Validation of the WATCH‐DM and TRS‐HFDM Risk Scores to Predict the Risk of Incident Hospitalization for Heart Failure Among Adults With Type 2 Diabetes: A Multicohort Analysis by Matthew W. Segar, Kershaw V. Patel, Anne S. Hellkamp, Muthiah Vaduganathan, Yuliya Lokhnygina, Jennifer B. Green, Siu‐Hin Wan, Ahmed A. Kolkailah, Rury R. Holman, Eric D. Peterson, Vaishnavi Kannan, Duwayne L. Willett, Darren K. McGuire, Ambarish Pandey

“…Background The WATCH‐DM (weight [body mass index], age, hypertension, creatinine, high‐density lipoprotein cholesterol, diabetes control [fasting plasma glucose], ECG QRS duration, myocardial infarction, and coronary artery bypass grafting) and TRS‐HFDM (Thrombolysis in Myocardial Infarction [TIMI] risk score for heart failure in diabetes) risk scores were developed to predict risk of heart failure (HF) among individuals with type 2 diabetes. …”
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Incorporation of synthetic water-soluble curcumin polymeric drug within calcium phosphate cements for bone defect repairing by Ying Zhang, Hailiang Xu, Jing Wang, Xiaochen Fan, Fang Tian, Zhiyuan Wang, Botao Lu, Weidong Wu, Youjun Liu, Yixiang Ai, Xiaohui Wang, Lei Zhu, Shuaijun Jia, Dingjun Hao

“…In this study, we incorporated the CUR-HA and glucose microparticles (GMPs) into the CPC powder to fabricate the CUR-HA/GMP/CPC composite, which not only retained the good injectability and mechanical strength of bone cements, but also significantly increased the cement porosity and sustained release property of CUR-HA in vitro. …”
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Effects of a Dulaglutide plus Calorie-Restricted Diet versus a Calorie-Restricted Diet on Visceral Fat and Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Randomized... by Yuqin Zhang, Zhihua Qu, Ting Lu, Xiaowen Shao, Meili Cai, Diliqingna Dilimulati, Xinxin Gao, Weiqing Mao, Fan Hu, Lili Su, Qiong Liao, Ting Han, Manna Zhang, Shen Qu

“…As compared with CRD alone, dulaglutide + CRD had significant advantages in reducing glycated hemoglobin A1c and postprandial plasma glucose levels. The results of the analyses showed different changes in menstruation frequency, additional metabolic profiles, hormonal markers, liver fat, and body composition between the two groups did not differ significantly. …”
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A 3D convolutional neural network to classify subjects as Alzheimer's disease, frontotemporal dementia or healthy controls using brain 18F-FDG PET by Antoine Rogeau, Florent Hives, Cécile Bordier, Hélène Lahousse, Vincent Roca, Thibaud Lebouvier, Florence Pasquier, Damien Huglo, Franck Semah, Renaud Lopes

“…The purpose of this study is to introduce and validate a 3D neural network for classification of Alzheimer's disease (AD), frontotemporal dementia (FTD) or cognitively normal (CN) subjects based on brain glucose metabolism. Retrospective [18F]-FDG-PET scans of 199 CE, 192 FTD and 200 CN subjects were collected from our local database, Alzheimer's disease and frontotemporal lobar degeneration neuroimaging initiatives. …”
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Beneficial Effects of Graded Levels of Fish Protein Hydrolysate (FPH) on the Growth Performance, Blood Biochemistry, Liver and Intestinal Health, Economics Efficiency, and Disease... by Afrina Yeasmin Suma, Shishir Kumar Nandi, Zulhisyam Abdul Kari, Khang Wen Goh, Lee Seong Wei, Albaris B. Tahiluddin, Paul Seguin, Mikael Herault, Abdullah Al Mamun, Guillermo Téllez-Isaías, Muhammad Anamul Kabir

“…The fish fed with a 2% FPH diet had significantly higher neutrophil, monocyte, lymphocyte, red blood cell, and platelet levels (<i>p</i> < 0.05). The blood glucose, creatinine, total protein, and globulin were significantly lower in control fish compared to other treatment groups (<i>p</i> < 0.05). …”
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Association Between Serum Glycated Hemoglobin Levels at Early Gestation and the Risk of Subsequent Pregnancy Loss in Pregnant Women Without Diabetes Mellitus: Prospective Cohort St... by Xiaotian Chen, Yi Zhang, Hongyan Chen, Yalan Dou, Yin Wang, Wennan He, Xiaojing Ma, Wei Sheng, Weili Yan, Guoying Huang

