DNA methylation alterations in muscle of critically ill patients by Lisa Van Dyck, Fabian Güiza, Inge Derese, Lies Pauwels, Michaël P. Casaer, Greet Hermans, Pieter J. Wouters, Greet Van den Berghe, Ilse Vanhorebeek

“…Many of the associated genes appeared highly relevant for muscle structure and function/weakness, including genes involved in myogenesis, muscle regeneration, nerve/muscle membrane excitability, muscle denervation/re‐innervation, axon guidance/myelination/degeneration/regeneration, synapse function, ion channelling with especially calcium signalling, metabolism (glucose, protein, and fat), insulin signalling, neuroendocrine hormone regulation, mitochondrial function, autophagy, apoptosis, oxidative stress, Wnt signalling, transcription regulation, muscle fat infiltration during regeneration, and fibrosis. …”
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The impact of heart failure therapy in patients with mildly reduced ejection fraction: a network meta‐analysis by Marta Leite, Francisco Sampaio, Francisca A. Saraiva, Sílvia O. Diaz, António S. Barros, Ricardo Fontes‐Carvalho

“…Aims A network meta‐analysis (NMA) was performed to compare treatment effect of mineralocorticoid receptor antagonists (MRA), angiotensin receptor neprilysin inhibitor (ARNi), angiotensin receptor blockers (ARB), angiotensin‐converting‐enzyme inhibitors (ACEi), sodium‐glucose cotransporter‐2 inhibitors (SGLT2i), and beta‐blockers (BB) in HFmrEF cardiovascular (CV) outcomes. …”
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Effects of Recombinant Human Growth Hormone Treatment, Depending on the Therapy Start in Different Nutritional Phases in Paediatric Patients with Prader–Willi Syndrome: A Polish Mu... by Agnieszka Lecka-Ambroziak, Marta Wysocka-Mincewicz, Katarzyna Doleżal-Ołtarzewska, Agata Zygmunt-Górska, Anna Wędrychowicz, Teresa Żak, Anna Noczyńska, Dorota Birkholz-Walerzak, Renata Stawerska, Maciej Hilczer, Monika Obara-Moszyńska, Barbara Rabska-Pietrzak, Elżbieta Gołębiowska, Adam Dudek, Elżbieta Petriczko, Mieczysław Szalecki, on behalf of the Polish Coordination Group for rhGH Treatment

“…IGF1 SDS values were lower in group 1 vs. other groups at rhGH1 and vs. groups 2 and 3 at rhGH2 (<i>p</i> < 0.05). Glucose metabolism parameters were favourable in groups 1 and 2, and the lipid profile was comparable in all groups. …”
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Screening for Liver Steatosis and Fibrosis in Patients with Inflammatory Bowel Disease Using Vibration Controlled Transient Elastography with Controlled Attenuation Parameter by Anca Trifan, Remus Stafie, Adrian Rotaru, Ermina Stratina, Sebastian Zenovia, Robert Nastasa, Laura Huiban, Tudor Cuciureanu, Cristina Muzica, Stefan Chiriac, Irina Girleanu, Ana-Maria Singeap, Catalin Sfarti, Camelia Cojocariu, Oana Petrea, Carol Stanciu

“…Age (<i>β</i> = 0.357, <i>p</i> = 0.021), body mass index (BMI) (<i>β</i> = 0.185, <i>p</i> = 0.048), disease duration (<i>β</i> = 0.297, <i>p</i> = 0.041), C—reactive protein (<i>β</i> = 0.321, <i>p</i> = 0.013), fasting plasma glucose (<i>β</i> = 0.269, <i>p</i> = 0.038), and triglycerides (<i>β</i> = 0.273, <i>p</i> = 0.023) were strongly associated with the presence of liver steatosis. …”
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Evaluation study of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in the treatment of Chinese obese patients based on efficacy and nutrition by Lifu Hu, Lun Wang, Shixing Li, Yang Liu, Zheng Zhang, Minghao Xiao, Zhenhua Zhang, Zhiqiang Wei, Liang Cui, Tao Jiang

