-
51381
Effects of GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation on offspring outcomes: a systematic review of the evidence
Published 2023-10-01“…Aims/hypothesisGlucagon-like peptide 1 (GLP-1) agonists and sodium-glucose co-transporter-2 (SGLT2) inhibitors are novel drugs which have recently seen rapid uptake in the treatment of type 2 diabetes and obesity. …”
Get full text
Article -
51382
Predicting metabolic syndrome by obesity- and lipid-related indices in mid-aged and elderly Chinese: a population-based cross-sectional study
Published 2023-07-01“…We examined 13 indicators, including waist circumference (WC), body mass index (BMI), waist-height ratio (WHtR), visceral adiposity index (VAI), a body shape index (ABSI), body roundness index (BRI), lipid accumulation product index (LAP), conicity index (CI), Chinese visceral adiposity index (CVAI), triglyceride-glucose index (TyG-index) and their combined indices (TyG-BMI, TyG-WC, TyG-WHtR). …”
Get full text
Article -
51383
Genetic variants in HFE are associated with non-alcoholic fatty liver disease in lean individuals
Published 2023-07-01“…Results: Lean NAFLD manifested a distinct metabolic profile, featured by elevated hepatic iron and fasting glucose. Four loci, namely, HFE rs1800562, SLC17A3-SLC17A2-TRIM38 rs9348697, PNPLA3 rs738409, and TM6SF2 rs58542926, were associated with lean NAFLD (p <5 × 10-8). …”
Get full text
Article -
51384
O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4
Published 2023-12-01“…An indirect downstream target of ATF4 mitochondrial chaperone glucose-regulated protein 75 (GRP75) is significantly elevated. …”
Get full text
Article -
51385
Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development
Published 2022-09-01“…In human tumor cells, apelin induced a long-lasting activation of PI3K/Akt, upregulated β-catenin and the oncogenes c-myc and cyclin D1 and promoted proliferation, migration and glucose uptake. Apelin receptor blockades reduced cancer cell proliferation along with a reduction in pancreatic tumor burden. …”
Get full text
Article -
51386
Estimation of life's essential 8 score with incomplete data of individual metrics
Published 2023-07-01“…BackgroundThe American Heart Association's Life's Essential 8 (LE8) is an updated construct of cardiovascular health (CVH), including blood pressure, lipids, glucose, body mass index, nicotine exposure, diet, physical activity, and sleep health. …”
Get full text
Article -
51387
The Bioactivities and Chemical Profile of Turnip-Rooted Parsley Germplasm
Published 2022-07-01“…Sucrose was the most abundant free sugar detected, especially in the “Sonata” cultivar (16.96 g/100 g dw), followed by apiose (2.93–5.55 g/100 g dw), glucose (1.3–3.47 g/100 g dw) and fructose (1.37–3.03 g/100 g dw). …”
Get full text
Article -
51388
Ischemia and reperfusion injury combined with cisplatin induces immunogenic cell death in lung cancer cells
Published 2022-09-01“…The in vitro model of I/R, oxygen-glucose deprivation and reperfusion (OGD/R), effectively induced CRT exposure, ATP secretion, high mobility group box 1 (HMGB1) release and eIF2α phosphorylation in both Lewis lung carcinoma (LLC) and A549 cells when combined with CDDP. …”
Get full text
Article -
51389
Investigating the causal impact of polycystic ovary syndrome on gestational diabetes mellitus: a two-sample Mendelian randomization study
Published 2024-02-01“…However, the study did find a causal relationship between several other factors such as testosterone, high-density lipoprotein, sex hormone-binding globulin, body mass index, waist-hip ratio, apolipoprotein A-I, number of children, diabetes illnesses of mother, father and siblings, hemoglobin A1c, fasting insulin, fasting blood glucose, years of schooling, and GDM based on the IVW method.ConclusionWe observed no association between genetically predicted PCOS and the risk of GDM, implying that PCOS itself does not confer an increased susceptibility to GDM. …”
Get full text
Article -
51390
High Expression of Solute Carrier Family 2 Member 1 (SLC2A1) in Cancer Cells Is an Independent Unfavorable Prognostic Factor in Pediatric Malignant Peripheral Nerve Sheath Tumor
Published 2021-03-01“…Tumor tissue microarrays were stained for hypoxia-inducible factor-1α (HIF1A), solute carrier family 2 member 1 (SLC2A1, also known as glucose transporter 1 (GLUT1)), carbonic anhydrase 9 (CA9), and vascular endothelial growth factor A (VEGFA) and classified into low- or high-expression groups. …”
Get full text
Article -
51391
Prevalence of Abdominal Obesity in Chinese Middle-Aged and Older Adults with a Normal Body Mass Index and Its Association with Type 2 Diabetes Mellitus: A Nationally Representative...
