Phytochemical profile and antioxidant capacity, α-amylase and α-glucosidase inhibitory activities of Oxalis pes-caprae extracts in alloxan-induced diabetic mice by Imad Kabach, Najat Bouchmaa, Zakia Zouaoui, Abdelhamid Ennoury, Sara El Asri, Abdelmounaim Laabar, Loubna Oumeslakht, Francesco Cacciola, Yassine Oulad El Majdoub, Luigi Mondello, Abdelmajid Zyad, Naima Nhiri, Mohamed Nhiri, Reda Ben Mrid

“…The effect of the methanolic extract on body weight and blood glucose level of extract-treated diabetic mice were also investigated. …”
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Identification of novel key genes and potential candidate small molecule drugs in diabetic kidney disease using comprehensive bioinformatics analysis by Bin Li, Bin Li, Siyang Ye, Siyang Ye, Yuting Fan, Yuting Fan, Yi Lin, Yi Lin, Suchun Li, Suchun Li, Huajing Peng, Huajing Peng, Hui Diao, Hui Diao, Wei Chen, Wei Chen

“…More importantly, the mRNA transcripts and protein abundance of YAP1 were significantly higher in high glucose-treated renal tubule cells and diabetic mice kidney, and the small molecules exhibiting the best binding affinities with YAP1 were predicted and acquired.Conclusion: Our findings for the first time indicate that NFKB1, DYRK2, ATAD2, YAP1, and CHD3 might be potential novel biomarkers and therapeutic targets for DKD, providing insights into the molecular mechanisms underlying the pathogenesis of DKD.…”
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Intracellular Antioxidant and Anti-Inflammatory Effects and Bioactive Profiles of Coffee Cascara and Black Tea Kombucha Beverages by Amanda L. Sales, Amaia Iriondo-DeHond, Juliana DePaula, Mafalda Ribeiro, Isabel M. P. L. V. O. Ferreira, Marco Antonio L. Miguel, María Dolores del Castillo, Adriana Farah

“…Oxidative stress was induced in HK-2 cells with indoxyl sulfate (IS) and high glucose (G). Inflammation was induced with lipopolysaccharide (LPS) in RAW 264.7 macrophage. …”
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Increased Expression of Proinflammatory Genes in Peripheral Blood Cells Is Associated with Cardiac Cachexia in Patients with Heart Failure with Reduced Ejection Fraction by Anja Sandek, Christoph Gertler, Miroslava Valentova, Nadja Jauert, Manuel Wallbach, Wolfram Doehner, Stephan von Haehling, Stefan D. Anker, Jens Fielitz, Hans-Dieter Volk

“…Increased SLC2A4 in cachectic SM biopsies indicates altered glucose metabolism.…”
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Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome by Na Xiao, Jie Wang, Ting Wang, Xingliang Xiong, Junyi Zhou, Xian Su, Jing Peng, Chao Yang, Xiaofeng Li, Ge Lin, Guangxiu Lu, Fei Gong, Lamei Cheng

“…Furthermore, metformin induced metabolic reprogramming of B cells in PCOS patients, including the alteration in mitochondrial morphology, the decrease in mitochondrial membrane potential, Reactive Oxygen Species (ROS) production and glucose uptake. In DHEA-induced mouse PCOS model, metformin altered metabolic intermediates in splenic B cells. …”
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From Karl Wurm and Guy Scadding's staging to 18F-FDG PET/CT scan phenotyping and far beyond: perspective in the evading history of phenotyping in sarcoidosis by Spyros A. Papiris, Lykourgos Kolilekas, Natalia Rivera, Michail Spanos, Guoping Li, Priyanka Gokulnath, Emeli Chatterjee, Alexandros Georgakopoulos, Maria Kallieri, Andriana I. Papaioannou, Thomas Raptakis, Vasiliki Apollonatou, Elvira-Markela Antonogiannaki, Elias Gialafos, Elias Gialafos, Sofia Chatziioannou, Sofia Chatziioannou, Johan Grunewald, Effrosyni D. Manali

“…The hybrid molecular imaging of the 18F-FDG PET/CT scan, by unveiling the glucose metabolism of inflammatory cells, can identify high sensitivity inflammatory active granulomas, the hallmark of sarcoidosis—even in clinically and physiologically silent sites—and, as recently shown, is successful in identifying an unexpected ordered stratification into four phenotypes: (I) hilar–mediastinal nodal, (II) lungs and hilar–mediastinal nodal, (III) an extended nodal supraclavicular, thoracic, abdominal, inguinal, and (IV) all the above in addition to systemic organs and tissues, which is therefore the ideal phenotyping instrument. …”
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National and subnational burden of female and male breast cancer and risk factors in Iran from 1990 to 2019: results from the Global Burden of Disease study 2019 by Armin Aryannejad, Sahar Saeedi Moghaddam, Baharnaz Mashinchi, Mohammadreza Tabary, Negar Rezaei, Sarvenaz Shahin, Nazila Rezaei, GBD 2019 Iran Breast Cancer Collaborators, Mohsen Naghavi, Bagher Larijani, Farshad Farzadfar

