Abscisic Acid Affects Phenolic Acid Content to Increase Tolerance to UV-B Stress in <i>Rhododendron chrysanthum</i> Pall. by Xiangru Zhou, Fushuai Gong, Jiawei Dong, Xiaoru Lin, Kun Cao, Hongwei Xu, Xiaofu Zhou

“…The contents of 2-phenylethanol, 1-o-p-coumaroyl-β-d-glucose, 2-hydroxy-3-phenylpropanoic acid, 3-(4-hydroxyphenyl)-propionic acid and 3-o-feruloylquinic ac-id-o-glucoside were significantly elevated in <i>R. chrysanthum</i> after external application of ABA to protect against UV-B stress. …”
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Using a mixed method to identify communication skills training priorities for Chinese general practitioners in diabetes care by Mi Yao, Gang Yuan, Kai Lin, Lijuan Liu, Hao Tang, Jieying Xie, Xinxin Ji, Rongxin Wang, Binkai Li, Jiajia Hao, Huichang Qiu, Dongying Zhang, Hai Li, Shamil Haroon, Dawn Jackson, Wei Chen, Kar Keung Cheng, Richard Lehman

“…Based on the mean scores of importance and feasibility rating scores, the top 3 ranked priorities for communication training were ‘health education’ (importance 8.39, feasibility 7.67), ‘discussing and explaining blood glucose monitoring’ (8.31, 7.46), and ‘diabetes complications and cardiovascular disease risk communication’ (8.36, 7.12). …”
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Mammary Development in Gilts at One Week Postnatal Is Related to Plasma Lysine Concentration at 24 h after Birth, but Not Colostrum Dose by Bryce Bitsie, Erin Kay Ison, Leah Parker Jenkins, Rebecca Klopp, Conor McCabe, Kayla Mills, Griffin Nicholls, Andrew Richards, Larissa Shirley, Kelsey Teeple, Allan P. Schinckel, Angela Kwon, Kara R. Stewart, Amber Jannasch, Aridany Suarez-Trujillo, Theresa M. Casey

“…The study objective was to determine the relationship between the level of colostrum intake and 24 h-level of circulating amino acid, glucose and insulin with mammary parenchyma histological features, cell division and protein synthesis over the first week postnatal. …”
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Establishment of Hematological and Serum Biochemical Parameters in 4,834 Healthy Cynomolgus Monkeys (Macaca fascicularis) by Xueying Ling, Ting Luo, Qingyu Huang, Ying He, Longbao Lv, Yun Wang, Ronghua Ma, Jiewen Chen, Jicun He, Jinrong Zhang, Hongyu Lu, Jian He, Danrong Lin, Siyu Chen, Taiqi Liu, Yangqing Guo, Zhuhong Liu, Jiaqi Feng, Yudan Mao, Zhiying Chen, Ren Huang, Wen De Li

“…Significant differences were observed in White blood cell, Red blood cell, Hemoglobin, Hematocrit, Total protein, Albumin, Total bilirubin, Direct bilirubin, Alkaline phosphatase, Glucose, Blood urea nitrogen, Creatinine, Calcium, Total cholesterol, Triglyceride, and Lactate dehydrogenase values according to age in the juvenile and young groups (P<0.05). …”
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Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development by Changpei Gan, Jing Wang, Yaogeng Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Maria C. Lebre, Els Wagenaar, Hilde Rosing, Sjoerd Klarenbeek, Onno B. Bleijerveld, Ji-Ying Song, Maarten Altelaar, Jos H. Beijnen, Alfred H. Schinkel

“…On a 5-week high-fat diet exposure, Ces1c/d/e deficiency predisposed to developing obesity, enlarged and fatty liver, glucose intolerance and insulin resistance, with severe inflammation in gWAT and increased lipid load in BAT. …”
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Empagliflozin alleviates atherosclerotic calcification by inhibiting osteogenic differentiation of vascular smooth muscle cells by Junping Li, Junping Li, Changping Li, Changping Li, Zhaoqi Huang, Zhaoqi Huang, Chunling Huang, Juanzhang Liu, Juanzhang Liu, Tao Wu, Tao Wu, Shuwan Xu, Peibiao Mai, Dengfeng Geng, Dengfeng Geng, Shuxian Zhou, Shuxian Zhou, Kun Zhang, Kun Zhang, Zhaoyu Liu

“…Empagliflozin treatment significantly alleviated arterial calcification assessed by alizarin red and von kossa staining in aortic roots and reduced the lipid levels, while had little effect on body weight and blood glucose levels in ApoE−/− mice. In vitro studies, empagliflozin significantly inhibits calcification of primary vascular smooth muscle cells (VSMCs) and aortic rings induced by osteogenic media (OM) or inorganic phosphorus (Pi). …”
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Incidence of gestational diabetes mellitus in the United Arab Emirates; comparison of six diagnostic criteria: The Mutaba’ah Study by Maryam M. Bashir, Luai A. Ahmed, Luai A. Ahmed, Iffat Elbarazi, Tom Loney, Rami H. Al-Rifai, Rami H. Al-Rifai, Juma M. Alkaabi, Fatma Al-Maskari, Fatma Al-Maskari

