CD4+ T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV by Celestine N. Wanjalla, Curtis L. Gabriel, Hubaida Fuseini, Samuel S. Bailin, Mona Mashayekhi, Joshua Simmons, Christopher M. Warren, David R. Glass, Jared Oakes, Rama Gangula, Erin Wilfong, Erin Wilfong, Stephen Priest, Tecla Temu, Evan W. Newell, Suman Pakala, Spyros A. Kalams, Sara Gianella, David Smith, David G. Harrison, Simon A. Mallal, John R. Koethe, John R. Koethe

“…The traditional risk factor most correlated with CGC+CD4+ T cell frequency was fasting blood glucose, as well as starch/sucrose metabolites. While unstimulated CGC+CD4+ T cells, like other memory T cells, depend on oxidative phosphorylation for energy, they exhibited higher expression of carnitine palmitoyl transferase 1A compared to other CD4+ T cell subsets, suggesting a potentially greater capacity for fatty acid β-oxidation. …”
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Assessment of Cell-Free Long Non-Coding RNA-H19 and miRNA-29a, miRNA-29b Expression and Severity of Diabetes by Alfaifi M, Verma AK, Alshahrani MY, Joshi PC, Alkhathami AG, Ahmad I, Hakami AR, Beg MMA

“…Mohammed Alfaifi,1,* Amit Kumar Verma,2,* Mohammad Yahya Alshahrani,1 Prakash C Joshi,2 Ali G Alkhathami,1 Irfan Ahmad,1 Abdulrahim Refdan Hakami,1 Mirza Masroor Ali Beg3,4 1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia; 2Department of Zoology and Environmental Sciences, GKV, Haridwar, India; 3Department of Medical Elementology and Toxicology, Jamia Hamdard, New Delhi, India; 4Department of Biochemistry, Maulana Azad Medical College, New Delhi, India*These authors contributed equally to this workCorrespondence: Mirza Masroor Ali BegDepartment of Medical Elementology and Toxicology, Jamia Hamdard, New Delhi, IndiaTel +917827655616Email mirzamasroor1986@gmail.comBackground: Type 2 diabetes mellitus [T2DM] has been one of the common diseases and is characterized by increased blood glucose levels and suggested that cell-free non-coding RNAs and microRNAs (miRNAs) have been demonstrated to serve as important diagnostic/prognostic biomarkers in diabetes.Materials/Methods: The present study included clinically confirmed newly diagnosed 200 cases of T2DM and 200 healthy subjects, and all the parameters were taken care in diagnosis. …”
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Microbiome in soils of Mendoza: microbial resources for the development of agroecological management in viticulture by Marcos Paolinelli, Laura Elizabeth Martinez, Sandra García-Lampasona, Camilo Diaz-Quirós, Marcelo Belmonte, Gastón Ahumada, Miguel Ángel Pirrone, Marisa Diana Farber, Georgina Escoriaza, Valeria Longone, Magalí González, Cecilia Lerena, Mariana Combina, Laura Analía Mercado

“…Regarding functional analysis, soils from SR showed a higher denitrification activity of nitrifiers as well as glucose-related metabolism, while in G soils, bacterial photosynthesis activities were a differential trait. …”
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Pigs’ aggressive temperament affects pre-slaughter mixing aggression, stress and meat quality by R.B. D’Eath, S.P. Turner, E. Kurt, G. Evans, L. Thölking, H. Looft, K. Wimmers, E. Murani, R. Klont, A. Foury, S.H. Ison, A.B. Lawrence, P. Mormède

“…High numbers of skin lesions on the carcass were associated with high levels of cortisol and lactate and low glucose at slaughter, but not with meat quality measures. …”
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Residue from Açai Palm, <i>Euterpe oleracea</i><i>,</i> as Substrate for Cilantro, <i>Coriandrum sativum</i>, Seedling Production in an Aquaponic System with Tambaqui, <i>Colossoma... by José Alexandre Santos da Costa, Fabio Carneiro Sterzelecki, Joane Natividade, Rafael José Furtado Souza, Thayanne Cristine Caetano de Carvalho, Nuno Filipe Alves Correia de Melo, Ronald Kennedy Luz, Glauber David Almeida Palheta

“…Mean blood hematocrit (30.20 ± 5.99%) and glucose (59.5 ± 10.06 mg dL⁻¹) indicates good physiological status of the <i>C. macropomum</i>. …”
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From Pathogens to Cancer: Are Cancer Cells Evolved Mitochondrial Super Cells? by Mario G. Balzanelli, Pietro Distratis, Rita Lazzaro, Van Hung Pham, Raffaele Del Prete, Adriana Mosca, Francesco Inchingolo, Sergey K. Aityan, Luigi Santacroce, Kieu C. D. Nguyen, Ciro Gargiulo Isacco

