4.6 Effects of Combined Therapy of Empagliflozin and Linagliptin Versus Metformin and Insulin Glargine on Blood Pressure and Vascular Function in Patients with Type 2 Diabetes by Christian Ott, Susanne Jung, Agnes Bosch, Dennis Kannenkeril, Kristina Striepe, Roland Schmieder

“…Methods: In this study 101 patients with T2DM were randomized to receive either empagliflozin 10 mg and linagliptin 5 mg (E+L group) orally or metformin and insulin glargine (M+I group, with dose adjustments according to glucose levels), for 3 months. Patients underwent BP and vascular examination at baseline and after 12 weeks of treatment, including measurement of office and ambulatory BP and vascular function under clinical and ambulatory conditions by validated systems. …”
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Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia by Jie Yang, Mengjia Sun, Renzheng Chen, Xiaowei Ye, Boji Wu, Zhen Liu, Jihang Zhang, Xubin Gao, Ran Cheng, Chunyan He, Jingyu He, Xuhong Wang, Lan Huang

“…Metabolomics analysis indicated suppression of glucose and fatty acids aerobic oxidation in HH conditions. …”
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2,4‐Dihydroxybenzoic Acid, a Novel SA Derivative, Controls Plant Immunity via UGT95B17‐Mediated Glucosylation: A Case Study in Camellia Sinensis by Mengqian Lu, Yifan Zhao, Yingying Feng, Xiaoyan Tang, Wei Zhao, Keke Yu, Yuting Pan, Qiang Wang, Jilai Cui, Mengting Zhang, Jieyang Jin, Jingming Wang, Mingyue Zhao, Wilfried Schwab, Chuankui Song

“…The exogenous application of 2,4‐DHBA and 2,5‐DHBA, as well as the accumulation of DHBA and plant resistance comparison, indicate that 2,4‐DHBA functions as a potentially bioactive molecule and is stored mainly as a glucose conjugate in tea plants, differs from the mechanism described in Arabidopsis. …”
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Identification of Myocardial Insulin Resistance by Using Liver Tests: A Simple Approach for Clinical Practice by José Raúl Herance, Queralt Martín-Saladich, Mayra Alejandra Velásquez, Cristina Hernandez, Carolina Aparicio, Clara Ramirez-Serra, Roser Ferrer, Marina Giralt-Arnaiz, Miguel Ángel González-Ballester, Juan M. Pericàs, Joan Castell-Conesa, Santiago Aguadé-Bruix, Rafael Simó

“…In addition, we found that patients with mIR presented a reduced glucose uptake by the liver in comparison with patients with mIS. …”
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Cardamom (<i>Elettaria cardamomum</i> (L.) Maton) Seeds Intake Increases Energy Expenditure and Reduces Fat Mass in Mice by Modulating Neural Circuits That Regulate Adipose Tissue... by Claudia Delgadillo-Puga, Ivan Torre-Villalvazo, Yonatan Y. Cariño-Cervantes, Cinthia García-Luna, Paulina Soberanes-Chávez, Patricia de Gortari, Lilia G. Noriega, Claudia J. Bautista, Luis Cisneros-Zevallos

“…Accordingly, fasting and postprandial oxygen consumption, as well as fasting fat oxidation and postprandial glucose utilization were higher in mice fed with EC than in control. …”
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Zootechnical Performance and Some Physiological Indices of Tambaqui, <i>Colossoma macropomum</i> Juveniles during Biofloc Maturation and in Different Feed Regimes by Cintia Labussière Nakayama, Luiz Felipe Silveira Silva, Fabio Aremil Costa dos Santos, Tulio Pacheco Boaventura, Gisele Cristina Favero, Glauber David Almeida Palheta, Nuno Filipe Alves Correia de Melo, Luiz Alberto Romano, Ronald Kennedy Luz

“…FCR (1.90 ± 0.21), weight gain (9.81 ± 1.08 g), and SGR (1.26 ± 0.12%) were highest at 30 days of phase 1. The glucose level (118.23 ± 26.30 mg dL⁻¹) was highest on the 30th day. …”
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Bone remodeling in experimental diabetes mellitus and surgical menopause in Wistar rats by N. V. Timkina, A. V. Simanenkova, A. A. Bayramov, M. A. Kokina, N. Yu. Semenova, A. Z. Gagiev, T. L. Karonova, E. N. Grineva

“…A weak negative correlation (r= -0.5, p&lt;0,05) was found between glucose and osteocalcin levels (p=0.03). RANKL level was significantly lower in the «OE+DM» group (278,1 [273.1; 289.7] pg/mL) compared to the «OE» group (400.6 [394.5; 415.1] pg/mL), besides the OPG/RANKL ratio was higher in this group (0.03 [0.02; 0.035] and 0.01 [0.004; 0.014], respectively), p=0.05. …”
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Sex-Dependent Role of Adipose Tissue HDAC9 in Diet-Induced Obesity and Metabolic Dysfunction by Brandee Goo, Samah Ahmadieh, Abdalrahman Zarzour, Nicole K. H. Yiew, David Kim, Hong Shi, Jacob Greenway, Stephen Cave, Jenny Nguyen, Swetha Aribindi, Mark Wendolowski, Praneet Veerapaneni, Mourad Ogbi, Weiqin Chen, Yun Lei, Xin-Yun Lu, Ha Won Kim, Neal L. Weintraub

