Fluoride exposure disrupts the cytoskeletal arrangement and ATP synthesis of HT-22 cell by activating the RhoA/ROCK signaling pathway by Lingli Chen, Penghuan Jia, Yuye Liu, Rui Wang, Zhihong Yin, Dongfang Hu, Hongmei Ning, Yaming Ge

“…Moreover, fluoride exposure affects the expression of glucose transporters (GLUT1 and 3) and ATP synthesis. …”
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Fluorescent bioaerosol particle, molecular tracer, and fungal spore concentrations during dry and rainy periods in a semi-arid forest by M. I. Gosselin, M. I. Gosselin, C. M. Rathnayake, I. Crawford, C. Pöhlker, J. Fröhlich-Nowoisky, B. Schmer, V. R. Després, G. Engling, M. Gallagher, E. Stone, U. Pöschl, J. A. Huffman

“…Average mass concentrations of erythritol, levoglucosan, glucose, and (1 → 3)-<i>β</i>-D-glucan in TSP samples are reported separately for dry and rainy weather conditions. …”
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Comparison of Communication Channels for Large-Scale Type 2 Diabetes Risk Screening and Intervention Recruitment: Empirical Study by Kari Jalkanen, Riia Järvenpää, Tanja Tilles-Tirkkonen, Janne Martikainen, Emma Aarnio, Reija Männikkö, Eeva Rantala, Leila Karhunen, Marjukka Kolehmainen, Marja Harjumaa, Kaisa Poutanen, Miikka Ermes, Pilvikki Absetz, Ursula Schwab, Timo Lakka, Jussi Pihlajamäki, Jaana Lindström

“…The risk estimate was based on the Finnish Diabetes Risk Score; history of repeatedly measured high blood glucose concentration; or, among women, previous gestational diabetes. …”
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Stroke Causes DNA Methylation at Ncx1 Heart Promoter in the Brain Via DNMT1/MeCP2/REST Epigenetic Complex by Natascia Guida, Angelo Serani, Luca Sanguigno, Luigi Mascolo, Ornella Cuomo, Salvatore Fioriniello, Domenico Marano, Floriana Della Ragione, Serenella Anzilotti, Paola Brancaccio, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Luigi Formisano

“…Consistently, in cortical neurons subjected to oxygen and glucose deprivation plus reoxygenation Ncx1 knockdown counteracted neuronal protection induced by the demethylating agent 5‐azacytidine. …”
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Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohor... by Shiming He, Shiming He, Shiming He, Changhui Yu, Changhui Yu, Changhui Yu, Maobin Kuang, Maobin Kuang, Maobin Kuang, Jiajun Qiu, Jiajun Qiu, Jiajun Qiu, Ruijuan Yang, Ruijuan Yang, Shuhua Zhang, Guotai Sheng, Yang Zou

“…ObjectiveBoth alanine aminotransferase (ALT) and high-density lipoprotein cholesterol (HDL-C) are closely related to glucose homeostasis in the body, and the main objective of this study was to investigate the association between ALT to HDL-C ratio (ALT/HDL-C ratio) and the risk of diabetes in a Chinese population.MethodsThe current study included 116,251 participants who underwent a healthy physical examination, and the study endpoint was defined as a diagnosis of new-onset diabetes. …”
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Genotoxicity assessment of antidiabetic formulation (ADPHF6) in human lymphocytes by single cell gel electrophoresis (comet assay) - an in vitro study by Devanand Shanmugasundaram, Kumar Perumal, Sanjay M Cherian, Kotturathu Mammen Cherian

“…During hyperglycaemic condition, accumulation of excess fatty acids & glucose in adipose tissue (Wright Jr E., 2006) results in increased levels of ROS. …”
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Relação entre retinopatia diabética e dermopatia diabética em pacientes portadores de diabetes mellitus tipo 2 Relation between diabetic retinopathy and diabetic dermopathy in type... by Hugo Roberto Kurtz Lisboa, Aline Boff, João Rafael de Oliveira Dias, Madalena Rotta, Maiara Garib Guzzo, Saionara Zago, Gláucia Sarturi Tres, Roger Syllos

“…The duration of the disease greater than 10 years (p = 0,001) and age over 50 years (p = 0,014) were associated to retinopathy, but no association was found with elevated levels of HbA1c (p = 0,5) and fasting plasma glucose of 126 or higher (p = 0,8). The frequency of diabetic retinopathy in patients with diabetic dermopathy was not higher than in patients without dermopathy (7,7%, 7 cases, p = 0,586). …”
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Statistical models for the deterioration of kidney function in a primary care population: A retrospective database analysis [version 2; peer review: 2 approved] by Jason L Oke, Iryna Schlackow, Benjamin G Feakins, Claire Simons, Borislava Mihaylova, Daniel S Lasserson, Chris A O'Callaghan, Richard J Stevens, Rafael Perera, F D Richard Hobbs

