The impact of ethnicity and intra-pancreatic fat on the postprandial metabolome response to whey protein in overweight Asian Chinese and European Caucasian women with prediabetes by Aidan Joblin-Mills, Aidan Joblin-Mills, Zhanxuan Wu, Zhanxuan Wu, Zhanxuan Wu, Karl Fraser, Karl Fraser, Beatrix Jones, Beatrix Jones, Wilson Yip, Wilson Yip, Jia Jiet Lim, Jia Jiet Lim, Louise Lu, Louise Lu, Ivana Sequeira, Ivana Sequeira, Sally Poppitt, Sally Poppitt

“…This was influenced by degree of visceral adipose deposition and ectopic fat accumulation in key organs, including liver and pancreas, leading to altered fasting plasma glucose, insulin resistance, and differences in plasma lipid and metabolite profiles. …”
Get full text

Transcriptome analysis in hepatopancreases reveals the response of domesticated common carp to a high-temperature environment in the agricultural heritage rice–fish system by Xiangbing Cheng, Xiangbing Cheng, Xiangbing Cheng, Fangcheng Li, Fangcheng Li, Fangcheng Li, Gilbert Kumilamba, Gilbert Kumilamba, Gilbert Kumilamba, Jiayi Liao, Jiayi Liao, Jiayi Liao, Jiangwei Cao, Jiangwei Cao, Jiangwei Cao, Jiamin Sun, Jiamin Sun, Jiamin Sun, Qigen Liu, Qigen Liu, Qigen Liu

“…Compared with the control group, the serum levels of malondialdehyde (MDA), glucose (GLU), glutathione peroxidase (GSH-Px), catalase (CAT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) show no significant change. …”
Get full text

Metabolic syndrome in children and adolescents with phenylketonuria by Viviane C. Kanufre, Rosângelis D.L. Soares, Michelle Rosa A. Alves, Marcos J.B. Aguiar, Ana Lúcia P. Starling, Rocksane C. Norton

“…The biochemical variables assessed were phenylalanine (phe), total cholesterol, HDL-c, triglycerides, glucose, and basal insulin. The patients had Homeostasis Model Assessment (HOMA) and waist circumference assessed. …”
Get full text

<i>Artemisia absinthium</i> L. Aqueous and Ethyl Acetate Extracts: Antioxidant Effect and Potential Activity In Vitro and In Vivo against Pancreatic α-Amylase and Intestinal α-Gluc... by Asmae Hbika, Nour Elhouda Daoudi, Abdelhamid Bouyanzer, Mohamed Bouhrim, Hicham Mohti, El Hassania Loukili, Hamza Mechchate, Rashad Al-Salahi, Fahd A. Nasr, Mohamed Bnouham, Abdelhamid Zaid

“…These extracts were also evaluated for their ability to inhibit the activity of the pancreatic α-amylase enzyme, as well as the intestinal α-glucosidase enzyme, in vitro and in vivo, thus causing the reduction of blood glucose. The results of this study showed that high polyphenol and flavonoid contents were obtained in ethyl acetate extract with values of 60.34 ± 0.43 mg GAE/g and 25.842 ± 0.241 mg QE/g, respectively, compared to the aqueous extract. …”
Get full text

Effect of High-Fat and Low-Fat Dairy Products on Cardiometabolic Risk Factors and Immune Function in a Low Birthweight Swine Model of Diet-Induced Insulin Resistance by Yongbo She, Yongbo She, Kun Wang, Kun Wang, Alexander Makarowski, Alexander Makarowski, Rabban Mangat, Rabban Mangat, Sue Tsai, Benjamin P. Willing, Spencer D. Proctor, Spencer D. Proctor, Caroline Richard, Caroline Richard

“…Feeding high-fat dairy products improved fasting plasma glucose concentrations more than low-fat dairy compared to LBW-CHF (P &lt; 0.05). …”
Get full text

Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study by Yau-Lam Alex Chau, Ji Won Yoo, Jiandong Zhou, Cosmos LiutaoGuo, Wing Tak Wong, Carlin Chang, Tong Liu, Kamalan Jeevaratnam, Qingpeng Zhang, Gary Tse, Sharen Lee

“…Multivariable Cox regression identified older age (HR: 1.09 [95% CI: 1.08–1.10]) and antiplatelet use (HR: 1.36 [1.14–1.62]) as risk factors for incident dementia, and older age (HR: 1.07 [1.06–1.08]), ischemic stroke (HR: 1.47 [1.09–1.98]), fasting blood glucose (HR: 1.10 [1.01–1.20]), antiplatelets (HR: 1.92 [1.51–2.44]), and calcium channel blocker (HR: 1.28 [1.04–1.57]) use as risk factors of incident vascular dementia.…”
Get full text

Myocardial ¹⁸F-FDG Uptake Pattern for Cardiovascular Risk Stratification in Patients Undergoing Oncologic PET/CT by Ahmed Haider, Susan Bengs, Katharina Schade, Winandus J. Wijnen, Angela Portmann, Dominik Etter, Sandro Fröhlich, Geoffrey I. Warnock, Valerie Treyer, Irene A. Burger, Michael Fiechter, Ken Kudura, Tobias A. Fuchs, Aju P. Pazhenkottil, Ronny R. Buechel, Philipp A. Kaufmann, Alexander Meisel, Paul Stolzmann, Catherine Gebhard

“…Objective: Positron emission tomography/computed tomography with ¹⁸F-fluorodeoxy-glucose (¹⁸F-FDG-PET/CT) has become the standard staging modality in various tumor entities. …”
Get full text

Do we overestimate intravenous fluid therapy needs? Adverse effects related to isotonic solutions during pediatric hospital admissions by Jimena Pérez-Moreno, Ana Gutiérrez-Vélez, Laura Torres Soblechero, Felipe González Martínez, Blanca Toledo del Castillo, Eva Vierge Hernán, Rosa Rodríguez-Fernández

“…We included hospitalised patients between 3 months-old and 15-years-old were included with 0,9% isotonic solutions with 5% glucose within the first 24 h of administration. They were divided into two groups, depending on the quantity of liquid they received (restricted <100% vs 100% maintenance needs). …”
Get full text

Clinical and biochemical parameters associated with substance-induced psychotic disorder: which differences between alcohol, cannabis and psychostimulants by G. Nosari, A. Ceresa, M. Di Paolo, C. M. Esposito, V. Ciappolino, A. Calabrese, F. Legnani, A. M. Auxilia, M. Capellazzi, I. Tagliabue, L. Cirella, E. Capuzzi, A. Caldiroli, A. Dakanalis, M. Clerici, M. Buoli

“…Furthermore, we collected a blood sample for dosing Na+, K+, Na+/K+, hemogram with formula and platelets, glucose , urea, creatinine, uric acid, transaminases, γGT, bilirubin, plasma proteins, albumin, LDH, CPK, PCHE, cholesterol, HDL, LDL, Tg, TSH. …”
Get full text

Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model by Qunwen Pan, Xiaobing Xu, Wen He, Yan Wang, Zhi Xiang, Xiaojuan Jin, Qiong Tang, Ting Zhao, Xiaotang Ma

“…Vascular endothelial cells (ECs) and myoblast cells (C2C12 cells) were subjected to hypoxia plus high glucose (HG) and cocultured with EPC-EXs and EPC-EXsmiR-17-5p. …”
Get full text

Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice by Alena Akhmetshina, Valentina Bianco, Ivan Bradić, Melanie Korbelius, Anita Pirchheim, Katharina B. Kuentzel, Thomas O. Eichmann, Helga Hinteregger, Dagmar Kolb, Hansjoerg Habisch, Laura Liesinger, Tobias Madl, Wolfgang Sattler, Branislav Radović, Simon Sedej, Ruth Birner-Gruenberger, Nemanja Vujić, Dagmar Kratky