Published 2021-12-01“…This positive association was observed in women but not in men or adults with normal glucose tolerance (NGT).Conclusion: Abdominal obesity is highly prevalent among middle-aged and older Chinese adults with a normal BMI, and maintaining a normal waist circumference may be beneficial in the prevention of T2DM.Keywords: abdominal obesity, normal body mass index, prevalence, type 2 diabetes mellitus, hazard ratio…”
Get full text
Article -
51392
Effects of climate and environment on migratory old people with allergic diseases in China: Protocol for a Sanya cohort study
Published 2023-11-01“…Blood samples were promptly tested routine blood test, liver function, kidney function, glucose, triglyceride, allergens, and inflammatory factors. …”
Get full text
Article -
51393
Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya
Published 2023-06-01“…P. falciparum exerts strong selection pressure on sickle cell trait (SCT), alpha thalassemia (-α3.7/αα), glucose-6-phosphate dehydrogenase (G6PD), and merozoite surface protein 2 (MSP-2) variants (FC27, 3D7) that confer reduced malarial disease severity. …”
Get full text
Article -
51394
In Vitro Evaluation of α-amylase and α-glucosidase Inhibition of 2,3-Epoxyprocyanidin C1 and Other Constituents from <i>Pterocarpus erinaceus</i> Poir
Published 2022-12-01“…The ability to inhibit α-amylase and α-glucosidase indicates that <i>P. erinaceus</i> and its compounds can lower blood glucose levels by delaying hydrolysis of carbohydrates into sugars, thereby providing a source of natural antidiabetic remedy.…”
Get full text
Article -
51395
Vitamin D levels in seven non-identical occupational groups entail redefining of existing vitamin D deficiency diagnostic cut off level for native Bangladeshi population
Published 2023-03-01“…Blood was collected for the estimation of 25(OH) vitamin D, fasting glucose,lipid profiles, calcium, phosphate, magnesium and intact parathyroid (iPTH) hormone. …”
Get full text
Article -
51396
Integration of microRNA and mRNA analyses depicts the potential roles of Momordica charantia saponin administration in insulin resistance of juvenile common carp (Cyprinus carpio)...
Published 2023-04-01“…Background: The regulation of target gene mRNA mediated by microRNA may play an important role in glucose metabolism in fish. Previous research findings of our research group revealed that Momordica charantia saponin (MS) administration in a high-starch diet could improve insulin resistance of common carp through renovating insulin signaling pathways, whose fundamental mechanisms have remained unknown by far. …”
Get full text
Article -
51397
产卟啉杆菌对棕鞭藻絮凝收获的影响机制Influence mechanism of Porphyrobacter on flocculation harvest of Ochromonas sp.
Published 2023-01-01“…In order to reveal the influence mechanism of Porphyrobacter on the flocculation harvest of Ochromonas sp., the flocculation efficiency of Ochromonas sp. in BG11 medium,BG11 medium containing 5 g/L glucose (glu+BG11) pure algal system and coculture system with Porphyrobacter were compared, and the algal organic matter (AOM) yield and composition and the community structure of bacteria in the phycosphere in different systems were analyzed. …”
Get full text
Article -
51398
Real-World Evaluation of Demographics, Treatment Pattern, and Economic Burden of Heart Failure and Kidney Disease in Type 2 Diabetes Mellitus Patient Population in Dubai, United Ar...
Published 2023-06-01“…A similar observation was noted with prescribing rates (0.6–4.4%) of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in cohorts 2–5. …”
Get full text
Article -
51399
Auricularia auricula polysaccharides attenuate obesity in mice through gut commensal Papillibacter cinnamivorans
Published 2023-10-01“…Results: High-fat diet (HFD) murine exposure to AAP thwarted weight gains, reduced fat depositing and enhanced glucose tolerance, together with upregulating thermogenesis proteomic biomarkers within adipose tissue. …”
Get full text
Article -
51400
Gfi1 Loss Protects against Two Models of Induced Diabetes
Published 2021-10-01“…However, in depth analyses demonstrated a significant decrease in pancreatic <i>amylase</i> expression, leading to a diminution in intestinal carbohydrates processing and thus glucose absorption. In fact, <i>Gfi1</i>-deficient mice were found resistant to diet-induced hyperglycemia, appearing normoglycemic even after long-term high-fat/high-sugar diet. …”
Get full text
Article