Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding by Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Shanshan Zhang, Marina Rieder, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Rüdiger Eberhard Scharf, Rüdiger Eberhard Scharf, Rüdiger Eberhard Scharf, Daniel Duerschmied, Daniel Duerschmied, Daniel Duerschmied, Nancy Schanze, Nancy Schanze

“…Metabolic phenotyping (metabolic caging, glucose and insulin tolerance testing, body and organ weight measurements, qPCR, histology) and assessment of adipose tissue inflammation (flow cytometry, histology, qPCR) were carried out at the end of the 19-week high-fat diet feeding period. …”
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The Chinese herbal medicine Fufang Zhenzhu Tiaozhi ameliorates diabetic cardiomyopathy by regulating cardiac abnormal lipid metabolism and mitochondrial dynamics in diabetic mice by Meiling Yan, Suping Liu, Wenru Zeng, Qiaoling Guo, Yu Mei, Xiaoqi Shao, Liyan Su, Zhou Liu, Yue Zhang, Lexun Wang, Hongtao Diao, Xianglu Rong, Jiao Guo

“…Our study indicated that FTZ improves the cardiac function of diabetic mice by attenuating the increase in fasting blood glucose levels, inhibiting the decrease in body weight, alleviating disordered lipid metabolism, and restoring mitochondrial dynamics and myocardial apoptosis in diabetic mouse hearts.…”
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Ferrous Ion Alleviates Lipid Deposition and Inflammatory Responses Caused by a High Cottonseed Meal Diet by Modulating Hepatic Iron Transport Homeostasis and Controlling Ferroptosi... by Hengchen Liu, Shiyou Chen, Yan Lin, Wenqiang Jiang, Yongfeng Zhao, Siyue Lu, Linghong Miao, Xianping Ge

“…Furthermore, the plasma levels of liver functional indices, including alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and glucose (GLU), were significantly lower in the HCM + 0.4%Fe²⁺ group (<i>p</i> < 0.05). …”
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Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery by Qing-Run Li, Zi-Ming Wang, Nicolai J. Wewer Albrechtsen, Dan-Dan Wang, Zhi-Duan Su, Xian-Fu Gao, Qing-Qing Wu, Hui-Ping Zhang, Li Zhu, Rong-Xia Li, SivHesse Jacobsen, Nils Bruun Jørgensen, Carsten Dirksen, Kirstine N. Bojsen-Møller, Jacob S. Petersen, Sten Madsbad, Trine R. Clausen, Børge Diderichsen, Luo-Nan Chen, Jens J. Holst, Rong Zeng, Jia-Rui Wu

“…In this study, we profiled plasma metabolites and proteins of 10 normal glucose-tolerant obese (NO) and 9 diabetic obese (DO) patients before and 1-week, 3-months, 1-year after RYGB. 146 proteins and 128 metabolites from both NO and DO groups at all four stages were selected for further analysis. …”
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The female syndecan-4−/− heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels by Thea Parsberg Støle, Marianne Lunde, Marianne Lunde, Xin Shen, Xin Shen, Marita Martinsen, Marita Martinsen, Per Kristian Lunde, Per Kristian Lunde, Jia Li, Jia Li, Francesca Lockwood, Francesca Lockwood, Ivar Sjaastad, Ivar Sjaastad, William Edward Louch, William Edward Louch, Jan Magnus Aronsen, Jan Magnus Aronsen, Geir Christensen, Geir Christensen, Cathrine Rein Carlson

“…LV and skeletal muscle (TA) from sedentary male syndecan-4−/− and WT mice were immunoblotted with Akt antibodies for comparison. Glucose levels were measured by a glucometer, and fasting blood serum insulin and C-peptide levels were measured by ELISA.Results: Compared to female WT hearts, sedentary female syndecan-4−/− LV cardiomyocytes were smaller and hearts had higher levels of pSer473-Akt and its downstream target pSer9-GSK-3β. …”
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Aged oolong tea manages type 2 diabetes mellitus by inhibiting fat ectopic deposition and alleviating insulin resistance in db/db mice by Hongzhe Zeng, Kuofei Wang, Changwei Liu, Jie Ouyang, Shuai Wen, Fang Zhou, Jingyi Tang, Wenwen Fang, Lin Yue, Jian'an Huang, Zhonghua Liu