“…Interestingly, female, but not male, adipocyte-specific <i>HDAC9</i> KO mice on HFD exhibited reduced body weight and visceral adipose tissue mass, adipocyte hypertrophy, and improved insulin sensitivity, glucose tolerance and adipogenic differentiation gene expression. …”
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The Impact of LEP rs7799039 Polymorphism and Obesity on the Severity of Coronavirus Disease-19 by Mohamed AA, Alrohaimi AH, Sayed Abdelgeliel A, Albogami S, Jafri I, Fayad E, Mohamed N, Nassar NA, Adaroas AS, Eldeeb HH, Abdel Halim A, Ramadan A, Elnagar RM, Abdelghafour RAM, Mohamed AY, Mahmoud MO, El-Kasses A, El-Sayed M, Mohammed MA, Alwaleed EA, Mousa S, Abdel Salam S, Abd el salam SM

“…Also, obesity commonly provokes the severity of respiratory diseases so the correlation of LEP rs7799039 Polymorphism in corpulent patients with COVID-19 infection was clearly investigated in the current study.Methods: A total of 232 patients were recruited, 116 patients were obese with COVID-19 infection, and 116 patients were non obese COVID-19. Fasting blood glucose test (FBG), hemoglobin A1C (HbA1C), complete blood count (CBC), international normalized ratio (INR), urea, alanine transaminase (ALT), aspartate aminotransferase (AST), D dimer and C-reactive protein (CRP) were estimated. …”
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Adiponectin preserves metabolic fitness during aging by Na Li, Shangang Zhao, Zhuzhen Zhang, Yi Zhu, Christy M Gliniak, Lavanya Vishvanath, Yu A An, May-yun Wang, Yingfeng Deng, Qingzhang Zhu, Bo Shan, Amber Sherwood, Toshiharu Onodera, Orhan K Oz, Ruth Gordillo, Rana K Gupta, Ming Liu, Tamas L Horvath, Vishwa Deep Dixit, Philipp E Scherer

“…We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. …”
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Ginsenoside Rd promotes omentin secretion in adipose through TBK1-AMPK to improve mitochondrial biogenesis via WNT5A/Ca2+ pathways in heart failure by Shiyao Wan, ZeKun Cui, Lingling Wu, Fan Zhang, Tao Liu, Jingui Hu, Jiangwei Tian, Boyang Yu, Fuming Liu, Junping Kou, Fang Li

“…Consistently, exogenous omentin reduced mtROS levels and restored ΔψM to improve oxygen and glucose deprivation (OGD)-induced cardiomyocytes injury. …”
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Exploring Synergistic Combinations in Extended and Pan-Drug Resistant (XDR and PDR) Whole Genome Sequenced <i>Acinetobacter baumannii</i> by Munawr AL Quraini, Zaaema AL Jabri, Hiba Sami, Jaspreet Mahindroo, Neelam Taneja, Zakariya AL Muharrmi, Ibrahim AL Busaidi, Meher Rizvi

“…<b>Methods:</b> Non-replicate whole genome sequenced (illumina next-generation sequencing platform, Clevergene, India), <i>A. baumanii</i> (7 XDR, 1PDR) were subjected to in vitro synergy testing by checkerboard (CB) and time kill assay (TKA) after MIC determination, with glucose-6-phosphate being incorporated in all runs. …”
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Fat mass and obesity-associated gene (FTO) hypermethylation induced by decabromodiphenyl ethane causing cardiac dysfunction via glucolipid metabolism disorder by Leqiang Gao, Yue Zhang, Jianhui Liu, Xiangyang Li, Yujian Sang, Guiqing Zhou, Jinglong Xue, Li Jing, Zhixiong Shi, Jialiu Wei, Xiangfeng Lu, Xianqing Zhou

“…Furthermore, DBDPE could increase the serum levels of glucose and low-density lipoprotein but decrease the content of high-density lipoprotein. …”
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Concurrent training and interindividual response in women with a high number of metabolic syndrome risk factors by Pedro Delgado-Floody, Pedro Delgado-Floody, Luis Chirosa-Ríos, Felipe Caamaño-Navarrete, Pablo Valdés-Badilla, Pablo Valdés-Badilla, Tomás Herrera-Valenzuela, Matías Monsalves-Álvarez, Matías Monsalves-Álvarez, Cristian Núñez-Espinosa, Cristian Núñez-Espinosa, Cristian Núñez-Espinosa, Mauricio Castro-Sepulveda, Eduardo Guzmán-Muñoz, David C. Andrade, Cristian Álvarez

