PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1 by Fei Xie, Han Zhang, Kongkai Zhu, Cheng‐Shi Jiang, Xiaoya Zhang, Hongkai Chang, Yaya Qiao, Mingming Sun, Jiyan Wang, Mukuo Wang, Junzhen Tan, Tao Wang, Lianmei Zhao, Yuan Zhang, Jianping Lin, Chunze Zhang, Shuangping Liu, Jianguo Zhao, Cheng Luo, Shuai Zhang, Changliang Shan

“…Moreover, PRMT5 signals high glucose to increase the methylation modification of ENO1. …”
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Effect of herbal extracts and Saroglitazar on high-fat diet-induced obesity, insulin resistance, dyslipidemia, and hepatic lipidome in C57BL/6J mice by Deepika Kumari, Jyoti Gautam, Vipin Sharma, Sonu Kumar Gupta, Soumalya Sarkar, Pradipta Jana, Vikas Singhal, Prabhakar Babele, Parul Kamboj, Sneh Bajpai, Ruchi Tandon, Yashwant Kumar, Madhu Dikshit

“…Saroglitazar reversed changes in body weight, IR, plasma triglycerides, glucose, insulin, and various hepatic lipid species (fatty acids, phospholipids, glycerophospholipids, sphingolipids, and triglycerides). …”
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G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1–Bax-mediated mitochondrial apoptosis pathway by Ting Zhang, Rui-Jie Cao, Jiang-Ling Niu, Zhi-Huan Chen, Shi-Qing Mu, Tong Cao, Jie-Xin Pang, Li-Hua Dong

“…Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) plays an important role in vascular smooth muscle cell (VSMC) phenotypic switching, which is an early pathogenic event in various vascular remodeling diseases (VRDs). …”
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The optimal definition and prediction nomogram for left ventricular remodelling after acute myocardial infarction by Sicheng Zhang, Zheng Zhu, Manqing Luo, Lichuan Chen, Chen He, Zhebin You, Haoming He, Maoqing Lin, Liwei Zhang, Kaiyang Lin, Yansong Guo

“…Seven variables were selected to construct the remodelling nomogram, including diastolic blood pressure, heart rate, AMI type, stent length, N‐terminal pro brain natriuretic peptide, troponin I, and glucose. The prediction model had an area under the receiver operating characteristics curve of 0.766. …”
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Potential Role of the mTORC1-PGC1α-PPARα Axis under Type-II Diabetes and Hypertension in the Human Heart by Tianyu Hang, Jairo Lumpuy-Castillo, Naroa Goikoetxea-Usandizaga, Mikel Azkargorta, Gonzalo Aldámiz, Juan Martínez-Milla, Alberto Forteza, José M. Cortina, Jesús Egido, Félix Elortza, Malu Martínez-Chantar, José Tuñón, Óscar Lorenzo

“…Additionally, cultured rat cardiomyocytes were used for the analysis (protein level and activation, mRNA expression, and bioenergetic performance) of key molecular mediators under stimulation of main components of HTN and T2DM (high glucose and/or fatty acids and angiotensin-II). As results, in cardiac biopsies, we found significant alterations of 677 proteins and after filtering for non-cardiac factors, 529 and 41 were changed in HTN-T2DM and in HTN subjects, respectively, against the control. …”
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Area deprivation and demographic factors associated with diabetes technology use in adults with type 1 diabetes in Germany by Marie Auzanneau, Marie Auzanneau, Alexander J. Eckert, Alexander J. Eckert, Sebastian M. Meyhöfer, Sebastian M. Meyhöfer, Martin Heni, Martin Heni, Anton Gillessen, Lars Schwettmann, Peter M. Jehle, Michael Hummel, Reinhard W. Holl, Reinhard W. Holl

“…We therefore aimed to analyze whether demographic factors and area deprivation are associated with technology use in a representative population of adults with T1D.Materials and methodsIn adults with T1D from the German prospective diabetes follow-up registry (DPV), we analyzed the use of continuous subcutaneous insulin infusion (CSII), continuous glucose monitoring (CGM), and sensor augmented pump therapy (SAP, with and without automated insulin delivery) in 2019-2021 by age group, gender, migration background, and area deprivation using multiple adjusted regression models. …”
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Progressive microbial adaptation of the bovine rumen and hindgut in response to a step-wise increase in dietary starch and the influence of phytogenic supplementation by Sara Ricci, Cátia Pacífico, Ezequias Castillo-Lopez, Raul Rivera-Chacon, Heidi E. Schwartz-Zimmermann, Nicole Reisinger, Franz Berthiller, Qendrim Zebeli, Renee M. Petri