“…Regardless of increased glucose uptake, expression of the slow oxidative fiber marker MYH7 was markedly increased in Lal−/−SM, indicating a fiber switch from glycolytic, fast-twitch fibers to oxidative, slow-twitch fibers. …”
Get full text

Deep Vein Thrombosis Is Facilitated by Endothelial-Derived Extracellular Vesicles via the PDI–GRP94–GPIIb/IIIa Pathway in Mice by Hongtao Lan, Zhoujie Tong, Yaqiong Jiao, Haitao Han, Ying Ma, Yulin Li, Xu Jia, Boang Hu, Wei Zhang, Ming Zhong, Zhihao Wang

“…Methods: The interaction between protein disulfide isomerase (PDI) and glucose-regulated protein 94 (GRP94) was founded by molecular docking. …”
Get full text

Design, Synthesis and Biological Evaluation of Multi-Target Anti-Cancer Agent PYR26 by Sirong He, Peiting He, Haojing Wu, Yao Feng, Jiejin Situ, Yiling Chen, Junxi Du, Jin Qin, Pengcheng Lv, Kun Chen

“…PI3K signaling pathway is involved in signal transduction of a variety of growth factors, cytokines and extracellular matrix and plays an important role in preventing cell apoptosis, promoting cell survival and influencing cell glucose metabolism. CDK4 is a catalytic subunit of the protein kinase complex and is important for G1 phase progression of the cell cycle. …”
Get full text

Vitamin C deficiency reveals developmental differences between neonatal and adult hematopoiesis by Ira Phadke, Ira Phadke, Ira Phadke, Marie Pouzolles, Alice Machado, Alice Machado, Alice Machado, Josquin Moraly, Pedro Gonzalez-Menendez, Pedro Gonzalez-Menendez, Valérie S. Zimmermann, Valérie S. Zimmermann, Valérie S. Zimmermann, Sandrina Kinet, Sandrina Kinet, Mark Levine, Pierre-Christian Violet, Naomi Taylor, Naomi Taylor

“…Even though humans cannot synthesize ascorbate, due to a pseudogenization of the L-gulono-γ-lactone oxidase (GULO) gene, its generation from glucose is an ancestral mammalian trait. Taking advantage of a Gulo-/- mouse model, we show that ascorbic acid deficiency profoundly impacts perinatal hematopoiesis, resulting in a hypocellular bone marrow (BM) with a significant reduction in hematopoietic stem cells, multipotent progenitors, and hematopoietic progenitors. …”
Get full text

Telehealth for the Longitudinal Management of Chronic Conditions: Systematic Review by Allison A Lewinski, Conor Walsh, Sharron Rushton, Diana Soliman, Scott M Carlson, Matthew W Luedke, David J Halpern, Matthew J Crowley, Ryan J Shaw, Jason A Sharpe, Anastasia-Stefania Alexopoulos, Amir Alishahi Tabriz, Jessica R Dietch, Diya M Uthappa, Soohyun Hwang, Katharine A Ball Ricks, Sarah Cantrell, Andrzej S Kosinski, Belinda Ear, Adelaide M Gordon, Jennifer M Gierisch, John W Williams Jr, Karen M Goldstein

“…Intervention design varied greatly from remote monitoring of blood glucose combined with video versus in-person visits to an endocrinology clinic to a brief, 3-week remote intervention to stabilize uncontrolled diabetes. …”
Get full text

Impact of the Remission of Type 2 Diabetes on Cardiovascular Structure and Function, Exercise Capacity and Risk Profile: A Propensity Matched Analysis by Joanna M. Bilak, Jian L. Yeo, Gaurav S. Gulsin, Anna-Marie Marsh, Manjit Sian, Abhishek Dattani, Sarah L. Ayton, Kelly S. Parke, Moira Bain, Wenjie Pang, Sherif Boulos, Tim G. St Pierre, Melanie J. Davies, Thomas Yates, Gerry P. McCann, Emer M. Brady

