Pequi Oil (<i>Caryocar brasiliense</i> Camb.) Attenuates the Adverse Effects of Cyclical Heat Stress and Modulates the Oxidative Stress-Related Genes in Broiler Chickens by Jéssica Moraes Cruvinel, Priscila Michelin Groff Urayama, Cássio Yutto Oura, Fernanda Kaiser de Lima Krenchinski, Tatiane Souza dos Santos, Beatriz Alves de Souza, Samir Moura Kadri, Camila Renata Correa, José Roberto Sartori, Antonio Celso Pezzato

“…The results showed that HS increased glucose (<i>p</i> = 0.006), triglycerides (<i>p</i> < 0.001), and HDL (<i>p</i> = 0.042) at 21 days and reduced (<i>p</i> = 0.005) serum total cholesterol at 42 days. …”
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Early to mid-pregnancy HbA1c levels and its association with adverse pregnancy outcomes in three low middle-income countries in Asia and Sub-Saharan Africa by Muhammad Imran Nisar, Sayan das, Rasheda Khanam, Javairia Khalid, Swagata Chetia, Tarik Hasan, Shahira Shahid, Msafiri Ladislaus Marijani, Salahuddin Ahmed, Farah Khalid, Said Mohammed Ali, Nabidul Haque Chowdhury, Usma Mehmood, Arup Dutta, Sayedur Rahman, Muhammad Farrukh Qazi, Saikat Deb, Dipak Kumar Mitra, Asra Abeer Usmani, Usha Dhingra, Rubhana Raqib, Alexander Manu, Sachiyo Yoshida, Nicole Minckas, Rajiv Bahl, Abdullah H. Baqui, Sunil Sazawal, Fyezah Jehan

“…Thus, strict monitoring of blood glucose levels is warranted. This study aims to determine the association of early to mid-pregnancy HbA1c levels with the development of pregnancy complications in women from three countries in South Asia and Sub-Saharan Africa. …”
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Endosperm structure and Glycemic Index of Japonica Italian rice varieties by Filip Haxhari, Francesco Savorani, Mariangela Rondanelli, Enrico Cantaluppi, Luigi Campanini, Edoardo Magnani, Cinzia Simonelli, Gentian Gavoci, Alessandro Chiadò, Mattia Sozzi, Nicola Cavallini, Angelica Chiodoni, Clara Gasparri, Gaetan Claude Barrile, Alessandro Cavioni, Francesca Mansueto, Giuseppe Mazzola, Alessia Moroni, Zaira Patelli, Martina Pirola, Alice Tartara, Davide Guido, Simone Perna, Roberto Magnaghi

“…Using an ad-hoc developed algorithm, morphological features were extracted from the FESEM images, to be then inspected by means of multivariate data analysis methods.Results and DiscussionLarge variability was observed in GI values (49 to 92 with respect to glucose), as well as in endosperm morphological features. …”
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Pathological modeling of glycogen storage disease type III with CRISPR/Cas9 edited human pluripotent stem cells by Lucille Rossiaud, Lucille Rossiaud, Lucille Rossiaud, Lucille Rossiaud, Lucille Rossiaud, Pascal Fragner, Pascal Fragner, Pascal Fragner, Elena Barbon, Elena Barbon, Antoine Gardin, Antoine Gardin, Manon Benabides, Manon Benabides, Manon Benabides, Emilie Pellier, Emilie Pellier, Emilie Pellier, Jérémie Cosette, Lina El Kassar, Lina El Kassar, Lina El Kassar, Karine Giraud-Triboult, Karine Giraud-Triboult, Karine Giraud-Triboult, Xavier Nissan, Xavier Nissan, Xavier Nissan, Giuseppe Ronzitti, Giuseppe Ronzitti, Lucile Hoch, Lucile Hoch, Lucile Hoch

