Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets afte... by Guangmang Liu, Jingyuan Tao, Jiajia Lu, Gang Jia, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Ruinan Zhang, Jing Wang

“…Moreover, tryptophan downregulated the expression of ER stress (ER oxidoreductase-1α, ER oxidoreductase-1β, glucose-regulated protein-78, activating transcription factor 6, C/EBP homologous protein), apoptosis (B-cell lymphoma-2, BCL2-associated X protein, caspase 3), and pyroptosis signaling pathway (nucleotide-binding oligomerization domain-like receptor protein 3, caspase 1, gasdermin-D, apoptosis-associated speck-like protein containing a CARD). …”
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Exploring lncRNAs associated with human pancreatic islet cell death induced by transfer of adoptive lymphocytes in a humanized mouse model by Md Munir Hossain, Md Munir Hossain, Regan Roat, Jenica Christopherson, Colette Free, Ansarullah, Brian James, Brian James, Zhiguang Guo

“…These lncRNAs were deregulated in human islets from donors with different BMIs and with type 2 diabetes (T2D), as well as in cultured human islets with glucose stimulation and induced cell death induced by cytokines. …”
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Feeding Yellow Worms to Meagre: Effects on Whole-Body Fatty Acid Profile and Hepatic and Intestine Oxidative Status by Inês Guerreiro, Carolina Castro, Cláudia R. Serra, Filipe Coutinho, Ana Couto, Helena Peres, Pedro Pousão-Ferreira, Geneviève Corraze, Aires Oliva-Teles, Paula Enes

“…Hepatic superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G6PDH), and glutathione reductase (GR) activities increased and catalase (CAT) and glutathione peroxidase (GPX) activities decreased with dietary TM inclusion. …”
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The Three-Month Effects of a Ketogenic Diet on Body Composition, Blood Parameters, and Performance Metrics in CrossFit Trainees: A Pilot Study by Wesley C. Kephart, Coree D. Pledge, Paul A. Roberson, Petey W. Mumford, Matthew A. Romero, Christopher B. Mobley, Jeffrey S. Martin, Kaelin C. Young, Ryan P. Lowery, Jacob M. Wilson, Kevin W. Huggins, Michael D. Roberts

“…DXA total lean body mass changes were not different between groups, although DXA dual-leg lean mass decreased in the KD group by 1.4% (p = 0.068), and vastus lateralis thickness values decreased in the KD group by ~8% (p = 0.065). Changes in fasting glucose, HDL cholesterol, and triglycerides were similar between groups, although LDL cholesterol increased ~35% in KD (p = 0.048). …”
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Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer by Kai Jannusch, Ann-Kathrin Bittner, Nils Martin Bruckmann, Janna Morawitz, Cleo Stieglitz, Frederic Dietzel, Harald H. Quick, Hideo A. Baba, Ken Herrmann, Lale Umutlu, Gerald Antoch, Julian Kirchner, Sabine Kasimir-Bauer, Oliver Hoffmann

“…Conclusions: [¹⁸F]FDG-PET/MRI may give a first impression of BC-receptor status and BC-tumor biology during initial staging by measuring glucose metabolism but cannot distinguish between DTC-positive/-negative patients and replace biopsy.…”
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Circulating miRNAs in Women with Polycystic Ovary Syndrome: A Longitudinal Cohort Study by Pernille B. Udesen, Anja E. Sørensen, Rikke Svendsen, Nanna L. S. Frisk, Anne L. Hess, Mubeena Aziz, Marie Louise M. Wissing, Anne Lis M. Englund, Louise T. Dalgaard

“…All participants were evaluated for degree of metabolic disease (hypertension, dyslipidemia, central obesity, and impaired glucose tolerance). MiRNA levels were measured using Taqman^® Array cards of 96 pre-selected miRNAs associated with PCOS and/or metabolic disease. …”
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Crosstalk between Irisin Levels, Liver Fibrogenesis and Liver Damage in Non-Obese, Non-Diabetic Individuals with Non-Alcoholic Fatty Liver Disease by Angelo Armandi, Chiara Rosso, Aurora Nicolosi, Gian Paolo Caviglia, Maria Lorena Abate, Antonella Olivero, Daphne D’Amato, Marta Vernero, Melania Gaggini, Giorgio Maria Saracco, Davide Giuseppe Ribaldone, Diana Julie Leeming, Amalia Gastaldelli, Elisabetta Bugianesi