“…Based on the GBD risk factors hierarchy, high fasting plasma glucose (FPG) and alcohol were estimated to have the most and the least attributed DALYs for BC among females, respectively. …”
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Myocardial infarction in the population of some Russian regions and its prognostic value by S. A. Shalnova, O. M. Drapkina, V. A. Kutsenko, A. V. Kapustina, G. A. Muromtseva, E. B. Yarovaya, Yu. A. Balanova, S. E. Evstifeeva, A. E. Imaeva, E. V. Shlyakhto, S. A. Boytsov, Z. T. Astakhova, O. L. Barbarash, O. A. Belova, Yu. I. Grinshtein, A. Yu. Efanov, O. N. Kalachikova, N. V. Kulakova, S. V. Nedogoda, O. P. Rotar, I. A. Trubacheva, T. M. Chernykh on behalf of the ESSE-RF study participants.

“…MI newly diagnosed within the follow-up  period was associated with the following risk factors (RFs): smoking, increased BP, HR, triglycerides and glucose.  For individuals with prior MI, a significant relationship was found only with smoking.  …”
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Pancreas Rejection in the Artificial Intelligence Era: New Tool for Signal Patients at Risk by Emanuel Vigia, Luís Ramalhete, Rita Ribeiro, Inês Barros, Beatriz Chumbinho, Edite Filipe, Ana Pena, Luís Bicho, Ana Nobre, Sofia Carrelha, Mafalda Sobral, Jorge Lamelas, João Santos Coelho, Aníbal Ferreira, Hugo Pinto Marques

“…In feature selection approach, it was possible to identify 10 features, namely: previous treatment for diabetes mellitus with long-term Insulin (U/I/day), type of dialysis (peritoneal dialysis, hemodialysis, or pre-emptive), de novo DSA, vPRA_Pre-Transplant (%), donor blood glucose, pancreas donor risk index (pDRI), recipient height, dialysis time (days), warm ischemia (minutes), recipient of intensive care (days). …”
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Different associations between amyloid-βeta 42, amyloid-βeta 40, and amyloid-βeta 42/40 with soluble phosphorylated-tau and disease burden in Alzheimer’s disease: a cerebrospinal f... by Caterina Motta, Martina Gaia Di Donna, Chiara Giuseppina Bonomi, Martina Assogna, Agostino Chiaravalloti, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana

“…Our study aimed to compare the ability of Aβ42 and amyR to detect AD pathology in terms of p-tau/Aβ42 ratio and brain glucose metabolic patterns using fluorodeoxyglucose-positron emission tomography (FDG-PET). …”
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Effects of Astragalus membranaceus extract and Eucommia ulmoides leaf extract on growth performance, blood biochemistry, and antioxidant capacity of gibel carp juveniles (Carassius... by Yan Lin, Siyue Lu, Farhan Aye Tahir, Qunlan Zhou, Linghong Miao, Bo Liu, Xianping Ge

“…After 8 weeks, A0.02E0 diet significantly increased the final body weight (FBW), weight gain rate (WGR), specific growth rate (SGR), and decreased the glucose (GLU), triglyceride content (TG), and total cholesterol (TC) of the plasma, the malonaldehyde (MDA) content of the liver, the A0E0.1 group significantly increased the total protein (TP) and albumin (ALB) content of the plasma, decreased the alanine aminotransferase (ALT) content of the plasma when compared with A0E0 group (Independent T-test: P < 0.05). …”
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Adipose and Plasma microRNAs miR-221 and 222 Associate with Obesity, Insulin Resistance, and New Onset Diabetes after Peritoneal Dialysis by Gordon Chun Kau Chan, Win Hlaing Than, Bonnie Ching Ha Kwan, Ka Bik Lai, Ronald Cheong Kin Chan, Jeremy Yuen Chun Teoh, Jack Kit Chung Ng, Kai Ming Chow, Phyllis Mei Shan Cheng, Man Ching Law, Chi Bon Leung, Philip Kam Tao Li, Cheuk Chun Szeto

“…We aimed to measure the adipose and plasma miR-221 and -222 levels, and to evaluate their association with adiposity, glucose intolerance, and new onset diabetes mellitus (NODM) after the commencement of PD. …”
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Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress by Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar, Kyle L. Hoehn

“…BH10 has improved cancer-selective toxicity compared to doxorubicin, 17-AAG, vitamin K3, and other known anti-cancer quinones. BH10 increases glucose oxidation via both mitochondrial and pentose phosphate pathways, decreases glycolysis, lowers GSH:GSSG and NAPDH/NAPD+ ratios exclusively in cancer cells, and induces necrosis. …”
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Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways by Gongyan Liu, Ce Liu, Yin Zhang, Haitao Sun, Liping Yang, Liya Bai, Shuxia Gao