“…The Warburg’s law that states the ability of cancers to ferment glucose in the presence of oxygen, indicates mitochondria respiration abnormalities may be the underlying cause of this transformation towards super cancer cells. …”
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Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells by Toshiharu Onodera, Dae-Seok Kim, Risheng Ye, May-Yun Wang, Shiuhwei Chen, Bianca C. Field, Leon Straub, Xue-Nan Sun, Chao Li, Charlotte Lee, Megan Paredes, Clair Crewe, Shangang Zhao, Christine M. Kusminski, Ruth Gordillo, Philipp E. Scherer

“…To elucidate the function of β cell-specific PPARα and HNF4α expression, we developed doxycycline inducible pancreatic β cell-specific PPARα (β-PPARα) and HNF4α (β-HNF4α) overexpression mice. β-PPARα mice exhibited improved protection from lipotoxicity, but elevated β-oxidative damage in the islets, and also displayed lowered phospholipid levels and impaired glucose-stimulated insulin secretion. β-HNF4α mice showed a more severe phenotype when compared to β-PPARα mice, characterized by lower body weight, small islet mass and impaired insulin secretion. …”
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Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study by Laura Melero-Guijarro, Ancor Sanz-García, Ancor Sanz-García, Francisco Martín-Rodríguez, Francisco Martín-Rodríguez, Francisco Martín-Rodríguez, Vivian Lipari, Vivian Lipari, Cristina Mazas Perez Oleaga, Cristina Mazas Perez Oleaga, Cristina Mazas Perez Oleaga, Stefanía Carvajal Altamiranda, Stefanía Carvajal Altamiranda, Stefanía Carvajal Altamiranda, Nohora Milena Martínez López, Nohora Milena Martínez López, Nohora Milena Martínez López, Irma Domínguez Azpíroz, Irma Domínguez Azpíroz, Irma Domínguez Azpíroz, Miguel A. Castro Villamor, Miguel A. Castro Villamor, Miguel A. Castro Villamor, Irene Sánchez Soberón, Raúl López-Izquierdo, Raúl López-Izquierdo, Raúl López-Izquierdo

“…All the variables used in the scores, in addition to socio-demographic data, standard vital signs, prehospital analytical parameters (glucose, lactate, and creatinine) were collected. …”
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Pregnancy Cholesterol Metabolism Markers and the Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study by Yan Li, Yuanjue Wu, Yanyan Ge, Shanshan Huang, Yang Yang, Zhen Zhang, Ningning Cui, Junan Yan, Yonggang Li, Ping Luo, Liping Hao, Guoping Xiong, Xuefeng Yang

“…GDM was diagnosed according to the 75 g 2 h oral glucose tolerance test (OGTT) at 24–28 gestational weeks. …”
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Lactate metabolism-related genes to predict the clinical outcome and molecular characteristics of endometrial cancer by Rui Shi, Haojia Li, Sitian Wei, Zhicheng Yu, Jun Zhang, Qi Zhang, Ting Zhou, Yuwei Yao, Qian Zhang, Tangansu Zhang, Hongbo Wang

“…CCK8, EdU, and clone formation assays were applied to detect the proliferation ability of EC cells, Transwell assay was performed to detect the migration ability of EC cells, and intracellular lactate and glucose content was used to asses lactate metabolism. …”
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A Combination of Structural, Genetic, Phenotypic and Enzymatic Analyses Reveals the Importance of a Predicted Fucosyltransferase to Protein <i>O</i>-Glycosylation in the Bacteroide... by Markus B. Tomek, Bettina Janesch, Matthias L. Braun, Manfred Taschner, Rudolf Figl, Clemens Grünwald-Gruber, Michael J. Coyne, Markus Blaukopf, Friedrich Altmann, Paul Kosma, Hanspeter Kählig, Laurie E. Comstock, Christina Schäffer

“…To identify the linkage created by the FucT of <i>B. fragilis</i>, we elucidated the full structure of its nine-sugar <i>O</i>-glycan and found that <span style="font-variant: small-caps;">l</span>-fucose is linked β1,4 to glucose. Of the two fucose residues in the <i>T. forsythia</i> <i>O</i>-glycan, the fucose linked to the reducing-end galactose was shown by mutational analysis to be <span style="font-variant: small-caps;">l</span>-fucose. …”
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Platinum Nanoparticles Loaded Graphitic Carbon Nitride Nanosheets with Enhanced Peroxidase-like Activity for H₂O₂ and Oxidase-Based Sensing by Gege Yang, Ying Chen, Rui Shi, Rongrong Chen, Shanshan Gao, Xin Zhang, Yuan Rao, Ying Lu, Yuancheng Peng, Zhihe Qing, Chunxia Song