“…Although the disease manifests with hypoglycemia and liver metabolism impairment, the progressive myopathy is the major disease burden in adult GSDIII patients, without any curative treatment currently available.Methods: Here, we combined the self-renewal and differentiation capabilities of human induced pluripotent stem cells (hiPSCs) with cutting edge CRISPR/Cas9 gene editing technology to establish a stable AGL knockout cell line and to explore glycogen metabolism in GSDIII.Results: Following skeletal muscle cells differentiation of the edited and control hiPSC lines, our study reports that the insertion of a frameshift mutation in AGL gene results in the loss of GDE expression and persistent glycogen accumulation under glucose starvation conditions. Phenotypically, we demonstrated that the edited skeletal muscle cells faithfully recapitulate the phenotype of differentiated skeletal muscle cells of hiPSCs derived from a GSDIII patient. …”
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S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair by Adi Amar-Schwartz, Vered Ben Hur, Amina Jbara, Yuval Cohen, Georgina D Barnabas, Eliran Arbib, Zahava Siegfried, Bayan Mashahreh, Fouad Hassouna, Asaf Shilo, Mohammad Abu-Odeh, Michael Berger, Reuven Wiener, Rami Aqeilan, Tamar Geiger, Rotem Karni

“…The mTORC1 substrate, S6 Kinase 1 (S6K1), is involved in the regulation of cell growth, ribosome biogenesis, glucose homeostasis, and adipogenesis. Accumulating evidence has suggested a role for mTORC1 signaling in the DNA damage response. …”
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The effect of EMPAgliflozin on markers of inflammation in patients with concomitant type 2 diabetes mellitus and Coronary ARtery Disease: the EMPA-CARD randomized controlled trial by Sepehr Gohari, Tara Reshadmanesh, Hadi Khodabandehloo, Amir Karbalaee-Hasani, Hassan Ahangar, Shahram Arsang-Jang, Faramarz Ismail-Beigi, Mohsen Dadashi, Samin Ghanbari, Homa Taheri, Mojtaba Fathi, Muhammad Javad Muhammadi, Reyhaneh Mahmoodian, Atieh Asgari, Mohammadreza Tayaranian, Mehdi Moharrami, Mahsa Mahjani, Bijan Ghobadian, Hossein Chiti, Sheida Gohari

“…Markers of glycemic status (fasting blood glucose, HbA1c, and HOMA-IR (homeostatic model assessment for insulin resistance) significantly improved (P < 0.001). …”
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ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease by Zhonghui Cao, Xiao Gao, Jing Meng, Xiaoli Guo, Jiahao Xu, Junchao Cui, Xueyan Zhou

“…Knocking down ACSL1 in HK-2 cells was shown to reverse renal fibrosis induced by high glucose. Conclusions: We found a potential therapeutic target for preventing or ameliorating the progression of DKD fibrosis. …”
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Dietary choline can partially spare methionine to improve the feeds utilization and immune response in juvenile largemouth bass (Micropterus salmoides): Based on phenotypic respons... by Haoyu Geng, Peng Yang, Yang Chen, Yawen Qin, Xinyu Li, Chaoqun He, Kangsen Mai, Fei Song

“…Moreover, compared with NC group, PC, Met and Cho groups also activated growth hormone/insulin-like growth factor (GH-IGF), mammalian target of rapamycin (mTOR) pathway and shut down amino acid response (AAR) pathway to further enhanced glucose, lipid synthesis (P＜0.05). Dietary choline and methionine were similar in regulating the activity of signaling pathways (P > 0.05). …”
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Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats by Radha Dutt Singh, Radha Dutt Singh, Ratnakar Tiwari, Vineeta Sharma, Vineeta Sharma, Hafizurrahman Khan, Hafizurrahman Khan, Siddhartha Gangopadhyay, Siddhartha Gangopadhyay, Sukhveer Singh, Sukhveer Singh, Kavita Koshta, Kavita Koshta, Shagun Shukla, Nidhi Arjaria, Kapil Mandrah, Kapil Mandrah, Pankaj Ramji Jagdale, Satyakam Patnaik, Satyakam Patnaik, Somendu Kumar Roy, Somendu Kumar Roy, Dhirendra Singh, Ashok Kumar Giri, Vikas Srivastava, Vikas Srivastava

“…An altered level of these factors coincides with impaired glucose metabolism and homeostasis accompanied by progressive kidney damage. …”
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Human 3D nucleus pulposus microtissue model to evaluate the potential of pre-conditioned nasal chondrocytes for the repair of degenerated intervertebral disc by Jesil Kasamkattil, Jesil Kasamkattil, Anna Gryadunova, Anna Gryadunova, Anna Gryadunova, Raphael Schmid, Raphael Schmid, Max Hans Peter Gay-Dujak, Max Hans Peter Gay-Dujak, Max Hans Peter Gay-Dujak, Boris Dasen, Morgane Hilpert, Karoliina Pelttari, Ivan Martin, Stefan Schären, Andrea Barbero, Olga Krupkova, Olga Krupkova, Arne Mehrkens, Arne Mehrkens

