Efficacy of celecoxib add-on treatment for immuno-metabolic depression: Protocol of the INFLAMED double-blind placebo-controlled randomized controlled trial by J.C. Zwiep, P.M. Bet, D. Rhebergen, M.T. Nurmohamed, C.H. Vinkers, B.W.J.H. Penninx, Y. Milaneschi, F. Lamers

“…Explorative analyses will be performed on the role of CRP, IL-6, TNF-α, cholesterol, triglycerides, glucose, BMI, waist and hip circumference. Ethics and dissemination: This protocol has been approved by the Medical Ethics Review Board of the Amsterdam UMC, location VUmc (2022.0015) on 2-6-2022, as well as by the competent authority in The Netherlands: CCMO, on 3-8-2022. …”
Get full text

Characterization of Fruit Development, Antioxidant Capacity, and Potential Vasoprotective Action of Peumo (<i>Cryptocarya alba</i>), a Native Fruit of Chile by Mónika Valdenegro, Maricarmen Bernales, Marcela Knox, Raúl Vinet, Eduardo Caballero, Aníbal Ayala-Raso, Denisa Kučerová, Rohitesh Kumar, Jitka Viktorová, Tomáš Ruml, Carlos R. Figueroa, Lida Fuentes

“…Also, the assay of isolated rat aorta with endothelium-dependent relaxation damage demonstrated that the peumo extract induced vascular protection, depending on its concentration under a high glucose condition. These results demonstrate that these endemic fruits have a good chance as ingredients or foods with functional properties.…”
Get full text

Coronary inflammation based on pericoronary adipose tissue attenuation in type 2 diabetic mellitus: effect of diabetes management by Yuankang Liu, Lisong Dai, Yue Dong, Cong Ma, Panpan Cheng, Cuiping Jiang, Hongli Liao, Ying Li, Xiang Wang, Xiangyang Xu

“…Abstract Background Coronary inflammation plays crucial role in type 2 diabetes mellitus (T2DM) induced cardiovascular complications. Both glucose-lowering drug interventions (GLDIS) and glycemic control (GC) status potentially correlate coronary inflammation, as indicated by changes in pericoronary adipose tissue (PCAT) attenuation, and thus influence cardiovascular risk. …”
Get full text

¹H-NMR-Based Metabolomics in Autism Spectrum Disorder and Pediatric Acute-Onset Neuropsychiatric Syndrome by Antonella Gagliano, Federica Murgia, Agata Maria Capodiferro, Marcello Giuseppe Tanca, Aran Hendren, Stella Giulia Falqui, Michela Aresti, Martina Comini, Sara Carucci, Eleonora Cocco, Lorena Lorefice, Michele Roccella, Luigi Vetri, Stefano Sotgiu, Alessandro Zuddas, Luigi Atzori

“…In supervised models, the metabolomic profile of ASD was significantly different from controls (<i>p</i> = 0.0001), with skewed concentrations of asparagine, aspartate, betaine, glycine, lactate, glucose, and pyruvate. Metabolomic separation was also observed between PANS and ASD subjects (<i>p</i> = 0.02), with differences in the concentrations of arginine, aspartate, betaine, choline, creatine phosphate, glycine, pyruvate, and tryptophan. …”
Get full text

Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors by Shivanand Pudakalakatti, Mark Titus, José S. Enriquez, Sumankalai Ramachandran, Niki M. Zacharias, Imad Shureiqi, Yi Liu, James C. Yao, Xiangsheng Zuo, Pratip K. Bhattacharya

“…As the PPARD mice aged from 10 weeks to 35 weeks and 55 weeks, we observed significant changes in levels of the metabolites inosine monophosphate (<i>p</i> = 0.0054), adenosine monophosphate (<i>p</i> = 0.009), UDP-glucose (<i>p</i> = 0.0006), and oxypurinol (<i>p</i> = 0.039). …”
Get full text

Mechanisms of Dihuang (Rehmanniae Radix) in treating diabetic nephropathy complicated with depression based on network pharmacology by Lei Xing, Chen Qingyao, Wang Xiaoping, Xu Jie, Gao Yazhen, Lin Qiaohong, Ye Zuwen, Zhang Jieyan, Si Qin, Wang Fang

“…Conclusion: Based on network parmacology, this study preliminarily predict the effects of Dihuang (Rehmanniae Radix) in treating DN complicated with depression by regulating inflammation, glucose metabolism, nution nerve, etc.…”
Get full text

Untargeted Plasma Metabolomics Unravels a Metabolic Signature for Tissue Sensitivity to Glucocorticoids in Healthy Subjects: Its Implications in Dietary Planning for a Healthy Life... by Nicolas C. Nicolaides, Maria-Konstantina Ioannidi, Eleni Koniari, Ifigeneia Papageorgiou, Anastasia Bartzeliotou, Amalia Sertedaki, Maria I. Klapa, Evangelia Charmandari

