Features of cerebral stroke course in patients with diabetes mellitus according to the REGION-M register by V. P. Voronina, A. V. Zagrebelnyi, Yu. V. Lukina, N. P. Kutishenko, N. A. Dmitrieva, O. V. Lerman, M. M. Lukyanov, Е. Yu. Okshina, S. V. Blagodatskikh, L. P. Ivanova, S. А. Boytsov, O. M. Drapkina, S. Yu. Martsevich

“…Patients with diabetes were older than patients without diabetes and impaired glucose tolerance (73,7+11,1 years vs 69,6±14,7 years (p<0,05)), more often had a history of coronary artery disease (74,2% vs 52,3%, respectively (p<0,05)) myocardial infarction (29,6% and 16,6%, respectively (p<0,05)). …”
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The Level of Adipokine Metrnl and Its Relationship with Inflammation and Insulin Resistance in Patients with Obstructive Sleep Apnea Syndrome by HU Jiayu, REN Lijue, JIN Huanhuan, SUN Tingting, JIN Meina, ZHOU Xueli, WEI Cuiying

“…General data of the 3 groups was collected, including fasting blood glucose (FBG), fasting insulin (FINS), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glycosylated hemoglobin A1c (HbA1c), uric acid (UA), Metrnl, nuclear factor-κB (NF-κB), IL-6, TNF-α, IL-10 and IL-4 levels. …”
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The opportunities and challenges of the disease-modifying immunotherapy for type 1 diabetes: A systematic review and meta-analysis by Chu Lin, Suiyuan Hu, Xiaoling Cai, Fang Lv, Wenjia Yang, Geling Liu, Xiaolin Yang, Linong Ji

“…We included clinical trials of immunotherapy conducted in patients with T1D that reported the incidence of hypoglycemia or changes from baseline in at least one of following outcomes: 2 h and 4 h mixed-meal-stimulated C-peptide area under the curve (AUC), fasting C-peptide, daily insulin dosage, glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG). The results were computed as the weighted mean differences (WMDs) or odds ratios (ORs) and 95% confidence intervals (CIs) in random-effect model. …”
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2型糖尿病患者的随访频率和临床结局:一项基于多中心真实数据的前瞻性分析 by Qiubo Zhao, Hongwei Li, Qicheng Ni, Yuancheng Dai, Qidong Zheng, Yufan Wang, Tingyu Ke, Li Li, Dong Zhao, Qijuan Dong, Bangqun Ji, Juan Shi, Ying Peng, Yifei Zhang, Fengmei Xu, Weiqing Wang

“…Patients with HFF showed significantly greater decrease in percentage changes of fasting blood glucose (−4.95% ± 37.96% vs −2.21% ± 43.08%, P < .0001) and glycosylated hemoglobin (HbA1c) (−12.14% ± 19.78% vs −9.67% ± 20.29%, P < .0001) after adjustments compared to those with LFF. …”
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Effects of Daily Raspberry Consumption on Immune-Metabolic Health in Subjects at Risk of Metabolic Syndrome: A Randomized Controlled Trial by Maximilien Franck, Juan de Toro-Martín, Véronique Garneau, Valérie Guay, Michèle Kearney, Geneviève Pilon, Denis Roy, Patrick Couture, Charles Couillard, André Marette, Marie-Claude Vohl

“…The intervention did not significantly affect plasma insulin, glucose, inflammatory marker concentrations, nor blood pressure. …”
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Risk factors of hemorrhagic transformation in acute ischaemic stroke: A systematic review and meta-analysis by Jiacheng Sun, Jiacheng Sun, Christina Lam, Christina Lam, Lauren Christie, Lauren Christie, Lauren Christie, Christopher Blair, Christopher Blair, Christopher Blair, Xingjuan Li, Freda Werdiger, Freda Werdiger, Qing Yang, Andrew Bivard, Andrew Bivard, Longting Lin, Longting Lin, Mark Parsons, Mark Parsons, Mark Parsons

“…Common predictors for symptomatic ICH (sICH) after reperfusion therapies were age and serum glucose level. Atrial fibrillation (OR = 3.867, 95% CI 1.970–7.591, I2 = 29.1%), NIHSS score (OR = 1.082, 95% CI 1.060–1.105, I2 = 54.5%) and onset-to-treatment time (OR = 1.003, 95% CI 1.001–1.005, I2 = 0.0%) were predictors of sICH after IVT. …”
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Comparative evaluation of ethyl acetate and n‐Hexane extracts of Cannabis sativa L. leaves for muscle function restoration after peripheral nerve lesion by Javeria Maqbool, Haseeb Anwar, Azhar Rasul, Ali Imran, Malik Saadullah, Shoaib Ahmad Malik, Asghar Shabbir, Rabia Akram, Faiqa Sajid, Shamaila Zafar, Suman Saeed, Muhammad Numan Akram, Fakhar Islam, Ghulam Hussain, Saiful Islam

