Development and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells by Ana Santos-Rebelo, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Carla Eleutério, Mariana Figueira, Ana S. Viana, Lia Ascensão, Jesús Molpeceres, Patrícia Rijo, Isabel Correia, Joana Amaral, Susana Solá, Cecília M. P. Rodrigues, Maria Manuela Gaspar, Catarina Pinto Reis

“…Albumin nanoparticles (BSA NPs) were produced through a desolvation method. Glucose cross-linking and bioactive functionalization profiles of BSA platform were elucidated and analysed using static lattice atomistic simulations in vacuum. …”
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Prospective Study Reveals Host Microbial Determinants of Clinical Response to Fecal Microbiota Transplant Therapy in Type 2 Diabetes Patients by Dafa Ding, Huijuan Yong, Na You, Wei Lu, Xu Yang, Xu Yang, Xu Yang, Xiaolong Ye, Yayun Wang, Tingting Cai, Xiaoling Zheng, Hui Chen, Bota Cui, Faming Zhang, Xingyin Liu, Jian-Hua Mao, Jian-Hua Mao, Yibing Lu, Hang Chang, Hang Chang

“…We observed a statistically significant decrease in HbA1c% (from 7.565 ± 0.148 to 7.190 ± 0.210, p<0.01), blood glucose (from 8.483 ± 0.497 to 7.286 ± 0.454 mmol/L, p<0.01), and uric acid (from 309.4 ± 21.5 to 259.1 ± 15.8 µmol/L, p<0.01) while a significant increase in postprandial C-peptide (from 4.503 ± 0.600 to 5.471 ± 0.728 ng/ml, p<0.01) at 12 weeks after FMT. …”
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Co-Treatment of Purified Annatto Oil (<i>Bixa orellana</i> L.) and Its Granules (Chronic^®) Improves the Blood Lipid Profile and Bone Protective Effects of Testosterone i... by Arlindo César Matias Pereira, Helison de Oliveira Carvalho, Danna Emanuelle Santos Gonçalves, Karyny Roberta Tavares Picanço, Abrahão Victor Tavares de Lima Teixeira dos Santos, Heitor Ribeiro da Silva, Francinaldo Sarges Braga, Roberto Messias Bezerra, Alessandro de Sousa Nunes, Maira Tiyomi Sacata Tongo Nazima, Júlia Gomes Cerqueira, Talisson Taglialegna, Janayra Maris Teixeira, José Carlos Tavares Carvalho

“…The following parameters were evaluated: food/water intake, weight, HDL, LDL, glucose, triglycerides (TG), total cholesterol (TC), alkaline phosphatase levels, blood phosphorus and calcium contents, femur weight, structure (through scanning electron microscopy), and calcium content (through atomic absorption spectrophotometry). …”
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The effects of cool roofs on health, environmental, and economic outcomes in rural Africa: study protocol for a community-based cluster randomized controlled trial by Aditi Bunker, Guillaume Compoaré, Maquins Odhiambo Sewe, Jose Guillermo Cedeno Laurent, Pascal Zabré, Valentin Boudo, Windpanga Aristide Ouédraogo, Lucienne Ouermi, Susan T. Jackson, Nicholas Arisco, Govind Vijayakumar, Ferhat Baran Yildirim, Sandra Barteit, Martina Anna Maggioni, Alistair Woodward, Jonathan J. Buonocore, Mekdim Dereje Regassa, Tilman Brück, Ali Sié, Till Bärnighausen

“…We are collecting outcome data on one primary endpoint - heart rate, (a measure of heat stress) and 22 secondary outcomes encompassing indoor climate parameters, blood pressure, body temperature, heat-related outcomes, blood glucose, sleep, cognition, mental health, health facility utilization, economic and productivity outcomes, mosquito count, life satisfaction, gender-based violence, and food consumption. …”
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Nanomicellar Formulations Loaded with Histamine and Paclitaxel as a New Strategy to Improve Chemotherapy for Breast Cancer by Melisa B. Nicoud, Ignacio A. Ospital, Mónica A. Táquez Delgado, Jennifer Riedel, Pedro Fuentes, Ezequiel Bernabeu, Mara R. Rubinstein, Paolo Lauretta, Rocío Martínez Vivot, María de los Ángeles Aguilar, María J. Salgueiro, Daniela Speisky, Marcela A. Moretton, Diego A. Chiappetta, Vanina A. Medina