“…The results showed that aged oolong tea extracts (aged TEs) alleviated the abnormal fasting blood glucose levels, lipid profiles, insulin resistance, and reduced ectopic fat deposition in liver. …”
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The temporal trend of disease burden attributable to metabolic risk factors in China, 1990–2019: An analysis of the Global Burden of Disease study by Yingzhao Jin, Ho So, Ester Cerin, Ester Cerin, Anthony Barnett, Sumaira Mubarik, Kamal Hezam, Kamal Hezam, Xiaoqi Feng, Xiaoqi Feng, Xiaoqi Feng, Ziyue Wang, Ziyue Wang, Junjie Huang, Chenwen Zhong, Khezar Hayat, Khezar Hayat, Fang Wang, Ai-Min Wu, Suowen Xu, Zhiyong Zou, Lee-Ling Lim, Lee-Ling Lim, Jiao Cai, Yimeng Song, Lai-shan Tam, Dongze Wu, Dongze Wu

“…The objective of this study was to (i) estimate the pattern and trend of six metabolic risk factors and attributable causes in China from 1990 to 2019, (ii) ascertain its association with societal development, and (iii) compare the disease burden among the Group of 20 (G20) countries.MethodsThe main outcome measures were disability-adjusted life-years (DALYs) and mortality (deaths) attributable to high fasting plasma glucose (HFPG), high systolic blood pressure (HSBP), high low-density lipoprotein (HLDL) cholesterol, high body-mass index (HBMI), kidney dysfunction (KDF), and low bone mineral density (LBMD). …”
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White matter fiber-specific degeneration in older adults with metabolic syndrome by Christina Andica, Koji Kamagata, Wataru Uchida, Kaito Takabayashi, Keigo Shimoji, Hideyoshi Kaga, Yuki Someya, Yoshifumi Tamura, Ryuzo Kawamori, Hirotaka Watada, Masaaki Hori, Shigeki Aoki

“…Objective: Metabolic syndrome (MetS) is defined as a complex of interrelated risk factors for type 2 diabetes and cardiovascular disease, including glucose intolerance, abdominal obesity, hypertension, and dyslipidemia. …”
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Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma by Hweixian Leong Penny, Je Lin Sieow, Sin Yee Gun, Mai Chan Lau, Bernett Lee, Jasmine Tan, Cindy Phua, Florida Toh, Yvonne Nga, Wei Hseun Yeap, Baptiste Janela, Dilip Kumar, Hao Chen, Joe Yeong, Justin A. Kenkel, Angela Pang, Diana Lim, Han Chong Toh, Tony Lim Kiat Hon, Christopher I. Johnson, Hanif Javanmard Khameneh, Alessandra Mortellaro, Edgar G. Engleman, Olaf Rotzschke, Florent Ginhoux, Jean-Pierre Abastado, Jinmiao Chen, Siew Cheng Wong

“…Macrophage-specific deletion of Glucose Transporter 1 (GLUT1) significantly reduced tumor burden, which was accompanied by increased Natural Killer and CD8+ T cell activity and suppression of the NLRP3-IL1β inflammasome axis. …”
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Effect of sodium (S)-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway by Eduardo Cienfuegos-Pecina, Tannya R. Ibarra-Rivera, Alma L. Saucedo, Luis A. Ramírez-Martínez, Deanna Esquivel-Figueroa, Ixel Domínguez-Vázquez, Karina J. Alcántara-Solano, Diana P. Moreno-Peña, Gabriela Alarcon-Galvan, Diana Raquel Rodríguez-Rodríguez, Liliana Torres-González, Linda E. Muñoz-Espinosa, Edelmiro Pérez-Rodríguez, Paula Cordero-Pérez