“…These results, combined with a higher glucose, sorbitol, and lactate abundance, suggest a higher Cori cycle, polyol pathway, and inter-tissue one-carbon metabolism rate and a lower fat mobilization rate at the fasting state in the most sensitive compared to the most resistant group. …”
Get full text

In Silico-Based Design and In Vivo Evaluation of an Anthranilic Acid Derivative as a Multitarget Drug in a Diet-Induced Metabolic Syndrome Model by Héctor González-Álvarez, Astrid Bravo-Jiménez, Matilda Martínez-Arellanes, Gabriela Odette Gamboa-Osorio, Edwin Chávez-Gutiérrez, Lino A. González-Hernández, Karina Gallardo-Ignacio, Osvaldo J. Quintana-Romero, Armando Ariza-Castolo, Christian Guerra-Araiza, Laura Martino-Roaro, Dulce María Meneses-Ruiz, Rodolfo Pinto-Almazán, Marco A. Loza-Mejía

“…It was evaluated in a diet-induced MetS rat model and simultaneously lowered blood pressure, glucose, total cholesterol, and triglyceride levels after a 14-day treatment. …”
Get full text

Initial indicators for the prognosis of Acinetobacter Baumannii bacteremia in children by Yi Hong, Xiaochen Lin, Chunxu Zhang, Xingqiang Dong, Meihua Lu, Saihu Huang, Lili Huang, Chunmei Su, Zhenjiang Bai, Shuiyan Wu

“…However, CRP (p = 0.000) and blood glucose(p = 0.036) were significantly higher in the death group than those in the survival group. …”
Get full text

Associations of antidiabetic drugs with diabetic retinopathy in people with type 2 diabetes: an umbrella review and meta-analysis by Luyuan Tan, Zhaonan Wang, Kelvin Okoth, Konstantinos A. Toulis, Alastair K. Denniston, Alastair K. Denniston, Baldev M. Singh, Baldev M. Singh, Francesca L. Crowe, Christopher Sainsbury, Jingya Wang, Krishnarajah Nirantharakumar

“…This study was registered with PROSPERO (CRD42022332052).ResultsWith trial evidence from 11 systematic reviews and meta-analyses, we found that the use of glucagon-like peptide-1 receptor agonists (GLP-1 RA), sodium-glucose cotransporter-2 inhibitors (SGLT-2i), or dipeptidyl peptidase-4 inhibitors (DPP-4i) was not statistically associated with the risk of DR, compared to either placebo (RR: GLP-1 RA, 0.98, 0.89-1.08; SGLT-2i, 1.00, 95% CI 0.79-1.27; DPP-4i, 1.17, 0.99-1.39) or other antidiabetic drugs. …”
Get full text

Phenolic Constituents from <i>Wendlandia tinctoria</i> var. <i>grandis</i> (Roxb.) DC. Stem Deciphering Pharmacological Potentials against Oxidation, Hyperglycemia, and Diarrhea: P... by Mamtaz Farzana, Md. Jamal Hossain, Ahmed M. El-Shehawi, Md. Al Amin Sikder, Mohammad Sharifur Rahman, Muhammad Abdullah Al-Mansur, Sarah Albogami, Mona M. Elseehy, Arpita Roy, M. Aftab Uddin, Mohammad A. Rashid

“…Furthermore, the computational modeling study supported the current in vitro and in vivo findings, and the isolated constituents had a higher or comparable binding affinity for glutathione reductase and urase oxidase enzymes, glucose transporter 3 (GLUT 3), and kappa-opioid receptor, inferring potential antioxidant, hypoglycemic, and antidiarrheal properties, respectively. …”
Get full text

Supplementation of feed and water after long-duration road transportation: The effects on welfare and rumen fermentation in goats by Ke Xu, Ke Xu, Kang Yang, Kang Yang, Yi Yang, Yi Yang, Wenxuan Wu, Wenxuan Wu, Wenxuan Wu, Chuanshe Zhou

“…TRT0 and TRT1 goats had POST plasma glucose concentrations above their PRE values (p &lt; 0.05). …”
Get full text

Comparing the differences of physicochemical properties and volatiles in semi-dry Hakka rice wine and traditional sweet rice wine via HPLC, GC–MS and E-tongue analysis by Wenhong Zhao, Fengxi Ruan, Min Qian, Xiaoyuan Huang, Xiangluan Li, Yanxin Li, Weidong Bai, Hao Dong

“…The total sugar (16.13 mg/mL) of semi-dry HRW was significantly lower than that of TSRW (135.79 mg/mL), especially the trehalose, glucose, sucrose and maltose. Its alcohol content was significantly higher than that of TSRW. …”
Get full text

Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation by Gabriela Venturini, Gabriela Venturini, Juliana M. Alvim, Kallyandra Padilha, Christopher N. Toepfer, Christopher N. Toepfer, Christopher N. Toepfer, Joshua M. Gorham, Lauren K. Wasson, Diogo Biagi, Sergio Schenkman, Valdemir M. Carvalho, Jessica S. Salgueiro, Karina H. M. Cardozo, Jose E. Krieger, Alexandre C. Pereira, Alexandre C. Pereira, Jonathan G. Seidman, Christine E. Seidman, Christine E. Seidman, Christine E. Seidman

“…Using gene editing and pharmacological inhibitors, we found that T. cruzi uptake was mediated in part by the glucose-facilitated transporter GLUT4 and that the attenuation of glycolysis, HIF-1α activation, or GLUT4 expression decreased T. cruzi infection. …”
Get full text

使用基础胰岛素治疗成人2型糖尿病:亚太地区循证临床实践指南 by Linong Ji, Yingying Luo, Yong Mong Bee, Jun Xia, Khue Thy Nguyen, Weigang Zhao, Liming Chen, Siew Pheng Chan, Chaicharn Deerochanawong, Soo Lim, Daisuke Yabe, Margaret McGill, Ketut Suastika, Xiaoying Li, Alice Pik Shan Kong, Wei Chen, Zhan Zhao, Chenchen Xu, Marisa Deodat, Xiaomei Yao

“…Abstract The objective of this study was to provide recommendations regarding effectiveness, safety, optimal starting dose, optimal maintenance dose range, and target fasting plasma glucose of five basal insulins (glargine U‐300, degludec U‐100, glargine U‐100, detemir, and insulin protamine Hagedorn) in insulin‐naïve adult patients with type 2 diabetes in the Asia‐Pacific region. …”
Get full text

فرط سكر الدم عند القبول و الاختلاطات ضمن المشفى عند مرضى احتشاء العضلة القلبية الحاد مع ارتفاع قطعة ST .... by Akram Jahjah, Roba Salman, Kenan Ali

“…Patients were classified according to their admission blood glucose into two groups , the first group was admission hyperglycemia (defined ≥ 200 mg/dl) , whereas the second group was without admission hyperglycemia , to assess its impact on In-hospital complications (Acute heart failure , Cardiogenic shock , Bleeding ). …”
Get full text

Dietary Antioxidants, Quality of Nutrition and Cardiovascular Characteristics among Omnivores, Flexitarians and Vegetarians in Poland—The Results of Multicenter National Representa... by Magdalena Kwaśniewska, Małgorzata Pikala, Oliwia Grygorczuk, Anna Waśkiewicz, Urszula Stepaniak, Andrzej Pająk, Krystyna Kozakiewicz, Paweł Nadrowski, Tomasz Zdrojewski, Aleksandra Puch-Walczak, Andrzej Tykarski, Wojciech Drygas

“…In women, vegetarians had substantially lower BMI than omnivores (<i>p</i> < 0.05) and flexitarians (<i>p</i> < 0.05) and a lower mean serum glucose compared with omnivores (<i>p</i> < 0.01) and flexitarians (<i>p</i> < 0.05). …”
Get full text

Diagnostic milk biomarkers for predicting the metabolic health status of dairy cattle during early lactation by S. Heirbaut, X.P. Jing, B. Stefańska, E. Pruszyńska-Oszmałek, L. Buysse, P. Lutakome, M.Q. Zhang, M. Thys, L. Vandaele, V. Fievez

“…Blood metabolic parameters included β-hydroxybutyrate (BHB), nonesterified fatty acids, glucose, insulin-like growth factor-1 (IGF-1) and insulin. …”
Get full text

A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity by Yao Liu, Chunjun Sheng, Wenhuan Feng, Fang Sun, Jingjing Zhang, Jingjing Zhang, Ying Chen, Lili Su, Jia Liu, Lei Du, Xuyang Jia, Hui You, Xiu Huang, Shandong Wu, Shandong Wu, Shandong Wu, Ziwei Lin, Shen Qu

“…Still, the bariatric surgery significantly reduced their blood glucose (median HbA1c decreased by 27.2%). The hypermetabolic obesity-hyperinsulinemia (HMO-I) group was characterized by severe insulin resistance and high incidence of hyperinsulinemia (87.8%) pre-surgery, which had been greatly alleviated post-surgery. …”
Get full text

The Expression of Two Distinct Sets of Glycolytic Enzymes Reveals Differential Effects of Glycolytic Reprogramming on Pancreatic Ductal Tumorigenesis in Mice by Yannan Zhang, Fangfang Zheng, Fan Wang, Xingqian Liu, Cong Xiang, Shiyu Fu, Kun Shen, Geng Liu

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with enhanced aerobic glycolysis through elevated glucose uptake and the upregulated expression of genes encoding rate-limiting glycolytic enzymes. …”
Get full text