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50641
Energetic Contributions Including Gender Differences and Metabolic Flexibility in the General Population and Athletes
Published 2022-10-01“…During GIET, heart rate (HR), oxygen uptake (<inline-formula><math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mover><mi mathvariant="normal">V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O<sub>2mean</sub> and <inline-formula><math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mover><mi mathvariant="normal">V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>CO<sub>2mean</sub>), metabolic equivalents (METs) in <inline-formula><math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mover><mi mathvariant="normal">V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O<sub>2mean</sub>, and blood glucose and lactate concentrations (La<sup>−</sup>) were measured. …”
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50642
Newborn screening for G6PD deficiency in HeFei, FuYang and AnQing, China: Prevalence, cut-off value, variant spectrum
Published 2024-01-01“…Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive Mendelian genetic disorder characterized by neonatal jaundice and hemolytic anemia, affecting more than 400 million people worldwide. …”
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50643
Neuroprotective and Regenerative Effects of Growth Hormone (GH) in the Embryonic Chicken Cerebral Pallium Exposed to Hypoxic–Ischemic (HI) Injury
Published 2022-08-01“…For the in vitro experiments, pallial cell cultures obtained from chick embryos were incubated under HI conditions (<5% O<sub>2</sub>, 1 g/L glucose) for 24 h and treated with 10 nM GH, and then collected for analysis. …”
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50644
Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice
Published 2021-12-01“…In addition, the administration of uncarboxylated osteocalcin during pregnancy upregulates Pygl expression via both direct CREBH and ATF4 and indirect epigenomic pathways, mitigating the maternal diet-induced obesity and abnormal glucose and lipid metabolism in adulthood. Conclusions: We propose that maternal energy status is reflected in the hepatic glycogenolysis capacity of the offspring via epigenetic modification of Pygl and uncarboxylated osteocalcin regulates glycogenolysis.…”
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50645
Analysis of gut microbiome composition, function, and phenotype in patients with osteoarthritis
Published 2022-11-01“…The functions of DNA transcription, amino acid metabolism (including histidine, lysine, and isoleucine), ATP metabolism, and phospholipid metabolism significantly decreased, while glucose metabolism, protein acetylation, and aspartate kinase activity significantly increased in the OA group. …”
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50646
Assessment of prenatal care performed in primary care: a cross-sectional study linked to a pregnancy cohort
Published 2023-12-01“…Prevalence was also higher among pregnant women who underwent the following tests: cervical cancer screening, 147 (82.58%), ABO-RH system 129 (72.47%), complete blood count 121 (68.75%), and fasting blood glucose in the first trimester, 107 (60.11%). As for the anti-HIV test, the highest prevalence was for pregnant women who had not undergone the test, 103 (57.87%). …”
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50647
Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: A multicontinental retrospective study
Published 2023-08-01“…The final model included complete blood count, blood glucose, and oxygen saturation features. To make COEWS more actionable in real clinical situations, we transformed the predictive coefficients of the COEWS model into individual scores for each selected feature. …”
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50648
An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter
Published 2024-04-01“…This relationship is further linked to changes in psychosocial factors, lifestyle choices, and cardiometabolic variables, including glucose levels, insulin resistance, and hyperlipidemia.…”
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50649
Analysis of risk factors for COVID-19-related fatal outcome in 337991 patients with type 1 and type 2 diabetes mellitus in 2020–2022 years: Russian nationwide retrospective study
Published 2022-12-01“…In T2DM, the type of antidiabetic therapy (ADT) prior to COVID -19 (last visit before the development of infection) had a significant impact: Insulin therapy (OR = 1.64, 95% CI: 1.30–2.07), sulfonylureas (SU) (OR =1.51, 95% CI: 1.23–1.84)); dipeptidyl peptidase-4 inhibitor (iDPP-4) therapy (OR =0.57, 95% CI: 0.39–0.83) and sodium-glucose cotransporter-2 inhibitor (iSGLT2) therapy (OR =0.64, 95% CI: 0.46–0.88). …”
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50650
Glucuronic acid is a novel source of pentosidine, associated with schizophrenia
Published 2023-11-01“…PEN is thought to be produced from glucose, fructose, pentoses, or ascorbate. However, patients with schizophrenia with high PEN levels present no elevation of these precursors of PEN in their blood. …”
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50651
Alteration of Branched-Chain and Aromatic Amino Acid Profile as a Novel Approach in Studying Polycystic Ovary Syndrome Pathogenesis
Published 2023-09-01“…No significant differences in BMI, fasting glucose, and HOMA-IR between MHO and MUO were found: respectively, 35.0 ± 4.8 vs. 36.1 ± 4.6 kg/m<sup>2</sup> (<i>p</i> = 0.59); 88.0 ± 6.0 vs. 87.73 ± 6.28 mg/dL (<i>p</i> = 0.67); and 3.36 ± 1.70 vs. 4.17 ± 1.77 (<i>p</i> = 0.1). …”
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50652
Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography–Tandem Mass Spectrometry; Quantitation and Compariso...