“…The main outcomes were waist circumference (WC), fasting plasma glucose (FPG), high-density lipids (HDL-c), triglycerides (Tg), and systolic (SBP) and diastolic (DBP) blood pressure, and secondary outcomes were body composition, anthropometric and physical fitness, determined before and after 20 weeks of concurrent training. …”
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Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis by Fang Li, Yu Wang, Jianwei Tian, Zhanmei Zhou, Wei Yin, Xianhui Qin, Huizhen Wang, Tao Zeng, Aiqing Li, Jianping Jiang

“…Next we inhibited Calpain activity or reduced Calpain9 expression, and then assessed changes in extracellular matrix and β-catenin.Results: Inhibition of calpain activity attenuated chlorhexidine glucose and peritoneal dialysis-induced peritoneal thickening and β-catenin expression in mice. …”
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“How we do it”: A qualitative study of strategies for adopting an exercise routine while living with type 1 diabetes by Cristine Vlcek, Dana Greenberg, Jane E. Yardley, Jane E. Yardley, Jane E. Yardley, Jane E. Yardley, Jane E. Yardley, Nika Klaprat, Nika Klaprat, Nika Klaprat, Andrea MacIntosh, Andrea MacIntosh, Andrea MacIntosh, Marley Greenberg, Joel Brandt, Natasha Gregoire, Sylvie Dostie, Denis Boutin, Conrad Pow, Mandy Archibald, Mandy Archibald, Mandy Archibald, Jonathan McGavock, Jonathan McGavock, Jonathan McGavock, Jonathan McGavock, Jonathan McGavock

“…IntroductionFor people living with type 1 diabetes (T1D) the challenge of increasing daily physical activity (PA) is compounded by the increased risks of hypoglycemia and glucose variability. Little information exists on the lived experience of overcoming these barriers and adopting and maintaining an active lifestyle while living with T1D.Research Design and MethodsWe conducted a patient-led qualitative study consisting of semi-structured interviews or focus groups with 22 individuals at least 16 years old living with T1D. …”
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Effect of arginine supplementation on the production of milk fat in dairy cows by L. Ding, Y. Shen, M. Jawad, T. Wu, S.K. Maloney, M. Wang, N. Chen, D. Blache

“…On the last day of each experimental period, blood was sampled to measure insulin, nitric oxide, glucose, and nonesterified fatty acid, and the liver and mammary gland were biopsied to measure the expression of genes. …”
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Activated B cells suppress T-cell function through metabolic competition by Li Li, Michael Green, Fang Wang, Ye Li, Jennifer Wargo, Marina Konopleva, Elizabeth J Shpall, Rafet Basar, May Daher, Ana Karen Nunez Cortes, Hila Shaim, Natalia Baran, Ken Chen, Luis Muniz-Feliciano, Nobuhiko Imahashi, Yuefan Huang, Pinaki Prosad Banerjee, Junjun Lu, Nadima Uprety, Emily Ensley, Tamara J Laskowski, Judy S Moyes, Mayela Mendt, Lucila N Kerbauy, Mayra Shanley, Francesca Lorraine Wei Inng Lim, Katayoun Rezvani

“…Moreover, activated B cells deprived T cells of glucose and produced lactic acid through their high glycolytic activity. …”
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Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for type 2 diabetes remission (ORDER): protocol of a multicentre, randomised controlled, open-... by Yang Liu, Peng Zhang, Yuanyuan Kong, Yan Gu, Maud Robert, Cunchuan Wang, Zhongtao Zhang, Mengyi Li, Wei-Jei Lee, Scott A Shikora, Weu Wang, Simon Kin Hung Wong, Daniel King Hung Tong, Chun Hai Tan, Na Zeng, Shaihong Zhu, Pin Zhang, Rixing Bai, Fanqiang Meng, Zhongqi Mao, Xiangwen Zhao, Liangping Wu, Yanjun Liu, Songhai Zhang

“…The primary endpoint is the complete diabetes remission rate defined as HbA1c≤6.0% and fasting plasma glucose≤5.6 mmol/L without any antidiabetic medications at 1 year after surgery. …”
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CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline by Frances Evans, Daniela Alí-Ruiz, Natalia Rego, María Luciana Negro-Demontel, Natalia Lago, Fabio Andrés Cawen, Bruno Pannunzio, Paula Sanchez-Molina, Laura Reyes, Andrea Paolino, Jorge Rodríguez-Duarte, Valentina Pérez-Torrado, Almudena Chicote-González, Celia Quijano, Inés Marmisolle, Ana Paula Mulet, Geraldine Schlapp, María Noel Meikle, Mariana Bresque, Martina Crispo, Eduardo Savio, Cristina Malagelada, Carlos Escande, Hugo Peluffo

“…This was associated with systemic inflammaging, increased cognitive decline, reduced brain glucose uptake observed by 18FDG PET scans, enrichment in microglial aging/neurodegeneration phenotypes, proteostasis alterations, senescence, increased frailty, and sex-dependent systemic metabolic changes. …”
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