Energetic Contributions Including Gender Differences and Metabolic Flexibility in the General Population and Athletes by Woo-Hwi Yang, Jeong-Hyun Park, So-Young Park, Yongdoo Park

“…During GIET, heart rate (HR), oxygen uptake (<inline-formula><math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mover><mi mathvariant="normal">V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O_2mean and <inline-formula><math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mover><mi mathvariant="normal">V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>CO_2mean), metabolic equivalents (METs) in <inline-formula><math display="inline" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mover><mi mathvariant="normal">V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O_2mean, and blood glucose and lactate concentrations (La⁻) were measured. …”
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Newborn screening for G6PD deficiency in HeFei, FuYang and AnQing, China: Prevalence, cut-off value, variant spectrum by Li Hui, Ch'ih Yah, Li Meiling, Luo Yulei, Liu Hao, Xu Junyang, Song Wangsheng, Ma Qingqing, Shao Ziyu

“…Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive Mendelian genetic disorder characterized by neonatal jaundice and hemolytic anemia, affecting more than 400 million people worldwide. …”
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Neuroprotective and Regenerative Effects of Growth Hormone (GH) in the Embryonic Chicken Cerebral Pallium Exposed to Hypoxic–Ischemic (HI) Injury by Juan David Olivares-Hernández, Martha Carranza, Jerusa Elienai Balderas-Márquez, David Epardo, Rosario Baltazar-Lara, José Ávila-Mendoza, Carlos G. Martínez-Moreno, Maricela Luna, Carlos Arámburo

“…For the in vitro experiments, pallial cell cultures obtained from chick embryos were incubated under HI conditions (<5% O₂, 1 g/L glucose) for 24 h and treated with 10 nM GH, and then collected for analysis. …”
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Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice by Tomoyo Kawakubo-Yasukochi, Ena Yano, Soi Kimura, Takuya Nishinakagawa, Akiko Mizokami, Yoshikazu Hayashi, Yuji Hatakeyama, Kenji Ohe, Atsushi Yasukochi, Seiji Nakamura, Eijiro Jimi, Masato Hirata

“…In addition, the administration of uncarboxylated osteocalcin during pregnancy upregulates Pygl expression via both direct CREBH and ATF4 and indirect epigenomic pathways, mitigating the maternal diet-induced obesity and abnormal glucose and lipid metabolism in adulthood. Conclusions: We propose that maternal energy status is reflected in the hepatic glycogenolysis capacity of the offspring via epigenetic modification of Pygl and uncarboxylated osteocalcin regulates glycogenolysis.…”
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Analysis of gut microbiome composition, function, and phenotype in patients with osteoarthritis by Su Liu, Su Liu, Guoqing Li, Guoqing Li, Yuanchao Zhu, Yuanchao Zhu, Chang Xu, Qi Yang, Ao Xiong, Ao Xiong, Jian Weng, Jian Weng, Fei Yu, Fei Yu, Hui Zeng, Hui Zeng

“…The functions of DNA transcription, amino acid metabolism (including histidine, lysine, and isoleucine), ATP metabolism, and phospholipid metabolism significantly decreased, while glucose metabolism, protein acetylation, and aspartate kinase activity significantly increased in the OA group. …”
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Assessment of prenatal care performed in primary care: a cross-sectional study linked to a pregnancy cohort by Tayla Thais Jatahy Pereira, Adriana Sousa Rêgo, Francisca Bruna Arruda Aragão, Janaina Maiana Abreu Barbosa, Yuri Alfredo Araújo Mendonça Silva, Thayane Leila Gonçalves da Silva, Magali Kelli Nitz, Marcia Rodrigues Veras Batista, Wellyson da Cunha Araujo Firmo, Flor de Maria Mendonça Silva

“…Prevalence was also higher among pregnant women who underwent the following tests: cervical cancer screening, 147 (82.58%), ABO-RH system 129 (72.47%), complete blood count 121 (68.75%), and fasting blood glucose in the first trimester, 107 (60.11%). As for the anti-HIV test, the highest prevalence was for pregnant women who had not undergone the test, 103 (57.87%). …”
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Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: A multicontinental retrospective study by Riku Klén, Ivan A Huespe, Felipe Aníbal Gregalio, Antonio Lalueza Lalueza Blanco, Miguel Pedrera Jimenez, Noelia Garcia Barrio, Pascual Ruben Valdez, Matias A Mirofsky, Bruno Boietti, Ricardo Gómez-Huelgas, José Manuel Casas-Rojo, Juan Miguel Antón-Santos, Javier Alberto Pollan, David Gómez-Varela

