Directional DBS of the Fornix in Alzheimer’s Disease Achieves Long-Term Benefits: A Case Report by Juan A. Barcia, María Aurora Viloria, Raquel Yubero, Raquel Yubero, Leyre Sanchez-Sanchez-Rojas, Leyre Sanchez-Sanchez-Rojas, Amanda López, Amanda López, Bryan Andrew Strange, María Cabrera, Leonides Canuet, Pedro Gil, Cristina Nombela, Cristina Nombela

“…Stimulation parameters were set between 3.9 and 7.5 mA, 90 μs, 130 Hz for 24 months, controlling stimulation effects by 18F-fluoro-2-deoxy-D-glucose (18F-FDG) scans (baseline, 12 and 24 months), magnetoencephalography (MEG) and clinical/neuropsychological assessment (baseline, 6, 12, 18, and 24 months).ResultsThere were no important complications related to the procedure. …”
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Production of a Novel Protopanaxatriol-Type Ginsenoside by Yeast Cell Factories by Chen Zhou, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang, Ping Zhu

“…Then, we modified this engineered strain by replacing UGT109A1 with its mutant UGT109A1-K73A, overexpressing the cytochrome P450 reductase ATR2 from <i>Arabidopsis thaliana</i> and the key enzymes of UDP-glucose biosynthesis to increase the production of 3<i>β</i>,12<i>β</i>-Di-<i>O</i>-Glc-PPT, although these strategies did not show any positive effect on the yield of 3<i>β</i>,12<i>β</i>-Di-<i>O</i>-Glc-PPT. …”
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Supplementing Diets with <i>Agriophyllum squarrosum</i> Reduced Blood Lipids, Enhanced Immunity and Anti-Inflammatory Capacities, and Mediated Lipid Metabolism in Tan Lambs by Dan Jiao, Yanping Liang, Shanshan Zhou, Xiukun Wu, Abraham Allan Degen, Jonathan Hickford, Huitong Zhou, Haitao Cong, Xinxin Shi, Xiaofei Ma, Guo Yang

“…Supplementation with <i>A. squarrosum</i> also enriched immune and anti-inflammatory related and lipid and glucose-metabolic pathways and associated differentially expressed gene expressions in adipose tissue. …”
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Binding Interaction of Betulinic Acid to α-Glucosidase and Its Alleviation on Postprandial Hyperglycemia by Shaodan Chen, Bing Lin, Jiangyong Gu, Tianqiao Yong, Xiong Gao, Yizhen Xie, Chun Xiao, Janis Yaxian Zhan, Qingping Wu

“…Significantly, oral administration of BA alleviated the postprandial blood glucose fluctuations in mice. This work may provide new insights into the utilization of BA as a functional food and natural medicine for the control of postprandial hyperglycemia.…”
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Agronomic and Physicochemical Properties Facilitating the Synchronization of Grain Yield and the Overall Palatability of <i>Japonica</i> Rice in East China by Huanhe Wei, Jialin Ge, Xubin Zhang, Wang Zhu, Yinglong Chen, Tianyao Meng, Qigen Dai

“…HYGP had higher (<i>p</i> < 0.05) adenosine diphosphate glucose pyrophosphorylase and starch branching enzyme activities at the middle and late grain-filling stages than HYPP and LYGP. …”
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Polysaccharides from Moroccan Green and Brown Seaweed and Their Derivatives Stimulate Natural Defenses in Olive Tree Leaves by Meriem Aitouguinane, Zainab El Alaoui-Talibi, Halima Rchid, Imen Fendri, Slim Abdelkafi, Mohamed Didi Ould El-Hadj, Zakaria Boual, Pascal Dubessay, Philippe Michaud, Mounir Traïkia, Guillaume Pierre, Cherkaoui El Modafar, Cédric Delattre

“…The AGB and AGP fractions were characterized by the presence of a high degree of sulfation and protein (12–23% (<i>w</i>/<i>w</i>)) and were composed mainly of galactose, glucose, and arabinose. The aqueous saccharide solutions were applied to the leaf discs of the olive tree at 0.5 g/L, 1 g/L, and 2 g/L, for 24 h. …”
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Serum Osmolarity and Vasopressin Concentration in Acute Heart Failure—Influence on Clinical Course and Outcome by Mateusz Guzik, Mateusz Sokolski, Magdalena Hurkacz, Agata Zdanowicz, Gracjan Iwanek, Dominik Marciniak, Robert Zymliński, Piotr Ponikowski, Jan Biegus