“…Male gender, cancer, heart failure and age were independently associated with declining renal function, whereas the impact of raised blood pressure and glucose on renal function was entirely predicted by albuminuria. …”
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Preliminary Research on the Effect of Hyperbaric Oxygen Therapy in Patients with Post-COVID-19 Syndrome by Diana Kitala, Wojciech Łabuś, Jerzy Kozielski, Przemysław Strzelec, Mariusz Nowak, Grzegorz Knefel, Piotr Dyjas, Krzysztof Materniak, Jolanta Kosmala, Jolanta Pająk, Jolanta Czop, Barbara Janda-Kalus, Barbara Marona, Anna Nowak-Wróżyna, Marcin Gierek, Jan Szczegielniak, Marek Kucharzewski

“…In contrast, there were no changes in pH, pO2, pCO2, glucose, and excess alkaline values. A follow-up interview confirmed that the beneficial effects were maintained over time. …”
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Cuidados farmacêuticos em instituições de ação social: A extensão como estratégia de ensino e promoção da saúde by Jacqueline Aparecida Eidam Horst, Paulo Roberto Parecy Júnior, Luciana Erzinger Alves de Camargo, Tatiana Herrerias, Daniel de Paula

“…Health screening was performed with capillary blood glucose tests and blood pressure measurements. The association between comorbidities, age groups, and drug consumption was analyzed by Pearson's test. …”
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Dietary supplementation with sodium gluconate improves the growth performance and intestinal function in weaned pigs challenged with a recombinant Escherichia coli strain by Yanyan Zhang, Dan Yi, Haiwang Xu, Zihan Tan, Yuxuan Meng, Tao Wu, Lei Wang, Di Zhao, Yongqing Hou

“…Results showed that dietary SG supplementation had a tendency to increase average daily gain, and reduced (P < 0.05) feed to gain ratio, plasma glucose concentration, and mean corpuscular hemoglobin concentration as compared with control group on days 0-10 of trial. …”
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Isolation, Identification and Function of <i>Pichia anomala</i> AR₂₀₁₆ and Its Effects on the Growth and Health of Weaned Pigs by Yajun Ma, Zhihong Sun, Yan Zeng, Ping Hu, Weizhong Sun, Yubo Liu, Hong Hu, Zebin Rao, Zhiru Tang

“…Our results show that compared with the CK group, orally administered <i>P. anomala</i> AR₂₀₁₆ increases average daily gain, the ileal villus height, the ileal mucosal concentrations of occludin and zonula occluens-1, the serum glucose and total protein concentration, total superoxide dismutase, glutathione peroxidase, and total antioxidative capacity activity, the trypsin and lipase activity in jejunal and ileal contents, the jejunal and ileal mucosa mRNA levels of ALP, TNF-α, and TLR-2, and the relative abundance of Bacteroidetes, Actinobacteria, Succinivibrionaceae, Lachnospiraceae, and Prevotellaceae (<i>p</i> < 0.05). …”
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Exploring the clinical efficacy and mechanism of high-position colon dialysis combined with Traditional Chinese Medicine retention enema in real-world patients with stage 3–5 chron... by Yanli Deng, Leixiao Zhang, Si Chen, Dongxian Xu, Wei Wu, Tao Shen, Zhen Liu, Lin Yang, Aiwei Wen, Yuhao Hou, Fanyun Shao

“…Both groups adhered to a high-quality low-protein, low-salt, low-phosphorus, and low-fat diet supplemented with essential amino acids, and were monitored for blood pressure, blood glucose, and blood lipids. The treatment group received high-position colon dialysis combined with TCM retention enemas (administered at least 12 times every other day).Results: Thirteen compounds were identified from the herbs by UPLC-Q-Orbitrap-HRMS. …”
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Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis by Somnath Shee, Reshma T Veetil, Karthikeyan Mohanraj, Mayashree Das, Nitish Malhotra, Devleena Bandopadhyay, Hussain Beig, Shalini Birua, Shreyas Niphadkar, Sathya Narayanan Nagarajan, Vikrant Kumar Sinha, Chandrani Thakur, Raju S Rajmani, Nagasuma Chandra, Sunil Laxman, Mahavir Singh, Areejit Samal, Aswin N Seshasayee, Amit Singh