“…The final model included complete blood count, blood glucose, and oxygen saturation features. To make COEWS more actionable in real clinical situations, we transformed the predictive coefficients of the COEWS model into individual scores for each selected feature. …”
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An industrialized diet as a determinant of methylation in the 1F region of the NR3C1 gene promoter by Tamires dos Santos Vieira, Flávia Vitorino Freitas, Luiz Cláudio Barreto Silva Neto, Aline Ribeiro Borçoi, Suzanny Oliveira Mendes, Amanda Sgrancio Olinda, Ivana Alece Arantes Moreno, Bárbara Risse Quaioto, Marcele Lorentz Mattos de Souza, Wagner Miranda Barbosa, Juliana Krüger Arpini, Bruna Pereira Sorroche, Julia de Assis Pinheiro, Anderson Barros Archanjo, Joaquim Gasparini dos Santos, Lidia Maria Rebolho Batista Arantes, Daniela Rodrigues de Oliveira, Adriana Madeira Alvares da Silva, Adriana Madeira Alvares da Silva

“…This relationship is further linked to changes in psychosocial factors, lifestyle choices, and cardiometabolic variables, including glucose levels, insulin resistance, and hyperlipidemia.…”
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Analysis of risk factors for COVID-19-related fatal outcome in 337991 patients with type 1 and type 2 diabetes mellitus in 2020–2022 years: Russian nationwide retrospective study by N. G. Mokrysheva, M. V. Shestakova, O. K. Vikulova, A. R. Elfimova, M. A. Isakov, N. A. Gins, A. A. Deviatkin, I. I. Dedov

“…In T2DM, the type of antidiabetic therapy (ADT) prior to COVID -19 (last visit before the development of infection) had a significant impact: Insulin therapy (OR = 1.64, 95% CI: 1.30–2.07), sulfonylureas (SU) (OR =1.51, 95% CI: 1.23–1.84)); dipeptidyl peptidase-4 inhibitor (iDPP-4) therapy (OR =0.57, 95% CI: 0.39–0.83) and sodium-glucose cotransporter-2 inhibitor (iSGLT2) therapy (OR =0.64, 95% CI: 0.46–0.88). …”
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Glucuronic acid is a novel source of pentosidine, associated with schizophrenia by Kazuya Toriumi, Kyoka Iino, Azuna Ozawa, Mitsuhiro Miyashita, Syudo Yamasaki, Kazuhiro Suzuki, Hikari Sugawa, Koichi Tabata, Satoshi Yamaguchi, Satoshi Usami, Masanari Itokawa, Atsushi Nishida, Ryoji Nagai, Hidenori Kamiguchi, Makoto Arai

“…PEN is thought to be produced from glucose, fructose, pentoses, or ascorbate. However, patients with schizophrenia with high PEN levels present no elevation of these precursors of PEN in their blood. …”
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Alteration of Branched-Chain and Aromatic Amino Acid Profile as a Novel Approach in Studying Polycystic Ovary Syndrome Pathogenesis by Katarzyna Paczkowska, Dominik Rachoń, Andrzej Berg, Jacek Rybka, Katarzyna Kapczyńska, Marek Bolanowski, Jacek Daroszewski

“…No significant differences in BMI, fasting glucose, and HOMA-IR between MHO and MUO were found: respectively, 35.0 ± 4.8 vs. 36.1 ± 4.6 kg/m² (<i>p</i> = 0.59); 88.0 ± 6.0 vs. 87.73 ± 6.28 mg/dL (<i>p</i> = 0.67); and 3.36 ± 1.70 vs. 4.17 ± 1.77 (<i>p</i> = 0.1). …”
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Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography–Tandem Mass Spectrometry; Quantitation and Compariso... by Ramji Rathod, Bharat Gajera, Kenneth Nazir, Janne Wallenius, Vidya Velagapudi

“…Linearity was clearly seen over a calibration range of: 6.25 to 6400 ng/mL (r² &gt; 0.980) for malic acid; 11.72 to 12,000 ng/mL (r² &gt; 0.980) for cis-aconitic acid and L-aspartic acid; 29.30 to 30,000 ng/mL (r² &gt; 0.980) for isocitric acid, <span style="font-variant: small-caps;">l</span>-serine, and <span style="font-variant: small-caps;">l</span>-glutamic acid; 122.07 to 125,000 ng/mL (r² &gt; 0.980) for citric acid, glycine, <i>oxo</i>-glutaric acid, <span style="font-variant: small-caps;">l</span>-alanine, and <span style="font-variant: small-caps;">l</span>-glutamine; 527.34 to 540,000 ng/mL (r² &gt; 0.980) for <span style="font-variant: small-caps;">l</span>-lactic acid; 976.56 to 1,000,000 ng/mL (r² &gt; 0.980) for <span style="font-variant: small-caps;">d</span>-glucose; 23.44 to 24,000 ng/mL (r² &gt; 0.980) for fumaric acid and succinic acid; and, 244.14 to 250,000 ng/mL (r² &gt; 0.980) for pyruvic acid. …”
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lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis by Yanni Ge, Juan Wang, Dengke Wu, Yu Zhou, Shuangfa Qiu, Junxiang Chen, Xuejin Zhu, Xudong Xiang, Huiling Li, Dongshan Zhang

