The Influence of Recombinant Bovine Somatotropin (rbST) on the Metabolic Profile and Milk Composition of Lactating Murrah Buffalo by Marcelo Arne Feckinghaus, Mariana Guimarães de Oliveira Diogo, Vanessa Martins Storillo, Fabio Celidonio Pogliani, Bruno Moura Monteiro, Paulo Fantinato Neto, Melina Marie Yasuoka, Daniela Becker Birgel, Eduardo Harry Birgel Junior

“…The treatment did not influence blood glucose, non-esterified fatty acids (NEFAs), triglycerides, cholesterol, total protein, albumin, AST, GGT, bilirubin, urea, or creatinine levels. …”
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Productive Performance, Ovarian Follicular Development, Lipid Peroxidation, Antioxidative Status, and Egg Quality in Laying Hens Fed Diets Supplemented with <i>Salvia officinalis</... by Ahmed A. Saleh, Shimaa Hamed, Aziza M. Hassan, Khairy Amber, Wael Awad, Mohammed H. Alzawqari, Mustafa Shukry

“…The dietary utilization of <i>Salvia officinalis</i> and <i>Origanum majorana</i> did not significantly alter the plasma glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT), total protein, albumin, globulin, and High density lipoprotein (HDL) parameters. Cholesterol, glucose, triglyceride, and Low density lipoprotein (LDL) were decreased (<i>p</i> < 0.05) in the birds fed with <i>Salvia officinalis</i> and/or <i>Origanum majorana</i> supplemented diets. …”
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Human CD4⁺CD45RA⁺ T Cells Behavior after In Vitro Activation: Modulatory Role of Vasoactive Intestinal Peptide by Raúl Villanueva-Romero, Alicia Cabrera-Martín, Emigdio Álvarez-Corrales, Mar Carrión, Selene Pérez-García, Amalia Lamana, David Castro-Vázquez, Carmen Martínez, Rosa P. Gomariz, Irene Gutiérrez-Cañas, Yasmina Juarranz

“…The metabolic biomarker Glut1 was increased, pointing to an increase in glucose requirement whereas Hif-1α expression was higher in resting than in activated cells. …”
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CXCL13 expressed on inflamed cerebral blood vessels recruit IL-21 producing TFH cells to damage neurons following stroke by Aditya Rayasam, Julie A. Kijak, Lee Kissel, Yun Hwa Choi, Taehee Kim, Martin Hsu, Dinesh Joshi, Collin J. Laaker, Peter Cismaru, Anders Lindstedt, Krisztian Kovacs, Raghu Vemuganti, Shing Yan Chiu, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor, Zsuzsanna Fabry

“…Finally, to evaluate cellular mechanisms of stroke, we exposed mouse primary neurons to oxygen glucose deprivation (OGD) conditions with or without IL-21 and measured cell viability, caspase activity and JAK/STAT signaling. …”
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Neohesperidin dihydrochalcone can improve intestinal structure and microflora composition of diabetic zebrafish by Pei Wang, Fuying Tao, Ziru Dai, Tianci Wang, Chenxiao Zhang, Heliang Fan, Mei Qin, Cen Qi, Ying Li, Junguang Hao

“…By analyzing the relationship between gut microbiota changes and glucose metabolism, it revealed the mechanism through which NHDC improves insulin resistance by modulating the gut microbiota. …”
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Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells by Xiaohui Bian, Sabena M. Conley, Alfonso Eirin, Eric A. Zimmerman Zuckerman, Anastasia L. Smith, Cody C. Gowan, Zachary K. Snow, Tambi Jarmi, Houssam Farres, Young M. Erben, Albert G. Hakaim, Matthew A. Dietz, Abba C. Zubair, Saranya P. Wyles, Joy V. Wolfram, Lilach O. Lerman, LaTonya J. Hickson

“…Paracrine-mediated angiogenic repair capacity of MSC conditioned medium (MSCcm) was assessed in vitro using human umbilical vein endothelial cells incubated in high glucose and indoxyl sulfate for a hyperglycemic, uremic state. …”
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Chemical characteristics and anti-Escherichia coli mechanism of water-soluble extracts from yeast cell walls by Yana Liu, Baojing Dou, Fayuan Gong, Junpeng Hu, Meifang Zhou, Yuanhu Pan, Xiangyun Wu, Xin Huang, Zhiwen Xie, Haihong Hao, Guyue Cheng, Zhenli Liu, Yulian Wang