“…By utilizing H₂O₂ as a mediator, this strategy can be applied to oxidase-based biomolecules (glucose, organophosphorus, and so on, that generate or consume hydrogen peroxide) sensing. …”
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Influencing Factors of Anemia in Patients with Diabetic Kidney Disease by Shili SHANG, Zijuan SUN, Lina BI, Wenjing ZHOU, Daiyu SHEN, Jingshan CHEN, Sha LUO, Yuerong FENG, Qian YANG, Jun LI

“…Data of them were retrospectively collected, including demographic information 〔gender, age, height, weight, blood pressure, duration of diabetes, calculated body mass index (BMI) , and smoke prevalence〕, and laboratory test indices 〔red blood cells (RBC) , serum hemoglobin (Hb) , total protein (TP) , albumin (ALB) , globulin (GLB) , alkaline phosphatase (ALP) , cholinesterase (CHE) , uric acid (SUA) , blood urea nitrogen (BUN) , creatinine (Scr) , cystatin C (Cys C) , retinol binding protein (RBP) , fasting plasma glucose (FPG) , calcium (Ca) , phosphorus (P) , magnesium (Mg) , zinc (Zn) , iron, unsaturatediron binding capacity (UIBC) , total iron binding capacity (TIBC) , ferritin, transferrin (TRF) , C-reactive protein (CRP) , and erythrocyte sedimentation rate (ESR) , glycated hemoglobin (HbA1c) , UALB/CRE, 24-hour urine for microalbumin (24 h-mALB) , 24-hour urine for total protein (24 h-MTP) 〕 and estimated glomerular filtration rate (eGFR) . …”
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Neighbourhood socioeconomic characteristics and blood pressure among Jamaican youth: a pooled analysis of data from observational studies by Trevor S. Ferguson, Novie O.M. Younger-Coleman, Jasneth Mullings, Damian Francis, Lisa-Gaye Greene, Parris Lyew-Ayee, Rainford Wilks

“…Among males, PCA-SES1 was inversely associated with systolic BP (β-1.48 [95%CI −2.11, −0.84] mmHg, p < 0.001, for each standard deviation unit increase in PCA-SES1 score) in multivariable model accounting for age, household SES, study, BMI, fasting glucose, physical activity and diet. PCA-SES1 was not significantly associated with systolic BP among females (β −0.48 [−1.62, 0.66], p = 0.410) in a similar model. …”
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Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis by Abrar Ahmad, Lee-Ling Lim, Mario Luca Morieri, Claudia Ha-ting Tam, Feifei Cheng, Tinashe Chikowore, Monika Dudenhöffer-Pfeifer, Hugo Fitipaldi, Chuiguo Huang, Sarah Kanbour, Sudipa Sarkar, Robert Wilhelm Koivula, Ayesha A. Motala, Sok Cin Tye, Gechang Yu, Yingchai Zhang, Michele Provenzano, Diana Sherifali, Russell J. de Souza, Deirdre Kay Tobias, ADA/EASD PMDI, Maria F. Gomez, Ronald C. W. Ma, Nestoras Mathioudakis

“…Results of pooled meta-analyses, non-pooled analyses, and assessments of improvement in prediction performance and risk of bias, yielded the highest predictive utility for N-terminal pro b-type natriuretic peptide (NT-proBNP) (high-evidence), troponin-T (TnT) (moderate-evidence), triglyceride-glucose (TyG) index (moderate-evidence), Genetic Risk Score for Coronary Heart Disease (GRS-CHD) (moderate-evidence); moderate predictive utility for coronary computed tomography angiography (low-evidence), single-photon emission computed tomography (low-evidence), pulse wave velocity (moderate-evidence); and low predictive utility for C-reactive protein (moderate-evidence), coronary artery calcium score (low-evidence), galectin-3 (low-evidence), troponin-I (low-evidence), carotid plaque (low-evidence), and growth differentiation factor-15 (low-evidence). …”
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Protective Effect of Date Pits on Growth Performance, Carcass Traits, Blood Indices, Intestinal Morphology, Nutrient Digestibility, and Hepatic Aflatoxin Residues of Aflatoxin B1-E... by Abdulrahman S. Alharthi, Ali R. Al Sulaiman, Riyadh S. Aljumaah, Abdulaziz A. Alabdullatif, Ahmed A. Elolimy, Abdulmohsen H. Alqhtani, Maged A. Al-Garadi, Alaeldein M. Abudabos