“…At 3, 6 and 12 months, the average %EWL was 62.07 ± 26.56, 85.93 ± 27.92, and 106.65 ± 29.65%, %TWL was 22.67 ± 4.94, 32.10 ± 5.18, and 40.56 ± 7.89%, respectively. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), uric acid (UA), triglycerides (TG), blood pressure (BP), and other indexes were significantly lower after one year post-surgery compared with the preoperative period (P < 0.05). …”
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Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes by Ayoung Kim, Ja Hyun Koo, Xing Jin, Wondong Kim, Shi‐Young Park, Sunghyouk Park, Eugene P. Rhee, Cheol Soo Choi, Sang Geon Kim

“…Methods An initial screening using quantitative trait locus analysis enabled us to extract a set of genes including ubiquitin‐specific proteases21 (USP21) (r = 0.738; P = 0.004) as potential targets associated with fasting blood glucose content. Given tight regulation of the ubiquitination status of proteins in muscle, we focused on USP21 and generated whole‐body (KO) and skeletal muscle‐specific USP21 knockout (MKO) mice. …”
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Differential Metabotypes in Synovial Fibroblasts and Synovial Fluid in Hip Osteoarthritis Patients Support Inflammatory Responses by Hussein Farah, Susanne N. Wijesinghe, Thomas Nicholson, Fawzeyah Alnajjar, Michelangelo Certo, Abdullah Alghamdi, Edward T. Davis, Stephen P. Young, Claudio Mauro, Simon W. Jones

“…Obese OA patient synovial fluid (n = 5) exhibited a different metabotype, compared to normal-weight patient fluid (n = 6), with significantly increased levels of 1, 3-dimethylurate, N-Nitrosodimethylamine, succinate, tyrosine, pyruvate, glucose, glycine and lactate, and enrichment of the glutamine–glutamate metabolic pathway, which correlated with increasing adiposity. …”
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Effect of the GLP-1 receptor agonist semaglutide on metabolic disturbances in clozapine-treated or olanzapine-treated patients with a schizophrenia spectrum disorder: study protoco... by Jimmi Nielsen, Christoph U Correll, Tina Vilsbøll, Maj Vinberg, Claus Ekstrøm, Anders Fink-Jensen, Heidi Storgaard, Filip K Knop, Ole Mors, Marie Reeberg Sass, Andreas Aalkjær Danielsen, Ole Köhler-Forsberg, Mette Ødegaard Nielsen, Anders Mikael Sjödin

“…Secondary endpoints include changes in body weight, hip and waist circumference and plasma levels of insulin, glucagon, glucose, and C-peptide, insulin sensitivity, beta cell function, hepatic function, fibrosis-4 score, lipid profile, incretin hormones, bone markers, body composition, bone density, proteomic analyses and oxidative stress markers. …”
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Total metabolic tumor volume on 18F-FDG PET/CT is a game-changer for patients with metastatic lung cancer treated with immunotherapy by Nicolas Martin, Pierre Tricarico, David Chardin, Sara Contu, Florent Hugonnet, Josiane Otto, Olivier Humbert

“…The aim of this prospective study was to evaluate the prognostic value of volume-derived positron-emission tomography (PET) parameters on baseline and follow-up 18F-fluoro-deoxy-glucose PET (18F-FDG-PET) scans and compare it with the conventional PET Response Criteria in Solid Tumors (PERCIST).Methods Patients with metastatic NSCLC were included in two different single-center prospective trials. 18F-FDG-PET studies were performed before the start of immunotherapy (PETbaseline), after 6–8 weeks (PETinterim1) and after 12–16 weeks (PETinterim2) of treatment, using PERCIST criteria for tumor response assessment. …”
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Sensory Neuropathy Affects Cardiac miRNA Expression Network Targeting <i>IGF-1</i>, <i>SLC2a-12</i>, <i>EIF-4e</i>, and <i>ULK-2</i> mRNAs by Péter Bencsik, Krisztina Kiss, Bence Ágg, Júlia A. Baán, Gergely Ágoston, Albert Varga, Kamilla Gömöri, Luca Mendler, Nóra Faragó, Ágnes Zvara, Péter Sántha, László G. Puskás, Gábor Jancsó, Péter Ferdinandy

