Quality and cost of healthcare services in patients with diabetes in Iran: Results of a nationwide short-term longitudinal survey by Mohsen Abbasi-Kangevari, Farnam Mohebi, Seyyed-Hadi Ghamari, Mitra Modirian, Nazila Shahbal, Naser Ahmadi, Yosef Farzi, Mehrdad Azmin, Shahin Roshani, Shahin Roshani, Hossein Zokaei, Maryam Khezrian, Shahedeh Seyfi, Mohammad Keykhaei, Mohammad Keykhaei, Fatemeh Gorgani, Saral Rahimi, Negar Rezaei, Negar Rezaei, Shahab Khatibzadeh, Saeid Shahraz

“…During the previous year, 90% of respondents had a laboratory fasting blood glucose assessment; however, less than 70% reported a quarterly follow-up physician visit. …”
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Commercial Bio-Packaging to Preserve the Quality and Extend the Shelf-Life of Vegetables: The Case-Study of Pumpkin Samples Studied by a Multimethodological Approach by Giacomo Di Matteo, Paola Di Matteo, Matteo Sambucci, Jacopo Tirillò, Anna Maria Giusti, Giuliana Vinci, Laura Gobbi, Sabrina Antonia Prencipe, Andrea Salvo, Cinzia Ingallina, Mattia Spano, Anatoly P. Sobolev, Noemi Proietti, Valeria Di Tullio, Paola Russo, Luisa Mannina, Marco Valente

“…After an 11-day period, NMR spectroscopy results showed a sucrose increase and a malic acid decrease in all the biofilms with respect to FP; fructose, glucose, galactose levels remained quite constant in biofilms B and C; the most abundant amino acids remained quite constant in biofilm A and decreased significantly in biofilm B. …”
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Selective use of pancreatic duct occlusion during pancreaticoduodenectomy in patients with a small-size duct and atrophic parenchyma in the distal pancreas: A retrospective study by Guangbin Chen, Guangbin Chen, Guangbin Chen, Jie Yin, Jie Yin, Qun Chen, Qun Chen, Jishu Wei, Jishu Wei, Kai Zhang, Kai Zhang, Lingdong Meng, Lingdong Meng, Yichao Lu, Yichao Lu, Pengfei Wu, Pengfei Wu, Baobao Cai, Baobao Cai, Zipeng Lu, Zipeng Lu, Yi Miao, Yi Miao, Yi Miao, Kuirong Jiang, Kuirong Jiang

“…Among the four patients, three developed new-onset diabetes mellitus, and one had impaired glucose tolerance. Furthermore, three patients received pancreatic enzyme supplementation at a dose of 90,000 Ph. …”
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The Differences in the Prevalence of Cardiovascular Disease, Its Risk Factors, and Achievement of Therapeutic Goals among Urban and Rural Primary Care Patients in Poland: Results f... by Krzysztof Studziński, Tomasz Tomasik, Adam Windak, Maciej Banach, Ewa Wójtowicz, Mirosław Mastej, Maciej Tomaszewski, Dimitri P. Mikhailidis, Peter P. Toth, Alberico Catapano, Kausik K. Ray, George Howard, Gregory Y.H. Lip, Fadi J. Charchar, Naveed Sattar, Bryan Williams, Thomas M. MacDonald, Peter E. Penson, Jacek J. Jóźwiak, on behalf of the LIPIDOGRAM2015 Investigators

“…There were no important differences in the prevalence of hypertension, diabetes, dyslipidaemia, and CVD, or in mean levels of blood pressure, cholesterol fractions, glucose, and HbA1c between Polish urban and rural primary care patient populations. …”
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Increasing the prepartum dose of rumen-protected choline: Effects of maternal choline supplementation on growth, feed efficiency, and metabolism in Holstein and Holstein × Angus ca... by H.T. Holdorf, W.E. Brown, G.J. Combs, S.J. Henisz, S.J. Kendall, M.J. Caputo, K.E. Ruh, H.M. White

“…Maternal choline supplementation increased plasma glucose compared with CTL, while increasing serum insulin-like growth factor-1 and decreasing serum lipopolysaccharide binding protein at 7 d of age in Holstein calves. …”
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Differential temperature sensitivity of intracellular metabolic processes and extracellular soil enzyme activities by A. A. Adekanmbi, A. A. Adekanmbi, L. Dale, L. Shaw, T. Sizmur

“…We pre-incubated soils at 5, 15, or 26 <span class="inline-formula">^∘</span>C to acclimatize the microbial communities to different thermal regimes for 60 d before measuring potential activities of <span class="inline-formula"><i>β</i></span>-glucosidase and chitinase (extracellular enzymes), glucose-induced respiration (intracellular metabolic processes), and basal respiration at a range of assay temperatures (5, 15, 26, 37, and 45 <span class="inline-formula">^∘</span>C). …”
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Flurochloridone-induced apoptosis via IRE1α-JNK signaling pathway in mice testicular cells and TM4 cells by Fen ZHANG, Rui LI, Shuqi ZHAO, Yanna WANG, Zhijing NI, Xiuli CHANG, Zhijun ZHOU

