Fisetin represses oxidative stress and mitochondrial dysfunction in NAFLD through suppressing GRP78-mediated endoplasmic reticulum (ER) stress by Xianling Dai, Qin Kuang, Yan Sun, Minxuan Xu, Liancai Zhu, Chenxu Ge, Jun Tan, Bochu Wang

“…What’s more, ER stress was strongly induced by PA via increasing 78-kDa glucose-regulated protein (GRP78) and C/EBP-homologous protein (CHOP), which were, however, dramatically repressed after FisT co-exposure. …”
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Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes by Anna Janz, Katharina Walz, Alexandra Cirnu, Jessica Surjanto, Daniela Urlaub, Miriam Leskien, Michael Kohlhaas, Alexander Nickel, Theresa Brand, Naoko Nose, Philipp Wörsdörfer, Nicole Wagner, Takahiro Higuchi, Christoph Maack, Jan Dudek, Kristina Lorenz, Eva Klopocki, Süleyman Ergün, Henry J. Duff, Brenda Gerull

“…Additionally, increased extracellular acidification rates suggested an increase in overall metabolic flux, while radioactive tracer uptake studies revealed decreased fatty acid uptake and utilization of glucose. Mutant iPSC-CMs also showed increased reactive oxygen species (ROS) and an elevated mitochondrial membrane potential. …”
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A Brazilian Rare-Disease Center’s Experience with Glucosylsphingosine (lyso-Gb1) in Patients with Gaucher Disease: Exploring a Novel Correlation with IgG Levels in Plasma and a Bio... by Matheus Vernet Machado Bressan Wilke, Gabrielle Dineck Iop, Larissa Faqueti, Layzon Antonio Lemos da Silva, Francyne Kubaski, Fabiano O. Poswar, Kristiane Michelin-Tirelli, Dévora Randon, Wyllians Vendramini Borelli, Roberto Giugliani, Ida Vanessa D. Schwartz

“…Gcase catalyzes the conversion of glucosylceramide (GlcCer) into ceramide and glucose. As GlcCer accumulates in lysosomal macrophages, it undergoes deacylation to become glycosylsphingosine (lyso-Gb1), which has shown to be a useful and reliable biomarker for the diagnosis and monitoring of treated and untreated patients with GD. …”
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Suppression of estrogen receptor beta classical genomic activity enhances systemic and adipose-specific response to chronic beta-3 adrenergic receptor (β3AR) stimulation by Eric D. Queathem, Eric D. Queathem, Maggie Fitzgerald, Rebecca Welly, Candace C. Rowles, Kylie Schaller, Kylie Schaller, Shahad Bukhary, Christopher P. Baines, Christopher P. Baines, R. Scott Rector, R. Scott Rector, R. Scott Rector, Jaume Padilla, Jaume Padilla, Camila Manrique-Acevedo, Dennis B. Lubahn, Victoria J. Vieira-Potter

“…Systemic physiological assessments of body composition (EchoMRI), bioenergetics (metabolic chambers), adipocyte mitochondrial respiration (oroboros) and glucose tolerance were performed, alongside perigonadal (PGAT), subcutaneous (SQAT) and brown adipose tissue (BAT) protein expression assessment (Western blot). …”
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Evaluation of Biochemical Properties, Antioxidant Activities and Phenolic Content of Two Wild-Grown Berberis Fruits: <i>Berberis nummularia</i> and <i>Berberis</i> <i>atrocarpa</i> by Buhailiqiemu Abudureheman, Xinyue Zhou, Xipan Shu, Ziqi Chai, Yongping Xu, Shuying Li, Jinhu Tian, Haibo Pan, Xingqian Ye

