Effects of GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation on offspring outcomes: a systematic review of the evidence by Dion R. P. Muller, Dion R. P. Muller, Dirk J. Stenvers, Dirk J. Stenvers, Arjan Malekzadeh, Frederik Holleman, Rebecca C. Painter, Rebecca C. Painter, Sarah E. Siegelaar, Sarah E. Siegelaar

“…Aims/hypothesisGlucagon-like peptide 1 (GLP-1) agonists and sodium-glucose co-transporter-2 (SGLT2) inhibitors are novel drugs which have recently seen rapid uptake in the treatment of type 2 diabetes and obesity. …”
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Predicting metabolic syndrome by obesity- and lipid-related indices in mid-aged and elderly Chinese: a population-based cross-sectional study by Yuqing Li, Jiaofeng Gui, Haiyang Liu, Lei-lei Guo, Jinlong Li, Yunxiao Lei, Xiaoping Li, Lu Sun, Liu Yang, Ting Yuan, Congzhi Wang, Dongmei Zhang, Huanhuan Wei, Jing Li, Mingming Liu, Ying Hua, Lin Zhang

“…We examined 13 indicators, including waist circumference (WC), body mass index (BMI), waist-height ratio (WHtR), visceral adiposity index (VAI), a body shape index (ABSI), body roundness index (BRI), lipid accumulation product index (LAP), conicity index (CI), Chinese visceral adiposity index (CVAI), triglyceride-glucose index (TyG-index) and their combined indices (TyG-BMI, TyG-WC, TyG-WHtR). …”
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Genetic variants in HFE are associated with non-alcoholic fatty liver disease in lean individuals by Zewen Sun, Xingchen Pan, Aowen Tian, Ida Surakka, Tao Wang, Xu Jiao, Shanshan He, Jinfang Song, Xin Tian, Dan Tong, Jianping Wen, Yonggang Zhang, Wanqing Liu, Peng Chen

“…Results: Lean NAFLD manifested a distinct metabolic profile, featured by elevated hepatic iron and fasting glucose. Four loci, namely, HFE rs1800562, SLC17A3-SLC17A2-TRIM38 rs9348697, PNPLA3 rs738409, and TM6SF2 rs58542926, were associated with lean NAFLD (p <5 × 10-8). …”
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O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4 by Ibtihal M. Alghusen, Marisa S. Carman, Heather Wilkins, Heather Wilkins, Heather Wilkins, Sophiya John Ephrame, Amy Qiang, Wagner B. Dias, Halyna Fedosyuk, Aspin R. Denson, Russell H. Swerdlow, Russell H. Swerdlow, Russell H. Swerdlow, Chad Slawson, Chad Slawson

“…An indirect downstream target of ATF4 mitochondrial chaperone glucose-regulated protein 75 (GRP75) is significantly elevated. …”
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Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development by Carline Chaves-Almagro, Johanna Auriau, Alizée Dortignac, Pascal Clerc, Hubert Lulka, Simon Deleruyelle, Fabrice Projetti, Jessica Nakhlé, Audrey Frances, Judit Berta, Véronique Gigoux, Daniel Fourmy, Marlène Dufresne, Anne Gomez-Brouchet, Julie Guillermet-Guibert, Pierre Cordelier, Bernard Knibiehler, Ralf Jockers, Philippe Valet, Yves Audigier, Bernard Masri

“…In human tumor cells, apelin induced a long-lasting activation of PI3K/Akt, upregulated β-catenin and the oncogenes c-myc and cyclin D1 and promoted proliferation, migration and glucose uptake. Apelin receptor blockades reduced cancer cell proliferation along with a reduction in pancreatic tumor burden. …”
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Estimation of life's essential 8 score with incomplete data of individual metrics by Yi Zheng, Tianyi Huang, Tianyi Huang, Marta Guasch-Ferre, Marta Guasch-Ferre, Marta Guasch-Ferre, Jaime Hart, Jaime Hart, Francine Laden, Francine Laden, Francine Laden, Jorge Chavarro, Jorge Chavarro, Jorge Chavarro, Eric Rimm, Eric Rimm, Eric Rimm, Brent Coull, Brent Coull, Hui Hu

“…BackgroundThe American Heart Association's Life's Essential 8 (LE8) is an updated construct of cardiovascular health (CVH), including blood pressure, lipids, glucose, body mass index, nicotine exposure, diet, physical activity, and sleep health. …”
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The Bioactivities and Chemical Profile of Turnip-Rooted Parsley Germplasm by Spyridon A. Petropoulos, Ângela Fernandes, Tiane C. Finimundy, Nikolaos Polyzos, José Pinela, Marija Ivanov, Marina Soković, Isabel C. F. R. Ferreira, Lillian Barros

