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50561
DNA methylation alterations in muscle of critically ill patients
Published 2022-06-01“…Many of the associated genes appeared highly relevant for muscle structure and function/weakness, including genes involved in myogenesis, muscle regeneration, nerve/muscle membrane excitability, muscle denervation/re‐innervation, axon guidance/myelination/degeneration/regeneration, synapse function, ion channelling with especially calcium signalling, metabolism (glucose, protein, and fat), insulin signalling, neuroendocrine hormone regulation, mitochondrial function, autophagy, apoptosis, oxidative stress, Wnt signalling, transcription regulation, muscle fat infiltration during regeneration, and fibrosis. …”
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50562
The impact of heart failure therapy in patients with mildly reduced ejection fraction: a network meta‐analysis
Published 2023-06-01“…Aims A network meta‐analysis (NMA) was performed to compare treatment effect of mineralocorticoid receptor antagonists (MRA), angiotensin receptor neprilysin inhibitor (ARNi), angiotensin receptor blockers (ARB), angiotensin‐converting‐enzyme inhibitors (ACEi), sodium‐glucose cotransporter‐2 inhibitors (SGLT2i), and beta‐blockers (BB) in HFmrEF cardiovascular (CV) outcomes. …”
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50563
Effects of Recombinant Human Growth Hormone Treatment, Depending on the Therapy Start in Different Nutritional Phases in Paediatric Patients with Prader–Willi Syndrome: A Polish Mu...
Published 2021-07-01“…IGF1 SDS values were lower in group 1 vs. other groups at rhGH1 and vs. groups 2 and 3 at rhGH2 (<i>p</i> < 0.05). Glucose metabolism parameters were favourable in groups 1 and 2, and the lipid profile was comparable in all groups. …”
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50564
Screening for Liver Steatosis and Fibrosis in Patients with Inflammatory Bowel Disease Using Vibration Controlled Transient Elastography with Controlled Attenuation Parameter
Published 2022-10-01“…Age (<i>β</i> = 0.357, <i>p</i> = 0.021), body mass index (BMI) (<i>β</i> = 0.185, <i>p</i> = 0.048), disease duration (<i>β</i> = 0.297, <i>p</i> = 0.041), C—reactive protein (<i>β</i> = 0.321, <i>p</i> = 0.013), fasting plasma glucose (<i>β</i> = 0.269, <i>p</i> = 0.038), and triglycerides (<i>β</i> = 0.273, <i>p</i> = 0.023) were strongly associated with the presence of liver steatosis. …”
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50565
Evaluation study of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in the treatment of Chinese obese patients based on efficacy and nutrition
Published 2024-03-01“…At 3, 6 and 12 months, the average %EWL was 62.07 ± 26.56, 85.93 ± 27.92, and 106.65 ± 29.65%, %TWL was 22.67 ± 4.94, 32.10 ± 5.18, and 40.56 ± 7.89%, respectively. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), uric acid (UA), triglycerides (TG), blood pressure (BP), and other indexes were significantly lower after one year post-surgery compared with the preoperative period (P < 0.05). …”
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50566
Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes
Published 2021-12-01“…Methods An initial screening using quantitative trait locus analysis enabled us to extract a set of genes including ubiquitin‐specific proteases21 (USP21) (r = 0.738; P = 0.004) as potential targets associated with fasting blood glucose content. Given tight regulation of the ubiquitination status of proteins in muscle, we focused on USP21 and generated whole‐body (KO) and skeletal muscle‐specific USP21 knockout (MKO) mice. …”
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50567
Differential Metabotypes in Synovial Fibroblasts and Synovial Fluid in Hip Osteoarthritis Patients Support Inflammatory Responses
Published 2022-03-01“…Obese OA patient synovial fluid (n = 5) exhibited a different metabotype, compared to normal-weight patient fluid (n = 6), with significantly increased levels of 1, 3-dimethylurate, N-Nitrosodimethylamine, succinate, tyrosine, pyruvate, glucose, glycine and lactate, and enrichment of the glutamine–glutamate metabolic pathway, which correlated with increasing adiposity. …”
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50568
Effect of the GLP-1 receptor agonist semaglutide on metabolic disturbances in clozapine-treated or olanzapine-treated patients with a schizophrenia spectrum disorder: study protoco...
