Characterization and Process Optimization for Enhanced Production of Polyhydroxybutyrate (PHB)-Based Biodegradable Polymer from <i>Bacillus flexus</i> Isolated from Municipal Solid... by Mohd Adnan, Arif Jamal Siddiqui, Syed Amir Ashraf, Mejdi Snoussi, Riadh Badraoui, Angum M. M. Ibrahim, Mousa Alreshidi, Manojkumar Sachidanandan, Mitesh Patel

“…The highest PHB production by <i>B. flexus</i> was obtained after 48 h of incubation (3.9 g/L) at pH 7.0 (3.7 g/L), 35 °C (3.5 g/L) with glucose (4.1 g/L) and peptone (3.4 g/L) as carbon and nitrogen sources, respectively. …”
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Targeting YAP1‐regulated Glycolysis in Fibroblast‐Like Synoviocytes Impairs Macrophage Infiltration to Ameliorate Diabetic Osteoarthritis Progression by Jie Yang, Shanshan Li, Zhenyan Li, Lutian Yao, Meijing Liu, Kui‐Leung Tong, Qiutong Xu, Bo Yu, Rui Peng, Tao Gui, Wang Tang, Yidi Xu, Jiaxu Chen, Jun He, Kewei Zhao, Xiaogang Wang, Xiaoying Wang, Zhengang Zha, Huan‐Tian Zhang

“…In addition, the yes‐associated protein 1 (YAP1)/thioredoxin‐interacting protein (TXNIP) signaling axis is demonstrated to play a crucial role in regulating glucose transporter 1 (GLUT1)‐dependent glycolysis in FLSs, thereby controlling the expression of a series of adhesion molecules such as intercellular adhesion molecule‐1 (ICAM‐1) which may subsequently fine‐tune the infiltration of M1‐polarized synovial macrophages in DOA patients and db/db diabetic OA mice. …”
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Radiological Findings Increased the Successful of COVID-19 Diagnosis in Hospitalized Patients Suspected of Respiratory Viral Infection but with a Negative First SARS-CoV-2 RT-PCR R... by Margarita L Martinez-Fierro, Carolina González-Fuentes, Dagoberto Cid-Guerrero, Samantha González Delgado, Santiago Carrillo-Martínez, Edgar Fernando Gutierrez-Vela, Juan Yadid Calzada-Luévano, Maria R. Rocha-Pizaña, Jacqueline Martínez-Rendón, Maria E. Castañeda-López, Idalia Garza-Veloz

“…There were differences between the groups in the platelet count and the levels of D-dimer, procalcitonin, and glucose (<i>p</i> < 0.05). Chest CT scans categorized as COVID-19 Reporting and Data System 5 (CO-RADS 5) were more frequent in the COVID-19 group than in the control group (91.7% vs. 52.6%; <i>p</i> = 0.003). …”
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Simultaneously Screening for Liver Steatosis and Fibrosis in Romanian Type 2 Diabetes Mellitus Patients Using Vibration-Controlled Transient Elastography with Controlled Attenuatio... by Anca Trifan, Ermina Stratina, Robert Nastasa, Adrian Rotaru, Remus Stafie, Sebastian Zenovia, Laura Huiban, Catalin Sfarti, Camelia Cojocariu, Tudor Cuciureanu, Cristina Muzica, Stefan Chiriac, Irina Girleanu, Ana-Maria Singeap, Carol Stanciu

“…In multivariate analyses, BMI (β = 0.349, <i>p</i> < 0.001), fasting plasma glucose (β = 0.211, <i>p</i> = 0.006), and triglycerides (β = 0.132, <i>p</i> = 0.044) were predictors of S3. …”
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Prognostic effect of stress hyperglycemia ratio on patients with severe aortic stenosis receiving transcatheter aortic valve replacement: a prospective cohort study by Xiangming Hu, Dejing Feng, Yuxuan Zhang, Can Wang, Yang Chen, Guannan Niu, Zheng Zhou, Zhenyan Zhao, Hongliang Zhang, Moyang Wang, Yongjian Wu

“…The formula used to determine SHR was as follows: admission blood glucose (mmol/L)/(1.59×HbA1c[%]–2.59). The primary endpoint was defined as all-cause mortality, while secondary endpoints included a composite of cardiovascular mortality or readmission for heart failure, and major adverse cardiovascular events (MACE) including cardiovascular mortality, non-fatal myocardial infarction, and non-fatal stroke. …”
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Mulberry leaf extract improves non-specific immunity and antioxidant capacity of largemouth bass (Micropterus salmoides) fed a high-starch diet by Jing Tingsen, Luo Hui, Luo Hui, Huang Junwa, Li Zhe, Li Yu, Jin Honghao, Zou Xinxi, Ke Zhenlin, Sun Wenbo, Hou Mengdan, Yang Huijun, Ye Hua, Ye Hua