“…We developed an advanced 3D nucleus pulposus (NP) microtissues (µT) model generated with cells isolated from human degenerating NP tissue (Pfirrmann grade: 2–3), which were exposed to hypoxia, low glucose, acidity and low-grade inflammation. This model was then used to test the performance of nasal chondrocytes (NC) suspension or spheroids (NCS) after pre-conditioning with drugs known to exert anti-inflammatory or anabolic activities.Methods: NPµTs were formed by i) spheroids generated with NP cells (NPS) alone or in combination with ii) NCS or iii) NC suspension and cultured in healthy or degenerative disc disease condition. …”
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Genetic testing of sperm donors at a human sperm bank in China by Chuan Huang, Hui-Lan Wu, Wen-Jun Zhou, Zeng-Hui Huang, Zeng-Hui Huang, Xue-Feng Luo, Yu-Ling Tang, Qian Liu, Li-Qing Fan, Li-Qing Fan, Hong-Chuan Nie, Wen-Bing Zhu, Wen-Bing Zhu

“…We included a total of 3231 qualified sperm donors: all donors underwent primary screening for thalassemia and glucose-6-phosphate dehydrogenase (G6PD) deficiency. …”
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PD-L1 Overexpression, SWI/SNF Complex Deregulation, and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4⁺ T Cells by Iga Jancewicz, Joanna Szarkowska, Ryszard Konopinski, Malgorzata Stachowiak, Monika Swiatek, Katarzyna Blachnio, Szymon Kubala, Paulina Oksinska, Pawel Cwiek, Natalia Rusetska, Agnieszka Tupalska, Natalia Zeber-Lubecka, Ewa Grabowska, Bianka Swiderska, Agata Malinowska, Michal Mikula, Beata Jagielska, Jan Walewski, Janusz A. Siedlecki, Tomasz J. Sarnowski, Sergiusz Markowicz, Elzbieta A. Sarnowska

“…Here, we show that breast cancer cells expressing PD-L1 can accelerate exhaustion of persistently activated human effector CD4⁺ T cells, manifesting in high PD-1 and PD-L1 expression level son T cell surfaces, decreased glucose metabolism genes, strong downregulation of SWI/SNF chromatin remodeling complex subunits, and p21 cell cycle inhibitor upregulation. …”
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Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women by Wan-jun Yin, Wan-jun Yin, Wan-jun Yin, Wan-jun Yin, Li-jun Yu, Li-jun Yu, Li-jun Yu, Li-jun Yu, Peng Wang, Peng Wang, Peng Wang, Peng Wang, Rui-xue Tao, Xiao-min Jiang, Ying Zhang, Dao-min Zhu, Dao-min Zhu, Dao-min Zhu, Peng Zhu, Peng Zhu, Peng Zhu, Peng Zhu

“…Data on poor CVH was based on four “clinical” CVH metrics, including body mass index, blood pressure, total cholesterol, and glucose levels.ResultsThe proportion of women with poor CVH was 25.0%. …”
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Physiological and psychological effects of a 12-week home-based telemonitored training in metabolic syndrome by Éva Máthéné Köteles, Beatrix Rafael, Andrea Korom, Anna Vágvölgyi, Judit Erzsébet Ábrahám, Andrea Domján, Mónika Szűcs, Attila Nemes, Mária Barnai, Csaba Lengyel, István Kósa, István Kósa

“…Patients showed statistically significant changes in: all the measured waist and hip circumferences; 6-min walk distance (6MWD; from 539.69 ± 78.62 to 569.72 ± 79.96 m, p &lt; 0.001); maximal exercise capacity (11.02 ± 2.6 to 12.14 ± 2 MET, p &lt; 0.001), stress-electrocardiogram duration time (13.74 ± 3.29 to 15.66 ± 2.64 min, p &lt; 0.001); body weight (98.72 ± 21.7 to 97.45 ± 21.76 kg, p = 0.004); high-density lipoprotein cholesterol (n = 45, 1.28 ± 0.31 to 1.68 ± 0.36 mmol/L, p &lt; 0.001); fasting plasma glucose (FPG; n = 47, 6.16 ± 1.26 to 5.44 ± 1.31 mmol/L, p = 0.001); glycated hemoglobin A1c (HbA1c; n = 41, 6.22 ± 0.68 to 5.87 ± 0.78%, p = 0.01). …”
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The effect of Tabata-style functional high-intensity interval training on cardiometabolic health and physical activity in female university students by Yining Lu, Yining Lu, Huw D. Wiltshire, Julien Steven Baker, Qiaojun Wang, Shanshan Ying

