A study of some aspects of the epidemiology and treatment of peripheral vascular disease by Hughson, W

“…Patients with elevated glucose, cholesterol, or triglyceride, did not have a worse prognosis than people with normal levels.…”

A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction by Rikako Nakajima, Motohiro Sekiya, Yasuhisa Furuta, Takafumi Miyamoto, Masashi Sato, Kuniaki Fukuda, Keiichiro Hattori, Yasuhito Suehara, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Yuka Okajima, Takashi Matsuzaka, Satoru Takase, Mikio Takanashi, Hiroaki Okazaki, Yusuke Takashima, Mikiko Yuhara, Yuta Mitani, Nako Matsumoto, Yuki Murayama, Mariko Ohyama Osawa, Nami Ohuchi, Daichi Yamazaki, Sayuri Mori, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Hiroaki Suzuki, Hitoshi Shimano

“…Interestingly, her NASH progression was ameliorated by treatment with a sodium– glucose co-transporter 2 (SGLT2) inhibitor. This inheritability prompted us to comprehensively decode her genomic information using whole-exome sequencing. …”
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Regulatory T cells in the peripheral blood of women with gestational diabetes: a systematic review and meta-analysis by Hania Arain, Tina Patel, Nicoleta Mureanu, Nicoleta Mureanu, Athina Efthymiou, Athina Efthymiou, Giovanna Lombardi, Timothy Tree, Kypros H. Nicolaides, Kypros H. Nicolaides, Panicos Shangaris, Panicos Shangaris, Panicos Shangaris

“…The inclusion criteria were any original studies published in the English language, measuring differentiated Tregs in women with GDM compared with glucose-tolerant pregnant women. Meta-analysis was performed between comparable Treg markers. …”
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Etiology analysis and G6PD deficiency for term infants with jaundice in Yangjiang of western Guangdong by Yi-Kang Yang, Yi-Kang Yang, Chun-Fan Lin, Fen Lin, Zi-Kai Chen, Yu-Wei Liao, Yu-Wei Liao, Yu-Chan Huang, Yu-Chan Huang, Bei-Ru Xiao, Shan-Hua Huang, Yu-Mei Xu, Yue-E. Chen, Yan-Bin Cao, Yan-Bin Cao, Li-Ye Yang, Li-Ye Yang

“…ObjectiveGlucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of neonatal hyperbilirubinemia. …”
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Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis by Miguel Angel Casillas Santana, Juan Antonio Arreguín Cano, Alejandro Dib Kanán, Farid Alonso Dipp Velázquez, Paulina del Carmen Sosa Munguía, Gabriel Alejandro Martínez Castañón, Brenda Eréndida Castillo Silva, Carolina Sámano Valencia, Marco Felipe Salas Orozco

“…T2DM is a metabolic disorder characterized by high blood glucose levels resulting from altered insulin secretion or action. …”
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Effects of Heated Drinking Water during the Cold Season on Serum Biochemistry, Ruminal Fermentation, Bacterial Community, and Metabolome of Beef Cattle by Tengfei He, Guang Yi, Xilin Wang, Yan Sun, Jiangong Li, Zhenlong Wu, Yao Guo, Fang Sun, Zhaohui Chen

“…The HW group displayed a significant decrease in serum glucose (<i>p</i> < 0.01) and non-esterified fatty acid (<i>p</i> < 0.01), but increases in insulin (<i>p</i> = 0.04) and high-density lipoprotein (<i>p</i> = 0.03). …”
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Pan-cancer analysis reveals that G6PD is a prognostic biomarker and therapeutic target for a variety of cancers by Tao Zeng, Tao Zeng, Bin Li, Xin Shu, Jiahui Pang, Heping Wang, Xianghao Cai, Yingying Liao, Xiaolong Xiao, Yutian Chong, Jiao Gong, Xinhua Li

“…BackgroundDespite accumulating evidence revealing that Glucose-6-phosphate dehydrogenase (G6PD) is highly expressed in many tumor tissues and plays a remarkable role in cancer tumorigenesis and progression, there is still a lack of G6PD pan-cancer analysis. …”
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Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease by Yiping Cheng, Yiping Cheng, Qiang Zhang, Haizhen Li, Guangshuai Zhou, Ping Shi, Ping Shi, Xu Zhang, Xu Zhang, Liying Guan, Fang Yan, Chao Xu, Chao Xu