“…HbA1c and fasting blood glucose (FBG) levels were examined at enrollment. …”
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Comparison of adiposity indices and their association with insulin resistance and β-cell dysfunction in primary prevention for diabetes in Mexican population by Froylan David Martínez-Sánchez, Alejandra Diaz-Jarquin, Valerie Paola Vargas-Abonce, Jose Luis Torres-Cuevas, Anna Paula Guerrero-Castillo, David Medina-Julio, Clara Elena Meza-Arana, Alfonso Gulias-Herrero, Miguel Ángel Gómez-Sámano

“…Materials and Methods: This was a cross-sectional study that included 401 asymptomatic subjects with at least two risk factors for T2D that underwent an oral glucose tolerance test. A HOMA-IR ≥2.5 and a Disposition Index ≤1.24 were used to define IR and β-cell dysfunction, respectively. …”
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Abstract 149: Metabolic Neuroimaging in the Assessment of Cardiovascular Risk: A Regional FDG‐PET Analysis by Robert C. Subtirelu, Eric M. Teichner, Yvonne Su, Thomas Werner, Abass Alavi, Poul Flemming Høilund‐Carlsen, Mona‐Elisabeth Revheim

“…This study analyzed regional glucose metabolism in individuals with known CVD risk factors. …”
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Alteraciones clínicas y bioquímicas en ratas tratadas con dosis altas de vitamina A by Alfonso R Alarcón-Corredor OM

“…Administration of excess of vitamin A produced a significant (p<0.05) increase in the content of liver vitamin A, determined diverse and variable clinical signs (such as, anorexia, loss of body weight, alopecia, conjunctivitis, external and internal hemorrhages, skin abnormalities and death) and increased (p<0.05) the activity of the following enzymes: alanine aminotransferase, aspartate aminotransferase, acid maltase (acid &#945;-1,4-glucosidase), acid proteases, lactate dehydrogenase and alkaline phosphatase while glucose-6-phosphatase, glycogen phosphorylase, &#945;-amylase, cholinesterase and arginase decreased (p<0.05) as compared with untreated controls. …”
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Heat stress affects the milk yield, milk composition, serum oxidative status, and metabolites of Holstein cows during mid-lactation by Xue Chen, Yongqiang Li, Jun Xiao, Jianan Dong, Wei Zhao, Zhiyi Han, Liang Xin, Guixin Qin, Tao Wang, Yuguo Zhen, Zhe Sun, Xuefeng Zhang

“…The serum concentrations of d-glucose, 9,12-octadecadienoic acid, and d-lactose were significantly higher in  the NHS group than in the HS group (P &lt; 0.05). …”
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Histone demethylase KDM1A promotes hepatic steatosis and inflammation by increasing chromatin accessibility in NAFLD by Zifeng Yang, Siyao Zhang, Xiang Liu, Rui Shu, Wei Shi, Weiyi Qu, Dianyu Liu, Zhiwei Cai, Ye Wang, Xu Cheng, Yemao Liu, Xiao-Jing Zhang, Lan Bai, Hongliang Li, Zhi-Gang She

“…KDM1A, commonly known as lysine-specific histone demethylase 1, has been reported to increase glucose uptake in hepatocellular carcinoma. In addition, a recent study suggests that inhibition of KDM1A reduces lipid accumulation in primary brown adipocytes. …”
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Clinical Value of Systemic Immune-inflammation Index in the Diagnosis of Diabetic Kidney Disease in Community-dwelling Elderly Patients with Type 2 Diabetes by ZHAO Lizhen, LI Weimin, JIANG Ruixia

“…Moreover, the proportion of patients with hypertension history, fasting plasma glucose (FPG), low-density lipoprotein (LDL), blood urea nitrogen, serum creatinine (Scr), UACR, neutrophils, platelets, NLR, PLR and SII in DKD group were higher than those in non-DKD group (P&lt;0.05). …”
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Characteristics, Treatment Strategies and Outcome in Cardiogenic Shock Complicating Acute Myocardial Infarction: A Contemporary Dutch Cohort by Elma J. Peters, Sanne ten Berg, Margriet Bogerd, Marijke J. C. Timmermans, Adriaan O. Kraaijeveld, Jeroen J. H. Bunge, Koen Teeuwen, Erik Lipsic, Krischan D. Sjauw, Robert-Jan M. van Geuns, Admir Dedic, Eric A. Dubois, Martijn Meuwissen, Peter Danse, Niels J. W. Verouden, Gabe Bleeker, José M. Montero Cabezas, Irlando A. Ferreira, Annemarie E. Engström, Wim K. Lagrand, Luuk C. Otterspoor, Alexander P. J. Vlaar, José P. S. Henriques, on behalf of the Participating Centers of the PCI Registration Committee of the Netherlands Heart Registration