“…Compared to the NC diet, feeding the PC diet decreased the daily feed intake (DFI) during the grower and overall periods (<i>p</i> < 0.01); reduced the daily weight gain (DWG) and production efficiency factor (PEF); increased the feed conversion ratio (FCR) during all experimental periods (<i>p</i> < 0.001); diminished the dressing percentage, breast meat yield, serum concentrations of total protein (TP), albumin (ALB), glucose (GLU), total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), villus height (VH), villus surface area (VSA), apparent digestibility of crude protein (CP) and ether extract (EE), apparent metabolizable energy (AME), and nitrogen-corrected AME (AMEn) (<i>p</i> < 0.001); and raised the proportional liver weight, serum activities of glutamic oxaloacetic transaminase (GOT) and glutamate pyruvate transaminase (GPT), and residues of AFB1 in the liver (<i>p</i> < 0.001). …”
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Milk Production Responses and Digestibility of Dairy Buffaloes (<i>Bubalus bubalis</i>) Partially Supplemented with Forage Rape (<i>Brassica napus</i>) Silage Replacing Corn Silage by Di Zhou, Mohamed Abdelrahman, Xinxin Zhang, Shuai Yang, Jing Yuan, Zhigao An, Kaifeng Niu, Yanxia Gao, Jianguo Li, Bo Wang, Guangsheng Zhou, Liguo Yang, Guohua Hua

“…Furthermore, FRS inclusion led to a significantly higher milk urea and non-fat milk solid content, higher blood glucose, total globulins, blood urea nitrogen, and lower blood high-density lipoprotein. …”
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Antenatal Determinants of Postnatal Renal Function in Fetal Megacystis: A Systematic Review by Ugo Maria Pierucci, Irene Paraboschi, Guglielmo Mantica, Sara Costanzo, Angela Riccio, Giorgio Giuseppe Orlando Selvaggio, Gloria Pelizzo

“…Regarding the predictive value of fetal urinary analytes, sodium and β2-microglobulin were the two most common urinary analytes investigated (n = 10 articles), followed by calcium (n = 6), chloride (n = 5), urinary osmolarity (n = 4), and total protein (n = 3). Phosphorus, glucose, creatinine, and urea were analyzed by two articles, and ammonium, potassium, N-Acetyl-l3-D-glucosaminidase, and microalbumin were investigated by one article. …”
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Identifying hormones and other perioperative risk factors for postoperative delirium after endoscope‐assisted transsphenoidal pituitary adenoma resection: A retrospective, matched... by Jin Liu, Jinyu Qian, Xia Wang, Jie Lin, Sunyan Yang, Rong Hu, Jishu Xian, Hua Feng, Yujie Chen, Binbin Tan

“…Results Lower insulin‐like growth factor‐1 (IGF‐1, p = .024) and corticotropin‐releasing hormone (CRH, p = .005) levels were closely associated with postoperative delirium and with high levels of blood glucose (GLU, p = .023) after surgery. Subsequent analysis indicated that serum potassium (OR: 0.311, 95% CI 0.103–0.935), sodium (OR: 0.991, 95% CI 0.983–1.000), CRH (OR: 0.964, 95% CI 0.936–0.994), and GLU (OR: 1.654, 95% CI 1.137–2.406) levels in the perioperative period were independent risk factors for delirium. …”
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Blood Metabolomics May Discriminate a Sub-Group of Patients with First Demyelinating Episode in the Context of RRMS with Increased Disability and MRI Characteristics Indicative of... by Marina Boziki, Alexandros Pechlivanis, Christina Virgiliou, Christos Bakirtzis, Styliani Aggeliki Sintila, Eleni Karafoulidou, Evangelia Kesidou, Paschalis Theotokis, Ioannis Nikolaidis, Georgios Theodoridis, Helen Gika, Nikolaos Grigoriadis

“…RRMS-patients-cluster-3 exhibited higher mean cell numbers in the Cerebro-spinal Fluid (CSF) compared to patients with CIS (18.17 ± 6.3 vs. 1.09 ± 0.41, <i>p</i> = 0.004). Mean glucose CSF/serum ratio and infratentorial lesion burden significantly differed across CIS- and HCL-derived RRMS-patient clusters (F = 14.95, <i>p</i> < 0.001 and F = 6.087, <i>p</i> = 0.002, respectively), mainly due to increased mean values for patients with RRMS-cluster-3. …”
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