“…Sucrose was the most abundant free sugar detected, especially in the “Sonata” cultivar (16.96 g/100 g dw), followed by apiose (2.93–5.55 g/100 g dw), glucose (1.3–3.47 g/100 g dw) and fructose (1.37–3.03 g/100 g dw). …”
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Ischemia and reperfusion injury combined with cisplatin induces immunogenic cell death in lung cancer cells by Shuai Zhang, Yumei Li, Shuqing Liu, Pei Ma, Mengfei Guo, E. Zhou, Limin Duan, Jinshuo Fan, Tingting Liao, Qi Tan, Xuan Wang, Feng Wu, Yang Jin

“…The in vitro model of I/R, oxygen-glucose deprivation and reperfusion (OGD/R), effectively induced CRT exposure, ATP secretion, high mobility group box 1 (HMGB1) release and eIF2α phosphorylation in both Lewis lung carcinoma (LLC) and A549 cells when combined with CDDP. …”
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Investigating the causal impact of polycystic ovary syndrome on gestational diabetes mellitus: a two-sample Mendelian randomization study by Guan Guixue, Guan Guixue, Guan Guixue, Pu Yifu, Tang Xiaofeng, Sun Qian, Sun Qian, Sun Qian, Gao Yuan, Gao Yuan, Gao Yuan, Yang Wen, Yang Wen, Yang Wen, Han Conghui, Han Conghui, Zhu Zuobin

“…However, the study did find a causal relationship between several other factors such as testosterone, high-density lipoprotein, sex hormone-binding globulin, body mass index, waist-hip ratio, apolipoprotein A-I, number of children, diabetes illnesses of mother, father and siblings, hemoglobin A1c, fasting insulin, fasting blood glucose, years of schooling, and GDM based on the IVW method.ConclusionWe observed no association between genetically predicted PCOS and the risk of GDM, implying that PCOS itself does not confer an increased susceptibility to GDM. …”
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High Expression of Solute Carrier Family 2 Member 1 (SLC2A1) in Cancer Cells Is an Independent Unfavorable Prognostic Factor in Pediatric Malignant Peripheral Nerve Sheath Tumor by Malgorzata A. Krawczyk, Michal Kunc, Malgorzata Styczewska, Anna Gabrych, Gabrielle Karpinsky, Ewa Izycka-Swieszewska, Ewa Bien

“…Tumor tissue microarrays were stained for hypoxia-inducible factor-1α (HIF1A), solute carrier family 2 member 1 (SLC2A1, also known as glucose transporter 1 (GLUT1)), carbonic anhydrase 9 (CA9), and vascular endothelial growth factor A (VEGFA) and classified into low- or high-expression groups. …”
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Prevalence of Abdominal Obesity in Chinese Middle-Aged and Older Adults with a Normal Body Mass Index and Its Association with Type 2 Diabetes Mellitus: A Nationally Representative... by Chen X, Duan M, Hou R, Zheng M, Li H, Singh M, Li C, Liu K, Zhang F, Yang X, Luo Y, He Y, Wu L, Zheng D

“…This positive association was observed in women but not in men or adults with normal glucose tolerance (NGT).Conclusion: Abdominal obesity is highly prevalent among middle-aged and older Chinese adults with a normal BMI, and maintaining a normal waist circumference may be beneficial in the prevention of T2DM.Keywords: abdominal obesity, normal body mass index, prevalence, type 2 diabetes mellitus, hazard ratio…”
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Effects of climate and environment on migratory old people with allergic diseases in China: Protocol for a Sanya cohort study by Qian Hu, Xiufeng Shi, Dan Wang, Yongzhen Huang, Jiashi Gao, Haidao Guan, Han Ren, Xiaoya Lin, Zhaoui Lu, Shilu Tong, Guiyan Yang, Shijian Liu

“…Blood samples were promptly tested routine blood test, liver function, kidney function, glucose, triglyceride, allergens, and inflammatory factors. …”
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Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya by Perez K. Olewe, Shehu Shagari Awandu, Elly O. Munde, Samuel B. Anyona, Evans Raballah, Asito S. Amolo, Sidney Ogola, Erick Ndenga, Clinton O. Onyango, Rosemary Rochford, Douglas J. Perkins, Collins Ouma

“…P. falciparum exerts strong selection pressure on sickle cell trait (SCT), alpha thalassemia (-α3.7/αα), glucose-6-phosphate dehydrogenase (G6PD), and merozoite surface protein 2 (MSP-2) variants (FC27, 3D7) that confer reduced malarial disease severity. …”
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In Vitro Evaluation of α-amylase and α-glucosidase Inhibition of 2,3-Epoxyprocyanidin C1 and Other Constituents from <i>Pterocarpus erinaceus</i> Poir by Romeo Toko Feunaing, Alfred Ngenge Tamfu, Abel Joel Yaya Gbaweng, Larissa Mekontso Magnibou, Fidele Ntchapda, Celine Henoumont, Sophie Laurent, Emmanuel Talla, Rodica Mihaela Dinica