“…The fruits of the two species can be used in food coloring and nutritional supplements, and consumption of the fruits can aid in weight control and reduce blood glucose or cholesterol.…”
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Metabolic remodeling in cardiac hypertrophy and heart failure with reduced ejection fraction occurs independent of transcription factor EB in mice by Niklas Dörmann, Elke Hammer, Elke Hammer, Karlotta Struckmann, Julia Rüdebusch, Kirsten Bartels, Kristin Wenzel, Julia Schulz, Stefan Gross, Stefan Schwanz, Elisa Martin, Britta Fielitz, Britta Fielitz, Cristina Pablo Tortola, Alexander Hahn, Alexander Benkner, Uwe Völker, Uwe Völker, Stephan B. Felix, Stephan B. Felix, Jens Fielitz, Jens Fielitz, Jens Fielitz

“…BackgroundA metabolic shift from fatty acid (FAO) to glucose oxidation (GO) occurs during cardiac hypertrophy (LVH) and heart failure with reduced ejection fraction (HFrEF), which is mediated by PGC-1α and PPARα. …”
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Factors associated with critical care requirements in diabetic patients treated with dexamethasone for COVID-19 infection in the first wave of the pandemia by Sol Batule, Sol Batule, Berta Soldevila, Berta Soldevila, Carme Figueredo, María Teresa Julián, María Teresa Julián, Laia Egea-Cortés, Juliana Reyes-Ureña, Jordi Casabona, Lourdes Mateu, Roger Paredes, Roger Paredes, Bonaventura Clotet, Bonaventura Clotet, Rosa López, Manel Puig-Domingo, Manel Puig-Domingo, Núria Alonso, Núria Alonso

“…Besides, between these two groups of patients with DM, we observed no differences in glycemic parameters, including median capillary blood glucose values, glycosylated hemoglobin, coefficient of variability and hypoglycemic episodes. …”
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Novel Curcumin Analogue L6H4 in Treating Liver Fibrosis and Type 2 Diabetes by Ma J, Vaishnani DK, Mansi, Zeng J, Xie Z, Jin X, Zhang H, Wut Yi Hla K, Ying F

“…The analogue reduced markers of T2D severity, including blood glucose, insulin levels, and insulin resistance. L6H4 also decreased liver fibrosis by reducing the expression of TGF-β 1 and TIMP-2 and increasing MMP-2 expression. …”
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Obesity- and lipid-related indices as a predictor of type 2 diabetes in a national cohort study by Ying Wang, Xiaoyun Zhang, Yuqing Li, Jiaofeng Gui, Yujin Mei, Xue Yang, Haiyang Liu, Lei-lei Guo, Jinlong Li, Yunxiao Lei, Xiaoping Li, Lu Sun, Liu Yang, Ting Yuan, Congzhi Wang, Dongmei Zhang, Jing Li, Mingming Liu, Ying Hua, Lin Zhang

“…The study assessed the association of obesity- and lipid-related indices and T2DM by measuring 13 indicators, including body mass index (BMI), waist circumference(WC), waist-height ratio (WHtR), conicity index(CI), visceral adiposity index (VAI), Chinese visceral adiposity index (CVAI), lipid accumulation product (LAP), a body shape index (ABSI), body roundness index (BRI), triglyceride glucose index (TyG-index) and its correlation index (TyG-BMI, TyG-WC, TyG-WHtR). …”
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Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement by Julia Fontaine, Simon Leboube, Simon Leboube, Thomas Bochaton, Thomas Bochaton, Hélène Thibault, Hélène Thibault, Camille Amaz, Tae-Hee Cho, Tae-Hee Cho, Alexandre Paccalet, Claire Crola Da Silva, Suzanne Duhamel, Marielle Buisson, Lucie Rascle, Gabriel Bidaux, Michel Ovize, Michel Ovize, Norbert Nighoghossian, Norbert Nighoghossian, Laura Mechtouff, Laura Mechtouff

