Short-term effects of Mediterranean diet on nutritional status in adults affected by Osteogenesis Imperfecta: a pilot study by Ramona De Amicis, Simona Bertoli, Amalia Bruno, Giulia De Carlo, Alberto Battezzati, Andrea Foppiani, Alessandro Leone, Antonella Lo Mauro

“…Results Patients showed significant improvement in anthropometric measurements (BMI = 30.5 vs 28.1 kg/cm2, p < 0.001; Body Fat % = 32.9 vs 29.9, p = 0.006; Waist circumferences = 83.6 vs 79.6 cm; p < 0.001; Arm Fat Area = 29.8 vs 23.07 cm2; p < 0.011) and energy expenditure (REE/kg = 27.2 vs 29.2 kcal/kg, p < 0.001). Glucose and lipid profiles improved (Δglycemia = − 8.6 ± 7.3 mg/dL, p = 0.003; ΔTC = − 14.6 ± 20.1 mg/dL, p = 0.036; ΔLDL = − 12.0 ± 12.1 mg/dL, p = 0.009). …”
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Enhancing boll protein synthesis and carbohydrate conversion by the application of exogenous amino acids at the peak flowering stage increased the boll Bt toxin concentration and l... by Zhen-yu LIU, Yi-yang LI, Leila. I.M. TAMBEL, Yu-ting LIU, Yu-yang DAI, Ze XU, Xin-hua LENG, Xiang ZHANG, De-hua CHEN, Yuan CHEN

“…In addition, amino acid applications led to increases in the amino acid content, soluble protein content, glutamate pyruvate transaminase (GPT) activity, glutamate oxaloacetate transaminase (GOT) activity, glucose content, fructose content and soluble acid invertase (SAI) activity. …”
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MicroRNA-7-5p′s role in the O-GlcNAcylation and cancer metabolism by Sin Yung Woo, Su Yel Lee, Seong-Lan Yu, Se Jin Park, Daeun Kang, Jin Suk Kim, In Beom Jeong, Sun Jung Kwon, Wan Jin Hwang, Chang Ryul Park, Ji Woong Son

“…To investigate the role of miR-7-5p in the cancer metabolism of non-small cell lung cancer (NSCLC) cells, mimic of miR-7-5p was transfected into NSCLC cells, and the effect of miR-7-5p on cancer metabolism was analyzed by LDH assays, glucose uptake, and mitochondrial ATP synthase inhibitor assay. …”
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Increasing incidence and prevalence of metabolic syndrome in people living with HIV during the COVID-19 pandemic by Rebecka Papaioannu Borjesson, Laura Galli, Camilla Muccini, Andrea Poli, Tommaso Clemente, Martina Bottanelli, Nicola Gianotti, Silvia Nozza, Silvia Nozza, Antonella Castagna, Antonella Castagna, Vincenzo Spagnuolo

“…In addition, we observed a significant increase in the crude mean change during the pandemic period compared with the pre-pandemic period for: total cholesterol, LDL cholesterol, plasma glucose, blood pressure, and atherosclerotic cardiovascular disease (ASCVD) risk score. …”
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Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes by Jiaxiu Li, Ya Hui, Zhiqiang Xu, Jie Tan, Kai Yin, Liuyu Kuang, Yunyun Tang, Junjie Wei, Qiongsui Zhong, Tianpeng Zheng

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Structural Characterization and Cytotoxic Activity Evaluation of Ulvan Polysaccharides Extracted from the Green Algae <i>Ulva papenfussii</i> by Vy Ha Nguyen Tran, Maria Dalgaard Mikkelsen, Hai Bang Truong, Hieu Nhu Mai Vo, Thinh Duc Pham, Hang Thi Thuy Cao, Thuan Thi Nguyen, Anne S. Meyer, Thuy Thu Thi Thanh, Tran Thi Thanh Van

“…The compositional constitution encompassed L-Rhamnose (Rha<i>p</i>), D-Xylose (Xyl<i>p</i>), D-Glucuronic acid (GlcA<i>p</i>), L-Iduronic acid (IdoA<i>p</i>), D-Galactose (Gal<i>p</i>), and D-Glucose (Glc<i>p</i>) with a molar ratio of 1:0.19:0.35:0.52:0.05:0.11, respectively. …”
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Application of psychological intervention combined with wet compress of Traditional Chinese Medicine in nursing of patients with diabetic foot ulcer (心理干预联合中药塌渍技术在糖尿病足溃疡护理中的应用)... by WANG Xiuyan (王秀燕), CAO Hongjing (曹红京), LI Ning (李宁), LI Yueru (李月茹), LI Jing (李静), YANG Kun (杨坤), LI Lin (李林), TANG Hong (汤虹)