“…The ability to inhibit α-amylase and α-glucosidase indicates that <i>P. erinaceus</i> and its compounds can lower blood glucose levels by delaying hydrolysis of carbohydrates into sugars, thereby providing a source of natural antidiabetic remedy.…”
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Vitamin D levels in seven non-identical occupational groups entail redefining of existing vitamin D deficiency diagnostic cut off level for native Bangladeshi population by Tahniyah Haq, Nehlin Tomalika, Masuda Mohsena, Hasina Momtaz, Akhter Banu, Mohammad Mainul Hasan Chowdhury, Kazi Natasha Hashem, Md Mohiuddin Tagar, Md. Shahed Morshed, MA Sayeed

“…Blood was collected for the estimation of 25(OH) vitamin D, fasting glucose,lipid profiles, calcium, phosphate, magnesium and intact parathyroid (iPTH) hormone. …”
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Integration of microRNA and mRNA analyses depicts the potential roles of Momordica charantia saponin administration in insulin resistance of juvenile common carp (Cyprinus carpio)... by Ze Fan, Liansheng Wang, Chenhui Li, Di Wu, Jinnan Li, Haitao Zhang, Siwei Xiong, Siwei Xiong, Linghong Miao, Xianping Ge, Zhengwei Li

“…Background: The regulation of target gene mRNA mediated by microRNA may play an important role in glucose metabolism in fish. Previous research findings of our research group revealed that Momordica charantia saponin (MS) administration in a high-starch diet could improve insulin resistance of common carp through renovating insulin signaling pathways, whose fundamental mechanisms have remained unknown by far. …”
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产卟啉杆菌对棕鞭藻絮凝收获的影响机制Influence mechanism of Porphyrobacter on flocculation harvest of Ochromonas sp. by 张波1,2，文然2，孙文昕2，苏琰儒1，任琴1 ZHANG Bo1,2, WEN Ran2, SUN Wenxin2, SU Yanru1, REN Qin1

“…In order to reveal the influence mechanism of Porphyrobacter on the flocculation harvest of Ochromonas sp., the flocculation efficiency of Ochromonas sp. in BG11 medium，BG11 medium containing 5 g/L glucose (glu+BG11) pure algal system and coculture system with Porphyrobacter were compared, and the algal organic matter (AOM) yield and composition and the community structure of bacteria in the phycosphere in different systems were analyzed. …”
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Real-World Evaluation of Demographics, Treatment Pattern, and Economic Burden of Heart Failure and Kidney Disease in Type 2 Diabetes Mellitus Patient Population in Dubai, United Ar... by Alaaeldin Bashier, Mohamed Farghaly, Juwairia Yousif Alali, Amna Khalifa AlHadari, Yasmin Ajaz, Vani Krishna Warrier, Elamin Abdelgadir, Muhammad Hamed Farooqi, Sana Qamar, Mohamed Alsayed, Mohamed Samir Fahmy, Dali Tannouri, Arun Jayarame Gowda, Nancy Syed Awad, Badarinath Chickballapur Ramachandrachar, Ashok Natarajan

“…A similar observation was noted with prescribing rates (0.6–4.4%) of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in cohorts 2–5. …”
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Auricularia auricula polysaccharides attenuate obesity in mice through gut commensal Papillibacter cinnamivorans by Xin Zong, Hao Zhang, Luoyi Zhu, Edward C. Deehan, Jie Fu, Yizhen Wang, Mingliang Jin

“…Results: High-fat diet (HFD) murine exposure to AAP thwarted weight gains, reduced fat depositing and enhanced glucose tolerance, together with upregulating thermogenesis proteomic biomarkers within adipose tissue. …”
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Gfi1 Loss Protects against Two Models of Induced Diabetes by Tiziana Napolitano, Fabio Avolio, Serena Silvano, Sara Forcisi, Anja Pfeifer, Andhira Vieira, Sergi Navarro-Sanz, Marika Elsa Friano, Chaïma Ayachi, Anna Garrido-Utrilla, Josipa Atlija, Biljana Hadzic, Jérôme Becam, Anette Sousa-De-Veiga, Magali Dodille Plaisant, Shruti Balaji, Didier F. Pisani, Magali Mondin, Philippe Schmitt-Kopplin, Ez-Zoubir Amri, Patrick Collombat

“…However, in depth analyses demonstrated a significant decrease in pancreatic <i>amylase</i> expression, leading to a diminution in intestinal carbohydrates processing and thus glucose absorption. In fact, <i>Gfi1</i>-deficient mice were found resistant to diet-induced hyperglycemia, appearing normoglycemic even after long-term high-fat/high-sugar diet. …”
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