Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy by Di-fei Gong, Shu-chan Sun, Ran-ran Wang, Awaguli Dawuti, De-wen Kong, Rui-qi Liu, Li-da Du, Shou-bao Wang, Yang Lu, Tian-yi Yuan, Guan-hua Du, Lian-hua Fang

“…Treatment with SAA improved cardiac function, glucose, and lipid levels, mitochondrial respiration, and suppressed myocardial inflammation and apoptosis. …”
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Calcium Biofortification of Rocha Pear Fruits: Implications on Mineral Elements, Sugars and Fatty Acids Accumulation in Tissues by Cláudia Campos Pessoa, Fernando C. Lidon, Diana Daccak, Inês Carmo Luís, Ana Coelho Marques, Ana Rita F. Coelho, Paulo Legoinha, José Cochicho Ramalho, António E. Leitão, Mauro Guerra, Roberta G. Leitão, Paula Scotti Campos, Isabel P. Pais, Maria Manuela Silva, Fernando H. Reboredo, Maria Fernanda Pessoa, Manuela Simões

“…At harvest, the Ca treatments did not affect the levels of sucrose, glucose, fructose and sorbitol and, after storage, their concentrations remained higher in Ca-treated fruits. …”
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Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseasesResearch in context by Bedair Dewidar, Lucia Mastrototaro, Cornelia Englisch, Claudia Ress, Cesare Granata, Elisabeth Rohbeck, Dominik Pesta, Geronimo Heilmann, Martin Wolkersdorfer, Irene Esposito, Michelle Reina Do Fundo, Fariba Zivehe, Aslihan Yavas, Michael Roden

“…Mitochondrial respiration was measured by high-resolution respirometry and insulin-sensitive glucose metabolism by hyperinsulinemic-euglycemic clamps with stable isotope dilution. …”
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Exploring the impact of short daily haemodialysis on muscle strength and bone health in end‐stage kidney disease patients by Fernanda Silveira Tavares, Hugo deLuca Corrêa, Kenneth R. Wilund, Lysleine Alves Deus, Thais Branquinho deAraújo, Carmen Tzanno‐Martins, Vitória Marra daMotta Vilalva Mestrinho, Rafael Lavarini dosSantos, Andrea Lucena Reis, Fernando Honorato Souza, Luiz Roberto deSousa Ulisses, Helen Souto Siqueira Cardoso, Istênio José Fernandes Pascoal, Valéria Cunha Campos Guimarães, Lucy deOliveira Gomes, Rodrigo Vanerson Passos Neves, Thiago dosSantos Rosa

“…SDH patients had lower levels of the uremic toxin asymmetric dimethyl‐l‐arginine (ADMA) (1.8 vs. 2.07 μM, P = 0.002) and fasting blood glucose (132.6 vs. 141.7 mg/dL, P < 0.02) than CHD group. …”
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Community pharmacists’ perspectives on cardiovascular disease pharmaceutical care in the United Arab Emirates: a questionnaire survey-based analysis by Ammar Abdulrahman Jairoun, Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Himyari, Sabaa Saleh Al-Himyari, Moyad Shahwan, Moyad Shahwan, Mina Al Ani, Mustafa Habeb, Maimona Jairoun, Maimona Jairoun, Sa’ed H. Zyoud, Sa’ed H. Zyoud, Mustfa Faisal Alkhanani, Reem Hasaballah Alhasani, Alqassem Y. Hakami, Bayan A. Ainousah, Fahad S. Alshehri, Nasser M. Alorfi, Abdulhaq Suliman

“…However, they showed low levels of involvement in other healthcare services, specifically in screening and measuring patients’ weight, glucose levels, and blood pressure, monitoring treatment responses, maintaining medical records, and reviewing medication refill histories. …”
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Etiología de las infecciones urinarias adquiridas en la comunidad. Un estudio de 9 años by Galué N, Ginestre M, Martínez A, Romero S, Rincón G, Harris B

“…Other microorganisms present were: Klebsiella pneumoniae (7,29%), Proteus mirabilis (6,33%), other Enterobacteriaceae (5,00%), Pseudomonas aeruginosa and other Gram-negative glucose non-fermenting rods (4,00%), Streptococcus Group B and others Streptococcus (2,00%), Enterococcus (2,00%), Staphylococcus aureus (1,00%), Aeromonas sp. (0,30%), Haemophilus influenzae (0,10%) and Candida sp. (1,00%). …”
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Efficacy of empagliflozin in heart failure with preserved ejection fraction according to frailty status in EMPEROR‐Preserved by Andrew J.S. Coats, Javed Butler, Hiroyuki Tsutsui, Wolfram Doehner, Gerasimos Filippatos, João Pedro Ferreira, Michael Böhm, Vijay K. Chopra, Subodh Verma, Matias Nordaby, Tomoko Iwata, Daisuke Nitta, Piotr Ponikowski, Faiez Zannad, Milton Packer, Stefan D. Anker