Published 2020-03-01“…Linearity was clearly seen over a calibration range of: 6.25 to 6400 ng/mL (r<sup>2</sup> > 0.980) for malic acid; 11.72 to 12,000 ng/mL (r<sup>2</sup> > 0.980) for cis-aconitic acid and L-aspartic acid; 29.30 to 30,000 ng/mL (r<sup>2</sup> > 0.980) for isocitric acid, <span style="font-variant: small-caps;">l</span>-serine, and <span style="font-variant: small-caps;">l</span>-glutamic acid; 122.07 to 125,000 ng/mL (r<sup>2</sup> > 0.980) for citric acid, glycine, <i>oxo</i>-glutaric acid, <span style="font-variant: small-caps;">l</span>-alanine, and <span style="font-variant: small-caps;">l</span>-glutamine; 527.34 to 540,000 ng/mL (r<sup>2</sup> > 0.980) for <span style="font-variant: small-caps;">l</span>-lactic acid; 976.56 to 1,000,000 ng/mL (r<sup>2</sup> > 0.980) for <span style="font-variant: small-caps;">d</span>-glucose; 23.44 to 24,000 ng/mL (r<sup>2</sup> > 0.980) for fumaric acid and succinic acid; and, 244.14 to 250,000 ng/mL (r<sup>2</sup> > 0.980) for pyruvic acid. …”
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50653
lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis
Published 2019-09-01“…In the present study, we found that lncRNA NR_038323 overexpression ameliorated the high glucose (HG)-induced expression levels of collagen I, collagen IV, and fibronectin, whereas lncRNA NR_038323 knockdown exerted the opposite effects. …”
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50654
Early effects of roflumilast on insulin sensitivity in adults with prediabetes and overweight/obesity involve age-associated fat mass loss – results of an exploratory study
Published 2019-05-01“…We conclude that roflumilast’s early effects on insulin sensitivity is indirect and likely mediated through roflumilast’s prioritization of lipid over glucose handling.Clinical trials registration: NCT01862029. …”
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50655
Age-Related Changes in Topological Properties of Individual Brain Metabolic Networks in Rats
Published 2022-05-01“…Normal aging causes profound changes of structural degeneration and glucose hypometabolism in the human brain, even in the absence of disease. …”
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50656
Gallic acid inhibits neuroinflammation and reduces neonatal hypoxic-ischemic brain damages
Published 2022-12-01“…In this report we found that oxygen-glucose deprivation and/reoxygenation (OGD/R)-induced cell death, and the generation of excessive reactive oxygen species (ROS) and inflammatory cytokines by microglia were inhibited by GA treatment. …”
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50657
Obese fathers lead to an altered metabolism and obesity in their children in adulthood: review of experimental and human studies
Published 2017-11-01“…In animals, paternal obesity led to offspring alterations on glucose-insulin homeostasis, hepatic lipogenesis, hypothalamus/feeding behavior, kidney of the offspring; it also impairs the reproductive potential of male offspring with sperm oxidative stress and mitochondrial dysfunction. …”
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50658
Mechanistic Insights into Nitrite Degradation by Metabolites of <i>L. plantarum</i> A50: An LC-MS-Based Untargeted Metabolomics Analysis
Published 2024-02-01“…Lipids and lipid-like molecules, derivatives of glucose and galactose, amino acids and their derivatives, as well as organoheterocyclic compounds, are likely to play a role in nitrite elimination. …”
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50659
Retinal arterial occlusive vasculitis after multiple intravitreal brolucizumab injections for diabetic macular edema
Published 2023-03-01“…However, it requires monitoring of side effects, such as elevated blood glucose levels. PRP is also an option in cases where progression of proliferative changes is a concern, as was done in this case. …”
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50660
Effective Treatment Recommendations for Type 2 Diabetes Management Using Reinforcement Learning: Treatment Recommendation Model Development and Validation
Published 2021-07-01“…ConclusionsComprehensive management by combining knowledge-driven and data-driven models has good potential to help physicians improve the clinical outcomes of patients with T2DM; achieving good control on blood glucose, blood pressure, and blood lipids; and reducing the risk of diabetes complications in the long term.…”
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