“…Metabolite measurement confirmed the high prevalence of glucose and volatile fatty acids (VFAs) in the rumen due to the increased substrate availability and metabolic activity of the microbiota. …”
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Retinol-Binding Protein 4 and Visfatin Levels in Patients with Periodontitis and Obesity/Overweight: A Systematic Review and Meta-Analysis by Yuwei Zhang, Ru Jia, Yifei Zhang, Rui Zou, Lin Niu, Shaojie Dong

“…And, then, there was a positive association between the serum visfatin and periodontal parameters, including the probing depth, CAL, and plaque index, as well as metabolic parameters, including the total cholesterol, triglycerides, fasting blood glucose, and low-density lipoprotein cholesterol. …”
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Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease by Amandine Jullienne, Jenny I. Szu, Ryan Quan, Michelle V. Trinh, Tannoz Norouzi, Brenda P. Noarbe, Amanda A. Bedwell, Kierra Eldridge, Scott C. Persohn, Paul R. Territo, Paul R. Territo, Andre Obenaus

“…Despite numerous studies, the 5xFAD mouse has not been comprehensively phenotyped for vascular and metabolic perturbations over its lifespan.MethodsMale and female 5xFAD and wild type (WT) littermates underwent in vivo18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging at 4, 6, and 12 months of age to assess regional glucose metabolism. A separate cohort of mice (4, 8, 12 months) underwent “vessel painting” which labels all cerebral vessels and were analyzed for vascular characteristics such as vessel density, junction density, vessel length, network complexity, number of collaterals, and vessel diameter.ResultsWith increasing age, vessels on the cortical surface in both 5xFAD and WT mice showed increased vessel length, vessel and junction densities. …”
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Impact of diabetes duration on left ventricular mass regression with empagliflozin by Michael Moroney, Raj Verma, Makoto Hibino, C. David Mazer, Kim A. Connelly, Andrew T. Yan, Adrian Quan, Hwee Teoh, Subodh Verma, Pankaj Puar

“…The EMPA‐HEART CardioLink‐6 trial reported significant left ventricular (LV) mass indexed to body surface area (LVMi) regression in patients treated with the sodium‐glucose cotransporter 2 inhibitor (SGLT2i) empagliflozin for 6 months. …”
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Association of dipeptidyl peptidase‐4 inhibitor use and risk of pancreatic cancer in individuals with diabetes in Japan by Sodai Kubota, Takuya Haraguchi, Hitoshi Kuwata, Yusuke Seino, Kenta Murotani, Takumi Tajima, Gen Terashima, Makiko Kaneko, Yoshihiro Takahashi, Ken Takao, Takehiro Kato, Kenichiro Shide, Saeko Imai, Atsushi Suzuki, Yasuo Terauchi, Yuichiro Yamada, Yutaka Seino, Daisuke Yabe

“…The primary outcome was duration to the first occurrence of PC (International Classification of Diseases 10th Revision code C25), both all and hospitalized, from prescription of DPP‐4is or other oral glucose‐lowering agents (GLAs). Results Individuals with diabetes who received DPP‐4is (n = 61,430) or other oral GLAs (n = 83,304) were analyzed. …”
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Characterisation of an Atrx Conditional Knockout Mouse Model: Atrx Loss Causes Endocrine Dysfunction Rather Than Pancreatic Neuroendocrine Tumour by Tiago Bordeira Gaspar, Sofia Macedo, Ana Sá, Mariana Alves Soares, Daniela Ferreira Rodrigues, Mafalda Sousa, Nuno Mendes, Rui Sousa Martins, Luís Cardoso, Inês Borges, Sule Canberk, Fátima Gärtner, Leandro Miranda-Alves, Manuel Sobrinho-Simões, José Manuel Lopes, Paula Soares, João Vinagre

“…Homozygous <i>floxed</i> mice presented hyperglycaemia, increased weights, and glucose intolerance after 6 months, but alterations in insulinaemia were not detected. …”
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FGF21 Levels in Pheochromocytoma/Functional Paraganglioma by Judita Klímová, Tomáš Zelinka, Ján Rosa, Branislav Štrauch, Denisa Haluzíková, Martin Haluzík, Robert Holaj, Zuzana Krátká, Jan Kvasnička, Viktorie Ďurovcová, Martin Matoulek, Květoslav Novák, David Michalský, Jiří Widimský Jr., Ondřej Petrák

“…Our aim was to evaluate the relationship between the serum FGF21, and energy and glucose metabolism in 40 patients with pheochromocytoma/functional paraganglioma (PPGL), in comparison with 21 obese patients and 26 lean healthy controls. 27 patients with PPGL were examined one year after tumor removal. …”
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Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice by Melina Amor, Valentina Bianco, Martin Buerger, Margarete Lechleitner, Nemanja Vujić, Anja Dobrijević, Alena Akhmetshina, Anita Pirchheim, Birgit Schwarz, Ariane R. Pessentheiner, Franziska Baumgartner, Katharina Rampitsch, Silvia Schauer, Iva Klobučar, Vesna Degoricija, Gudrun Pregartner, Daniel Kummer, Monika Svecla, Gerhard Sommer, Dagmar Kolb, Gerhard A. Holzapfel, Gerald Hoefler, Saša Frank, Giuseppe Danilo Norata, Dagmar Kratky