“…The aim of this work is to improve the therapeutic index of PTX through the design and characterization of novel nanomicellar polymeric formulations composed of a biocompatible copolymer Soluplus^® (S), surface-decorated with glucose (GS), and co-loaded either with histamine (HA, 5 mg/mL) and/or PTX (4 mg/mL). …”
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Association of outdoor artificial light at night with metabolic syndrome and the modifying effect of tree and grass cover by Weizhuo Yi, Weiqiang Wang, Zhiwei Xu, Li Liu, Ning Wei, Rubing Pan, Rong Song, Xuanxuan Li, Jintao Liu, Jiajun Yuan, Jian Song, Jian Cheng, Yuee Huang, Hong Su

“…MetS was defined by fasting blood glucose (FG), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), blood pressure (BP), and waist circumference (WC). …”
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Intramuscular [¹⁸F]F-FDG Administration for Successful PET Imaging of Golden Hamsters in a Maximum Containment Laboratory Setting by Hui Wang, Jurgen Seidel, Christopher Bartos, Russell Byrum, Philip J. Sayre, Kurt Cooper, Yu Cong, Dong-Yun Kim, Claudia Calcagno, Jens H. Kuhn, Anya Crane, Jiro Wada, Reed F. Johnson, Dima A. Hammoud, Ji Hyun Lee

“…We propose the use of intramuscular (IM) administration of 2-deoxy-2[¹⁸F]fluoro-D-glucose ([¹⁸F]F-FDG) for PET imaging of hamsters in a biosafety level 4 (BSL-4) laboratory setting. …”
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Empagliflozin is associated with lower cardiovascular risk compared with dipeptidyl peptidase-4 inhibitors in adults with and without cardiovascular disease: EMPagliflozin compaRat... by Dorte Vistisen, Bendix Carstensen, Patorno Elisabetta, Stefanie Lanzinger, Elise Chia-Hui Tan, Daisuke Yabe, Dae Jung Kim, Wayne H.-H. Sheu, Cheli Melzer-Cohen, Reinhard W. Holl, Júlio Núñez, Kyoung Hwa Ha, Sigrun Halvorsen, Gisle Langslet, Avraham Karasik, Thomas Nyström, Leo Niskanen, Sonia Guleria, Riho Klement, Marc Carrasco, Johannes Foersch, Christina Shay, Lisette Koeneman, Fabian Hoti, Soulmaz Fazeli Farsani, Kamlesh Khunti, Francesco Zaccardi, Anuradhaa Subramanian, Krishnarajah Nirantharakumar, EMPRISE EU, East Asia Study Group

“…Abstract Background Studies that have reported lower risk for cardiovascular outcomes in users of Sodium–Glucose Cotransporter-2 Inhibitors (SGLT-2i) are limited by residual cofounding and lack of information on prior cardiovascular disease (CVD). …”
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Variety and quantity of dietary protein intake from different sources and risk of new-onset diabetes: a Nationwide Cohort Study in China by Chun Zhou, Chengzhang Liu, Zhuxian Zhang, Mengyi Liu, Yuanyuan Zhang, Huan Li, Panpan He, Qinqin Li, Xianhui Qin

“…New-onset diabetes was defined as self-reported physician-diagnosed diabetes or fasting glucose ≥7.0mmol/L or glycated hemoglobin ≥6.5% during the follow-up. …”
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SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter by Zhenyang Guo, Xueting Yu, Shuang Zhao, Xin Zhong, Dong Huang, Runyang Feng, Peng Li, Zheyan Fang, Yiqing Hu, Zhentao Zhang, Mukaddas Abdurahman, Lei Huang, Yun Zhao, Xiangdong Wang, Junbo Ge, Hua Li