“…We included singleton pregnancies from the Mutaba’ah cohort screened with the oral glucose tolerance test (OGTT) at 24–32 weeks from May 2017 to March 2021. …”
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The genetic causal relationship between type 2 diabetes, glycemic traits and venous thromboembolism, deep vein thrombosis, pulmonary embolism: a two-sample Mendelian randomization... by Mingyi Yang, Xianjie Wan, Yani Su, Ke Xu, Pengfei Wen, Binfei Zhang, Lin Liu, Zhi Yang, Peng Xu

“…Abstract Objective To investigate the genetic underpinnings of the association between type 2 diabetes (T2D), glycemic indicators such as fasting glucose (FG), fasting insulin (FI), and glycated hemoglobin (GH), and venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), thereby contributing novel insights to the scholarly discourse within this domain. …”
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Ensemble machine learning prediction of hyperuricemia based on a prospective health checkup population by Yongsheng Zhang, Yongsheng Zhang, Yongsheng Zhang, Li Zhang, Haoyue Lv, Haoyue Lv, Haoyue Lv, Guang Zhang, Guang Zhang, Guang Zhang

“…The contributing risk factors were estimated using six randomly selected subjects, which showed that being female and relatively younger, together with having higher baseline uric acid, body mass index, γ-glutamyl transpeptidase, total protein, triglycerides, creatinine, and fasting blood glucose can increase the risk of HUA. To further validate our model’s applicability in the health checkup population, we used another cohort of 8559 subjects that also showed our ensemble prediction model had favorable performances with an AUC of 0.846.Conclusion: In this study, the stacking ensemble prediction model for HUA was developed, and it outperformed three individual models that compose it (support vector machine, decision tree C5.0, and eXtreme gradient boosting). …”
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Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice by Minxiu Wang, Qianhui Zhang, Shuaijie Lou, Leiming Jin, Gaojun Wu, Wenqi Wu, Qidong Tang, Yi Wang, Xiaohong Long, Ping Huang, Wu Luo, Guang Liang

“…In vitro, JM-9 suppressed high glucose (HG) and palmitic acid (PA)-induced inflammation in MPMs, accompanied by inhibition of MD2 activation and the downstream TLR4/MyD88-MAPKs/NFκB pro-inflammatory signaling pathway. …”
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ROS-responsive exogenous functional mitochondria can rescue neural cells post-ischemic stroke by Yanjiao Li, Yanjiao Li, Yachao Wang, Weiqi Yang, Zhen Wu, Daiping Ma, Jianxiu Sun, Huixian Tao, Qinlian Ye, Jingnan Liu, Zhaoxia Ma, Lihua Qiu, Weiping Li, Liyan Li, Min Hu, Min Hu, Min Hu

“…The ability of stressed cells to internalize F-Mito was analyzed using a mouse (C57BL/6 J) middle cerebral artery occlusion (MCAO) model and an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model. …”
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The anticancer activity of bile acids in drug discovery and development by Weijian Li, Weijian Li, Weijian Li, Weijian Li, Lu Zou, Lu Zou, Lu Zou, Lu Zou, Shuai Huang, Huijie Miao, Huijie Miao, Huijie Miao, Huijie Miao, Ke Liu, Ke Liu, Ke Liu, Ke Liu, Yajun Geng, Yajun Geng, Yajun Geng, Yajun Geng, Yingbin Liu, Yingbin Liu, Yingbin Liu, Yingbin Liu, Wenguang Wu, Wenguang Wu, Wenguang Wu, Wenguang Wu

“…They play a crucial role in nutrient absorption, lipid and glucose regulation, and the maintenance of metabolic homeostasis. …”
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Sex-specific associations between adipokine profiles and carotid-intima media thickness in the Cameron County Hispanic Cohort (CCHC) by Daeeun Kim, Aylin Memili, Hung-Hsin Chen, Heather M. Highland, Hannah G. Polikowsky, Mohammad Yaser Anwar, Susan T. Laing, Miryoung Lee, Joseph B. McCormick, Susan P. Fisher-Hoch, Jennifer E. Below, Kari E. North, Absalon D. Gutierrez