“…The potential confounders were adjusted in the models including age, sex, hip circumference (HC), body mass index (BMI), systolic blood pressure, diastolic blood pressure, fasting plasma glucose (FPG), diabetes status and cardiovascular disease (CVD) status.ResultsIn multivariable-adjusted Cox proportional hazard model analyses, triglycerides (hazard ratio[HR], 95% confidence interval [CI]:1.080,1.047-1.113;p&lt;0.001), high-density lipoprotein cholesterol (HDL-C) (HR, 95% CI: 0.571,0.487-0.670; p&lt;0.001), and remnant-C (HR, 95% CI: 1.143,1.052-1.242; p=0.002), but not total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C), were associated with incident NAFLD. …”
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Myostain is involved in ginsenoside Rb1-mediated anti-obesity by Hong-Shi Li, Jiang-Ying Kuang, Gui-Jun Liu, Wei-Jie Wu, Xian-Lun Yin, Hao-Dong Li, Lei Wang, Tao Qin, Wen-Cheng Zhang, Yuan-Yuan Sun

“…After 24 h, total RNA and protein from C2C12 cells and 3T3-L1 cells were used to detect myostatin (MSTN) and fibronectin type III domain-containing 5 (FNDC5) expression.Results Rb1 reduced the body weight and adipocyte size. Improved glucose tolerance and increased basic metabolic activity were also found in Rb1 treated mice. …”
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COVID-19 and related social distancing measures induce significant metabolic complications without prominent weight gain in Korean adults by Hae-Jin Ko, Yoon Jeong Cho, Kyoung-Kon Kim, Jee-Hyun Kang, Young-Sang Kim, Ji-Hee Haam, Ji-Hee Haam, Yang-Im Hur, Hye-In Choi, Kyu Rae Lee, Jung Ha Park, Soo Hyun Cho, Jong-Koo Kim, Taesic Lee, Myung-Jae Seo, Yeong Sook Yoon, Yoobin Seo, Ga Eun Nam, Sun Hyun Kim

“…However, the odds of metabolic syndrome and its components, including hypertension, high glucose, diabetes, hypercholesterolemia, hypertriglyceridemia, hyper-non-high-density lipoprotein cholesterolemia, and dyslipidemia were significantly higher on Visit 3 than on Visits 1 and 2. …”
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α-Glucosidase Inhibitors from Two Mangrove-Derived Actinomycetes by Xuejun Lu, Manlai Zhang, Yixian Qiu, Xiuxiu Liu, Cancan Wang, Jianwei Chen, Huawei Zhang, Bin Wei, Yanlei Yu, Youmin Ying, Kui Hong, Hong Wang

“…α-Glucosidase (AGS) inhibitors have been regarded as an ideal target for the management of type 2 diabetes mellitus (T2DM) since they can maintain an acceptable blood glucose level by delaying the digestion of carbohydrates and diminishing the absorption of monosaccharides. …”
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Relationship between bone mineral density and hyperuricemia in obesity: A cross-sectional study by Yi Zhang, Yi Zhang, Yi Zhang, Min Tan, Min Tan, Boyu Liu, Boyu Liu, Manxia Zeng, You Zhou, Mengru Zhang, Yikai Wang, Jing Wu, Jing Wu, Jing Wu, Min Wang, Min Wang, Min Wang

“…The multivariable logistic regressions were employed to examine the relationship between BMD and HU in obesity, with the adjustment of gender, age, fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, creatinine, blood urea nitrogen, high-sensitivity C-reactive protein (hs-CRP), cigarette smoking, and alcohol drinking status.ResultThe overall prevalence of HU was 66.9% in this obese population. …”
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EFFECT OF Boswellia serrata SUPPLEMENTATION IN ADDITION TO INSULIN ON GLYCEMIC CONTROL IN A DIABETIC DOG by Giulia Andreani, Enea Ferlizza, Elisabetta Macrì, Daniela Beghelli, Gloria Isani

“…Twenty weeks after the start of insulin therapy the duration of effect and glucose nadir were ideal and clinical symptoms had disappeared but hyperglycemia, although less severe, persisted. …”
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Polyphenols in Urine and Cardiovascular Risk Factors: A Cross-Sectional Analysis Reveals Gender Differences in Spanish Adolescents from the SI! Program by Emily P. Laveriano-Santos, Isabella Parilli-Moser, Sonia L. Ramírez-Garza, Anna Tresserra-Rimbau, Carolina E. Storniolo, Ana María Ruiz-León, Ramón Estruch, Patricia Bodega, Mercedes de Miguel, Amaya de Cos-Gandoy, Vanesa Carral, Gloria Santos-Beneit, Juan M. Fernández-Alvira, Rodrigo Fernández-Jiménez, Valentín Fuster, Rosa M. Lamuela-Raventós