“…The impact of frailty on HFpEF patients and any impact on the clinical benefits of sodium glucose co‐transporter 2 (SGLT2) inhibition in HFpEF have been described in only a limited number of trials. …”
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P14 Criblage phytochimique, toxicité aiguë et évaluation de l'activité antidiabétique de l'écorce du tronc de Cylicodiscus gabunensis (Fabaceae) by B P Ndzié Maniben, M O Ondoua Nguele, M Nyangono Ndongo, J H M Nko'O, Y L Tabi Ombga, B Ngameni, Nnanga Nga

“…Une hyperglycémie significative a été observée 30 minutes après l’administration du D-glucose chez tous les animaux. Le témoin positif a présenté une baisse significative de la glycémie (70 mg/dL) dès la soixantième minute. …”
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Inadequate diabetes knowledge is associated with poor glycemia control in patients with type 2 diabetes by Lubia Velázquez López, Abril Violeta Muñoz Torres, Patricia Guadalupe Medina Bravo, Jorge Escobedo de la Peña

“…Main measurements: Glycated hemoglobin (HbA1c), glucose, and lipid profile levels were measured from fasting venous blood samples. …”
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One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes—A Case-Control Study by María Marhuenda-Muñoz, Inés Domínguez-López, Emily P. Laveriano-Santos, Isabella Parilli-Moser, Cristina Razquin, Miguel Ruiz-Canela, Francisco Javier Basterra-Gortari, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, José Lapetra, Fernando Arós, Miquel Fiol, Lluis Serra-Majem, Xavier Pintó, Enrique Gómez-Gracia, Emilio Ros, Ramon Estruch, Rosa M. Lamuela-Raventós

“…However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.…”
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The advanced lung cancer inflammation index is the optimal inflammatory biomarker of overall survival in patients with lung cancer by Mengmeng Song, Qi Zhang, Chunhua Song, Tong Liu, Xi Zhang, Guotian Ruan, Meng Tang, Hailun Xie, Heyang Zhang, Yizhong Ge, Xiangrui Li, Kangping Zhang, Ming Yang, Qinqin Li, Xiaoyue Liu, Shiqi Lin, Yu Xu, Hongxia Xu, Kunhua Wang, Wei Li, Hanping Shi

“…However, the modified Glasgow prognostic score was superior to the other indicators in non‐small cell lung cancer patients (C‐index, 0.639) or patients aged ≥65 years (C‐index, 0.610), and the glucose‐to‐lymphocyte ratio performed better prognostic ability in patients with small cell lung cancer (C‐index, 0.601). …”
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Effects of Cardiovascular Risk Factors on the Progression of Carotid Intima-media Thickening by CHEN Runlin, HE Tufeng, TAO Lijun, QIN Lingqiao, ZHANG Dacheng, ZHANG Yifan, ZHAO Min, ZHONG Qiuan

“…And 12 factors potentially associated with CIMT were identified by adaptive Lasso linear regression analysis, i.e., internal diameter of the common carotid artery, SBP, TC, physical activity level, ACR, smoking, alcohol consumption, CRP, LPA, ApoA/ApoB ratio, fasting plasma glucose, and family history of diabetes mellitus. …”
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DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation by Domenica Scumaci, Erika Olivo, Claudia Vincenza Fiumara, Marina La Chimia, Maria Teresa De Angelis, Sabrina Mauro, Giosuè Costa, Francesca Alessandra Ambrosio, Stefano Alcaro, Valter Agosti, Francesco Saverio Costanzo, Giovanni Cuda

“…In cancer cells, the high glycolytic flux induces carbonyl stress, a damaging condition in which the increase of reactive carbonyl species makes DNA, proteins, and lipids more susceptible to glycation. Together with glucose, methylglyoxal (MGO), a byproduct of glycolysis, is considered the main glycating agent. …”
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Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts by Rebeca Mayo, Javier Crespo, Ibon Martínez‐Arranz, Jesus M Banales, Mayte Arias, Itziar Mincholé, Rocío Aller de la Fuente, Raúl Jimenez‐Agüero, Cristina Alonso, Daniel A. de Luis, Libor Vitek, Jan Stritesky, Joan Caballería, Manuel Romero‐Gómez, Antonio Martín‐Duce, Jose Maria Mugüerza Huguet, José Ignacio Busteros‐Moraza, Michael O. Idowu, Azucena Castro, M. Luz Martínez‐Chantar, Pablo Ortiz, Radan Bruha, Shelly C. Lu, Pierre Bedossa, Mazen Noureddin, Arun J. Sanyal, José M. Mato

“…When the analysis was performed excluding patients with glucose levels >136 mg/dL, the area under the receiver operating characteristic curve for the discrimination between NASH and NAFL increased to 0.81 ± 0.04 with sensitivity and specificity of 0.73 and 0.80, respectively. …”
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Baseline Testosterone Predicts Body Composition and Metabolic Response to Testosterone Therapy by FNU Deepika, FNU Deepika, Elliot Ballato, Georgia Colleluori, Lina Aguirre, Lina Aguirre, Rui Chen, Rui Chen, Clifford Qualls, Clifford Qualls, Clifford Qualls, Dennis T. Villareal, Dennis T. Villareal, Reina Armamento-Villareal, Reina Armamento-Villareal