“…All patients received local dressing change in addition to the comprehensive treatment such as blood glucose control and infection prevention. Patients in the observation group were given psychological intervention combined with wet compress of Traditional Chinese Medicine. …”
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Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis by Yi Zhang, Yangyang Zhu, Jinghui Wang, Li Jin, Mingwei Guo, Liwei Chen, Lina Zhang, Yangyang Li, Baocheng Wan, Rong Zhang, Weiping Jia, Cheng Hu

“…Abstract Neuregulin 4 (Nrg4) is an adipose tissue‐enriched secreted factor that modulates glucose and lipid metabolism. Nrg4 is closely associated with obesity and preserves diet‐induced metabolic disorders. …”
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Associations of the vasoactive peptides CT-proET-1 and MR-proADM with incident type 2 diabetes: results from the BiomarCaRE Consortium by Chaterina Sujana, Veikko Salomaa, Frank Kee, Jochen Seissler, Pekka Jousilahti, Charlotte Neville, Cornelia Then, Wolfgang Koenig, Kari Kuulasmaa, Jaakko Reinikainen, Stefan Blankenberg, Tanja Zeller, Christian Herder, Ulrich Mansmann, Annette Peters, Barbara Thorand, for the BiomarCaRE Consortium

“…Less recognised is the fact that both peptides could affect glucose metabolism. Here, we investigated whether ET-1 and ADM, measured as C-terminal-proET-1 (CT-proET-1) and mid-regional-proADM (MR-proADM), respectively, were associated with incident type 2 diabetes. …”
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Exendin-4 ameliorates tau hyperphosphorylation and cognitive impairment in type 2 diabetes through acting on Wnt/β-catenin/NeuroD1 pathway by Xiaonan Kang, Dan Wang, Lu Zhang, Teng Huang, Siyue Liu, Xiaohui Feng, Yaoyao Guo, Ziyin Zhang, Zhongjing Wang, Huihui Ren, Gang Yuan

“…Methods  The db/db mice, high-fat-diet (HFD) / streptozotocin (STZ)—induced diabetic (HF-diabetic) mice, and high-glucose-damaged (HGD) HT-22 hippocampal cells were enrolled to examine the effects of Ex-4 on AD-like changes in T2D. …”
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Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice by Yue Deng, Jacob E. Dickey, Kenji Saito, Guorui Deng, Uday Singh, Jingwei Jiang, Brandon A. Toth, Zhiyong Zhu, Leonid V. Zingman, Jon M. Resch, Justin L. Grobe, Huxing Cui

“…Functionally, although Sim1-Cre-mediated prenatal deletion of Rgs2 in PVN neurons had no major effects on metabolic homeostasis, AAV-mediated adult deletion of Rgs2 in the PVN led to significantly increased food intake, body weight (both fat and fat-free masses), body length, and blood glucose levels in both male and female mice. Strikingly, we found that prolonged postnatal loss of Rgs2 leads to neuronal cell death in the PVN, while rapid body weight gain in the early phase of viral-mediated PVN Rgs2 deletion is independent of PVN neuronal loss. …”
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An optimal dietary sodium chloride supplemental level of broiler chicks fed a corn-soybean meal diet from 1 to 21 days of age by Weiyun Zhang, Bingxin Wu, Wei Wu, Xiaoyan Cui, Ding Li, Feiyu Gao, Tingting Li, Ling Zhu, Yanqiang Geng, Liyang Zhang, Yun Hu, Xugang Luo

“…As dietary supplemental NaCl levels increased, average daily gain (ADG), average daily feed intake (ADFI), blood partial pressure of CO2, total CO2, base excess and anion gap, blood concentrations of HCO3, Na and Cl, serum Na concentration, jejunal villus height (VH) and tibia ash content increased linearly and quadratically (P &lt; 0.05), while feed/gain ratio, relative weights of heart, liver and kidney, blood K concentration, serum concentrations of K, uric acid and glucose, and osmotic pressure decreased linearly and quadratically (P &lt; 0.05). …”
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Impaired Gut–Systemic Signaling Drives Total Parenteral Nutrition-Associated Injury by Miguel Guzman, Chandrashekhara Manithody, Joseph Krebs, Christine Denton, Sherri Besmer, Pranjali Rajalakshmi, Sonali Jain, Gustavo Adolfo Villalona, Ajay Kumar Jain

“…Key gut–systemic signaling regulators, liver farnesoid X receptor (FXR; <i>p</i> = 0.021), liver constitutive androstane receptor (CAR; <i>p</i> = 0.014), gut FXR (<i>p</i> = 0.028), G-coupled bile acid receptor (TGR5) (<i>p</i> = 0.003), epidermal growth factor (EGF; <i>p</i> = 0.016), organic anion transporter (OAT; <i>p</i> = 0.028), Mitogen-activated protein kinases-1 (MAPK1) (<i>p</i> = 0.037), and sodium uptake transporter sodium glucose-linked transporter (SGLT-1; <i>p</i> = 0.010) were significantly downregulated in TPN animals, whereas liver cholesterol 7 alpha-hydroxylase (CyP7A1) was substantially higher with TPN (<i>p</i> = 0.011). …”
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Effectiveness Analysis of Two Incontinence Care Plans Based on Guidelines for Elderly COVID-19 Patients with Incontinence by JIANG Qixia, XIE Haoting, WANG Huajun, LI Xiuyun, ZHU Yuling, WANG Yaling, MIN Yan, WANG Ke