“…Methods The HUVECs model of oxygen–glucose deprivation/reperfusion (OGD/R) was established to simulate the endothelial IRI in vitro. …”
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Effects of bisphenol A exposure at different circadian time on hepatic lipid metabolism in mice by Yan ZHANG, Min WANG, Mengya ZHOU, Zhitian LU, Xudong LI, Huihong ZHANG, Fan WU, Runxuan ZHUANG, Zhini HE, Wenxue LI, Guangyu YANG, Wei ZHU, Bo ZHANG

“…At ZT3 and ZT15, BPA did not alter body weight, plasma glucose, plasma total cholesterol, plasma low density lipoprotein cholesterol, and plasma triglycerides (P>0.05). …”
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The Effects of Eight Weeks’ Very Low-Calorie Ketogenic Diet (VLCKD) on Liver Health in Subjects Affected by Overweight and Obesity by Roberta Rinaldi, Sara De Nucci, Fabio Castellana, Martina Di Chito, Vito Giannuzzi, Endrit Shahini, Roberta Zupo, Luisa Lampignano, Giuseppina Piazzolla, Vincenzo Triggiani, Raffaele Cozzolongo, Gianluigi Giannelli, Giovanni De Pergola

“…Moreover, fasting blood glucose, insulin, triglycerides, total cholesterol, LDL-cholesterol, ALT, γGT, and FT3 blood concentrations, as well as insulin resistance (quantified by HOMAIR) and systolic and diastolic blood pressure levels, were significantly lower after VLCKD (<i>p</i> < 0.01 for all the parameters). …”
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Relationship between sheep feces scores and gastrointestinal microorganisms and their effects on growth traits and blood indicators by Xiaobin Yang, Jianghui Wang, Jiangbo Cheng, Deyin Zhang, Kai Huang, Yukun Zhang, Xiaolong Li, Yuan Zhao, Liming Zhao, Dan Xu, Zongwu Ma, Jia Liu, Zhiqiang Huang, Chong Li, Huibin Tian, Xiuxiu Weng, Weimin Wang, Xiaoxue Zhang

“…Significant differences were observed in Aspartate aminotransferase, Glucose, Total bilirubin, and Red Blood Cell Count between groups (p &lt; 0.05). …”
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Design, Synthesis, and Development of Pyrazolo[1,5-<i>a</i>]pyrimidine Derivatives as a Novel Series of Selective PI3K<i>δ</i> Inhibitors: Part II—Benzimidazole Derivatives by Mariola Stypik, Stanisław Michałek, Nina Orłowska, Marcin Zagozda, Maciej Dziachan, Martyna Banach, Paweł Turowski, Paweł Gunerka, Daria Zdżalik-Bielecka, Aleksandra Stańczak, Urszula Kędzierska, Krzysztof Mulewski, Damian Smuga, Wioleta Maruszak, Lidia Gurba-Bryśkiewicz, Arkadiusz Leniak, Wojciech Pietruś, Zbigniew Ochal, Mateusz Mach, Beata Zygmunt, Jerzy Pieczykolan, Krzysztof Dubiel, Maciej Wieczorek

“…Due to the high expression of these proteins in many human cells and their involvement in metabolism regulation, normal embryogenesis, or maintaining glucose homeostasis, the inhibition of PI3K (especially the first class which contains four subunits: <i>α</i>, <i>β</i>, <i>γ</i>, <i>δ</i>) is considered to be a promising therapeutic strategy for the treatment of inflammatory and autoimmune diseases such as systemic lupus erythematosus (SLE) or multiple sclerosis. …”
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Pesquisa sobre escleroterapia líquida em varizes dos membros inferiores Survey on liquid sclerotherapy of lower limb varicose veins by Marcondes Figueiredo, Matheus Fidelis Figueiredo