“…Irisin is an exercise-induced myokine involved in the regulation of energy homeostasis and glucose metabolism. Additionally, pre-clinical models have shown a potential role of irisin in the pathogenesis of NAFLD. …”
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Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival by Eleanor R. Burgess, Rebekah L. I. Crake, Rebekah L. I. Crake, Elisabeth Phillips, Helen R. Morrin, Helen R. Morrin, Janice A. Royds, Tania L. Slatter, George A. R. Wiggins, Margreet C. M. Vissers, Bridget A. Robinson, Bridget A. Robinson, Gabi U. Dachs

“…In tumours with above median ascorbate content, HIF-pathway activity as a whole was significantly suppressed (p = 0.005), and several members of the pathway showed decreased expression (carbonic anhydrase-9 and glucose transporter-1, both p < 0.01). Patients with either lower tumour HIF-pathway activity or higher tumour ascorbate content survived significantly longer than patients with higher HIF-pathway or lower ascorbate levels (p = 0.011, p = 0.043, respectively). …”
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High Fat Diet Exaggerate Metabolic and Reproductive PCOS Features by Promoting Oxidative Stress: An Improved EV Model in Rats by Dejana Rakic, Jovana Joksimovic Jovic, Vladimir Jakovljevic, Vladimir Zivkovic, Maja Nikolic, Jasmina Sretenovic, Marina Nikolic, Nikola Jovic, Marija Bicanin Ilic, Petar Arsenijevic, Aleksandra Dimitrijevic, Tatjana Vulovic, Natasa Ristic, Kristina Bulatovic, Sergej Bolevich, Lazar Stijak, Suzana Pantovic

“…<i>Results</i>: We observed alterations of anthropometric parameters and hormonal disturbances, along with estrus cycle impairment reassembly to obese-type PCOS phenotype. Moreover, glucose metabolism was impaired after addition of HFD to EV protocol, contrary to EV administered alone. …”
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Viscum album mother tinctures: Harvest conditions and host trees influence the plant metabolome and the glycolytic pathway of breast cancer cells by Michelle Nonato de Oliveira Melo, Michelle Nonato de Oliveira Melo, Alan Clavelland Ochioni, Patricia Zancan, Adriana Passos Oliveira, Mirio Grazi, Rafael Garrett, Carla Holandino, Carla Holandino, Stephan Baumgartner, Stephan Baumgartner, Stephan Baumgartner

“…This activity was related to a reduction in glucose uptake and lactate production, which were host-tree-time-dose-dependent. …”
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Lay health worker intervention in pre-diabetes management: Study protocol of a pragmatic randomized controlled trial for Chinese families living in inadequate houses by Crystal Ying Chan, Crystal Ying Chan, Becky Pek-kei Hoi, Becky Pek-kei Hoi, Eliza Lai-yi Wong, Eliza Lai-yi Wong

“…Glycated hemoglobin (HbA1c) and fasting blood glucose will be taken at the entry and exit assessment of this trial as primary outcomes.DiscussionOur randomized controlled trial is one of the first to investigate the effect of lay health worker intervention on pre-diabetes management in a low-income Chinese population residing in inadequate houses. …”
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Metyrosine-associated endocrinological changes in pheochromocytoma and paraganglioma by Yuko Matsuo, Kenji Ashida, Ayako Nagayama, Kanoko Moritaka, Mizuki Gobaru, Junichi Yasuda, Naoyuki Ogasawara, Hirofumi Kurose, Katsuaki Chikui, Shimpei Iwata, Yukihiro Inoguchi, Nao Hasuzawa, Seiichi Motomura, Tsukasa Igawa, Masatoshi Nomura

“…Adjustment of metyrosine administration may make surgical pretreatment more effective in achieving stabilized blood pressure and improving glucose metabolism. Endocrine parameters may manifest as the systemic effects of metyrosine administration.…”
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Outcomes of an Asynchronous Care Model for Chronic Conditions in a Diverse Population: 12-Month Retrospective Chart Review Study by Michael Hofner, Patrick Hurnaus, Dan DiStefano, Shaji Philip, Sarah Kim, Julie Shaw, Avantika Chander Waring

“…Patients received standard or cellular-connected glucose meters and BP cuffs in order to share data. …”
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Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population by Ramatu Wuni, Evelyn Adela Nathania, Ashok K. Ayyappa, Nagarajan Lakshmipriya, Kandaswamy Ramya, Rajagopal Gayathri, Gunasekaran Geetha, Ranjit Mohan Anjana, Gunter G. C. Kuhnle, Venkatesan Radha, Viswanathan Mohan, Vasudevan Sudha, Karani Santhanakrishnan Vimaleswaran