“…Markers of kidney injury (BUN, creatinine, glucose, and uric acid) and liver function (ALT, AST, ALP, LDH, serum proteins, and albumin), proinflammatory cytokines (IL-1β, IL-6, and TNF-α), oxidative stress biomarkers (malondialdehyde and superoxide dismutase), and histological parameters (tubular necrosis, acidophilic casts, and vascular congestion) were assessed. …”
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The atypical β‐blocker S‐oxprenolol reduces cachexia and improves survival in a rat cancer cachexia model by Luping Yuan, Jochen Springer, Sandra Palus, Silvia Busquets, Queralt Jové, Edson Alves de Lima Junior, Markus S. Anker, Stephan vonHaehling, Natalia Álvarez Ladrón, Oliver Millman, Annemijn Oosterlee, Agata Szymczyk, Francisco Javier López‐Soriano, Stefan D. Anker, Andrew J.S. Coats, Josep M. Argiles

“…Western blotting of proteins involved in the anabolic/catabolic homoeostasis suggest that anabolic signalling is persevered (IGF‐1 receptor, Akt) and catabolic signalling is inhibited (FXBO‐10, TRAF‐6) by S‐pindolol, but not he R‐enantiomer. Expression of glucose transporters Glut1 and Glut 4 was similar in all groups, as was AMPK. …”
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Corneal Endothelial Morphology and Central Corneal Thickness Changes in Type 2 Diabetes Mellitus using Specular Microscopy and Ultrasonic Pachymetry: A Cross-sectional Comparative... by Vijay Singh, Prakriti Chourasia, Sandeep Kumar

“…Introduction: Diabetes Mellitus (DM) is a metabolic condition characterised by chronic hyperglycaemia, causing raised blood glucose levels which result in microvascular and macrovascular disorders and may introduce ocular manifestations including changes in corneal Endothelial Cell Density (ECD), corneal thickness, and intraocular pressure. …”
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Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study by Lijie Kong, Yiying Wang, Chaojie Ye, Chun Dou, Dong Liu, Min Xu, Jie Zheng, Ruizhi Zheng, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Weiqing Wang, Ruixin Liu, Yufang Bi, Tiange Wang, Guang Ning

“…Cardiometabolic factors, including lipids and lipoproteins, glucose and insulin, blood pressure, and fatty acids, each mediated 4.09-23.71% of the total effect of birthweight on MI, followed by body composition and strength traits (i.e., appendicular lean mass, height, and grip strength) and socioeconomic indicators (i.e., education and household income), with the mediation proportion for each factor ranging from 8.08 to 16.80%. …”
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Sequential algorithm to stratify liver fibrosis risk in overweight/obese metabolic dysfunction-associated fatty liver disease by Chi-Ho Lee, Chi-Ho Lee, David Tak-Wai Lui, Raymond Hang-Wun Li, Michele Mae-Ann Yuen, Carol Ho-Yi Fong, Ambrose Pak-Wah Leung, Justin Chiu-Man Chu, Loey Lung-Yi Mak, Tai-Hing Lam, Jean Woo, Yu-Cho Woo, Aimin Xu, Aimin Xu, Hung-Fat Tse, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Man-Fung Yuen, Man-Fung Yuen, Karen Siu-Ling Lam, Karen Siu-Ling Lam

“…Here, we investigated whether incorporating additional metabolic risk factors into clinical evaluation improved liver fibrosis risk stratification among individuals with non-diabetic overweight/obese MAFLD.Materials and methodsComprehensive metabolic evaluation including 75-gram oral glucose tolerance test was performed in over 1000 participants from the New Hong Kong Cardiovascular Risk Factor Prevalence Study (HK-NCRISPS), a contemporary population-based study of HK Chinese. …”
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Effect of night shift work on metabolic syndrome in adults who suffered from earthquake stress in early life by Na Li, Na Li, Na Li, Ran Wang, Ran Wang, Ran Wang, Peihua Hu, Peihua Hu, Peihua Hu, Wenting Lu, Wenting Lu, Wenting Lu, Xiaochuan Zhao, Xiaochuan Zhao, Xiaochuan Zhao, Lan Wang, Lan Wang, Lan Wang, Mei Song, Mei Song, Mei Song, Yuanyuan Gao, Yuanyuan Gao, Yuanyuan Gao, Cuixia An, Cuixia An, Cuixia An, Shahid Bashir, Xueyi Wang, Xueyi Wang, Xueyi Wang