“…By an in silico network analysis, we identified common mRNA targets (insulin-like growth factor 1 (<i>IGF-1</i>), solute carrier family 2 facilitated glucose transporter member 12 (<i>SLC2a-12</i>), eukaryotic translation initiation factor 4e <i>(EIF-4e</i>), and Unc-51 like autophagy activating kinase 2 (<i>ULK-2</i>)) targeted by at least three altered miRNAs. …”
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Effects of Roux-en-Y gastric bypass on the metabolic profile and systemic inflammatory status of women with metabolic syndrome: randomized controlled clinical trial by Lucenda A. Felipe, André L. L. Bachi, Miriã C. Oliveira, Sandra M. B. P. Moreira, João Pedro R. Afonso, Maria E. M. Lino, Vitória Paixão, Carlos H. M. Silva, Rodolfo P. Vieira, Sergio Vencio, Elias I. Jirjos, Carlos A. Malheiros, Giuseppe Insalaco, Wilson R. Freitas Júnior, Luis V. F. Oliveira

“…Lipid profile, blood glucose and adipokines (adiponectin, leptin, and resistin) and (cytokines IL-1β, IL-6, IL-17, IL-23, and TNF-α) in blood plasma samples were evaluated before and six months after RYGB. …”
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Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus by Junjie Wang, Ziping Qi, Yun Wu, Aoli Wang, Qingwang Liu, Fengming Zou, Beilei Wang, Shuang Qi, Jiangyan Cao, Chen Hu, Chenliang Shi, Qianmao Liang, Li Wang, Jing Liu, Wenchao Wang, Qingsong Liu

“…Mechanistically, IHMT-MST1-39 activated AMPK signaling pathway in hepatocytes in vitro, combination of IHMT-MST1-39 and metformin synergistically prevented hyperglycemia and significantly ameliorated glucose tolerance and insulin resistance in diabetic mice. …”
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Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting by Maria Elisabeth Street, Sabrina Angelini, Sergio Bernasconi, Ernesto Burgio, Alessandra Cassio, Cecilia Catellani, Francesca Cirillo, Annalisa Deodati, Enrica Fabbrizi, Vassilios Fanos, Giancarlo Gargano, Enzo Grossi, Lorenzo Iughetti, Pietro Lazzeroni, Alberto Mantovani, Lucia Migliore, Paola Palanza, Giancarlo Panzica, Anna Maria Papini, Stefano Parmigiani, Barbara Predieri, Chiara Sartori, Gabriele Tridenti, Sergio Amarri

“…Although results are sometimes conflicting because of confounding factors, epidemiological studies in humans suggest effects of EDCs on prenatal growth, thyroid function, glucose metabolism and obesity, puberty, fertility, and on carcinogenesis mainly through epigenetic mechanisms. …”
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Anthrahydroquinone-2,6-disulfonate alleviates paraquat-induced kidney injury via the apelin-APJ pathway in rats by Qi Li, Bo Wang, Kai-Wen Lin, Tang Deng, Qi-Feng Huang, Shuang-Qin Xu, Hang-Fei Wang, Xin-Xin Wu, Nan Li, Yang Yi, Ji-Chao Peng, Yue Huang, Jin Qian, Xiao-Ran Liu

“…Western blotting was used to detect the expression levels of the following proteins in the kidney tissues: IL- 6, TNF-α, apelin-APJ (the apelin-angiotensin receptor), NF-κB p65, caspase-1, caspase-8, glucose-regulated protein 78 (GRP78), and the C/EBP homologous protein (CHOP). …”
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Cardiometabolic risk factors among children who are affected by overweight, obesity and severe obesity by Ahmad Kamil Nur Zati Iwani, Muhammad Yazid Jalaludin, Farah Aqilah Roslan, Fazliana Mansor, Fuziah Md Zain, Janet Yeow Hua Hong, Ruziana Mona Wan Mohd Zin, Abqariyah Yahya, Zahari Ishak, Rusidah Selamat, Abdul Halim Mokhtar