“…Disruption of rv0158 (rv0158 KO) impaired growth, redox balance, respiration, and metabolism of Mtb on glucose but not on fatty acids. Importantly, rv0158 KO exhibited enhanced growth on propionate, and the Rv0158 protein directly binds to methylmalonyl-CoA, a key intermediate in propionate catabolism. …”
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IL-17C neutralization protects the kidney against acute injury and chronic injuryResearch in context by Fangfei Zhang, Jianyong Yin, Li Liu, Shuiying Liu, Guangyuan Zhang, Yiwei Kong, Yajun Wang, Niansong Wang, Xiangmei Chen, Feng Wang

“…Mechanistical studies demonstrated that hypoxia or high glucose-induced IL-17C up-regulation was predominantly mediated by NF-κB pathway. …”
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Comparison of the effects of high-intensity interval and moderate-intensity continuous training on inflammatory markers, cardiorespiratory fitness, and quality of life in breast ca... by Amin Isanejad, Somayeh Nazari, Behroz Gharib, Ali Ghanbari Motlagh

“…There were no significant differences between groups for body weight, body mass index, fasting blood glucose, insulin resistance, sex hormone binding globulin, total cholesterol, low-density lipoprotein cholesterol, adipokines, interleukin-6, tumor necrosis factor-α, or interleukin-10. …”
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Biochemical and Computational Studies of the Interaction between a Glucosamine Derivative, NAPA, and the IKK<em>α</em> Kinase by Mariangela Lopreiato, Samuele Di Cristofano, Rossana Cocchiola, Alessia Mariano, Libera Guerrizio, Roberto Scandurra, Luciana Mosca, Domenico Raimondo, Anna Scotto d’Abusco

“…The glucosamine derivative 2-(N-Acetyl)-L-phenylalanylamido-2-deoxy-<inline-formula><math display="inline"><semantics><mi>β</mi></semantics></math></inline-formula>-D-glucose (NAPA), was shown to inhibit the kinase activity of IKK<inline-formula><math display="inline"><semantics><mi>α</mi></semantics></math></inline-formula>, one of the two catalytic subunits of IKK complex, decreasing the inflammatory status in osteoarthritis chondrocytes. …”
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Study of Transcriptomic Analysis of Yak (<i>Bos grunniens</i>) and Cattle (<i>Bos taurus</i>) Pulmonary Artery Smooth Muscle Cells under Oxygen Concentration Gradients and Differen... by Yiyang Zhang, Manlin Zhou, Yuxin Liang, Rui Li, Lan Zhang, Shuwu Chen, Kun Yang, Haie Ding, Xiao Tan, Qian Zhang, Zilin Qiao

“…The results showed that, at the level of transcriptome sequencing, the molecular regulatory mechanisms of the HIF-1 signaling pathway, glucose metabolism pathway, and related factors (HK2/PGK1/ENO1/ENO3/ALDOC/ALDOA) may be closely related to the adaptation of yaks to the hypoxic environment of the plateau; at the tissue level, the presence of filled alveoli and semi-filled alveoli, thicker alveolar septa and basement membranes, a large number of erythrocytes, capillary distribution, and collagen fibers accounted for all levels of fine bronchioles in the lungs of yaks as compared to cattle. …”
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Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials by Omid Asbaghi, Damoon Ashtary-Larky, Reza Bagheri, Seyedeh Parisa Moosavian, Hadi Pourmirzaei Olyaei, Behzad Nazarian, Mahnaz Rezaei Kelishadi, Alexei Wong, Darren G. Candow, Frédéric Dutheil, Katsuhiko Suzuki, Amirmansour Alavi Naeini

“…From 1814 detected studies, twenty-four studies reported fasting blood glucose (FBG), fasting insulin, hemoglobin A1C (HbA1C), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) as an outcome measure. …”
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The adult growth hormone multicentric retrospective observational study: a 24-month Italian experience of adherence monitoring via Easypod™ of recombinant growth hormone treatment... by Antonio Mancini, Edoardo Vergani, Carmine Bruno, Claudia Giavoli, Claudia Giavoli, Matteo Spaziani, Andrea M. Isidori, Maura Arosio, Maura Arosio, Alfredo Pontecorvi

“…All patients were evaluated for IGF-1, glucose, insulin, HOMA and QUICKI index, total/LDL/HDL cholesterol and triglycerides.ResultsMean adherence rate was consistently under 85% across the 2-year observation period (73% at year 2). …”
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