“…WSNP was composed of glucosamine (GlcN), glucose (Glc), mannose (Man) and glucuronic acid (GlcA) in a molar ratio of 8.6:55.2:34.4:1.8, WSAP-1 was consisted of GlcN, Glc and Man in a molar ratio of 10.9:42.2:46.9, and WSAP-2 was consisted of GlcN, galactose (Gal), Glc and Man in a molar ratio of 9.0:1.0:55.1:34.9. …”
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Regional differences in clinical care among patients with type 1 diabetes in Brazil: Brazilian Type 1 Diabetes Study Group by Gomes Marília B, Cobas Roberta A, Matheus Alessandra S, Tannus Lucianne R, Negrato Carlos, Rodacki Melanie, Braga Neuza, Cordeiro Marilena M, Luescher Jorge L, Berardo Renata S, Nery Marcia, Marques MariadoCarmo A, Calliari Luiz E, Noronha Renata M, Manna Thais D, Zajdenverg Lenita, Salvodelli Roberta, Penha Fernanda G, Foss Milton C, Foss-Freitas Maria C, Pires Antonio C, Robles Fernando C, Guedes MariadeFátimaS, Dib Sergio A, Dualib Patricia, Silva Saulo C, Sepulvida Janice, Almeida Henriqueta G, Sampaio Emerson, Rea Rosangela, Faria Ana Cristina R, Tschiedel Balduino, Lavigne Suzana, Cardozo Gustavo A, Azevedo Mirela J, Canani Luis, Zucatti Alessandra T, Coral Marisa Helena C, Pereira Daniela, Araujo Luiz, Tolentino Monica, Pedrosa Hermelinda C, Prado Flaviane A, Rassi Nelson, Araujo Leticia B, Fonseca Reine Marie C, Guedes Alexis D, Matos Odelissa S, Faria Manuel, Azulay Rossana, Forti Adriana C, Façanha Cristina, Montenegro Ana, Montenegro Renan, Melo Naira H, Rezende Karla F, Ramos Alberto, Felicio João, Santos Flavia M, Jezini Deborah L, Cordeiro Marilena M

“…HbA1c levels were associated with lower economic status, female gender, age and the daily frequency of self-blood glucose monitoring (SBGM) but not with insulin regimen and geographic region. …”
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Characterization of <i>Delonix regia</i> Flowers’ Pigment and Polysaccharides: Evaluating Their Antibacterial, Anticancer, and Antioxidant Activities and Their Application as a Nat... by Doaa Ebada, Hefnawy T. Hefnawy, Ayman Gomaa, Amira M. Alghamdi, Asmaa Ali Alharbi, Mohammed S. Almuhayawi, Mohanned Talal Alharbi, Ahmed Awad, Soad K. Al Jaouni, Samy Selim, Gehad S. Eldeeb, Mohammad Namir

“…The HPLC sugar profile detected the monosaccharides in the extracted polysaccharides, composed of mannose, galactose, glucose, arabinose, and gluconic acid, and the structure of saccharides was confirmed by FTIR, which showed three active groups: carbonyl, hydrocarbon, and hydroxyl. …”
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Effects of Different Water Amount in Total Mixed Ration on Performance, Rumen Hydrolytic Enzymes Activity and Rumen and Blood Metabolites of Fattening Lambs by Zahra Yousefi, Ayoub Azizi, Amir Fadayifar, Ali Kiani, Afrooz Sharifi

“…Increasing the level of dietary moisture up to 30% linearly increased (P<0.05) activity of carboxymethyl cellulase and ɑ-amylase, while activity of microcrystalline cellulase and filter paper degrading activity and blood metabolites (including glucose, total protein and blood urea nitrogen) were similar among treatments (P>0.05). …”
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Investigating HMGB1 as a potential serum biomarker for early diabetic nephropathy monitoring by quantitative proteomics by Rui Peng, Siyang Zuo, Xia Li, Yun Huang, Siyu Chen, Xue Zou, Hehua Long, Min Chen, Yuan Yang, Huixiong Yuan, Qingqing Zhao, Bing Guo, Lirong Liu

“…Experimental validation supported HMGB1’s upregulation under high glucose conditions, reinforcing its potential as an early detection biomarker for DN. …”
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Effects of canagliflozin on myocardial microvascular density, oxidative stress, and proteomic profile by Sharif A. Sabe, Cynthia M. Xu, Mohamed Sabra, Dwight D. Harris, Mark Broadwin, Krishna G. Bellam, Debolina Banerjee, Anny Usheva, M. Ruhul Abid, Frank W. Sellke

“…Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cardioprotective, and canagliflozin (CANA), an SGLT2i, has been shown to improve perfusion, AMPK signaling, and oxidative stress in chronically ischemic myocardium. …”
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Predictive Value of Total Metabolic Tumor Burden Prior to Treatment in NSCLC Patients Treated with Immune Checkpoint Inhibition by Ken Kudura, Nando Ritz, Arnoud J. Templeton, Tim Kutzker, Robert Foerster, Kwadwo Antwi, Michael C. Kreissl, Martin H. K. Hoffmann

“…Methods: Pre-treatment 2-deoxy-2-[¹⁸F]fluoro-D-glucose positron emission tomography/computed tomography (PET/CT) scans performed in two consecutive years for staging in adult patients with confirmed NSCLC were considered. …”
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Utilidade de um escore e de variáveis indicativas de drenagem pleural em crianças com derrame pleural parapneumônico Utility of a scoring system and indicative variables for assess... by Gláucia de Oliveira Moreira, José Dirceu Ribeiro, Antonia Terezinha Tresoldi