“…A prominent increase in total antioxidant capacity (TAC) (M = 3.76, SD = 0.38, p < .001) and momentous decrease in total oxidant status (TOS) (M = 11.28, SD = 5.71, p < .001) along with blood glucose level indicated significant difference (M = 105.5, SD = 9.12, p < 0.001) in treatment 1 group. …”
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Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFβ signalling pathway by Qingzhu Gao, Bin Cheng, Chang Chen, Chong Lei, Xue Lin, Dan Nie, Jingjing Li, Luyi Huang, Xiaosong Li, Kai Wang, Ailong Huang, Ni Tang

“…Results GSTZ1 was universally silenced in both human and murine HCC cells, and its deficiency contributed to HCC metastasis in vitro and in vivo. UDP‐glucose 6‐dehydrogenase (UGDH)‐mediated UDP‐glucuronic acid (UDP‐GlcUA) accumulation promoted hepatoma cell migration upon GSTZ1 loss. …”
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Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus by Maria Barranco-Altirriba, Núria Alonso, Ralf J. M. Weber, Gavin R. Lloyd, Marta Hernandez, Oscar Yanes, Jordi Capellades, Andris Jankevics, Catherine Winder, Mireia Falguera, Josep Franch-Nadal, Warwick B Dunn, Alexandre Perera-Lluna, Esmeralda Castelblanco, Didac Mauricio

“…The models were adjusted by sex, age, hypertension, dyslipidaemia, body mass index, glucose, smoking, systolic blood pressure, triglycerides, HDL cholesterol, LDL cholesterol, alternate Mediterranean diet score (aMED) and estimated glomerular filtration rate (eGFR); diabetes duration and glycated haemoglobin (HbA1c) were also included in the comparison between T1D and T2D. …”
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Cost-effectiveness of two screening strategies based on Chinese diabetes risk score for pre-diabetes in China by Jingjing Hao, Qiang Yao, Yidie Lin, Yue Sun, Baiyang Zhang, Meijing Hu, Jing Zhang, Ningxuan Zhao, Jiao Pei, Zhonghua Liu, Cairong Zhu

“…The screening strategy of the control group was screening for pre-DM by fasting plasma glucose (FPG) test in adults undergoing annual health examination and no screening in adults without an annual health examination (status quo). …”
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Positive association between insulin resistance and fatty liver disease in psoriasis: evidence from a cross-sectional study by Xiaoyuan Zhong, Xiaoyuan Zhong, Dawei Huang, Dawei Huang, Rongfen Chen, Rongfen Chen, Lingling Yao, Lingling Yao, Rui Ma, Rui Ma, Yingyuan Yu, Yingyuan Yu, Yuxiong Jiang, Yuxiong Jiang, Luyang Kong, Luyang Kong, Jiajing Lu, Jiajing Lu, Ying Li, Ying Li, Yuling Shi, Yuling Shi

“…IR was assessed using the triglyceride glucose (TyG) and TyG-body mass index (TyG-BMI) indicators. …”
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Sphenoid sinus is a rare site for tumor-induced osteomalacia: A case report and literature review by Fen Wang, Fen Wang, Wentao He, Wentao He, Delin Ma, Delin Ma, Weijie Xu, Weijie Xu, Junhui Xie, Junhui Xie, Gang Yuan, Gang Yuan

“…Interestingly, 2-deoxy-2-[fluorine-18]fluoro-d-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) detected a tumor in the axilla and another in the sphenoid sinus, but only the tumor in the sphenoid sinus had somatostatin receptor (SSTR) expression in 68-gallium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid octreotate (Ga-68 DOTATATE) PET/CT. …”
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Is it possible to achieve an acceptable disease control by dietary therapy alone in Berardinelli Seip type 1? Experience from a case report by Carolina Cecchetti, Carolina Cecchetti, Elisabetta Belardinelli, Elisabetta Belardinelli, Paola Dionese, Paola Dionese, Rita Teglia, Rita Teglia, Roberta Fazzeri, Roberta Fazzeri, M. Rosaria D’ Apice, Amanda Vestito, Uberto Pagotto, Uberto Pagotto, Alessandra Gambineri, Alessandra Gambineri

“…Biochemistry, hormonal evaluation, 75 mg oral glucose tolerance test, cardiac evaluation and abdominal ultrasound were performed, revealing no abnormalities. …”
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High-frequency repetitive transcranial magnetic stimulation (rTMS) protects against ischemic stroke by inhibiting M1 microglia polarization through let-7b-5p/HMGA2/NF-κB signaling... by Ye Hong, Jinfeng Lyu, Lin Zhu, Xixi Wang, Mengna Peng, Xiangliang Chen, Qiwen Deng, Jie Gao, Zhenhua Yuan, Di Wang, Gelin Xu, Mengyi Xu