“…In the present study, we found that lncRNA NR_038323 overexpression ameliorated the high glucose (HG)-induced expression levels of collagen I, collagen IV, and fibronectin, whereas lncRNA NR_038323 knockdown exerted the opposite effects. …”
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Early effects of roflumilast on insulin sensitivity in adults with prediabetes and overweight/obesity involve age-associated fat mass loss &ndash; results of an exploratory study by Muo IM, MacDonald SD, Madan R, Park SJ, Gharib AM, Martinez PE, Walter MF, Yang SB, Rodante JA, Courville AB, Walter PJ, Cai H, Glicksman M, Guerrieri GM, Ben-Dor RR, Ouwerkerk R, Mao S, Chung JH

“…We conclude that roflumilast&rsquo;s early effects on insulin sensitivity is indirect and likely mediated through roflumilast&rsquo;s prioritization of lipid over glucose handling.Clinical trials registration: NCT01862029. …”
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Age-Related Changes in Topological Properties of Individual Brain Metabolic Networks in Rats by Xin Xue, Jia-Jia Wu, Bei-Bei Huo, Xiang-Xin Xing, Xiang-Xin Xing, Jie Ma, Yu-Lin Li, Dong Wei, Yu-Jie Duan, Chun-Lei Shan, Chun-Lei Shan, Chun-Lei Shan, Mou-Xiong Zheng, Mou-Xiong Zheng, Xu-Yun Hua, Xu-Yun Hua, Jian-Guang Xu, Jian-Guang Xu, Jian-Guang Xu

“…Normal aging causes profound changes of structural degeneration and glucose hypometabolism in the human brain, even in the absence of disease. …”
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Gallic acid inhibits neuroinflammation and reduces neonatal hypoxic-ischemic brain damages by Xiangjun Dong, Shuyue Luo, Dongjie Hu, Ruixue Cao, Qunxian Wang, Zijun Meng, Zijuan Feng, Weihui Zhou, Weihong Song, Weihong Song, Weihong Song

“…In this report we found that oxygen-glucose deprivation and/reoxygenation (OGD/R)-induced cell death, and the generation of excessive reactive oxygen species (ROS) and inflammatory cytokines by microglia were inhibited by GA treatment. …”
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Obese fathers lead to an altered metabolism and obesity in their children in adulthood: review of experimental and human studies by Fernanda Ornellas, Priscila V. Carapeto, Carlos A. Mandarim-de-Lacerda, Marcia B. Aguila

“…In animals, paternal obesity led to offspring alterations on glucose-insulin homeostasis, hepatic lipogenesis, hypothalamus/feeding behavior, kidney of the offspring; it also impairs the reproductive potential of male offspring with sperm oxidative stress and mitochondrial dysfunction. …”
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Mechanistic Insights into Nitrite Degradation by Metabolites of <i>L. plantarum</i> A50: An LC-MS-Based Untargeted Metabolomics Analysis by Jiangbo An, Lin Sun, Mingjian Liu, Rui Dai, Qiang Si, Gentu Ge, Zhijun Wang, Yushan Jia

“…Lipids and lipid-like molecules, derivatives of glucose and galactose, amino acids and their derivatives, as well as organoheterocyclic compounds, are likely to play a role in nitrite elimination. …”
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Retinal arterial occlusive vasculitis after multiple intravitreal brolucizumab injections for diabetic macular edema by Takao Hirano, Yuichi Toriyama, Yoshiaki Takahashi, Ken Hoshiyama, Toshinori Murata

“…However, it requires monitoring of side effects, such as elevated blood glucose levels. PRP is also an option in cases where progression of proliferative changes is a concern, as was done in this case. …”
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Effective Treatment Recommendations for Type 2 Diabetes Management Using Reinforcement Learning: Treatment Recommendation Model Development and Validation by Xingzhi Sun, Yong Mong Bee, Shao Wei Lam, Zhuo Liu, Wei Zhao, Sing Yi Chia, Hanis Abdul Kadir, Jun Tian Wu, Boon Yew Ang, Nan Liu, Zuo Lei, Zhuoyang Xu, Tingting Zhao, Gang Hu, Guotong Xie

“…ConclusionsComprehensive management by combining knowledge-driven and data-driven models has good potential to help physicians improve the clinical outcomes of patients with T2DM; achieving good control on blood glucose, blood pressure, and blood lipids; and reducing the risk of diabetes complications in the long term.…”
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