“…Plasma C3 levels in the MLE3, MLE4, and MLE5 groups were significantly higher than those in the HSD group. In addition, glucose (GLU) levels in the MLE3, MLE4, and MLE5 groups were significantly lower than those in the HSD group. …”
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Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke by Ni Wang, Ni Wang, Ni Wang, Ni Wang, Ni Wang, Furui Chu, Furui Chu, Furui Chu, Furui Chu, Furui Chu, Lijuan Zhang, Lijuan Zhang, Changyi Fei, Changyi Fei, Chao Yu, Chao Yu, Sujun Xue, Sujun Xue, Yongzhong Wang, Ling Fang, Daiyin Peng, Daiyin Peng, Daiyin Peng, Xianchun Duan, Xianchun Duan, Xianchun Duan, Xianchun Duan, Xianchun Duan, Weidong Chen, Weidong Chen, Weidong Chen

“…Therefore, we constructed an IS model (I/R) in rats and performed oxygen-glucose deprivation/reoxygenation (OGD/R) on BV2 cells. …”
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Epidemic Status, Disease Burden and Prediction of Cardiovascular Diseases in China, 1990-2019 by YANG Ji, ZHANG Yao, MA Teng, TIAN Xintong, ZHAO Yingqiang

“…Risk factors associated with death from cardiovascular diseases mainly included smoking, second-hand smoke, alcohol consumption, low physical activity, high fasting blood glucose, high systolic blood pressure, high BMI, high low density lipoprotein cholesterol and renal insufficiency. …”
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The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside by María B. Birkisdóttir, María B. Birkisdóttir, Ivar van Galen, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Pier G. Mastroberardino, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij, Wilbert P. Vermeij

“…Here, we further utilize the short lifespan and early onset of signs of neurological degeneration in Ercc1Δ/− and Xpg−/− mice to test compounds that influence nutrient sensing (metformin, acarbose, resveratrol), inflammation (aspirin, ibuprofen), mitochondrial processes (idebenone, sodium nitrate, dichloroacetate), glucose homeostasis (trehalose, GlcNAc) and nicotinamide adenine dinucleotide (NAD+) metabolism. …”
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Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kβ inhibition on metabolic pathway activities in a PTEN null breast cancer cell line by Marcel Lackner, Marcel Lackner, Sylvia K. Neef, Sylvia K. Neef, Stefan Winter, Stefan Winter, Sandra Beer-Hammer, Sandra Beer-Hammer, Bernd Nürnberg, Matthias Schwab, Matthias Schwab, Matthias Schwab, Matthias Schwab, Ute Hofmann, Ute Hofmann, Mathias Haag, Mathias Haag

“…Cells were fed with [U-13C] glucose and treated for 1, 3, 6, and 24 h with 0.5 µM AZD8186 or vehicle, extracted by an optimized sample preparation protocol and analyzed by LC-QTOF-MS. …”
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Pyridyl Methylsulfinyl Benzimidazole Derivatives as Promising Agents against <i>Giardia lamblia</i> and <i>Trichomonas vaginalis</i> by Beatriz Hernández-Ochoa, Víctor Martínez-Rosas, Laura Morales-Luna, Ernesto Calderón-Jaimes, Luz María Rocha-Ramírez, Daniel Ortega-Cuellar, Yadira Rufino-González, Abigail González-Valdez, Roberto Arreguin-Espinosa, Sergio Enríquez-Flores, Rosa Angélica Castillo-Rodríguez, Noemí Cárdenas-Rodríguez, Carlos Wong-Baeza, Isabel Baeza-Ramírez, Saúl Gómez-Manzo

“…Here, we tested five synthesized benzimidazole derivatives as possible drugs for treating giardiasis and trichomoniasis, probing the bifunctional enzyme glucose 6-phosphate dehydrogenase::6-phosphogluconolactone from <i>G. lamblia</i> (GlG6PD::6PGL) and <i>T. vaginalis</i> (TvG6PD::6PGL) as a drug target. …”
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<i>Cannabis sativa</i> L. Inflorescences from Monoecious Cultivars Grown in Central Italy: An Untargeted Chemical Characterization from Early Flowering to Ripening by Cinzia Ingallina, Anatoly P. Sobolev, Simone Circi, Mattia Spano, Caterina Fraschetti, Antonello Filippi, Antonella Di Sotto, Silvia Di Giacomo, Giulia Mazzoccanti, Francesco Gasparrini, Deborah Quaglio, Enio Campiglia, Simone Carradori, Marcello Locatelli, Giuliana Vinci, Mattia Rapa, Salvatore Ciano, Anna Maria Giusti, Bruno Botta, Francesca Ghirga, Donatella Capitani, Luisa Mannina