“…In the in vitro study, TM4 cells were treated with different concentrations of FLC (40, 80, and 160 μmol·L−1) for 6 h, then apoptosis rate was detected by flow cytometry, and the levels of apoptosis-related proteins (Bcl-2, Bim, and Bax) and endoplasmic reticulum stress-related proteins [glucose regulated protein 78 (GRP78), phosphorylated-protein kinase R like endoplasmic reticulum kinase (p-PERK), activating transcription factor 6 (ATF6), phosphorylated-inosital-requiring enzyme 1α (p-IRE1α), and phosphorylated-JNK (p-JNK)] were measured by Western blotting. …”
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Synergistic antitumor effects of polysaccharides and anthocyanins from Lycium ruthenicum Murr. on human colorectal carcinoma LoVo cells and the molecular mechanism by Xinshu Qin, Xingyu Wang, Ke Xu, Xingbin Yang, Qing Wang, Chao Liu, Xinkun Wang, Xu Guo, Jinyue Sun, Lin Li, Shiqi Li

“…The results showed that the purified LRPS contained heteropolysaccharides, mainly composed of arabinose, galactose, and glucose with weight percentage of 41.2%, 33.6%, and 10.8%, respectively. …”
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Short-Term SGLT2 Inhibitor Administration Does Not Alter Systemic Insulin Clearance in Type 2 Diabetes by Motonori Sato, Yoshifumi Tamura, Hideyoshi Kaga, Nozomu Yamasaki, Mai Kiya, Satoshi Kadowaki, Daisuke Sugimoto, Takashi Funayama, Yuki Someya, Saori Kakehi, Shuko Nojiri, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada

“…Previous studies have shown that sodium-glucose cotransporter 2 inhibitor (SGLT2i) increases insulin–C-peptide ratio, a marker of insulin clearance, and improves metabolic parameters. …”
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Untargeted Multiomics Approach Coupling Lipidomics and Metabolomics Profiling Reveals New Insights in Diabetic Retinopathy by Patricia Ancel, Jean Charles Martin, Elisa Doukbi, Marie Houssays, Pierre Gascon, Maud Righini, Frédéric Matonti, Ljubica Svilar, Marie Valmori, Catherine Tardivel, Nicolas Venteclef, Jean Baptiste Julla, Jean François Gautier, Noémie Resseguier, Anne Dutour, Bénédicte Gaborit

“…Metabolite set enrichment analysis indicated that pathways such as metabolism of branched-chain amino acids (methylglutaryl carnitine <i>p</i> = 0.004), the kynurenine pathway (tryptophan <i>p</i> < 0.001), and microbiota metabolism (p-Cresol sulfate <i>p</i> = 0.004) were among the most enriched deregulated pathways in the DR group. Moreover, Glucose-6-phosphate (<i>p</i> = 0.001) and N-methyl-glutamate (<i>p</i> < 0.001) were upregulated in DR. …”
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Effects of high-intensity interval training with hyperbaric oxygen by Miguel Alvarez Villela, Sophia A. Dunworth, Sophia A. Dunworth, Bryan D. Kraft, Bryan D. Kraft, Nicole P. Harlan, Nicole P. Harlan, Michael J. Natoli, Hagir B. Suliman, Richard E. Moon, Richard E. Moon, Richard E. Moon

“…Subjects randomized to HIIT+HBO2 displayed higher skeletal muscle mRNA levels of PPARGC1A, a regulator of mitochondrial biogenesis, and HK2 and SLC2A4, regulators of glucose utilization and storage. All other tested markers of mitochondrial biogenesis showed no additional effect of HBO2 to HIIT. …”
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Socioeconomic Position and Type 2 Diabetes: The Mediating Role of Psychosocial Work Environment- the Maastricht Study by Bengisu Sezer, Bengisu Sezer, Annemarie Koster, Annemarie Koster, Jeroen Albers, Jeroen Albers, Rachelle Meisters, Rachelle Meisters, Miranda Schram, Miranda Schram, Miranda Schram, Miranda Schram, Simone Eussen, Simone Eussen, Simone Eussen, Nicole Dukers, Nicole Dukers, Nicole Dukers, Angelique de Rijk, Angelique de Rijk, Coen Stehouwer, Coen Stehouwer, Hans Bosma, Hans Bosma

“…SEP indicators (education, income, occupation), self-reported psychosocial work stressors, (pre)diabetes by oral glucose tolerance test were measured at baseline. …”
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ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease by Zhonghui Cao, Xiao Gao, Jing Meng, Xiaoli Guo, Jiahao Xu, Junchao Cui, Xueyan Zhou