“…Men with T ≥ 264 ng/dl showed significant decreases in HbA1c at 12 months (−3.1 ± 9.2 vs. 3.2 ± 13.9%; p = 0.005), fasting glucose at 18 months (−4.2 ± 31.9 vs. 13.0 ± 57.3%; p = 0.040), LDL at 6 months (−6.4 ± 27.5 vs. 12.8 ± 44.1%; p = 0.034), and leptin at 18 months (−40.2 ± 35.1 vs. −27.6 ± 31.0%; p = 0.034) compared to those with T &lt; 264 ng/dl. …”
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Treatment effect modification due to comorbidity: Individual participant data meta-analyses of 120 randomised controlled trials by Peter Hanlon, Elaine W. Butterly, Anoop SV Shah, Laurie J. Hannigan, Jim Lewsey, Frances S. Mair, David M. Kent, Bruce Guthrie, Sarah H. Wild, Nicky J. Welton, Sofia Dias, David A. McAllister

“…Although all were null, estimates of treatment effect modification were more precise in some cases (e.g., sodium-glucose co-transporter-2 (SGLT2) inhibitors for type 2 diabetes—interaction term for comorbidity count 0.004, 95% CI −0.01 to 0.02) while for others credible intervals were wide (e.g., corticosteroids for asthma—interaction term −0.22, 95% CI −1.07 to 0.54). …”
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Biosynthetic pathway of prescription bergenin from Bergenia purpurascens and Ardisia japonica by Xiang-Yu Liu, Xiang-Yu Liu, Yi-Na Wang, Yi-Na Wang, Jiang-Shun Du, Jiang-Shun Du, Bi-Huan Chen, Bi-Huan Chen, Kun-Yi Liu, Lei Feng, Lei Feng, Gui-Sheng Xiang, Gui-Sheng Xiang, Shuang-Yan Zhang, Shuang-Yan Zhang, Ying-Chun Lu, Sheng-Chao Yang, Sheng-Chao Yang, Guang-Hui Zhang, Guang-Hui Zhang, Bing Hao, Bing Hao

“…BpOMT1 and AjOMT1 facilitate the methylation reaction at the 4-OH position of GA, resulting in the formation of 4-O-methyl gallic acid (4-O-Me-GA). AjCGT1 transfers a glucose moiety to C-2 to generate 2-Glucosyl-4-O-methyl gallic acid (2-Glucosyl-4-O-Me-GA). …”
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Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence by Bin Xia, Qingyang Zhu, Yingya Zhao, Wenzhen Ge, Yan Zhao, Qi Song, Yuhan Zhou, Huijing Shi, Yunhui Zhang

“…Meanwhile, increased MnBP concentration was also significantly correlated with decreased levels of lactate, glucose 6-phosphate, d-fructose 6-phosphate, palmitic acid, 4-acetamidobutyric acid, l-glutamic acid, n-acetyl-l-phenylalanine, iminodiacetic acid, hydroxyproline, pipecolinic acid, l-ornithine, n-acetyl-l-glutamic acid, guanosine, cytosin, and (s)-mandelic acid in the normal weight subjects. …”
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Hypoglycemic Activity of Aqueous Extract of Latex from <i>Hancornia speciosa</i> Gomes: A Study in Zebrafish and In Silico by Rosana Tomazi, Ângela Costa Figueira, Adriana Maciel Ferreira, Diego Quaresma Ferreira, Gisele Custódio de Souza, Wandson Braamcamp de Souza Pinheiro, José Rodrigues Pinheiro Neto, Geilson Alcantara da Silva, Henrique Barros de Lima, Lorane Izabel da Silva Hage-Melim, Arlindo César Matias Pereira, José Carlos Tavares Carvalho, Sheylla Susan Moreira da Silva de Almeida

“…We then tested treatments with LxHs (500, 1000, and 1500 mg/kg) by assessing blood glucose levels in alloxan-induced diabetic animals, and metformin was used as a control. …”
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E96V Mutation in the <i>Kdelr3</i> Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice by Delsi Altenhofen, Jenny Minh-An Khuong, Tanja Kuhn, Sandra Lebek, Sarah Görigk, Katharina Kaiser, Christian Binsch, Kerstin Griess, Birgit Knebel, Bengt-Frederik Belgardt, Sandra Cames, Samaneh Eickelschulte, Torben Stermann, Axel Rasche, Ralf Herwig, Jürgen Weiss, Heike Vogel, Annette Schürmann, Alexandra Chadt, Hadi Al-Hasani

“…A linkage study performed in this population led to the identification of the novel T2D-associated quantitative trait locus (QTL) <i>Nbg15</i> (NZO blood glucose on chromosome 15, Logarithm of odds (LOD) 6.6). …”
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