Contrast-Induced Acute Kidney Injury and Endothelial Dysfunction: The Role of Vascular and Biochemical Parameters by Adolfo Marco Perrotta, Antonietta Gigante, Silverio Rotondi, Paolo Menè, Adriano Notturni, Stefano Schiavetto, Gaetano Tanzilli, Chiara Pellicano, Giuseppe Guaglianone, Francesca Tinti, Paolo Palange, Sandro Mazzaferro, Rosario Cianci, Silvia Lai

“…Patients underwent an assessment of renal function (serum nitrogen and basal creatinine, 48 and 72 h after administration of contrast medium), inflammation (C reactive protein (CRP), serum calcium and phosphorus, intact parathormone (iPTH), 25-hydroxyvitaminD (25-OH-VitD), serum uric acid (SUA), total cholesterol, serum triglycerides, serum glucose and insulin). All patients also carried out an evaluation of RRI, intima-media thickness (IMT), interventricular septum (IVS) and the ankle-brachial index (ABI). …”
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Predictive modeling for acute kidney injury after percutaneous coronary intervention in patients with acute coronary syndrome: a machine learning approach by Amir Hossein Behnoush, M. Moein Shariatnia, Amirmohammad Khalaji, Mahsa Asadi, Alireza Yaghoobi, Malihe Rezaee, Hamidreza Soleimani, Ali Sheikhy, Afsaneh Aein, Somayeh Yadangi, Yaser Jenab, Farzad Masoudkabir, Mehdi Mehrani, Mina Iskander, Kaveh Hosseini

“…Notably, left ventricular ejection fraction (LVEF) and fasting plasma glucose (FPG) had the highest feature importance when training the RF model on only pre-procedural features. …”
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TtCel7A: A Native Thermophilic Bifunctional Cellulose/Xylanase Exogluclanase from the Thermophilic Biomass-Degrading Fungus <i>Thielavia terrestris</i> Co3Bag1, and Its Application... by Azucena López-López, Alejandro Santiago-Hernández, Maribel Cayetano-Cruz, Yolanda García-Huante, Jorge E. Campos, Ismael Bustos-Jaimes, Rodolfo Marsch-Moreno, Claudia Cano-Ramírez, Claudia G. Benitez-Cardoza, María Eugenia Hidalgo-Lara

“…TtCel7A displayed the excellent capability to hydrolyze CMC, beechwood xylan, and complex substrates such as oat bran, wheat bran, and sugarcane bagasse, with glucose and cellobiose being the main products released; also, slightly less endo cellulase and xylanase activities were observed. …”
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Changing socioeconomic and geographic gradients in cardiovascular disease risk factors among Indians aged 15–49 years–evidence from nationally representative household surveysResea... by Sarah Wetzel, Pascal Geldsetzer, Sneha Sarah Mani, Aashish Gupta, Kavita Singh, Mohammed K. Ali, Dorairaj Prabhakaran, Nikhil Tandon, Nikkil Sudharsanan

“…Methods: Using nationally representative data with biomarker measurements from the fourth (2015–16) and fifth (2019–21) Indian National Family and Health Surveys, we investigated trends in the prevalence of four CVD risk factors: smoking (self-reported), unhealthy weight (BMI ≥25 kgm2), diabetes (random plasma glucose concentration ≥200 mg/dL or self-reported diabetes), and hypertension (one of: average systolic blood pressure ≥140 mmHg, average diastolic blood pressure ≥90 mmHg, self-reported past diagnosis, or self-reported current antihypertensive medication use) among adults aged 15–49 years. …”
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Serum levels of oxidative stress biomarkers is changed in pharmacoresistant mesial temporal lobe epilepsy patients with or without psychiatric disorders by Angélica Marta Lopes, Patrick Buosi, Bruna de Mattos Farina, Rafael Fernandes-Ferreira, Camila Ive Ferreira Oliveira-Brancati, Denise Poltronieri Martins, Danilo Grünig Humberto da Silva, Nayara Alves Chaves, Lucia Helena Neves Marques, Gerardo Maria de Araújo Filho, Dorotéia Rossi Silva Souza

“…Serum levels of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione plus oxidated glutathione (total GSH), glucose-6-phosphate dehydrogenase (G6PD), Trolox-equivalent antioxidant capacity (TEAC), and thiobarbituric acid reactive substances (TBARS) were analyzed through spectrometry. …”
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Anthocyanins from <i>Aristotelia chilensis</i> Prevent Olanzapine-Induced Hepatic-Lipid Accumulation but Not Insulin Resistance in Skeletal Muscle Cells by Andrea del Campo, Catalina Salamanca, Angelo Fajardo, Francisco Díaz-Castro, Catalina Bustos, Camila Calfío, Rodrigo Troncoso, Edgar R. Pastene-Navarrete, Claudio Acuna-Castillo, Luis A. Milla, Carlos A. Villarroel, Francisco A. Cubillos, Mario Aranda, Leonel E. Rojo