“…We adjusted for sex, age, body mass index (BMI), smoking status, cytokines, fasting blood glucose levels, blood pressure, lipid levels, and medication usage in the fully adjusted linear regression model. …”
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Prognostic Accuracy of N20 Somatosensory Potential in Patients With Acute Ischemic Stroke and Endovascular Thrombectomy by Alicia Martinez‐Piñeiro, Giuseppe Lucente, María Hernandez‐Perez, Jordi Cortés, Andrea Arbex, Natalia Pérez de la Ossa, Alba Ramos‐Fransí, Miriam Almendrote, Mònica Millán, Meritxell Gomis, Laura Dorado, Carlos Castaño, Sebastián Remollo, Patricia Cuadras, Alicia Garrido, Nicolau Guanyabens, Joaquim Broto, Elena López‐Cancio, Jaume Coll‐Canti, Antoni Dávalos

“…Its adjusted predictive value for functional independence (modified Rankin scale score, ≤2) at day 7 was analyzed by binary logistic regression adjusting by age, mean arterial blood pressure, National Institute of Health Stroke Scale, Alberta Stroke Program Early CT Score, and serum glucose. N20 predictive power was compared with that of clinical and imaging models by using receiver operating characteristics curve analysis. …”
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Combination of Pioglitazone and Metformin Actions on Liver Lipid Metabolism in Obese Mice by Jieying Liu, Dongmei Wang, Ziyan Xie, Lu Ding, Shunhua Li, Xuemei Ma, Jing Liu, Jing Ren, Cheng Xiao, Chunru Yang, Xinhua Xiao

“…After 8 weeks of pharmacological intervention, glucose and lipid metabolism characteristics, hepatic histology, lipidomics profiling and RNA-seq analysis were performed. …”
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Dietary Tryptophan Supplementation Implications on Performance, Plasma Metabolites, and Amino Acid Catabolism Enzymes in Meagre (<i>Argyrosomus regius</i>) by Cláudia Teixeira, Rita Pedrosa, Carolina Castro, Rui Magalhães, Elisabete Matos, Aires Oliva-Teles, Helena Peres, Amalia Pérez-Jiménez

“…After 12 h from feeding, plasma glucose levels were lower in all dietary treatments supplemented with tryptophan compared to those observed in the control. …”
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Effects of High Heat Load Conditions on Blood Constituent Concentrations in Dorper, Katahdin, and St. Croix Sheep from Different Regions of the USA by Dereje Tadesse, Amlan Kumar Patra, Ryszard Puchala, Arthur Louis Goetsch

“…There were breed differences (i.e., main effects; <i>p</i> < 0.05) in glucose (50.0, 52.6, and 52.1 mg/dL; SEM = 0.76), urea nitrogen (17.2, 17.3, and 19.4 mg/dL; SEM = 0.33), creatinine (0.991, 0.862, and 0.802 mg/dL; SEM = 0.0151), total protein (6.50, 6.68, and 6.95 g/l; SEM = 0.017), triglycerides (28.4, 29.1, and 23.5 mg/dL; SEM = 0.87), and cortisol (6.30, 8.79, and 6.22 ng/mL for DOR, KAT, and STC, respectively; SEM = 0.596). …”
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Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring by Saida Breuer, Philipp Kasper, Christina Vohlen, Ruth Janoschek, Thorben Hoffmann, Sarah Appel, Elena Müller-Limberger, Andrea Mesaros, Stefan Rose-John, Christoph Garbers, Stefan Müller, Jan-Wilm Lackmann, Esther Mahabir, Jörg Dötsch, Eva Hucklenbruch-Rother, Inga Bae-Gartz

“…At P21, offspring from WT and transgenic dams that were fed WSD displayed increased body weight and egWAT mass, while glucose tolerance testing showed the strongest impairment in ^GFAPsgp130WSD offspring. …”
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Isoflurane provides neuroprotection in neonatal hypoxic ischemic brain injury by suppressing apoptosis by De-An Zhao, Ling-Yun Bi, Qian Huang, Fang-Min Zhang, Zi-Ming Han

“…Methods: A hippocampal slice, in artificial cerebrospinal fluid with glucose and oxygen deprivation, was used as an in vitro model for brain hypoxia. …”
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Free Versus Fixed-Ratio Combination of Basal Insulin and GLP-1 Receptor Agonists in Type 2 Diabetes Uncontrolled With GLP-1 Receptor Agonists: A Systematic Review and Indirect Trea... by Han Na Jung, Han Na Jung, Yun Kyung Cho, Se Hee Min, Se Hee Min, Hwi Seung Kim, Hwi Seung Kim, Ye-Jee Kim, Joong-Yeol Park, Joong-Yeol Park, Woo Je Lee, Woo Je Lee, Chang Hee Jung, Chang Hee Jung

“…A comparison of adding basal insulin to maintaining GLP-1RA and an indirect comparison between the two strategies were conducted on the change in HbA1c, fasting plasma glucose (FPG), target achievement [HbA1c &lt; 7.0%], and the risk of confirmed hypoglycemia. …”
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