“…In terms of serum biochemistry, the glucose levels were higher in autumn and winter than in spring and summer (<i>p</i> < 0.05). …”
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The modification of individual factors on association between serum 25(OH)D and incident type 2 diabetes: Results from a prospective cohort study by Zhiyong Hu, Zhiyong Hu, Xueyuan Zhi, Xueyuan Zhi, Yiming Ma, Jiafu Li, Jinxiu Wang, Jianliang Zhu, Bingyan Li, Zengli Zhang, Zengli Zhang

“…However, stratified analyses suggested a non-linear inverse relationship among individuals with baseline fasting plasma glucose (FPG) &lt;5.6 mmol/L (Poverall = 0.061, Pnon–linear = 0.048). …”
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The relationship between hair metabolites, air pollution exposure and gestational diabetes mellitus: A longitudinal study from pre-conception to third trimester by Xuyang Chen, Xuyang Chen, Xue Zhao, Xue Zhao, Mary Beatrix Jones, Alexander Harper, Jamie V. de Seymour, Yang Yang, Yang Yang, Yinyin Xia, Ting Zhang, Ting Zhang, Ting Zhang, Hongbo Qi, Hongbo Qi, Hongbo Qi, John Gulliver, Richard D. Cannon, Richard Saffery, Hua Zhang, Hua Zhang, Ting-Li Han, Ting-Li Han, Ting-Li Han, Philip N. Baker

“…BackgroundGestational diabetes mellitus (GDM) is a metabolic condition defined as glucose intolerance with first presentation during pregnancy. …”
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Effectiveness of Acid Gibberellic and Magnetic Field on Shelf Life and Post-Harvest Life of Strawberry cv. Selva under Temperature Stress Conditions by M.R. Zandi, A.H. Aboutalebi Jahromi, B. Behroznam, A.R. Zakerin

“…Ripe strawberry fruit contains compounds such as protein, fiber, sugars such as fructose, glucose, sucrose, organic acids, vitamins, minerals, as well as phenolic compounds and anthocyanins. …”
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Tau Cleavage Contributes to Cognitive Dysfunction in Strepto-Zotocin-Induced Sporadic Alzheimer’s Disease (sAD) Mouse Model by Valentina Latina, Giacomo Giacovazzo, Pietro Calissano, Anna Atlante, Federico La Regina, Francesca Malerba, Marco Dell’Aquila, Egidio Stigliano, Bijorn Omar Balzamino, Alessandra Micera, Roberto Coccurello, Giuseppina Amadoro

“…Intracerebroventricular (ICV) infusion of streptozotocin (STZ)—a compound used in the systemic induction of diabetes due to its ability to damage the pancreatic β cells and to induce insulin resistance—mimics in rodents several behavioral, molecular and histopathological hallmarks of sAD, including memory/learning disturbance, amyloid-β (Aβ) accumulation, tau hyperphosphorylation, oxidative stress and brain glucose hypometabolism. We have demonstrated that pathological truncation of tau at its N-terminal domain occurs into hippocampi from two well-established transgenic lines of fAD animal models, such as Tg2576 and 3xTg mice, and that it’s in vivo neutralization via intravenous (i.v.) administration of the cleavage-specific anti-tau 12A12 monoclonal antibody (mAb) is strongly neuroprotective. …”
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Protective role of Dodonaea viscosa extract against streptozotocin-induced hepatotoxicity and nephrotoxicity in rats by Ahmed Z. Alanazi, Salim S. Al-Rejaie, Mohammed M. Ahmed, Khalid Alhazzani, Khaled Alhosaini, Homood M. As Sobeai, Sary Alsanea, Perwez Alam, Omer M. Almarfadi, Ali S. Alqahtani, Abdullah S. Alhamed, Mohammed Alqinyah, Hussain N. Alhamami, Mohammed F. Almutery, Mohamed Mohany

“…Our findings demonstrated that D. viscosa dramatically decreased pro-inflammatory indicators in blood, kidney, and liver tissues as well as blood glucose, and restored insulin levels, and lipid profiles. …”
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M2 Macrophage‐Derived sEV Regulate Pro‐Inflammatory CCR2+ Macrophage Subpopulations to Favor Post‐AMI Cardiac Repair by Lan Li, Jiasong Cao, Sheng Li, Tianyi Cui, Jingyu Ni, Han Zhang, Yan Zhu, Jingyuan Mao, Xiumei Gao, Adam C. Midgley, Meifeng Zhu, Guanwei Fan

“…Analysis of M2EV microRNA content revealed abundant miR‐181b‐5p, which regulated macrophage glucose uptake, glycolysis, and mitigated mitochondrial reactive oxygen species generation. …”
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