“…The study group consisted of 338 AHF patients (male (76.3%), mean age of 68 ± 13 years) with serum osmolarity calculated by the equation: 1.86 × sodium [mmol/L] + (glucose [mg/dL]/18) + (urea [mg/dL]/2.8) + 9 and divided into osmolarity quartiles marked as: low: <287 mOsm/L, intermediate low: 287–294 mOsm/L, intermediate high: 295–304 mOsm/L, and high: >304 mOsm/L. …”
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Intramammary administration of lipopolysaccharides at parturition enhances immunoglobulin concentration in goat colostrum by M. González-Cabrera, A. Torres, M. Salomone-Caballero, N. Castro, A. Argüello, L.E. Hernández-Castellano

“…Goat plasma immunoglobulin G (IgG) and M (IgM) and serum β-hydroxybutyrate, glucose, calcium, free fatty acids, lactate dehydrogenase and total protein concentrations were determined. …”
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Identification of SLC2A3 as a prognostic indicator correlated with the NF-κB/EMT axis and immune response in head and neck squamous cell carcinoma by Fangyu Chai, Jingfang Zhang, Tao Fu, Peng Jiang, Yichuan Huang, Lin Wang, Shu Yan, Xudong Yan, Longgang Yu, Zhen Xu, Ruohuang Wang, Bingqing Xu, Xiaoyun Du, Yan Jiang, Jisheng Zhang

“…ABSTRACTSLC2A3 is an important member of the glucose transporter superfamily. It has been recently suggested that upregulation of SLC2A3 is associated with poor survival and acts as a prognostic marker in a variety of tumors. …”
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Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin by Solène Denolly, Hongbo Guo, Miriam Martens, Anna Płaszczyca, Pietro Scaturro, Vibhu Prasad, Kessiri Kongmanas, Nuntaya Punyadee, Adisak Songjaeng, Dumrong Mairiang, Andreas Pichlmair, Panisadee Avirutnan, Ralf Bartenschlager

“…Proteomic analysis identified chaperones interacting with NS1, including GRp78 (78-kDa glucose-regulated protein, also known as HSPA5 or BIP). …”
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The relationship between body weight and the development of lipid and carbohydrate metabolism disorders in patients with gastrointestinal diseases by Yu.M. Stepanov, L.M. Mosiychuk, O.M. Shevtsova, I.A. Klenina, V.A. Karachynova, O.M. Tatarchuk, O.P. Petishko

“…Total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), glucose and insulin serum levels were evaluated. The atherogenic index (AI) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) were calculated. …”
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Oral ketone esters acutely improve myocardial contractility in post-hospitalized COVID-19 patients: A randomized placebo-controlled double-blind crossover study by Helena Zander Wodschow, Filip Søskov Davidovski, Jacob Christensen, Mats Christian Højbjerg Lassen, Kristoffer Grundtvig Skaarup, Hanne Nygaard, Niels Møller, Jørgen Rungby, Jørgen Rungby, Jørgen Rungby, Tor Biering-Sørensen, Peter Rossing, Peter Rossing, Peter Rossing, Nicole Jacqueline Jensen, Jens Christian Laursen

“…Ketone esters increased blood insulin, c-peptide, and creatinine, and decreased glucose and FFA (all p ≤ 0.01) but did not affect glucagon, pro-BNP, or troponin I levels (all p &gt; 0.05).ConclusionIn patients previously hospitalized with COVID-19, a single oral dose of ketone ester had no effect on LVEF, cardiac output or blood oxygen saturation, but increased GLS acutely.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT04377035.…”
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Effect of sarpogrelate treatment on 5-HT modulation of vascular sympathetic innervation and platelet activity in diabetic rats by Juan Francisco Fernández-González, José Ángel García-Pedraza, Ana Marín-Quílez, José María Bastida, María Luisa Martín, Asunción Morán, Mónica García-Domingo

“…This study aimed to investigate whether the 5-HT2 receptor blockade alters the 5-HT effect on vascular sympathetic neurotransmission and platelet activation in type 1 diabetes. 28-day diabetes was obtained by alloxan (150 mg/kg; s.c.) in male Wistar rats, administering sarpogrelate (5-HT2 blocker; 30 mg/kg/day; p.o.) for 14 days. Blood glucose and body weight were monitored for 28 days. …”
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Surgical Pharmacy for Optimizing Medication Therapy Management Services within Enhanced Recovery after Surgery (ERAS^®) Programs by Jingwen Xie, Xiaoyan Huang, Min Gao, Li Wei, Ruolun Wang, Jisheng Chen, Yingtong Zeng, Bo Ji, Tao Liu, Jinghao Wang, Hongwei Wu, Yong Wang, Li Qin, Yiting Wang, Zhuoling Zheng, Jing Xue, Junyan Wu, Xiao Chen, Zhihua Zheng, Xiaoyan Li