“…These values were more strongly correlated with the need for drainage (p = 0.001), as were those reported in the literature (pH = 7.0 and glucose < 40). The lactate dehydrogenase did not prove to be a good parameter for indicating a need for drainage. …”
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Daily consumption of γ-oryzanol-fortified canola oil, compared with unfortified canola and sunflower oils, resulted in a better improvement of certain cardiometabolic biomarkers of... by Bahareh Nikooyeh, Azizollaah Zargaraan, Samira Ebrahimof, Ali Kalayi, Maliheh Zahedirad, Hootan Yazdani, Marjan Rismanchi, Taher Karami, Marzieh Khazraei, Ali Jafarpour, Tirang R. Neyestani

“…Results Though body mass index (BMI) significantly decreased in all three groups, only in Groups 1 and 2 waist circumference (WC) showed a significant decrement (-2.6 ± 0.1 and -2.2 ± 0.1 cm in Groups 1 and 2 respectively, p < 0.001 for both) which was accompanied by a significant reduction of blood pressure just in Group 1. Fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) showed a significant decrease only in ORZ-fortified canola oil group (−7.7 ± 0.4 mg/dL, p = 0.039 and −0.7 ± 0.1%, p < 0.001, respectively). …”
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Multi-trajectories of systolic and diastolic hypertension and coronary heart disease in middle-aged and older adults by Mingzhuo Li, Miao Zhou, Yang Yang, Yafei Liu, Chaonan Yin, Wenting Geng, Chunxia Wang, Fang Tang, Yang Zhao, Fuzhong Xue, Fuzhong Xue, Xiubin Sun, Xiubin Sun, Zhongshang Yuan, Zhongshang Yuan

“…Age, gender, drinking, body mass index (BMI), triglyceride (TG), and fasting plasma glucose (FPG) were independent predictors for trajectory groups 4 and 6.ConclusionNovel, clinically defined multi-trajectories of systolic and diastolic hypertension were identified. …”
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An Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice by Christian Vossen, Patricia Schmidt, Claudia Maria Wunderlich, Melanie Joyce Mittenbühler, Claas Tapken, Peter Wienand, Paul Nicolas Mirabella, Leonie Cabot, Anna-Lena Schumacher, Kat Folz-Donahue, Christian Kukat, Ingo Voigt, Jens C. Brüning, Henning Fenselau, F. Thomas Wunderlich

“…Enteroendocrine cells (EECs) constitute only a small proportion of <i>Villin-1 (Vil1)</i>-expressing intestinal epithelial cells (IECs) of the gastrointestinal tract; yet, in sum, they build the largest endocrine organ of the body, with each of them storing and releasing a distinct set of peptides for the control of feeding behavior, glucose metabolism, and gastrointestinal motility. …”
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Association of Alanine Transaminase and Aspartate Aminotransferase/Alanine Transaminase Ratio with Type 2 Diabetes and Metabolic Syndrome in the Elderly by ZHOU Xiaoqi, LIU Xinhui, ZHANG Wei, LI Changfeng, YAN Yaqiong

“…The regular exercise rate, BMI, waist circumference, systolic pressure, diastolic pressure, ALT, TG and fasting plasma glucose (FPG) were significantly higher and smoking rate, drinking rate, AST, AST/ALT ratio, total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol (LDL-C) were significantly lower in T2DM subjects compared to non-T2DM subjects (P&lt;0.01). …”
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Effects of total flavones of Abelmoschus manihot (L.) on the treatment of diabetic nephropathy via the activation of solute carriers in renal tubular epithelial cells by Hongmei Yu, Haitao Tang, Mei Wang, Qing Xu, Jinshi Yu, Haitao Ge, Lei Qiang, Wei Tang, Harvest F. Gu

“…TFA (0.076 g/kg/d) or vehicle was administered in db/db mice, the animal model of type 2 diabetes and DN, daily via oral gavage for four weeks. Blood glucose levels and urinary albumin-to-creatinine ratio (UACR) were measured and used for the determination of T2D and DN. …”
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Effects of the SGLT2 Inhibition on Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats, a Model of Type 1 Diabetes Mellitus by Camila Moreno Rosa, Dijon Henrique Salome Campos, David Rafael Abreu Reyes, Felipe Cesar Damatto, Lucas Yamada Kurosaki, Luana Urbano Pagan, Mariana Janini Gomes, Camila Renata Corrêa, Ana Angelica Henrique Fernandes, Marina Politi Okoshi, Katashi Okoshi

“…Clinical trials have shown that sodium glucose co-transporter 2 (SGLT2) inhibitors improve clinical outcomes in diabetes mellitus (DM) patients. …”
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