“…T2D remission cases (Glycated hemoglobin (HbA1c) < 6.5% without glucose-lowering therapy, ≥3 months) were propensity score matched 1:4 based on age, sex, ethnicity and time of exposure to those with active T2D (<i>n</i> = 100) with the nearest-neighbour method and 1:1 with non-T2D controls (<i>n</i> = 25). …”
Get full text

Effects of maternal choline supplementation on performance and immunity of progeny from birth to weaning by M.G. Zenobi, J.M. Bollatti, A.M. Lopez, B.A. Barton, C.L. Hixson, F.P. Maunsell, W.W. Thatcher, K. Miller-Cushon, J.E.P. Santos, C.R. Staples, C.D. Nelson

“…Moreover, serum concentrations of metabolites (i.e., β-hydroxybutyric acid, fatty acids, and glucose), cytokines (i.e., tumor necrosis factor-α) and acute phase proteins (i.e., serum amyloid A) were consistent with less-severe inflammatory response to LPS in males born from dams fed RPC compared with control. …”
Get full text

Low eGFR Is a Strong Predictor of Worse Outcome in Hospitalized COVID-19 Patients by Antonio Mirijello, Pamela Piscitelli, Angela de Matthaeis, Michele Inglese, Maria Maddalena D’Errico, Valentina Massa, Antonio Greco, Andrea Fontana, Massimiliano Copetti, Lucia Florio, Maurizio Angelo Leone, Michele Antonio Prencipe, Filippo Aucella, Salvatore De Cosmo

“…Age (<i>p</i> < 0.001), SpO2 (<i>p</i> < 0.001), previous anti-platelet treatment (<i>p</i> = 0.006), Charlson’s Comorbidities Index (<i>p</i> < 0.001), serum creatinine (<i>p</i> < 0.001), eGFR (<i>p</i> = 0.003), low eGFR (<i>p</i> < 0.001), blood glucose levels (<i>p</i> < 0.001), and LDH (<i>p</i> = 0.003) were significantly associated with the main outcome in univariate analysis. …”
Get full text

PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness by Ronghui Liang, Zi-Wei Ye, Zhenzhi Qin, Yubin Xie, Xiaomeng Yang, Haoran Sun, Qiaohui Du, Peng Luo, Kaiming Tang, Bodan Hu, Jianli Cao, Xavier Hoi-Leong Wong, Guang-Sheng Ling, Hin Chu, Jiangang Shen, Feifei Yin, Dong-Yan Jin, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Shuofeng Yuan

“…Safe and inexpensive D-mannose can compete with glucose for the same transporter and hexokinase. Such competitions suppress glycolysis, reduce mitochondrial reactive-oxygen-species and succinate-mediated hypoxia-inducible factor-1α, and thus reduce virus-induced proinflammatory cytokine production. …”
Get full text

Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage by Jianhua Zeng, Jianhua Zeng, Jianhua Zeng, Hao Huang, Hao Huang, Hao Huang, Hao Huang, Yan Zhang, Yan Zhang, Yan Zhang, Xin Lv, Xin Lv, Xin Lv, Jiawei Cheng, Jiawei Cheng, Jiawei Cheng, Si Jue Zou, Si Jue Zou, Si Jue Zou, Yuanyuan Han, Yuanyuan Han, Yuanyuan Han, Songkai Wang, Songkai Wang, Songkai Wang, Li Gong, Li Gong, Li Gong, Zhangzhe Peng, Zhangzhe Peng, Zhangzhe Peng

“…Dapagliflozin has shown renal protection in some clinical trials as a glucose-lowering drug, but its role and mechanism on renal fibrosis remain unclear. …”
Get full text