Infection-specific PET imaging with 18F-fluorodeoxysorbitol and 2-[18F]F-ρ-aminobenzoic acid: An extended diagnostic tool for bacterial and fungal diseases by Marta Rua, Marta Rua, Jon Ander Simón, María Collantes, María Collantes, Margarita Ecay, José Leiva, José Leiva, Francisco Carmona-Torre, Francisco Carmona-Torre, Rocío Ramos, Félix Pareja, Krishna R. Pulagam, Jordi Llop, José Luis Del Pozo, José Luis Del Pozo, José Luis Del Pozo, Iván Peñuelas, Iván Peñuelas, Iván Peñuelas

“…The most widely used radiotracer for PET imaging (2-deoxy-2[18F] fluoro-D-glucose: [18F]FDG) shows uptake in both infected and sterile inflammation. …”
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Association of visit-to-visit HbA1c variability with cardiovascular diseases in type 2 diabetes within or outside the target range of HbA1c by Bao Sun, Bao Sun, Bao Sun, Yongchao Gao, Yongchao Gao, Yongchao Gao, Yongchao Gao, Fazhong He, Zhaoqian Liu, Zhaoqian Liu, Zhaoqian Liu, Zhaoqian Liu, Jiecan Zhou, Jiecan Zhou, Xingyu Wang, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang

“…Cox proportional hazard models were used to estimate adjusted hazard ratios (aHR).ResultsAmong 855 patients in the intensive glucose treatment group, 563 and 292 patients were assigned to the group of “within the target range of HbA1c” (WTH) (updated mean HbA1c ≤ 7.0%) and “outside the target range of HbA1c” (OTH) (updated mean HbA1c > 7.0%), respectively. …”
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Relationship between lipid parameters and vascular mechanical characteristics among a normotensive population without diabetes mellitus residing at the Qinghai–Tibet plateau: a cro... by Xianjin Hu, Xin Zhang, Zhipeng Zhang, Xinran Li, Qiling Gou, Runyu Ye, Xiaoping Chen

“…Multiple linear regression analysis revealed that TC (β = 0.165, p = 0.024) and non-HDL-C (β = 0.151, p = 0.042) remained independent predictors of change in Ba-PWV in men after adjusting for age, mean arterial pressure, waist circumference, hemoglobin, platelet count, fasting blood glucose, estimated glomerular filtration rate, and uric acid. …”
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Productivity enhancement in L-lysine fermentation using oxygen-enhanced bioreactor and oxygen vector by Jinduo Wang, Jinduo Wang, Shuo Wang, Shuo Wang, Siyu Zhao, Siyu Zhao, Pengjie Sun, Pengjie Sun, Zhen Zhang, Zhen Zhang, Qingyang Xu, Qingyang Xu

“…The increased viability of Corynebacterium glutamicum LS260 in the mid to late stages of growth resulted in a yield of 185.3 g/L of L-lysine, 74.57% conversion of lysine from glucose, and productivity of 2.57 g/L/h, an increase of 11.0%, 6.01%, and 8.2%, respectively, over a conventional bioreactor. …”
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Missed Opportunities for Screening and Management of Dysglycemia among Patients Presenting with Acute Myocardial Infarction in North India: The Prospective NORIN STEMI Registry by John W. Ostrominski, Muthiah Vaduganathan, Meennahalli Palleda Girish, Puneet Gupta, Michael J. Hendrickson, Arman Qamar, Sameer Arora, Ambarish Pandey, Ankit Bansal, Vishal Batra, Bhawna Mahajan, Saibal Mukhopadhyay, Jamal Yusuf, Sanjay Tyagi, Deepak L. Bhatt, Mohit D. Gupta, NORIN STEMI Investigators

“…In this group, baseline treatment with statins, sodium-glucose cotransporter 2 inhibitors, or glucagon-like peptide-1 receptor agonists was observed in 14%, <1%, and 1% of patients, respectively. …”
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Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis by Huan Feng, Qi Liu, Zhiyao Deng, Hao Li, Huajie Zhang, Jingyu Song, Xiaming Liu, Jihong Liu, Bo Wen, Tao Wang

“…HUCMSCs normalised mitochondrial morphology within corpus cavernosum smooth muscle cells (CCSMCs), which were characteristically altered by high glucose. Furthermore, the expression of ferroptosis inhibitory genes SLC7A11 and GPX4 was obviously elevated in CCSMCs after stem cell management, but the abundances of ACSL4, LPCAT3 and ALOX15 showed the polar opposite tendency. …”
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Size, surface charge and flexibility of vinegar-baked Radix Bupleuri polysaccharide affecting the immune response by Xiaoshuang Wang, Ya Zhao, Yayun Wu, Lijuan Liu, Minjie Liang, Minghui Han, Ping Li, Ziqing Chen, Hongbing Yan, Ruizhi Zhao