“…Therefore, this article reviews the main perioperative medical management strategies and precautions from several aspects, including antimicrobial agents, antithrombotic agents, pain medication, nutritional therapy, blood glucose monitoring, blood pressure treatment, fluid management, treatment of nausea and vomiting, and management of postoperative delirium. …”
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<i>Kandelia candel</i> Thioredoxin f Confers Osmotic Stress Tolerance in Transgenic Tobacco by Xiaoshu Jing, Jun Yao, Xujun Ma, Yanli Zhang, Yuanling Sun, Min Xiang, Peichen Hou, Niya Li, Rui Zhao, Jinke Li, Xiaoyang Zhou, Shaoliang Chen

“…Notably, <i>KcTrxf</i>-transgenic plants had increased glucose and fructose contents under drought stress conditions, presumably resulting from KcTrxf-promoted starch degradation under water stress. …”
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AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice by Elena A. Tukhovskaya, Elvira R. Shaykhutdinova, Irina A. Pakhomova, Gulsara A. Slashcheva, Natalya A. Goryacheva, Elena S. Sadovnikova, Ekaterina A. Rasskazova, Vitaly A. Kazakov, Igor A. Dyachenko, Alina A. Frolova, Alexey N. Brovkin, Vasiliy E. Kaluzhsky, Mikhail Yu. Beburov, Arkady N. Murashev

“…The animals were recorded with signs of metabolic syndrome and type 2 diabetes mellitus by recording their body weights, glucose and insulin levels, and the calculating HOMA-IRs. …”
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Insights into the Chemistry and Functional Properties of Edible Mushrooms Cropped in the Northeastern Highlands of Puebla, Mexico by Yesenia Pacheco-Hernández, Edmundo Lozoya-Gloria, Clemente Mosso-González, Jenaro Leocadio Varela-Caselis, Nemesio Villa-Ruano

“…The total phenol content and antioxidant capacity significantly (<i>p</i> < 0.05) varied among the studied species, and their capacity to inhibit enzymes involved in glucose, lipid, and polyamine metabolism. Nevertheless, the hydroalcoholic extracts from <i>A. jacksonii</i> and <i>L. indigo</i> efficiently inhibited alpha-glucosidase and ornithine decarboxylase (IC₅₀ < 50 µg mL⁻¹), respectively. …”
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The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese... by Xiaoling Cao, Vi Nguyen, Joseph Tsai, Chao Gao, Yan Tian, Yuping Zhang, Wayne Carver, Hippokratis Kiaris, Taixing Cui, Wenbin Tan

“…The cardiac transcriptional signatures in HFD mice at 3, 6, and 24 wpi showed systemic suppression of mitochondria respiratory chain genes including ATP synthases and nicotinamide adenine dinucleotide:ubiquinone oxidoreductase gene members, upregulation of stress pathway-related crucial factors such as nuclear factor-erythroid 2-related factor 1 and signal transducer and activator of transcription 5A, and increases in expression of glucose metabolism-associated genes. As compared with the age-matched HFD control mice, cardiac ejection fraction and fractional shortening were significantly decreased, while left ventricular end-systolic diameter and volume were significantly elevated, and cardiac fibrosis was increased in HFD mice at 24 wpi. …”
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High-protein compound yogurt with quinoa improved clinical features and metabolism of high-fat diet–induced nonalcoholic fatty liver disease in mice by Linlin Shi, Fang Tianqi, Can Zhang, Xuming Deng, Yonglin Zhou, Jianfeng Wang, Lin Wang

“…In addition, quinoa yogurt significantly reduced liver steatosis and enhanced glucose homeostasis and insulin sensitivity. Additional research indicates that quinoa yogurt can reduce the levels of proinflammatory cytokines (i.e., tumor necrosis factor α, IL-1β, and IL-6) and inhibit endotoxemia and systemic inflammation. …”
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Obesity during Pregnancy in the Horse: Effect on Term Placental Structure and Gene Expression, as Well as Colostrum and Milk Fatty Acid Concentration by Morgane Robles, Delphine Rousseau-Ralliard, Cédric Dubois, Tiphanie Josse, Émilie Nouveau, Michele Dahirel, Laurence Wimel, Anne Couturier-Tarrade, Pascale Chavatte-Palmer

“…These results are in line with the increased systemic inflammation and altered glucose metabolism observed until 18 months of age in this group. …”
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