“…Lipid accumulation was determined in HepG2 cells while the expression of p-Akt as a key regulator of the insulin-activated signaling pathways, mitochondrial function, and glucose uptake was assessed in L6 cells. DS and DG prevented olanzapine-induced lipid accumulation in liver cells. …”
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Serine/Threonine‐Protein Kinase 3 Facilitates Myocardial Repair After Cardiac Injury Possibly Through the Glycogen Synthase Kinase‐3β/β‐Catenin Pathway by Ya‐Fei Li, Tian‐Wen Wei, Yi Fan, Tian‐Kai Shan, Jia‐Teng Sun, Bing‐Rui Chen, Zi‐Mu Wang, Ling‐Feng Gu, Tong‐Tong Yang, Liu Liu, Chong Du, Yao Ma, Hao Wang, Rui Sun, Yong‐Yue Wei, Feng Chen, Xue‐Jiang Guo, Xiang‐Qing Kong, Lian‐Sheng Wang

“…Methods and Results The effect of SGK3 on proliferation and oxygen glucose deprivation/reoxygenation– induced apoptosis in isolated cardiomyocytes was evaluated using cardiomyocyte‐specific SGK3 overexpression or knockdown adenovirus5 vector. …”
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miR-155 down-regulation protects the heart from hypoxic damage by activating fructose metabolism in cardiac fibroblasts by Yu Zhang, Hong Zhang, Zhan Yang, Xin-hua Zhang, Qing Miao, Min Li, Tian-ying Zhai, Bin Zheng, Jin-kun Wen

“…Methods: Immunostaining, western blot and quantitative real-time reverse transcription PCR (qRT-PCR) were performed to detect the expression of glucose transporter 5 (GLUT5), ketohexokinase (KHK)-A and KHK-C in miR-155−/− and miR-155wt CFs under normoxia or hypoxia. …”
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DYNAMICS OF GLYCEMIC CONTROL AFTER RENAL DENERVATION IN PATIENTS WITH RESISTANT HYPERTENSION AND TYPE 2 DIABETES MELLITUS by A. Yu. Falkovskaya, V. F. Mordovin, S. Ye. Pekarsky, A. Ye. Bayev, G. V. Semke, T. M. Ripp, Ye. S. Kravtchenko, I. V. Zyubanova

“…Office BP measurement, ambulatory 24-h BP, renal Doppler ultrasound and assessment of renal function (proteinuria, creatinine, eGFR), HbА1c and fasting plasma glucose (FPG) levels, activity of TNF-α were performed at baseline and 6 and 12 months after TRD. …”
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Genotoxic and toxicopathological effect of aflatoxin b1 in grass carp (ctenopharyngodon idella) by Hayatullah KHAN, Farhan Anwar KHAN, Umar SADIQUE, Shakoor AHMAD, Zahoor Ul HASSAN, Faisal AHMAD, Abdul AHAD, Muqader SHAH, Ijaz AHMAD, Zahir SHAH, Zia-ur-REHMAN Zia-ur-REHMAN

“…Additionally, significant increase of aspartate amino transferase (AST), alanine amino transferase (ALT), glucose, urea and creatinine was determined in AFB1 treated groups by serum biochemistry. …”
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Efficacy of Various Feed Additives on Performance, Nutrient Digestibility, Bone Quality, Blood Constituents, and Phosphorus Absorption and Utilization of Broiler Chickens Fed Low P... by Shaimaa Selim, Nazema S. Abdel-Megeid, Hanem K. Khalifa, Khloud G. Fakiha, Kamlah A. Majrashi, Eman Hussein

“…At days 21 and 35 of age, the dietary supplements to low nPP diets reduced (<i>p</i> < 0.05) serum total cholesterol, triglyceride, triiodothyronine, thyroxine, glucose, and alkaline phosphatase levels, while serum Ca and P concentrations were improved (<i>p</i> < 0.05) compared to NC. …”
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Amide proton transfer weighted contrast has diagnostic capacity in detecting diabetic foot: an MRI-based case–control study by Shan Lu, Jiwei Tian, Shiyu Zhao, Xueyan Song, Xianglu Meng, Guangyang Ma, Dengping Liu, Zhiwei Shen, Baocheng Chang

“…Furthermore, the association between normalized MTRasym (3.5 ppm), rBF, and blood parameters [fasting blood glucose (FBG), glycosylated hemoglobin content, C-reactive protein, neutrophil percentage, and white blood cell count] was explored. …”
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IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming by Huayuan Tang, Yali Li, Shijia Wang, Jing Ji, Xiangbin Zhu, Yutong Bao, Can Huang, Ye Luo, Lei Huang, Yan Gao, Chaoliang Wei, Jie Liu, Xi Fang, Lu Sun, Kunfu Ouyang

“…Both IP3R-triple-knockout (IP3R-TKO) and calcineurin inhibition dramatically suppress the metabolic switch in oxidative phosphorylation and glycolysis of stimulated B cells through regulation of glucose uptake, glycolytic enzyme expression, and mitochondrial remodeling, leading to impaired cell-cycle entry and survival. …”
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New evidence for the effect of type 2 diabetes and glycemic traits on testosterone levels: a two-sample Mendelian randomization study by Chengyang Jiang, Yuwei Wang, Wenqiang Yang, Xinghai Yang