“…The measurement of all subjects’ waist circumference and blood pressure was made, and triglycerides, fasting blood glucose, high-density lipoproteins, and low-density lipoproteins were measured by collecting blood samples. …”
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دراسة مقارنة بين الأوكسي توسين والميزوبروستول في الوقاية من نزوف الخلاص by عدنان محمد, ديما سلوم

“…Patients were randomly divided into three groups: ( 1: uterine massage group, 2: 10 units oxytocin in 500 cc glucose 5% intravenously with delivery of the anterior sholder\ control group, 3: three 200µg rectal misoprostol tablets\study group). …”
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Adrenalectomy Improves Blood Pressure and Metabolic Control in Patients With Possible Autonomous Cortisol Secretion: Results of a RCT by Valentina Morelli, Sofia Frigerio, Sofia Frigerio, Carmen Aresta, Elena Passeri, Flavia Pugliese, Massimilano Copetti, Anna Maria Barbieri, Anna Maria Barbieri, Silvia Fustinoni, Silvia Fustinoni, Elisa Polledri, Sabrina Corbetta, Sabrina Corbetta, Maura Arosio, Maura Arosio, Alfredo Scillitani, Iacopo Chiodini, Iacopo Chiodini

“…Plasma adrenocorticotroph hormone (ACTH), 24-h urinary free cortisol, 24-h urinary free cortisone, F-1mgDST, glucose, lipids, glycated hemoglobin (HbA1c) levels, blood pressure (BP), body weight, and treatment variations were assessed. …”
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Antidiabetes study of Spondias mombin (Linn) stem bark fractions in high-sucrose diet-induced diabetes in Drosophila melanogaster by Damilola A. Omoboyowa, PhD, Mary D. Agoi, M.sc, Sidiqat A. Shodehinde, PhD, Oluwatosin A. Saibu, M.sc, Jamiyu A. Saliu, PhD

“…The fractions restored the glucose and antioxidant imbalance in diabetic flies, which is comparable with the standard drug (metformin). …”
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Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress by Xiuyu Wang, Xing Ma, Yue Zeng, Lingbo Xu, Minghao Zhang

“…Additionally, immunofluorescence staining was performed to detect the protein expression levels of CTRP9, glucose-regulated protein 78 kD (GRP78), phosphorylated protein kinase RNA-like ER kinase (p-PERK), activating transcription factor 6a (ATF6a), phosphorylated inositol-requiring enzyme-1α (p-IRE1α), sterol regulatory element binding proteins-1c (SREBP1c) and sterol regulatory element binding proteins-2 (SREBP2) in VSMC derived from murine aortic roots. …”
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Stroke-associated infection in patients with co-morbid diabetes mellitus is associated with in-hospital mortality by Minping Wei, Qin Huang, Fang Yu, Xianjing Feng, Yunfang Luo, Tingting Zhao, Ruxin Tu, Di Liao, Yang Du, Yang Du, Yang Du, Qing Huang, Qing Huang, Qing Huang, Wenping Gu, Wenping Gu, Wenping Gu, Yunhai Liu, Yunhai Liu, Yunhai Liu, Yingyu Jiang, Yingyu Jiang, Hongqiu Gu, Hongqiu Gu, Zixiao Li, Zixiao Li, Zixiao Li, Jian Xia, Jian Xia, Jian Xia

“…The in-hospital mortality after infection was associated with age (OR = 1.02, 95% CI: 1.01–1.03, P &lt; 0.0001), male (OR = 1.39, 95% CI: 1.13–1.71, P = 0.0018), reperfusion therapy (OR = 2.00, 95% CI: 1.56–2.56, P &lt; 0.0001), and fasting plasma glucose at admission (OR = 1.05, 95% CI: 1.03–1.08, P &lt; 0.0001). …”
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