“…A sample of 497 Asian Indian individuals (260 with type 2 diabetes and 237 with normal glucose tolerance) (mean age: 44 ± 10 years) were randomly chosen from the Chennai Urban Rural Epidemiological Study (CURES). …”
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Coffee Bioactive <i>N</i>-Methylpyridinium Attenuates Tumor Necrosis Factor (TNF)-α-Mediated Insulin Resistance and Inflammation in Human Adipocytes by Stefano Quarta, Egeria Scoditti, Maria Annunziata Carluccio, Nadia Calabriso, Giuseppe Santarpino, Fabrizio Damiano, Luisa Siculella, Martin Wabitsch, Tiziano Verri, Claudia Favari, Daniele Del Rio, Pedro Mena, Raffaele De Caterina, Marika Massaro

“…Among the plethora of minor organic compounds assessed as potential mediators of coffee health benefits, trigonelline and its pyrolysis product <i>N</i>-methylpyridinium (NMP) were preliminary shown to promote glucose uptake and exert anti-adipogenic properties. …”
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Comparison of artemether-lumefantrine and chloroquine with and without primaquine for the treatment of Plasmodium vivax infection in Ethiopia: A randomized controlled trial. by Tesfay Abreha, Jimee Hwang, Kamala Thriemer, Yehualashet Tadesse, Samuel Girma, Zenebe Melaku, Ashenafi Assef, Moges Kassa, Mark D Chatfield, Keren Z Landman, Stella M Chenet, Naomi W Lucchi, Venkatachalam Udhayakumar, Zhiyong Zhou, Ya Ping Shi, S Patrick Kachur, Daddi Jima, Amha Kebede, Hiwot Solomon, Addis Mekasha, Bereket Hailegiorgis Alemayehu, Joseph L Malone, Gunewardena Dissanayake, Hiwot Teka, Sarah Auburn, Lorenz von Seidlein, Ric N Price

“…<h4>Methods and findings</h4>Patients with normal glucose-6-phosphate dehydrogenase status with symptomatic P. vivax mono-infection were enrolled and randomly assigned to receive either chloroquine (CQ) or artemether-lumefantrine (AL), alone or in combination with 14 d of semi-supervised primaquine (PQ) (3.5 mg/kg total). …”
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The effect of hydroxyethyl starch as a cryopreservation agent during freezing of mouse pancreatic islets by Du Yeon Shin, Jae Suh Park, Han-Sin Lee, Wooyoung Shim, Lauren Jin, Kyo Won Lee, Jae Berm Park, Dong Hyun Kim, Jae Hyeon Kim

“…To investigate the effects of two types of nonpermeating CPA, we compared 4 % HES 130 and HES 200 to 10 % DMSO in terms of mouse islet yield, viability, and glucose-stimulated insulin secretion (GSIS). After one day of culture, islets were cryopreserved in each solution. …”
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Physicochemical Properties, Antioxidant and Antidiabetic Activities of Polysaccharides from Quinoa (<i>Chenopodium quinoa</i> Willd.) Seeds by Minghui Tan, Senlin Chang, Jianing Liu, Hang Li, Pengwei Xu, Peidong Wang, Xiaodong Wang, Mingxia Zhao, Bing Zhao, Liwei Wang, Qingsheng Zhao

“…The results implied that their total sugar contents were 52.82%, 63.69%, 67.15%, 44.56%, and 41.01%, and their weight-average molecular weights were 13,785 Da, 6489 Da, 4732 Da, 3318 Da, and 1960 Da, respectively. Glucose was a predominantly monosaccharide in these QPs, which together in QPE50, QPE60, QPE70, QPE80, and QPE90, respectively, made up 94.37%, 87.92%, 92.21%, 100%, and 100% of the total polysaccharide. …”
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Purification, characterization and probiotic proliferation effect of exopolysaccharides produced by Lactiplantibacillus plantarum HDC-01 isolated from sauerkraut by Liansheng Yu, Liansheng Yu, Guangbin Ye, Xintong Qi, Yi Yang, Bosen Zhou, Yunye Zhang, Renpeng Du, Renpeng Du, Jingping Ge, Jingping Ge, Wenxiang Ping, Wenxiang Ping

“…Fourier transform infrared spectrometry (FT-IR) and nuclear magnetic resonance (NMR) results showed that the EPS was composed of glucose/glucopyranose subunits linked by an α-(1 → 6) glycosidic bond and contained an α-(1 → 3) branching structure. …”
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Protective effect of functional food containing Dendrobium officinale via mediation of the FSHR/PI3K/AKT signaling pathway on menopausal syndrome in rats by Xiang Zheng, Jiujie Jia, Chuanjie Zhou, Linnan Zhang, Zehua Zhang, Xinglishang He, Bo Li, Qiaoxian Yu, Guiyuan Lv, Suhong Chen

“…Moreover, GSNF supplementation improved glucose-lipid metabolism disorders and mitigated hepatic steatosis in model rats. …”
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