“…Knocking down ACSL1 in HK-2 cells was shown to reverse renal fibrosis induced by high glucose. Conclusions: We found a potential therapeutic target for preventing or ameliorating the progression of DKD fibrosis. …”
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Diagnostic Usefulness of Spiroergometry and Risk Factors of Long COVID in Patients with Normal Left Ventricular Ejection Fraction by Katarzyna Gryglewska-Wawrzak, Agata Sakowicz, Maciej Banach, Ibadete Bytyçi, Agata Bielecka-Dabrowa

“…The laboratory results pointed out that patients with long COVID symptoms also had a lower rate of red blood cells (RBC) [4.4 vs. 4.6 × 10⁶/uL; <i>p</i> = 0.01]; a higher level of glucose [92 vs. 90 mg/dL; <i>p</i> = 0.03]; a lower glomerular filtration rate (GFR) estimate by Modification of Diet in Renal Disease (MDRD) [88 vs. 95; <i>p</i> = 0.03]; and a higher level of hypersensitive cardiac Troponin T (hs-cTnT) [6.1 vs. 3.9 pg/mL; <i>p</i> = 0.04]. …”
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Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8+ T cells by Weizhi He, Xicheng Wang, Miaomiao Chen, Chong Li, Wenjian Chen, Lili Pan, Yangyang Cui, Zhao Yu, Guoxiu Wu, Yang Yang, Mingyang Xu, Zhaoxuan Dong, Keming Ma, Jinghan Wang, Zhiying He

“…Results RNA‐sequencing analysis showed that chronic liver injury led to significant changes in AMPK‐, glucose‐ and retinol metabolism‐related pathways in Fah−/− mice. …”
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Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood–brain barrier permeability via regulating Caveolin-1-d... by Yiyang Li, Bowen Liu, Tingting Zhao, Xingping Quan, Yan Han, Yaxin Cheng, Yanling Chen, Xu Shen, Ying Zheng, Yonghua Zhao

“…Methods BMSC-EVs and BEC-EVs were isolated and characterized by nanoparticle tracking analysis, western blotting, and transmission electron microscope. Oxygen and glucose deprivation (OGD) treated b. End3 cells were utilized to evaluate brain endothelial cell leakage. …”
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Regulatory mechanisms of dopamine metabolism in a marine Meyerozyma guilliermondii GXDK6 under NaCl stress as revealed by integrative multi-omics analysis by Huijie Sun, Huashan Bai, Yonghong Hu, Sheng He, Ruihang Wei, Duotao Meng, Qiong Jiang, Hongping Pan, Peihong Shen, Qian Ou, Chengjian Jiang

“…GXDK6 was found to have the ability to biosynthesize dopamine when using glucose as the substrate. 14 key genes for the biosynthesis of dopamine were identified by whole genome-wide analysis. …”
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Genetic and environmental circadian disruption induce weight gain through changes in the gut microbiome by Baraa Altaha, Marjolein Heddes, Violetta Pilorz, Yunhui Niu, Elizaveta Gorbunova, Michael Gigl, Karin Kleigrewe, Henrik Oster, Dirk Haller, Silke Kiessling

“…In Bmal1SCNfl/- mice, loss of rhythmicity in microbial functioning associates with previously shown increased body weight, dysfunctional glucose homeostasis and adiposity. Similarly, we observe an increase in body weight in SSW mice. …”
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Endoplasmic reticulum stressed HNSCC cell-derived exosomal miR-26a-5p promotes PD-L1 expression in macrophage through PTEN/AKT signaling pathway by JIAO Pengfei, WANG Zeyu, WU Heming, YAO Siyue, WANG Huilin, YAO Enhui, ZHANG Yuyao, YUAN Yi, ZHONG Yi

“…The expression levels of ERS-associated proteins, including protein kinase R-like endoplasmic reticulum kinase (PERK) and glucose-regulated protein 78 (GRP78), in HNSCC tissues and para-tumor tissues were detected by Western blot (WB) and quantitative real-time PCR (RT-qPCR). …”
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Relationship between Cardiovascular Health Score of Life&apos;s Essential 8 and New-onset Atrial Fibrillation: a Large Sample, Long-Term Follow-up Study by ZHANG Yuan, HOU Qiqi, QI Qi, JIANG Yue, WANG Nan, YUE Bocheng, CHEN Shuohua, HAN Quanle, WU Shouling, LI Kangbo

“…Methods A study was conducted in which 91 131 employees of Kailuan Group in Tangshan, Hebei Province were selected for physical examination from June 2006 to October 2007, and the LE8 score was evaluated according to the algorithm developed by the American Heart Association, and combined with the actual situation of the Kailuan study to form the Kailuan study version of LE8, including 4 health behaviors (diet, physical activity, tobacco exposure, and sleep) and 4 health factors (BMI, blood lipids, blood glucose, and blood pressure). The study subjects were divided into the three groups of the low CVH group (n=8 407) with a LE8 score less than 50, the medium CVH group (n=73 493) with a LE8 score of 50 or more but less than 80, and the high CVH group (n=9 231) with a LE8 score of 80 or more. …”
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