“…On univariable analysis, we found that patients with LAE had higher soluble form suppression of tumorigenicity 2 (sST2), soluble tumor necrosis factor receptor I (sTNFR1), and vascular cellular adhesion molecule-1 (VCAM-1) AUC, were older, mostly female, had a higher National Institutes of Health Stroke Scale (NIHSS) score and blood glucose level at admission, had more often hypertension, and a cardioembolic source of AIS, such as atrial fibrillation, while they were less frequently current smokers and had a lower rate of tandem occlusion than patients without LAE. …”
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Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway by Ssu-Ju Li, Yu-Chun Lo, Hsin-Yi Tseng, Sheng-Huang Lin, Chao-Hung Kuo, Ting-Chieh Chen, Ching-Wen Chang, Yao-Wen Liang, Yi-Chen Lin, Chih-Yu Wang, Tsai-Yu Cho, Mu-Hua Wang, Ching-Te Chen, You-Yin Chen

“…To determine whether NAc-DBS alters glucose metabolism via mitochondrial alteration and neurogenesis and whether these changes increase neural plasticity that improves behavioral functions in a chronic social defeat stress (CSDS) mouse model. …”
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The role of age on the risk relationship between prediabetes and major morbidities and mortality: Analysis of the Hong Kong diabetes surveillance database of 2 million Chinese adul... by Xinge Zhang, Hongjiang Wu, Baoqi Fan, Mai Shi, Eric S.H. Lau, Aimin Yang, Elaine Chow, Alice P.S Kong, Juliana C.N Chan, Ronald C.W Ma, Andrea O.Y Luk

“…Similar associations were observed in prediabetes defined by impaired fasting glucose, but not HbA1c. Interpretation: Prediabetes is associated with higher risk of major clinical events, even excluding subsequent development of diabetes and adjusting for metabolic factors. …”
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Neuroprotective Mechanisms of Lycium barbarum Polysaccharides Against Ischemic Insults by Regulating NR2B and NR2A Containing NMDA Receptor Signaling Pathways by Zhongshan Shi, Zhongshan Shi, Zhongshan Shi, Zhongshan Shi, Lihui Zhu, Lihui Zhu, Lihui Zhu, Lihui Zhu, Tingting Li, Xiaoya Tang, Yonghui Xiang, Xinjia Han, Luoxing Xia, Ling Zeng, Junhua Nie, Yongxia Huang, Yongxia Huang, Chi Kwan Tsang, Ying Wang, Zhigang Lei, Zaocheng Xu, Kwok-fai So, Kwok-fai So, Kwok-fai So, Kwok-fai So, Yiwen Ruan, Yiwen Ruan, Yiwen Ruan, Yiwen Ruan

“…By in vitro study, we further confirmed that LBP increased the viability of primary cultured cortical neurons when exposed to oxygen-glucose deprivation (OGD) for 4 h. Importantly, we found that LBP antagonized increase in expression of major proteins in the NR2B signal pathway including NR2B, nNOS, Bcl-2-associated death promoter (BAD), cytochrome C (cytC) and cleaved caspase-3, and also reduced ROS level, calcium influx and mitochondrial permeability after 4 h OGD. …”
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Interactions between Social Hierarchy and Some Udder Morphometric Traits upon Colostrum and Milk Physicochemical Characteristics in Crossbred Dairy Goats by Ma. Silvia Castillo-Zuñiga, César A. Meza-Herrera, Guadalupe Calderón-Leyva, Nicolas López-Villalobos, Cayetano Navarrete-Molina, Jorge A. Bustamante-Andrade, Pablo I. Sifuentes-Lamónt, Jessica M. Flores-Salas, Francisco G. Véliz-Deras

“…Thereafter, in October, while a behavioral study was performed in confirmed-pregnant goats to define the SR classes (<i>n</i> = 15), live weight (LW), body condition (BCS), and serum glucose (GLUC) were registered on the last day of the behavioral study. …”
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Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry by Francisco Javier Carrasco-Sánchez, Mª Dolores López-Carmona, Francisco Javier Martínez-Marcos, Luis M. Pérez-Belmonte, Alicia Hidalgo-Jiménez, Verónica Buonaiuto, Carmen Suárez Fernández, Santiago Jesús Freire Castro, Davide Luordo, Paula Maria Pesqueira Fontan, Julio César Blázquez Encinar, Jeffrey Oskar Magallanes Gamboa, Andrés de la Peña Fernández, José David Torres Peña, Joaquim Fernández Solà, Jose Javier Napal Lecumberri, Francisco Amorós Martínez, María Esther Guisado Espartero, Carlos Jorge Ripper, Raquel Gómez Méndez, Natalia Vicente López, Berta Román Bernal, María Gloria Rojano Rivero, José Manuel Ramos Rincón, Ricardo Gómez Huelgas