“…Citric acid, malic acid and glucose showed the highest content in the late flowering period, whereas the content of proline drastically decreased after June in all cultivars. …”
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A case report of anti-GAD65 antibody-positive autoimmune encephalitis in children associated with autoimmune polyendocrine syndrome type-II and literature review by Tamang Sapana, Wei Li, Fengyan Tian, Wenhao Yan, Binghua Dou, Shuang Hua, Zhihong Zhuo

“…At presentation, he had uncontrolled blood glucose levels with elevated HbA1c levels. Additionally, the serum and CSF autoantibodies were positive against the anti-GAD65 antibody with the titer of 1:100 and 1:32 respectively. …”
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The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals by Justin D. Roberts, Ashley G. B. Willmott, Liam Beasley, Mariette Boal, Rory Davies, Laurence Martin, Havovi Chichger, Lata Gautam, Juan Del Coso

“…Fat oxidation (‘FAT_MAX’ and steady state exercise protocols), body composition, cardio-metabolic and blood measures (serum glucose, insulin, leptin, adiponectin, glycerol, free fatty acids, total cholesterol, high [HDL-c] and low-density lipoprotein cholesterol [LDL-c], triglycerides, liver enzymes and bilirubin) were assessed at baseline, week 4 and 8. …”
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Puerarin Inhibits NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis via P2X7 Receptor in Cardiomyocytes and Macrophages by Shuchan Sun, Difei Gong, Ruiqi Liu, Ranran Wang, Di Chen, Tianyi Yuan, Shoubao Wang, Cheng Xing, Yang Lv, Guanhua Du, Lianhua Fang

“…Additionally, we employed D-glucose-induced H9C2 rat cardiomyocytes and lipopolysaccharide-treated RAW264.7 mouse mononuclear macrophages as the in vitro model on DCM research, which is close to the pathological conditions. …”
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Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy by Abd El hakim Ramadan, Mahmoud M.A. Elsayed, Amani Elsayed, Marwa A. Fouad, Mohamed S. Mohamed, Sangmin Lee, Reda A. Mahmoud, Shereen A. Sabry, Mohammed M. Ghoneim, Ahmed H.E. Hassan, Reham A. Abd Elkarim, Amany Belal, Ahmed A. El-Shenawy

“…VLD-SLNPs-OCUs might benefit retinal microvascular blood flow beyond blood glucose control and may be considered a promising approach to treating diabetic retinopathy.…”
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Intrauterine Growth Restriction Affects Colonic Barrier Function <i>via</i> Regulating the Nrf2/Keap1 and TLR4-NF-κB/ERK Pathways and Altering Colonic Microbiome and Metabolome Hom... by Liang Xiong, Md. Abul Kalam Azad, Yang Liu, Wanghong Zhang, Qian Zhu, Chengjun Hu, Jinming You, Xiangfeng Kong

“…IUGR altered the concentrations of plasma glucose, total protein, triglycerides, and cholesterol. …”
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ANÁLISIS DE RESISTENCIA INSULÍNICA, TOLERANCIA A LA GLUCOSA Y TESTOSTERONA EN MUJERES JÓVENES CON SÍNDROME DE OVARIO POLIQUÍSTICO AGRUPADAS POR ÍNDICE DE MASA CORPORAL by María José del Río V, Juan Pablo Ramírez M, Manuel E. Cortés, Gerardo Martí O, Ana Godoy R, Pilar Vigil P

“…Total testosterone, 2-h oral glucose tolerance test (OGTT), and body mass index (BMI) were performed in all patients. …”
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Regulation of Fungal Morphogenesis and Pathogenicity of <i>Aspergillus flavus</i> by Hexokinase AfHxk1 through Its Domain Hexokinase_2 by Zongting Huang, Dandan Wu, Sile Yang, Wangzhuo Fu, Dongmei Ma, Yanfang Yao, Hong Lin, Jun Yuan, Yanling Yang, Zhenhong Zhuang

“…Hexokinase AfHxk1 is a critical enzyme in fungal glucose metabolism. However, the role of AfHxk1 in <i>A. flavus</i> development, aflatoxin biosynthesis, and virulence has not yet been explored. …”
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油茶蒲纯化多糖的制备与组分、结构分析Preparation and component, structure analysis of purified polysaccharides from Camellia oleifera fruit hull by 舒斌斌1,2,3，吴苏喜1,2,3，谢妍祎1，袁成华2，冯宗义3SHU Binbin1,2,3, WU Suxi1,2,3, XIE Yanyi1，YUAN Chenghua2，FENG Zongyi3

“…The monosaccharide composition of the purified polysaccharide of Camellia oleifera fruit hull was fucose 0.64%, arabinose 7.68%, galactose 3.74%, glucose 76.43%, xylose 2.77%, mannose 1.60%, galacturonic acid 5.34%, glucuronic acid 1.33%, and mannuronic acid 0.47%. …”
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