“…Results DKO mice showed lower cholesterol and plasma glucose concentrations and improved insulin sensitivity compared with LdlrKO mice. …”
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Risk Associations of Glycemic Burden and Obesity With Liver Cancer—A 10‐Year Analysis of 15,280 Patients With Type 2 Diabetes by Dandan Mao, Eric S.H. Lau, Hongjiang Wu, Aimin Yang, Baoqi Fan, Mai Shi, Claudia H.T. Tam, Elaine Chow, Alice P.S. Kong, Ronald C.W. Ma, Andrea Luk, Juliana C.N. Chan

“…Liver is a major site for glucose metabolism. Patients with type 2 diabetes (T2D) and obesity have increased risk of liver cancer. …”
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Evaluation of cardiovascular risk factors in long-term survivors of adult- and childhood-onset brain tumours: a pilot study by Nikolaos Kyriakakis, Marilena Giannoudi, Satish S Kumar, Khyatisha Seejore, Georgios K Dimitriadis, Harpal Randeva, Adam Glaser, Michelle Kwok-Williams, Georgina Gerrard, Carmel Loughrey, Ahmed Al-Qaissi, Ramzi Ajjan, Julie Lynch, Robert D Murray

“…Patients and methods: Fasting lipids, glucose, insulin, 24-h blood pressure (BP), and body composition were measured in 36 brain tumour survivors (20 AO; 16 childhood-onset (CO)) and 36 age- and gender-matched controls. …”
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Chemical Characterization of Honey and Its Effect (Alone as well as with Synthesized Silver Nanoparticles) on Microbial Pathogens’ and Human Cancer Cell Lines’ Growth by Hamed A. Ghramh, Sulaiman A. Alrumman, Irfan Ahmad, Abul Kalam, Serag Eldin I. Elbehairi, Abdulkhaleg M. Alfaify, Mohammed Elimam Ahamed Mohammed, Abdullah G. Al-Sehemi, Mohammad Alfaifi, Badria M. Al-Shehri, Rahaf Mohammed Hussein Alshareef, Wed Mohammed Ali ALaerjani, Khalid Ali Khan

“…Regarding the sugar profile, the contents of maltose and glucose were lower than the content of fructose. In addition, the results showed that the SPR band of AgNPs increased as the percentage of forest honey increased due to the elevation of the concentration of the bio-reducing agent. …”
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Advanced Glycation End Products in the Skin: Molecular Mechanisms, Methods of Measurement, and Inhibitory Pathways by Chun-yu Chen, Chun-yu Chen, Chun-yu Chen, Jia-Qi Zhang, Jia-Qi Zhang, Jia-Qi Zhang, Li Li, Li Li, Li Li, Miao-miao Guo, Miao-miao Guo, Miao-miao Guo, Yi-fan He, Yi-fan He, Yi-fan He, Yin-mao Dong, Yin-mao Dong, Yin-mao Dong, Hong Meng, Hong Meng, Hong Meng, Fan Yi, Fan Yi, Fan Yi

“…Advanced glycation end products (AGEs) are a series of stable compounds produced under non-enzymatic conditions by the amino groups of biomacromolecules and the free carbonyl groups of glucose or other reducing sugars commonly produced by thermally processed foods. …”
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Long-Term Insulin Independence following Repeated Islet Transplantation in Totally Pancreatectomized Diabetic Pigs by Eugenio Morsiani, Luciano Fogli M.D., Giovanni Lanza, Laura T. Lebow, Achilles A. Demetriou, Jacek Rozga

“…In all group I animals, normal fasting blood glucose (FBG) was restored within 2–3 weeks. Two normoglycemic pigs died of acute pneumonia at 33 and 112 days, respectively, and one animal became progressively hyperglycemic at 100 days. …”
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Aqueous Extract of Black Maca Prevents Metabolism Disorder via Regulating the Glycolysis/Gluconeogenesis-TCA Cycle and PPARα Signaling Activation in Golden Hamsters Fed a High-Fat,... by Wenting Wan, Wenting Wan, Hongxiang Li, Hongxiang Li, Jiamei Xiang, Jiamei Xiang, Fan Yi, Lijia Xu, Lijia Xu, Baoping Jiang, Baoping Jiang, Peigen Xiao, Peigen Xiao

“…Together, our data demonstrated that AEM intervention significantly improved lipid and glucose metabolism disorder by regulating the glycolysis/gluconeogenesis-TCA cycle and by modulating gene expression levels involved in the PPARα signaling pathway.…”
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