Published 2023-01-01“…Secondary endpoints include changes in body weight, hip and waist circumference and plasma levels of insulin, glucagon, glucose, and C-peptide, insulin sensitivity, beta cell function, hepatic function, fibrosis-4 score, lipid profile, incretin hormones, bone markers, body composition, bone density, proteomic analyses and oxidative stress markers. …”
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50569
Total metabolic tumor volume on 18F-FDG PET/CT is a game-changer for patients with metastatic lung cancer treated with immunotherapy
Published 2024-04-01“…The aim of this prospective study was to evaluate the prognostic value of volume-derived positron-emission tomography (PET) parameters on baseline and follow-up 18F-fluoro-deoxy-glucose PET (18F-FDG-PET) scans and compare it with the conventional PET Response Criteria in Solid Tumors (PERCIST).Methods Patients with metastatic NSCLC were included in two different single-center prospective trials. 18F-FDG-PET studies were performed before the start of immunotherapy (PETbaseline), after 6–8 weeks (PETinterim1) and after 12–16 weeks (PETinterim2) of treatment, using PERCIST criteria for tumor response assessment. …”
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50570
Sensory Neuropathy Affects Cardiac miRNA Expression Network Targeting <i>IGF-1</i>, <i>SLC2a-12</i>, <i>EIF-4e</i>, and <i>ULK-2</i> mRNAs
Published 2019-02-01“…By an in silico network analysis, we identified common mRNA targets (insulin-like growth factor 1 (<i>IGF-1</i>), solute carrier family 2 facilitated glucose transporter member 12 (<i>SLC2a-12</i>), eukaryotic translation initiation factor 4e <i>(EIF-4e</i>), and Unc-51 like autophagy activating kinase 2 (<i>ULK-2</i>)) targeted by at least three altered miRNAs. …”
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50571
Effects of Roux-en-Y gastric bypass on the metabolic profile and systemic inflammatory status of women with metabolic syndrome: randomized controlled clinical trial
Published 2023-02-01“…Lipid profile, blood glucose and adipokines (adiponectin, leptin, and resistin) and (cytokines IL-1β, IL-6, IL-17, IL-23, and TNF-α) in blood plasma samples were evaluated before and six months after RYGB. …”
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50572
Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus
Published 2023-04-01“…Mechanistically, IHMT-MST1-39 activated AMPK signaling pathway in hepatocytes in vitro, combination of IHMT-MST1-39 and metformin synergistically prevented hyperglycemia and significantly ameliorated glucose tolerance and insulin resistance in diabetic mice. …”
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50573
Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting
Published 2018-06-01“…Although results are sometimes conflicting because of confounding factors, epidemiological studies in humans suggest effects of EDCs on prenatal growth, thyroid function, glucose metabolism and obesity, puberty, fertility, and on carcinogenesis mainly through epigenetic mechanisms. …”
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50574
Anthrahydroquinone-2,6-disulfonate alleviates paraquat-induced kidney injury via the apelin-APJ pathway in rats
Published 2022-01-01“…Western blotting was used to detect the expression levels of the following proteins in the kidney tissues: IL- 6, TNF-α, apelin-APJ (the apelin-angiotensin receptor), NF-κB p65, caspase-1, caspase-8, glucose-regulated protein 78 (GRP78), and the C/EBP homologous protein (CHOP). …”
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50575
Cardiometabolic risk factors among children who are affected by overweight, obesity and severe obesity
Published 2023-04-01“…Cardiometabolic risk factors presented in this study included fasting plasma glucose (FPG), triglycerides (TGs), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), blood pressure, acanthosis nigricans, insulin resistance (IR), and MetS. …”
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50576
Isorhamnetin protects zearalenone-induced damage via the PI3K/Akt signaling pathway in porcine ovarian granulosa cells
Published 2022-12-01“…Changes in intracellular Ca2+ levels and C/EBP homologous protein (CHOP), recombinant activating transcription factor 6 (ATF6), glucose regulated protein78 kD (GRP78) indicated that isorhamnetin rescued (P < 0.05) ZEA-induced endoplasmic reticulum stress. …”
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50577
Multi-Organ Protective Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Rats with Type 1 Diabetes Mellitus
Published 2021-06-01“…Both curcumin formulations, CC and NC, prevented the following electrocardiographic changes: prolongation of the QRS complex, enlargement of QT and QTc intervals, and ST-segment elevation. Glucose levels and lipid profile parameters were reduced up to 1.9 times, while C-peptide serum levels were increased up to 1.6 times in groups that received CC or NC. …”
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50578
Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial
Published 2021-06-01“…Anthropometrics were measured and blood samples were taken pre- and post-supplementation. Fasting blood glucose, lipids, serum 25(OH)D, and inflammatory markers were measured. …”
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50579
Effects of Combined Motion Intervention on Body Composition, Cardiovascular Risk Factors and Cardiopulmonary Fitness of Obese Female Adolescents
Published 2024-03-01“…The indicators such as height, body mass, body fat rate (BFR) , waist circumference, BMI, blood pressure (BP) , fasting plasma glucose (FPG) , insulin, insulin resistance index (HOMA-IR) and maximal oxygen uptake (VO2max) were detected before and after the 12-week combined motion intervention and compared between the two groups, as well as before and after the intervention. …”
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50580
Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity
Published 2022-11-01“…Oral treatment of specific commercial Bifidobacterium longum and Bifidobacterium bifidum enhanced bile acid signaling contributing to potentiate oxidative phosphorylation (OXPHOS) in adipose tissues, leading to reduction of body weight gain and improvement in hepatic steatosis and glucose homeostasis. Bifidobacterium longum or Bifidobacterium bifidum manipulated intestinal sterol biosynthetic processes to protect against diet-induced obesity in germ-free mice. …”
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