“…Gloves were worn during the procedure by 79.74% of the physicians; compression was employed by 52.59%; regarding physical activity after sclerotherapy , 46.12% of the physicians did not restrict, while 52.59% of them approved exercise after 1-3 days; ways to reduce pain during the procedure were used by 43.53% of the respondents; glucose 75% turned out to be the sclerosing agent most used by 35.34%; the most frequent systemic complication was lipothymia at 7.76%, and the most frequent local complication was hyperchromia at 66.38%; regarding sun exposure after the procedure: 28.02% released after the sclerotherapy with sunscreen, 24.57% after 15-30 days, and 25.43% after a period less than 15 days. …”
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The <i>Opuntia</i> Effect Improves Dam-Kid Metabolic Markers, Augments Colostrum Quality and Enhances Kid-To-Dam Behavioral Interactions in Crossbred Goats and their Offspring unde... by Francisco G. Véliz-Deras, César A. Meza-Herrera, Sharon Herrera-Hernandez, Arnoldo Flores-Hernández, Juan M. Guillén-Muñoz, Cayetano Navarrete-Molina, Silvestre Moreno-Avalos, Rafael Rodríguez-Martínez

“…LW, BCS, and blood samples to quantify serum glucose (GLU) levels were collected weekly from day −25 up to day +15 in both dams (pre- and post-partum) and kids (post-partum). …”
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Metabolite patterns associated with individual response to supervised exercise therapy in patients with intermittent claudication by Tiffany R. Bellomo, MD, Noah L. Tsao, BS, Hillary Johnston-Cox, MD, Kamil Borkowski, PhD, Gabrielle Shakt, BS, Renae Judy, MS, Jonni Moore, PhD, Sarah J. Ractcliffe, PhD, Oliver Fiehn, PhD, Thomas F. Floyd, MD, Felix W. Wehrli, PhD, Emile Mohler, MD, John W. Newman, PhD, Scott M. Damrauer, MD

“…This alters energy expenditure in myoblasts by decreasing glucose uptake and may induce an acquired skeletal muscle myopathy. …”
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Long-term green-Mediterranean diet may favor fasting morning cortisol stress hormone; the DIRECT-PLUS clinical trial by Liav Alufer, Gal Tsaban, Ehud Rinott, Alon Kaplan, Anat Yaskolka Meir, Hila Zelicha, Uta Ceglarek, Berend Isermann, Matthias Blüher, Matthias Blüher, Michael Stumvoll, Michael Stumvoll, Meir J. Stampfer, Meir J. Stampfer, Iris Shai, Iris Shai, Iris Shai

“…Higher baseline FMC was directly associated with age, dysglycemia, MRI-assessed visceral adiposity, fasting plasma glucose (FPG), high-sensitivity C-reactive-protein (hsCRP), testosterone, Progesterone and TSH levels (p ≤ 0.05 for all). …”
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基础胰岛素治疗2型糖尿病的有效性、安全性、初始最佳剂量和最佳维持剂量范围:一项meta分析的系统综述 by Yingying Luo, Jun Xia, Zhan Zhao, Yaping Chang, Yong Mong Bee, Khue Thy Nguyen, Soo Lim, Daisuke Yabe, Margaret McGill, Alice Pik Shan Kong, Siew Pheng Chan, Marisa Deodat, Chaicharn Deerochanawong, Ketut Suastika, Chenchen Xu, Liming Chen, Wei Chen, Xiaoying Li, Weigang Zhao, Xiaomei Yao, Linong Ji

“…Abstract Aims To investigate the effectiveness, safety, optimal starting dose, optimal maintenance dose range, and target fasting plasma glucose of five basal insulins in insulin‐naïve patients with type 2 diabetes mellitus. …”
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Biogenic Synthesis of Silver Nanoparticles Using <i>Catharanthus roseus</i> and Its Cytotoxicity Effect on Vero Cell Lines by Khansa Jamil, Sahir Hameed Khattak, Anum Farrukh, Sania Begum, Muhammad Naeem Riaz, Aish Muhammad, Tahira Kamal, Touqeer Taj, Imran Khan, Sundus Riaz, Huma Batool, Kaleemullah Mandokhail, Sabahat Majeed, Sajid Ali Khan Bangash, Alia Mushtaq, Shahab Bashir, Imdad Kaleem, Fahed Pervaiz, Aamir Rasool, Muhammad Ammar Amanat, Ghulam Muhammad Ali

“…Moreover, five groups of rats including control and diabetic groups (NC1, PC2, DG1, DG2, and DG3) were investigated for their blood glucose and glycemic control analysis. Conclusions: The <i>C.…”
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