“…The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19.Methods This is a retrospective multi-centre study involving patients hospitalized in Spain. …”
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Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage by Usama Ashraf, Zhen Ding, Shunzhou Deng, Jing Ye, Shengbo Cao, Zheng Chen

“…Abbreviations AKT: a serine/threonine-specific protein kinase; AP1: activator protein 1; ASC: apoptosis-associated speck-like protein containing a CARD; ASK1: apoptosis signal-regulated kinase 1; ATF3/4/6: activating transcription factor 3/4/6; ATG5/7: autophagy-related 5/7; BBB: blood-brain barrier; Bcl-3/6: B-cell lymphoma 3/6 protein; CCL: C-C motif chemokine ligand; CCR2: C-C motif chemokine receptor 2; CHOP: C/EBP homologous protein; circRNA: circular RNA; CNS: central nervous system; CXCL: C-X-C motif chemokine ligand; dsRNA: double-stranded RNA; EDEM1: endoplasmic reticulum degradation enhancer mannosidase alpha-like 1; eIF2-ɑ: eukaryotic initiation factor 2 alpha; ER: endoplasmic reticulum; ERK: extracellular signal-regulated kinase; GRP78: 78-kDa glucose-regulated protein; ICAM: intercellular adhesion molecule; IFN: interferon; IL: interleukin; iNOS: inducible nitric oxide synthase; IRAK1/2: interleukin-1 receptor-associated kinase 1/2; IRE-1: inositol-requiring enzyme 1; IRF: interferon regulatory factor; ISG15: interferon-stimulated gene 15; JE: Japanese encephalitis; JEV: Japanese encephalitis virus; JNK: c-Jun N-terminal kinase; LAMP2: lysosome-associated membrane protein type 2; LC3-I/II: microtubule-associated protein 1 light chain 3-I/II; lncRNA: long non-coding RNA; MAPK: mitogen-activated protein kinase; miR/miRNA: microRNA; MK2: mitogen-activated protein kinase-activated protein kinase 2; MKK4: mitogen-activated protein kinase kinase 4; MLKL: mixed-linage kinase domain-like protein; MMP: matrix metalloproteinase; MyD88: myeloid differentiation factor 88; Nedd4: neural precursor cell-expressed developmentally downregulated 4; NF-κB: nuclear factor kappa B; NKRF: nuclear factor kappa B repressing factor; NLRP3: NLR family pyrin domain containing 3; NMDAR: N-methyl-D-aspartate receptor; NO: nitric oxide; NS2B/3/4: JEV non-structural protein 2B/3/4; P: phosphorylation. p38: mitogen-activated protein kinase p38; PKA: protein kinase A; PAK4: p21-activated kinase 4; PDFGR: platelet-derived growth factor receptor; PERK: protein kinase R-like endoplasmic reticulum kinase; PI3K: phosphoinositide 3-kinase; PTEN: phosphatase and tensin homolog; Rab7: Ras-related GTPase 7; Raf: proto-oncogene tyrosine-protein kinase Raf; Ras: a GTPase; RIDD: regulated IRE-1-dependent decay; RIG-I: retinoic acid-inducible gene I; RIPK1/3: receptor-interacting protein kinase 1/3; RNF11/125: RING finger protein 11/125; ROS: reactive oxygen species; SHIP1: SH2-containing inositol 5ʹ phosphatase 1; SOCS5: suppressor of cytokine signaling 5; Src: proto-oncogene tyrosine-protein kinase Src; ssRNA = single-stranded RNA; STAT: signal transducer and activator of transcription; TLR: toll-like receptor; TNFAIP3: tumor necrosis factor alpha-induced protein 3; TNFAR: tumor necrosis factor alpha receptor; TNF-α: tumor necrosis factor-alpha; TRAF6: tumor necrosis factor receptor-associated factor 6; TRIF: TIR-domain-containing adapter-inducing interferon-β; TRIM25: tripartite motif-containing 25; VCAM: vascular cell adhesion molecule; ZO-1: zonula occludens-1.…”
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Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice by George Firth, Eleni Georgiadou, Alexander Griffiths, Maral Amrahli, Jana Kim, Zilin Yu, Ming Hu, Theodora J. Stewart, Isabelle Leclerc, Isabelle Leclerc, Haruka Okamoto, Daniel Gomez, Philip J. Blower, Guy A. Rutter, Guy A. Rutter, Guy A. Rutter