“…Therefore, we designed a Mendelian randomization (MR) study to investigate the association of type 2 diabetes and 3 glycemic traits with testosterone levels.MethodsUncorrelated single nucleotide polymorphisms (SNPs) associated with T2DM (N = 228), fasting insulin (N = 38), fasting glucose (N = 71), and HbA1c (N = 75) at the genome-wide significance were selected as instrument variables. …”
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Altered Left Ventricular Rat Gene Expression Induced by the Myosin Activator Omecamtiv Mecarbil by Bachar El Oumeiri, Laurence Dewachter, Philippe Van de Borne, Géraldine Hubesch, Christian Melot, Pascale Jespers, Constantin Stefanidis, Kathleen Mc Entee, Frédéric Vanden Eynden

“…The LV expression of the major myocardial glucose transporter <i>Glut1</i> decreased, with no changes in <i>Glut4</i> expression, whereas the LV expression of oxidized low-density lipoprotein receptor 1 (<i>Olr1</i>) and arachidonate 15-lipoxygenase (<i>Alox15</i>) increased, with no changes in fatty acid transporter <i>Cd36</i>. …”
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Sex differences in cardiometabolic risk factors and in response to lifestyle intervention in prepubertal and pubertal subjects with obesity by Luisa Gilardini, Marina Croci, Luca Cavaggioni, Lucia Pasqualinotto, Simona Bertoli, Simona Bertoli

“…In the pubertal stage, boys had worse cardiometabolic risk profile than girls, including unfavourable measure of systolic BP (z score: 0.6 ± 1.0 vs. 0.3 ± 1.0, p &lt; 0.01), fasting glucose (87.2 ± 6.1 vs. 84.8 ± 7.7 mg/dl, p &lt; 0.01), ALT (26.9 ± 21.5 vs. 20.2 ± 10.6 U/L, p &lt; 0.001) and uric acid (6.1 ± 1.9 vs. 5.0 ± 1.0 mg/dl, p &lt; 0.001). …”
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L‐Arginine‐Loaded Gold Nanocages Ameliorate Myocardial Ischemia/Reperfusion Injury by Promoting Nitric Oxide Production and Maintaining Mitochondrial Function by Zekun Wang, Nana Yang, Yajun Hou, Yuqing Li, Chenyang Yin, Endong Yang, Huanhuan Cao, Gaofei Hu, Jing Xue, Jialei Yang, Ziyu Liao, Weiyun Wang, Dongdong Sun, Cundong Fan, Lemin Zheng

“…AASP significantly inhibits oxygen glucose deprivation/reoxygenation (OGD/R)‐induced H9C2 cell cytotoxicity and apoptosis. …”
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The role of lifestyle in the association between long-term ambient air pollution exposure and cardiovascular disease: a national cohort study in China by Xiangming Hu, Luke D. Knibbs, Yingling Zhou, Yanqiu Ou, Guang-Hui Dong, Haojian Dong

“…The lifestyle evaluation consists of six factors as proxies, including blood pressure, blood glucose, blood lipids, body mass index, tobacco exposure, and physical activity, and the participants were categorized into three lifestyle groups according to the number of ideal factors (unfavorable, 0–1; intermediate, 2–4; and favorable, 5–6). …”
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Selection Signature and CRISPR/Cas9-Mediated Gene Knockout Analyses Reveal <i>ZC3H10</i> Involved in Cold Adaptation in Chinese Native Cattle by Luyu Wang, Yaping Gao, Jinpeng Wang, Ning Huang, Qiang Jiang, Zhihua Ju, Chunhong Yang, Xiaochao Wei, Yao Xiao, Yaran Zhang, Ling Yang, Jinming Huang

“…Loss of ZC3H10 dysregulated pathways involved in thermogenesis and immunity, and ZC3H10 participated in immunity-related pathways induced by cold stress and regulated genes involved in glucose and lipid metabolism and lipid transport (PLTP and APOA1), thereby facilitating adaptability to cold stress. …”
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Quiescence preconditioned nucleus pulposus stem cells alleviate intervertebral disc degeneration by enhancing cell survival via adaptive metabolism pattern in rats by Qi Chen, Qi Chen, Qi Chen, Qi Chen, Qu Yang, Chongzhi Pan, Chongzhi Pan, Chongzhi Pan, Rui Ding, Rui Ding, Rui Ding, Tianlong Wu, Tianlong Wu, Tianlong Wu, Jian Cao, Jian Cao, Hui Wu, Hui Wu, Xiaokun Zhao, Xiaokun Zhao, Bin Li, Bin Li, Bin Li, Xigao Cheng, Xigao Cheng, Xigao Cheng, Xigao Cheng

“…In vitro, we investigated apoptosis and survival of quiescent NPSCs in a glucose-free medium without fetal bovine serum. Non-preconditioned proliferating NPSCs served as controls. …”
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