“…Results The general data of the both groups of patients showed no statistically significant differences, which included gender, age, types of incontinence, frequency of incontinence, chronic comorbidities, serum albumin, hemoglobin, blood glucose, pulse oxygen concentration, and Braden scores (P&gt;0.05). …”
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CAMTA1 gene affects the ischemia-reperfusion injury by regulating CCND1 by Yang Liu, Guohui Shang, Xuran Zhang, Fuyong Liu, Chi Zhang, Zhihao Li, Jing Jia, Yan Xu, Zhaojing Zhang, Shangdong Yang, Baixue Zhou, Yingying Luan, Yanyang Huang, Yue Peng, Tianyi Han, Ying He, Hong Zheng

“…Furthermore, a series of experiments demonstrated that in the oxygen-glucose deprivation/re-oxygenation (OGD/R) model system, the expression of cyclin D1, an essential regulator of cell cycle progression, was increased in SH-SY5Y CAMTA1 KO cells. …”
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Insulin Sensitization by PPARγ and GLUT-4 Overexpression/Translocation Mediates the Antidiabetic Effect of <i>Plantago australis</i> by Samuel Estrada-Soto, Kathia Ornelas-Mendoza, Gabriel Navarrete-Vázquez, Fabiola Chávez-Silva, Julio Cesar Almanza-Pérez, Rafael Villalobos-Molina, Erandi Ortiz-Barragán, Hilda Loza-Rodríguez, Julio César Rivera-Leyva, Angélica Flores-Flores, Irene Perea-Arango, Javier-German Rodríguez-Carpena, Gabriela Ávila-Villarreal

“…Once dry, it was evaluated through an oral glucose tolerance test (OGTT) in normoglycemic mice and in a non-insulin-dependent diabetic mice model. …”
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Evaluated Glomerular Filtration Rate Is Associated With Non-alcoholic Fatty Liver Disease: A 5-Year Longitudinal Cohort Study in Chinese Non-obese People by Ji Cen, Yong Han, Yong Han, Yong Han, Yufei Liu, Yufei Liu, Yufei Liu, Haofei Hu, Haofei Hu, Haofei Hu

“…Subgroup analysis showed that eGFR was more strongly associated with incident NAFLD in diastolic blood pressure (DBP) &lt; 90 mmHg, fasting plasma glucose (FPG) ≤ 6.1 mmol/L, high-density lipoprotein cholesterol (HDL-c) &lt; 1 mmol/L, and alanine aminotransferase (ALT) ≥ 40 U/L participants. …”
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Bidirectional Causality Between Immunoglobulin G N-Glycosylation and Metabolic Traits: A Mendelian Randomization Study by Xiaoni Meng, Weijie Cao, Di Liu, Isinta Maranga Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang

“…In the forward MR analysis, 59 (including nine putatively causal glycan peaks (GPs) for body mass index (BMI) (GP1, GP6, etc.) and seven for fasting plasma glucose (FPG) (GP1, GP5, etc.)) and 15 (including five putatively causal GPs for BMI (GP2, GP11, etc.) and four for FPG (GP1, GP10, etc.)) genetically determined IgG N-glycans were identified as being associated with metabolic traits in one- and two-sample MR studies, respectively, by integrating IgG N-glycan-QTL variants with GWAS results for metabolic traits (all P < 0.05). …”
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The absence of AQP4/TRPV4 complex substantially reduces acute cytotoxic edema following ischemic injury by Petra Sucha, Petra Sucha, Zuzana Hermanova, Zuzana Hermanova, Martina Chmelova, Martina Chmelova, Denisa Kirdajova, Sara Camacho Garcia, Valeria Marchetti, Valeria Marchetti, Ivan Vorisek, Jana Tureckova, Eyar Shany, Daniel Jirak, Daniel Jirak, Miroslava Anderova, Miroslava Anderova, Lydia Vargova, Lydia Vargova

“…Changes in these parameters reflect alterations in cell volume, and tissue structure during exposure of acute brain slices to models of ischemic conditions in situ, such as oxygen-glucose deprivation (OGD), hypoosmotic stress, or hyperkalemia. …”
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Effect of telehealth‐based versus in‐person nutritional and exercise intervention on type II diabetes mellitus improvement and efficiency of human resources utilization in patients... by Shruthi Rajkumar, Elana Davidson, Michael Bell, Christina Reardon, Abby Lapolla, Maria Michelakis, Yannis Raftopoulos

“…Telehealth‐based follow‐up required transmission via texting of weekly body composition measurements and any blood glucose levels below 100 mg/dl for medication adjustments. …”
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