“…Unexpectedly, rare loss-of-function (LoF) variants in the gene, described in heterozygous individuals only, are protective against the disease, even though knockout of the homologous SLC30A8 gene in mice leads to unchanged or impaired glucose tolerance. Here, we aimed to determine how one or two copies of the mutant R138X allele in the mouse SLC30A8 gene impacts the homeostasis of zinc at a whole-body (using non-invasive 62Zn PET imaging to assess the acute dynamics of zinc handling) and tissue/cell level [using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to map the long-term distribution of zinc and manganese in the pancreas].MethodsFollowing intravenous administration of [62Zn]Zn-citrate (~7 MBq, 150 μl) in wild-type (WT), heterozygous (R138X+/−), and homozygous (R138X+/+) mutant mice (14–15 weeks old, n = 4 per genotype), zinc dynamics were measured over 60 min using PET. …”
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Low fiber intake increase risk of Diabetes mellitus in overweight people by Yurista Permanasari, Rika Rachmawati

“…They were divided into 2 groups based on reference value of the Indonesian Endocrinology Associations <em>(Perkeni)</em> in 2006: Non DM=&lt;200 mg/dl; DM=≥ 200 mg/dl,</p> <p><strong>Results: </strong>Out of<strong> </strong>7,807 who underwent laboratory for glucose tests, 2.550 subjects were overweight and aged 15 years or over. …”
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β-Hydroxybutyrate impairs the release of bovine neutrophil extracellular traps through inhibiting phosphoinositide 3-kinase–mediated nicotinamide adenine dinucleotide phosphate oxi... by Siyuan Liu, Xiaobing Li, Xiaohan Zhou, Juan J. Loor, Qianming Jiang, Xiancheng Feng, Yuchen Yang, Lin Lei, Xiliang Du, Xinwei Li, Wang Zhe, Yuxiang Song, Guowen Liu

“…In this study, 5 healthy peripartal dairy cows (within 3 wk postpartum) with serum BHB concentrations <0.6 mM and glucose concentrations >3.5 mM were used as blood donors. …”
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Bioinoculant production composed by Pseudomonas sp., Serratia sp., and Kosakonia sp., preliminary effect on Allium cepa L., growth at plot scale by Andrea Blanco Vargas, Lina Rodríguez Gacha, Natalia Sánchez Castro, Laura Herrera Carlosama, Raúl Poutou Piñales, Lucía Díaz Ariza, Viviana Gutiérrez Romero, Claudia Rivera Hoyos, Leydi Ardila Leal, Aura Pedroza Rodriguez

“…Growth curve (12 h) in MT11B demonstrated consortium grew in presence of PR, brewer’s yeast hydrolysate, and glucose at concentrations (2.5 g L-1) fourfold lower than those in SMRS1 (10.0 g L-1); obtaining phosphate solubilizing bacteria of (10.60 ± 0.08/ log10 CFUmL-1 and, at 6 h of culture, acid and alkaline phosphatase enzyme volumetric activities of 2.3 ± 0.8 and (3.80 ± 0.13) UP, respectively. …”
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