“…Non-survivors presented with a lower mean blood pressure and increased heart rate, blood lactate and blood glucose levels (<i>p</i>-value for all <0.001). Also, an increased prevalence of diabetes, multivessel coronary artery disease and a prior coronary event were found. …”
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Deep Learning Algorithm for Management of Diabetes Mellitus via Electrocardiogram-Based Glycated Hemoglobin (ECG-HbA1c): A Retrospective Cohort Study by Chin-Sheng Lin, Yung-Tsai Lee, Wen-Hui Fang, Yu-Sheng Lou, Feng-Chih Kuo, Chia-Cheng Lee, Chin Lin

“…Methods: there were 104,823 ECGs with corresponding HbA1c or fasting glucose which were utilized to train a DLM for calculating ECG-HbA1c. …”
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Association between blood selenium levels and gestational diabetes mellitus: A systematic review and meta-analysis by Shuai Yan, Shuai Yan, Han Su, Han Su, Yang Xia, Zixuan Yan, Zixuan Yan, Yitao Gao, Yitao Gao, Mengyuan Shi, Huiyuan Liu, Yu Wen, Yuhong Zhao, Yuhong Zhao, Qing Chang, Qing Chang

“…Pregnancies with GDM had significantly lower blood selenium levels than those with normal glucose tolerance (weighted mean difference = −8.11; 95% confidence interval: −12.68 to −3.54, P = 0.001). …”
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Circulating miR-30a-5p and miR-182-5p in Prediabetes and Screen-Detected Diabetes Mellitus by Weale CJ, Matshazi DM, Davids SFG, Raghubeer S, Erasmus RT, Kengne AP, Davison GM, Matsha TE

“…Age, sex and BMI-adjusted partial correlation coefficient analysis revealed a significant correlation between the two miRNAs across glucose tolerance statuses (r&ge; 0.932, p&lt; 0.001). …”
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The supplementation of the multi-strain probiotics WHHPRO™ alleviates high-fat diet-induced metabolic symptoms in rats via gut-liver axis by Cailing Chen, Cailing Chen, Cailing Chen, Kan Gao, Kan Gao, Kan Gao, Zuoguo Chen, Zuoguo Chen, Zuoguo Chen, Qiwen Zhang, Qiwen Zhang, Qiwen Zhang, Xueqin Ke, Xueqin Ke, Xueqin Ke, Bingyong Mao, Qiuling Fan, Qiuling Fan, Qiuling Fan, Yanjun Li, Yanjun Li, Yanjun Li, Su Chen, Su Chen, Su Chen

“…Oral administration of WHHPRO™ for 12 weeks improved glucose tolerance, blood lipid, body weight, and liver index in HFD rats. …”
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Pre-pregnancy body mass index and glycated-hemoglobin with the risk of metabolic diseases in gestational diabetes: a prospective cohort study by Xinyue Wang, Simin Zhang, Wenlu Yu, Guohua Li, Jinglin Li, Jing Ji, Jing Ji, Yang Mi, Xiaoqin Luo

“…Those without other metabolic diseases by the time of oral glucose tolerance test (OGTT) detection were finally recruited and divided into four groups by pre-pregnancy BMI (Underweight &lt;18.5kg/m2; Normal weight 18.5-23.9 kg/m2; Overweight 24.0-27.9 kg/m2; Obesity ≥28.0 kg/m2, respectively) or two groups by HbA1c in late pregnancy (normal HbA1c&lt;5.7%; high HbA1c≥5.7%). …”
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The Effect of Sevoflurane and Fullerenol C 60 on the Liver and Kidney in Lower Extremity Ischemia-Reperfusion Injury in Mice with Streptozocin-Induced Diabetes by Şengel N, Küçük A, Özdemir Ç, Sezen ŞC, Kip G, Er F, Dursun AD, Polat Y, Kavutçu M, Arslan M

“…The best results in AST, ALT, glucose, TBARS levels, and SOD enzyme activities in liver tissue were in group DIR-FC60 compared with group DIR, followed by groups DIR-S-FC60 and DIR-S, respectively. …”
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A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes by Bethan E. Phillips, Benjamin M. Kelly, Mats Lilja, Jesús Gustavo Ponce-González, Robert J. Brogan, David L. Morris, Thomas Gustafsson, William E. Kraus, Philip J. Atherton, Niels B. J. Vollaard, Olav Rooyackers, James A. Timmons, James A. Timmons

“…Herein, we evaluate a new time-efficient and genuinely practical high-intensity interval training (HIT) protocol in men and women with pre-existing risk factors for type 2 diabetes.Materials and methodsOne hundred eighty-nine sedentary women (n = 101) and men (n = 88) with impaired glucose tolerance and/or a body mass index &gt;27 kg m−2 [mean (range) age: 36 (18–53) years] participated in this multi-center study. …”
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