“…Cardiometabolic risk factors presented in this study included fasting plasma glucose (FPG), triglycerides (TGs), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), blood pressure, acanthosis nigricans, insulin resistance (IR), and MetS. …”
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Isorhamnetin protects zearalenone-induced damage via the PI3K/Akt signaling pathway in porcine ovarian granulosa cells by Xiaoya Li, Huali Chen, Zelin Zhang, Jiaxin Duan, Rongmao Hua, Xiaodi Li, Li Yang, Jianyong Cheng, Qingwang Li

“…Changes in intracellular Ca2+ levels and C/EBP homologous protein (CHOP), recombinant activating transcription factor 6 (ATF6), glucose regulated protein78 kD (GRP78) indicated that isorhamnetin rescued (P < 0.05) ZEA-induced endoplasmic reticulum stress. …”
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Multi-Organ Protective Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Rats with Type 1 Diabetes Mellitus by Paul-Mihai Boarescu, Ioana Boarescu, Adriana Elena Bulboacă, Ioana Corina Bocșan, Raluca Maria Pop, Dan Gheban, Ruxandra-Mioara Râjnoveanu, Armand Râjnoveanu, Ştefan Horia Roşian, Anca Dana Buzoianu, Sorana D. Bolboacă

“…Both curcumin formulations, CC and NC, prevented the following electrocardiographic changes: prolongation of the QRS complex, enlargement of QT and QTc intervals, and ST-segment elevation. Glucose levels and lipid profile parameters were reduced up to 1.9 times, while C-peptide serum levels were increased up to 1.6 times in groups that received CC or NC. …”
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Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial by Shaun Sabico, Mushira A. Enani, Eman Sheshah, Naji J. Aljohani, Dara A. Aldisi, Naif H. Alotaibi, Naemah Alshingetti, Suliman Y. Alomar, Abdullah M. Alnaami, Osama E. Amer, Syed D. Hussain, Nasser M. Al-Daghri

“…Anthropometrics were measured and blood samples were taken pre- and post-supplementation. Fasting blood glucose, lipids, serum 25(OH)D, and inflammatory markers were measured. …”
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Effects of Combined Motion Intervention on Body Composition, Cardiovascular Risk Factors and Cardiopulmonary Fitness of Obese Female Adolescents by WANG Kai, XU Baichao, WANG Zhaoxin, SU Jianjiao

“…The indicators such as height, body mass, body fat rate (BFR) , waist circumference, BMI, blood pressure (BP) , fasting plasma glucose (FPG) , insulin, insulin resistance index (HOMA-IR) and maximal oxygen uptake (VO2max) were detected before and after the 12-week combined motion intervention and compared between the two groups, as well as before and after the intervention. …”
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Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity by Gihyeon Kim, Youngmin Yoon, Jin Ho Park, Jae Won Park, Myung-guin Noh, Hyun Kim, Changho Park, Hyuktae Kwon, Jeong-hyeon Park, Yena Kim, Jinyoung Sohn, Shinyoung Park, Hyeonhui Kim, Sun-Kyoung Im, Yeongmin Kim, Ha Yung Chung, Myung Hee Nam, Jee Young Kwon, Il Yong Kim, Yong Jae Kim, Ji Hyeon Baek, Hak Su Kim, George M. Weinstock, Belong Cho, Charles Lee, Sungsoon Fang, Hansoo Park, Je Kyung Seong

“…Oral treatment of specific commercial Bifidobacterium longum and Bifidobacterium bifidum enhanced bile acid signaling contributing to potentiate oxidative phosphorylation (OXPHOS) in adipose tissues, leading to reduction of body weight gain and improvement in hepatic steatosis and glucose homeostasis. Bifidobacterium longum or Bifidobacterium bifidum manipulated intestinal sterol biosynthetic processes to protect against diet-induced obesity in germ-free mice. …”
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