“…Its monosaccharides composed of mannose, rhamnose, galacturonic acid, glucose, galactose and arabinose at a molar ratio of 1.72: 9.59: 57.63: 5.37: 6.71: 18.99. …”
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Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance by Wouter M.A. Franssen, Charly Keytsman, Nastasia Marinus, Kenneth Verboven, Bert O. Eijnde, Lisa van Ryckeghem, Paul Dendale, Renate Zeevaert, Guy Massa, Dominique Hansen

“…Biochemistry (lipid profile, glycemic control, inflammation, and leptin) was studied in fasted blood samples and during an oral glucose tolerance test within obese adolescents. Regression analyses were applied to examine associations between the presence of CI and blood or exercise capacity parameters, respectively, within obese adolescents. …”
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Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells by Muhammad Saad Khilji, Pouya Faridi, Erika Pinheiro-Machado, Carolin Hoefner, Tina Dahlby, Ritchlynn Aranha, Søren Buus, Morten Nielsen, Justyna Klusek, Thomas Mandrup-Poulsen, Kirti Pandey, Anthony W. Purcell, Michal T. Marzec

“…We have shown that loss of the proinsulin chaperone glucose-regulated protein (GRP) 94 from the endoplasmic reticulum (ER) leads to mishandling of proinsulin, ER stress, and activation of the immunoproteasome. …”
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β-hydroxybutyrate impairs monocyte function via the ROS-NLR family pyrin domain-containing three inflammasome (NLRP3) pathway in ketotic cows by Zhihao Dong, Xudong Sun, Yan Tang, Shengbin Luo, Hongdou Jia, Qiushi Xu, Qianming Jiang, Juan J. Loor, Wei Xu, Chuang Xu

“…Serum concentrations of fatty acids (0.30 vs. 0.88 mM) and BHB (0.52 vs. 3.78 mM) were greater in cows with CK, whereas concentration of glucose was lower (4.09 vs. 2.23 mM). The adhesion, migration and phagocytosis of monocytes were lower in cows with CK, but apoptosis and ROS content were greater. …”
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Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway by Guang Shi, Junmin Chen, Cong Zhang, Xin Zhao, Jing Wang, Rong Chen, Renhao Xu, Degang Song, Xiangjian Zhang

“…In vitro, AS-IV promoted endothelial cells (ECs) proliferation and tube formation after oxygen-glucose deprivation (OGD), which was partially inhibited by the specific PI3K inhibitor LY294002. …”
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Effects of insulin therapy optimization with sensor augmented pumps on glycemic control and body composition in people with cystic fibrosis-related diabetes by V. Grancini, G. Alicandro, G. Alicandro, L. L. Porcaro, L. Zazzeron, A. Gramegna, A. Gramegna, L. C. Morlacchi, V. Rossetti, A. Gaglio, V. Resi, V. Daccò, F. Blasi, F. Blasi, E. Orsi

“…SAP therapy was also associated with a decrease in mean glucose (between group difference: -32 mg/dL; 95% CI: -44; -20) and an increase in TIR (between group difference: 19.3%; 95% CI 13.9; 24.7) and in fat-free mass (between group difference: +5.5 Kg, 95% CI: 3.2; 7.8).ConclusionTherapy optimization with SAP led to a significant improvement in glycemic control, which was associated with an increase in fat-free mass.…”
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Lysosomal Acid Lipase Deficiency in the Etiological Investigation of Cryptogenic Liver Disease in Adults: A Multicenter Brazilian Study by Aline Coelho Rocha Candolo, Guilherme Grossi Lopes Cançado, Patricia Momoyo Zitelli, Daniel Ferraz de Campos Mazo, Claudia Pinto Marques Oliveira, Marlone Cunha-Silva, Raquel Dias Greca, Roberta Chaves Araújo, Amanda Sacha Paulino Tolentino Alustau, Claudia Alves Couto, Mateus Jorge Nardelli, Roque Gabriel Rezende de Lima, Alberto Queiroz Farias, Flair José Carrilho, Mário Guimarães Pessôa

“…The mean serum levels of glucose, HDL-cholesterol, and triglycerides were 89.7 ± 3.2, 21.7 ± 3.2, and 206.7 ± 25.5 mg/dL, respectively. …”
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Postprandial metabolism and gut permeability in calves fed milk replacer with different macronutrient profiles or a whole milk powder by J.N. Wilms, M.H. Ghaffari, P. Stahel Darani, M. Jansen, H. Sauerwein, M.A. Steele, J. Martín-Tereso, L.N. Leal

“…The AUC for postprandial plasma glucose was lower in calves fed HL than WP and HF and lower in calves fed HP than WP. …”
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Butyrate reduces adherent-invasive E. coli-evoked disruption of epithelial mitochondrial morphology and barrier function: involvement of free fatty acid receptor 3 by Samira A. Hamed, Armaan Mohan, Saranya Navaneetha Krishnan, Arthur Wang, Marija Drikic, Nicole L. Prince, Ian A. Lewis, Jane Shearer, Åsa V. Keita, Johan D. Söderholm, Timothy E. Shutt, Derek M. McKay