“…Methods Previously reported 10 Hz rTMS protocol that regulated astrocytic polarization was used to stimulate transient middle cerebral artery occlusion (MCAO) rats and oxygen and glucose deprivation/reoxygenation (OGD/R) injured BV2 cells. …”
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Antioxidant Effect of the Ethyl Acetate Extract of <i>Potentilla indica</i> on Kidney Mitochondria of Streptozotocin-Induced Diabetic Rats by Cinthia I. Landa-Moreno, Cristian M. Trejo-Hurtado, Jenaro Lemus-de la Cruz, Donovan J. Peña-Montes, Marina Murillo-Villicaña, Maribel Huerta-Cervantes, Rocío Montoya-Pérez, Rafael Salgado-Garciglia, Salvador Manzo-Avalos, Christian Cortés-Rojo, Juan Luis Monribot-Villanueva, José Antonio Guerrero-Analco, Alfredo Saavedra-Molina

“…At the end of the treatment, fasting blood glucose (FBG) levels, creatinine, blood urea nitrogen (BUN), and uric acid were estimated. …”
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Fenbendazole Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Suppression of Fibroblast-to-Myofibroblast Differentiation by Lan Wang, Kai Xu, Ningdan Wang, Linke Ding, Wenyu Zhao, Ruyan Wan, Weiming Zhao, Xiaoshu Guo, Xin Pan, Juntang Yang, Ivan Rosas, Guoying Yu

“…Further studies showed that FBZ significantly inhibited glucose consumption, moderated glycolytic metabolism in fibroblasts, thus activated adenosine monophosphate-activated protein kinase (AMPK), and reduced the activation of the mammalian target of rapamycin (mTOR) pathway, thereby inhibiting transforming growth factor-β (TGF-β1)-induced fibroblast-to-myofibroblast differentiation and collagen synthesis. …”
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Study on the construction technology of β-alanine synthesizing Escherichia coli based on cellulosome assembly by Jie Lu, Jie Lu, Guodong Wang, Guodong Wang, Cuiping Yang, Cuiping Yang, Zehao Peng, Zehao Peng, Lu Yang, Lu Yang, Bowen Du, Bowen Du, Chuanzhuang Guo, Songsen Sui, Jianbin Wang, Junlin Li, Ruiming Wang, Ruiming Wang, Junqing Wang, Junqing Wang

“…To avoid pollution caused by traditional production methods, the synthesis of β-alanine has been gradually replaced by microbial fermentation and enzyme catalysis, which is a green, mild, and high-yield biosynthesis method.Methods: In this study, we constructed an Escherichia coli recombinant strain for efficient β-alanine production using glucose as the raw material. The microbial synthesis pathway of L-lysine-producing strain, Escherichia coli CGMCC 1.366, was modified using gene editing by knocking out the aspartate kinase gene, lysC. …”
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Diabetic ketoacidosis in a pediatric intensive care unit by Clarice L.S. Lopes, Paula Pitta Pinheiro, Luzia S. Barberena, Guilherme U. Eckert

“…The following data regarding 52 admissions were analyzed: age, sex, weight, body surface area, signs, symptoms and severity on admission, blood gas, blood glucose, glycated hemoglobin, serum osmolarity, and index of mortality. …”
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L’hormone de croissance recombinante : intérêt et risques potentiels de son utilisation pour la production laitière bovine by Y. CHILLIARD, J.J. COLLEAU, C. DISENHAUS, C. LERONDELLE, C. MOUCHET, A. PARIS

“…Simultanément, la GH oriente le métabolisme du tissu adipeux et du muscle vers une mobilisation et une oxydation accrues des acides gras, et une épargne du glucose. L’administration de rbGH a peu d’effets directs sur la fonction de reproduction, mais tend indirectement à la retarder, lorsqu’elle est initiée avant la fécondation, en raison de la diminution transitoire du bilan énergétique des vaches. …”
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3384 Serum Metabolites from the Trimethylamine Pathway Associate with Left Ventricular Diastolic Function: The Bogalusa Heart Study by Alexander C. Razavi, Camilo Fernandez, Xuenan Mi, Jiang He, Lydia Bazzano, Jovia Nierenberg, Shengxu Li, Tanika N. Kelly

“…Covariates adjusted for included sex, age, race, education, alcohol drinking, cigarette smoking, heart rate, systolic blood pressure, glomerular filtrate rate, body mass index, low density lipoprotein cholesterol, high density lipoprotein cholesterol, hemoglobin A1c, serum triglycerides, as well as blood pressure-, lipid-, and glucose-lowering medications. RESULTS/ANTICIPATED RESULTS: After stringent Bonferroni correction for multiple testing, four TMA-associated metabolites as well the TMA score were significantly associated with diastolic function. …”
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