“…Moreover, a structural equation model revealed that TPE was directly associated with body composition and blood glucose and indirectly associated with blood pressure, TG, LDL-C, and high-density lipoprotein-cholesterol (HDL-C) in boys. (4) Conclusions: Higher concentrations of TPE were associated with a better profile of cardiovascular health, especially in boys, while in girls, the association was not as strong.…”
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Generation of functional hepatocytes by forward programming with nuclear receptors by Rute A Tomaz, Ekaterini D Zacharis, Fabian Bachinger, Annabelle Wurmser, Daniel Yamamoto, Sandra Petrus-Reurer, Carola M Morell, Dominika Dziedzicka, Brandon T Wesley, Imbisaat Geti, Charis-Patricia Segeritz, Miguel C de Brito, Mariya Chhatriwala, Daniel Ortmann, Kourosh Saeb-Parsy, Ludovic Vallier

“…We also uncovered that the overexpression of nuclear receptors such as RORc can enhance specific functionalities of FoP-Heps thereby validating its role in lipid/glucose metabolism. Together, our results show that forward programming could offer a versatile alternative to direct differentiation for generating hepatocytes in vitro.…”
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IGFBP7 and left ventricular mass regression: a sub‐analysis of the EMPA‐HEART CardioLink‐6 randomized clinical trial by Pankaj Puar, Nikhil Mistry, Kim A. Connelly, Andrew T. Yan, Adrian Quan, Hwee Teoh, Yi Pan, Raj Verma, David A. Hess, Subodh Verma, C. David Mazer

“…Abstract Aims Given recent suggestions that serum levels of insulin‐like growth factor‐binding protein 7 (IGFBP7) may identify patients who derive greater cardiorenal benefits from treatment with sodium‐glucose transport 2 inhibitors (SGLT2i), this exploratory sub‐analysis of the EMPA‐HEART CardioLink‐6 randomized controlled trial evaluated the association between serum levels of IGFBP7 and empagliflozin‐mediated left ventricular mass regression. …”
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Working towards recalcitrance mechanisms: increased xylan and homogalacturonan production by overexpression of GAlactUronosylTransferase12 (GAUT12) causes increased recalcitrance a... by Ajaya K. Biswal, Melani A. Atmodjo, Sivakumar Pattathil, Robert A. Amos, Xiaohan Yang, Kim Winkeler, Cassandra Collins, Sushree S. Mohanty, David Ryno, Li Tan, Ivana Gelineo-Albersheim, Kimberly Hunt, Robert W. Sykes, Geoffrey B. Turner, Angela Ziebell, Mark F. Davis, Stephen R. Decker, Michael G. Hahn, Debra Mohnen

“…This included significantly reduced glucose, xylose, and total sugar release (12–13%), plant height (6–54%), stem diameter (8–40%), and overall total aerial biomass yield (48–61%) in 3-month-old, greenhouse-grown PtGAUT12.1-OE lines compared to controls. …”
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Effects of the therapy shift from cortisone acetate to modified-release hydrocortisone in a group of patients with adrenal insufficiency by Sofia Frigerio, Sofia Frigerio, Giulia Carosi, Giulia Carosi, Emanuele Ferrante, Elisa Sala, Elisa Polledri, Silvia Fustinoni, Bruno Ambrosi, Iacopo Chiodini, Iacopo Chiodini, Giovanna Mantovani, Giovanna Mantovani, Valentina Morelli, Maura Arosio, Maura Arosio

“…The lack of amelioration in glucose metabolism and total cortisol daily exposure could suggest the need for a dose reduction when shifting from CA to MRH, due to their different pharmacokinetics.…”
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Transcriptome and hormone metabolome reveal the mechanism of stem bending in water lily (Nymphaea tetragona) cut-flowers by Jie Li, Jie Li, Yuhui Sheng, Yuhui Sheng, Yuhui Sheng, Huixian Xu, Huixian Xu, Qinxue Li, Qinxue Li, Xiuya Lin, Xiuya Lin, Yang Zhou, Yang Zhou, Ying Zhao, Ying Zhao, Xiqiang Song, Xiqiang Song, Jian Wang, Jian Wang

“…Significant differences in genes associated with plant hormones, calcium ions, glucose metabolism, and photosynthesis pathways genes involved in the dorsal and ventral areas of the curved stem. …”
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Deep learning-based long-term risk evaluation of incident type 2 diabetes using electrocardiogram in a non-diabetic population: a retrospective, multicentre studyResearch in contex... by Junmo Kim, Hyun-Lim Yang, Su Hwan Kim, Siun Kim, Jisoo Lee, Jiwon Ryu, Kwangsoo Kim, Zio Kim, Gun Ahn, Doyun Kwon, Hyung-Jin Yoon

“…Type 2 diabetes was defined as glucose ≥126 mg/dL or glycated haemoglobin (HbA1c) ≥ 6.5%. …”
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