“…Metabolomics revealed that butyrate significantly altered E. coli-LF82 central carbon metabolism leading to diminished glucose uptake and increased succinate secretion. …”
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Prediction of Neurological Deterioration After Intracerebral Hemorrhage: The SIGNALS Score by Quanwei He, Hongxiu Guo, Rentang Bi, Shaoli Chen, Jing Shen, Chunnan Long, Man Li, Yuanpeng Xia, Lei Zhang, Zhou Sun, Xiaolu Chen, Zhaowei Wang, Daokai Gong, Jingwen Xu, Dondya Zhu, Yan Wan, Bo Hu

“…The site, size, gender, National Institutes of Health Stroke Scale, age, leukocyte, sugar (SIGNALS) score was developed as a sum of individual points (0–8) based on site (1 point for infratentorial location), size (3 points for >20 mL of supratentorial hematoma volume or 2 points for >10 mL of infratentorial hematoma volume), sex (1 point for male sex), National Institutes of Health Stroke Scale score (1 point for >10), age (1 point for ≥70 years), white blood cell (1 point for>9.0×109/L), and fasting blood glucose (1 point>7.0 mmol/L). The proportion of patients who suffered from neurological deterioration increased with higher SIGNALS score, showing good discrimination and good calibration in the training cohort (C statistic, 0.821; Hosmer‐Lemeshow test, P=0.687) and in the validation cohort (C statistic, 0.848; Hosmer‐Lemeshow test, P=0.592), respectively. …”
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Effects of Ethanolic and Aqueous Extracts of <i>Garcinia gardneriana</i> Leaves in an In Vivo Experimental Model Induced by a Hyperlipidic Diet by Bruna Larissa Spontoni do Espirito Santo, Lidiani Figueiredo Santana, Wilson Hino Kato Junior, Felipe de Oliveira de Araújo, Mariana Bento Tatara, Júlio Croda, Danielle Bogo, Karine de Cássia Freitas, Rita de Cássia Avellaneda Guimarães, Priscila Aiko Hiane, Arnildo Pott, Wander Fernando de Oliveira Filiú, Bernardo Bacelar de Faria, Patrícia de Oliveira Figueiredo, Valter Aragão do Nascimento, Frederico Louveira Ayres, Paulo Roberto Haidamus de Oliveira Bastos

“…The results showed an increase in the values of high density lipoprotein (HDL-c), total cholesterol, triglycerides and fasting blood glucose. <i>G. gardneriana</i> did not protect against insulin resistance, and caused in an increase in monocyte chemoattractant protein-1 (MCP-1) concentrations and a reduction in interleukin 10 (IL-10). …”
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Prevalence, awareness, treatment, and risk factor control of high atherosclerotic cardiovascular disease risk in Guangzhou, China by Hui Liu, Weiquan Lin, Weiquan Lin, Kexin Tu, Qin Zhou, Qin Zhou, Chang Wang, Minying Sun, Minying Sun, Yaohui Li, Xiangyi Liu, Guozhen Lin, Sidong Li, Wei Bao

“…The proportions of drug use in prevention were relatively low in primary prevention, with the rates of using BP-lowering, glucose-lowering, lipid-lowering, and aspirin being 37.7% (95% CI, 32.8%–42.8%), 41.4% (95% CI, 35.8%–47.3%), 6.7% (95% CI, 4.5%–10.0%), and 1.0% (95% CI, 0.6%–1.8%), respectively. …”
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Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050 by Hui-Ling Qiu, Shujun Fan, Kaixin Zhou, Zhini He, Matthew H.E.M. Browning, Luke D. Knibbs, Tianyu Zhao, Ya-Na Luo, Xiao-Xuan Liu, Li-Xin Hu, Jia-Xin Li, Yi-Dan Zhang, Yu-Ting Xie, Joachim Heinrich, Guang-Hui Dong, Bo-Yi Yang

“…To better inform prevention strategies, we aimed to delineate and predict the temporal, spatial, and demographic patterns in mean fasting plasma glucose (FPG) levels and their related disease burden globally. …”
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Integrated analysis of transcriptome, metabolome, and histochemistry reveals the response mechanisms of different ages Panax notoginseng to root-knot nematode infection by Zhuhua Wang, Wenpeng Wang, Wenpeng Wang, Wentao Wu, Huiling Wang, Shuai Zhang, Chen Ye, Liwei Guo, Zhaoxia Wei, Hongping Huang, Yixiang Liu, Shusheng Zhu, Youyong Zhu, Yang Wang, Xiahong He, Xiahong He

“…Three-year-old P. notoginseng reinforced its resistance by significantly increasing five phenolic acids related to monolignol biosynthesis, namely p-coumaric acid, chlorogenic acid, 1-O-sinapoyl-D-glucose, coniferyl alcohol, and ferulic acid. Notably, P. notoginseng can establish a lignin barrier that restricted RKN to the infection site. …”
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