“…Body composition, maximal oxygen uptake (VO2max), blood pressure (BP), blood lipids, fasting glucose and insulin, C-reactive protein and PA were objectively measured using standardized methods. …”
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A Social Media–Based Mindfulness Psycho-Behavioral Intervention (MCARE) for Patients With Acute Coronary Syndrome: Randomized Controlled Trial by Huijing Zou, Sek Ying Chair, Bilong Feng, Qian Liu, Yu Jia Liu, Yu Xin Cheng, Dan Luo, Xiao Qin Wang, Wei Chen, Leiqing Huang, Yunyan Xianyu, Bing Xiang Yang

“…Secondary outcomes included psychological stress, HRQoL, and cardiovascular risk factors (ie, smoking status, physical activity, dietary behavior, BMI, blood pressure, blood lipids, and blood glucose). Outcomes were measured at baseline (T0), immediately after the intervention (T1), and 12 weeks after the commencement of the intervention (T2). …”
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SGLT2-inhibitors are effective and safe in the elderly: The SOLD study by Maria Elena Lunati, Vincenzo Cimino, Alessandra Gandolfi, Matteo Trevisan, Laura Montefusco, Ida Pastore, Camilla Pace, Nazarena Betella, Giuseppe Favacchio, Monica Bulgheroni, Loredana Bucciarelli, Giulia Massari, Cristina Mascardi, Angela Girelli, Paola Silvia Morpurgo, Franco Folli, Livio Luzi, Marco Mirani, Basilio Pintaudi, Federico Bertuzzi, Cesare Berra, Paolo Fiorina

“…Background and aims: Sodium-glucose co-transporter-2 inhibitors (SGLT2i) may have important benefits for the elderly with type 2 diabetes (T2D), however some safety concerns still limit their use in patients over 70 years of age. …”
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Assessment of Pharmacological Potential of Novel Exopolysaccharide Isolated from Marine <i>Kocuria</i> sp. Strain AG5: Broad-Spectrum Biological Investigations by Samar Zuhair Alshawwa, Khalid S. Alshallash, Ahmed Ghareeb, Ahmed M. Elazzazy, Mohamed Sharaf, Afaf Alharthi, Fathy Elsayed Abdelgawad, Dalia El-Hossary, Mariusz Jaremko, Abdul-Hamid Emwas, Yosra A. Helmy

“…Analysis of the monosaccharide composition indicated that the EPSR5 fraction composes of glucose, galacturonic acid, arabinose, and xylose in a molar ratio of 2.0:0.5:0.25:1.0, respectively. …”
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Metabolomics analysis of the effects of different litter size on reproductive metabolism and oxidative stress in breeding pigeon (Columba livia) by Suiling Zhang, Yanlin Zhang, Wanyi Mo, Menglin Yang, Weiying Huang, Hongyan Gao, Yantao Lv, Ziying Wang, Wei Wang, Yanhua Huang, Jie Peng

“…Analysis of the glucolipid metabolism index and oxidative stress level of pigeons further revealed that the contents of triglyceride (TG), total cholesterol (T-CHO), and low-density lipoprotein cholesterol (LDL-C) in the plasma of male pigeons were significantly decreased with the increase in the number of squabs, but there was no obvious oxidative stress. On the contrary, glucose (GLU), TG, malondialdehyde (MDA) in the plasma of female pigeons were significantly increased, total antioxidant capacity (T-AOC) were significantly decreased, implying that the female pigeons suffered more oxidative stress and more dramatic changes in glucolipid metabolism. …”
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A Challenging Case of Visceral Leishmaniasis by Antonio Giovanni Solimando, Giuseppe Coniglio, Vanessa Desantis, Gianfranco Lauletta, Davide Fiore Bavaro, Lucia Diella, Anna Cirulli, Giuseppe Iodice, Piero Santoro, Sebastiano Cicco, Giuseppe Ingravallo, Fabio Signorile, Roberto Ria, Monica Montagnani, Annalisa Saracino, Angelo Vacca

“…FDG-PET revealed increased glucose uptake in the liver, spleen, and the whole bone marrow. …”
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