/or inherited instincts. …”
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Whole-brain atrophy differences between progressive supranuclear palsy and idiopathic Parkinson's disease by Carlos Guevara, Katya Bulatova, Gareth Barker, Guido Gonzalez, Nicolas A Crossley, Matthew J Kempton

“…Such mistakes occur particularly in the initial stages, when ‘plus syndrome’ has not yet clinically emerged.Objective. To investigate global brain volume and tissue loss in patients with PSP relative to patients with IPD and healthy controls and correlations between clinical parameters and magnetic resonance imaging (MRI)-derived brain volume estimates.Methods: T1-weighted images were obtained from three groups of Chilean Latin American adults: 21 patients with IPD, 18 patients with PSP and 14 healthy controls. …”
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Mechanisms Underlying the Cognitive and Behavioural Effects of Maternal Obesity by Kyoko Hasebe, Michael D. Kendig, Margaret J. Morris

“…Use of animal models permits investigation of changes in neuroinflammation, neurotransmitter activity and hormones across global brain network and sex differences, which could be directly and indirectly modulated by the gut microbiome.…”
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Decoding brain state transitions in the pedunculopontine nucleus: cooperative phasic and tonic mechanisms by Anne ePetzold, Miguel eValencia, Miguel eValencia, Balazs ePal, Juan eMena-Segovia, Juan eMena-Segovia

“…Their activation is deemed to cause a switch in the global brain activity from sleep to wakefulness, while their sustained discharge may contribute to upholding the waking state and enhancing arousal. …”
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Resting-state functional connectivity in multiple sclerosis patients receiving nabiximols for spasticity by Alberto Gajofatto, Nicolò Cardobi, Francesca Gobbin, Massimiliano Calabrese, Marco Turatti, Maria Donata Benedetti

“…On fMRI analysis, Sativex® exposure was associated with global brain connectivity increase (particularly in responders), decreased connectivity of motor areas, and bidirectional connectivity changes of the left cerebellum with a number of cortical areas. …”
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Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA) by Renuka Chintapalli, Roman Romero-Ortuno

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Rich club organization of macaque cerebral cortex and its role in network communication. by Logan Harriger, Martijn P van den Heuvel, Olaf Sporns

“…Overall, the demonstration of rich club organization in a non-human primate contributes to our understanding of the network principles underlying neural connectivity in the mammalian brain, and further supports the hypothesis that rich club regions and connections have a central role in global brain communication.…”
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Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy [v2; ref status: indexed, http://f1000r.es/5my] by A. Erramuzpe, J. M. Encinas, A. Sierra, M. Maletic-Savatic, A.L. Brewster, Anne E. Anderson, S. Stramaglia, Jesus M. Cortes

“…Our hypothesis is that FC can differentiate global brain interactions across a time-scale of days. …”
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Topography of 11C-Pittsburgh compound B uptake in Alzheimer’s disease: a voxel-based investigation of cortical and white matter regions by Daniele de P. Faria, Fabio L. Duran, Paula Squarzoni, Artur M. Coutinho, Alexandre T. Garcez, Pedro P. Santos, Sonia M. Brucki, Maira O. de Oliveira, Eduardo S. Trés, Orestes V. Forlenza, Ricardo Nitrini, Carlos A. Buchpiguel, Geraldo Busatto Filho

“…Objective: To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (11C-PIB) obtained with cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites with highest tracer uptake in subjects with mild Alzheimer’s disease (AD), and explore possible group differences in 11C-PIB binding to white matter. …”
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