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51961
Interorgan communication with the liver: novel mechanisms and therapeutic targets
Published 2023-12-01“…The liver is a multifunctional organ that plays crucial roles in numerous physiological processes, such as production of bile and proteins for blood plasma, regulation of blood levels of amino acids, processing of hemoglobin, clearance of metabolic waste, maintenance of glucose, etc. Therefore, the liver is essential for the homeostasis of organisms. …”
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51962
The Benefits of a Comprehensive Cardiac Rehabilitation Program for Patients with Acute Coronary Syndrome: A Follow-Up Study
Published 2023-10-01“…A multivariable analysis, following GDMT, showed the actual value or information and training of patients regarding optimal cardiovascular risk factor control was independently associated with lower values of systolic blood pressure (R<sup>2</sup> = 0.48), diastolic (R<sup>2</sup> = 0.38), serum glucose (R<sup>2</sup> = 0.48), glycated hemoglobin (R<sup>2</sup> = 0.50), total cholesterol (R<sup>2</sup> = 0.31), LDL-cholesterol (R<sup>2</sup> = 0.30), HDL-cholesterol (R<sup>2</sup> = 0.19) and serum triglycerides (R<sup>2</sup> = 0.20). …”
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51963
A pedigree-based cohort to study the genetic risk factors for cardiometabolic diseases: study design, baseline characteristics and preliminary results
Published 2023-07-01“…Based on the pedigree structure, the heritability of systolic blood pressure, diastolic blood pressure, fast blood glucose, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein was estimated at 0.379, 0.306, 0.386, 0.452, 0.568, 0.852, and 0.387, respectively.ConclusionAs an extended pedigree cohort in China, FTPC will provide an important source to study both genetic and environmental risk factors prospectively.…”
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51964
Doença de Moyamoya e anestesia com sevoflurano fora do centro cirúrgico: relato de caso Enfermedad de Moyamoya y anestesia con sevoflurano fuera del centro quirúrgico: relato de ca...
Published 2002-06-01“…An intravenous catheter was inserted for 5% glucose solution infusion. Manual controlled ventilation was started and anesthesia was maintained with 4% sevoflurane in 50% oxygen/nitrous oxide. …”
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51965
Effects of an Eight Week Very Low-Calorie Ketogenic Diet (VLCKD) on White Blood Cell and Platelet Counts in Relation to Metabolic Dysfunction-Associated Steatotic Liver Disease (MA...
Published 2023-10-01“…Seemingly, WBC (<i>p</i>-value < 0.001) and PLT (<i>p</i>-value < 0.001) counts were lowered by VLCKD in the whole group; however, the decrease in WBC and platelet counts were significant only in patients with steatosis (CAP ≥ 215 dB/m). Fasting blood glucose (<i>p</i>-value < 0.001), insulin (<i>p</i>-value < 0.001), HbA1c (<i>p</i>-value < 0.001), triglycerides (<i>p</i>-value < 0.001), total cholesterol (<i>p</i>-value < 0.001), LDL-cholesterol (<i>p</i>-value < 0.001), HDL-cholesterol (<i>p</i>-value < 0.001); γGT (<i>p</i>-value < 0.001) blood levels and insulin resistance (as measured by HOMAIR) (<i>p</i>-value < 0.001); and systolic (<i>p</i>-value < 0.001), and diastolic (<i>p</i>-value < 0.001) blood pressure levels, were all significantly lower after VLCKD. …”
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51966
NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (ND...
Published 2023-01-01“…Biochemical parameters including oral glucose tolerance test, lipid profile, and various lipid-derived parameter/ratios were also analyzed via standardized methods. …”
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51967
Data-driven clustering approach to identify novel phenotypes using multiple biomarkers in acute ischaemic stroke: A retrospective, multicentre cohort study
Published 2022-11-01“…Phenotype 1 was associated with abnormal glucose and lipid metabolism. Phenotype 2 was characterized by inflammation and abnormal renal function. …”
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51968
Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging
Published 2023-01-01“…Objective: In preclinical research, the use of [18F]Fluorodesoxyglucose (FDG) as a biomarker for neurodegeneration may induce bias due to enhanced glucose uptake by immune cells. In this study, we sought to investigate synaptic vesicle glycoprotein 2A (SV2A) PET with [18F]UCB-H as an alternative preclinical biomarker for neurodegenerative processes in two mouse models representing the pathological hallmarks of Alzheimer’s disease (AD). …”
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51969
Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome
Published 2023-04-01“…L-phenylalanine was found to be increased and correlated with the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (r = 0.22, p = 0.050) and fasting glucose (r = 0.33, p = 0.003) for rs2994652, while arachidonic acid metabolism was found to be decreased and associated with increased anti-Müllerian hormone (AMH; r = –0.51, p = 0.01) and total testosterone (TT; r = –0.71, p = 0.02) for rs182542888. …”
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51970
Role of Incretins in Muscle Functionality, Metabolism, and Body Composition in Breast Cancer: A Metabolic Approach to Understanding This Pathology
Published 2024-01-01“…A poorly studied issue in women with breast cancer is the role of incretins (GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1)) in the quantity and quality of muscle mass in lean and obese individuals. …”
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51971
Correlation of lncRNA NEAT1 and miRNA-182-5p with the Risk of Liver Fibrosis in Type 2 Diabetes Mellitus Patients with MAFLD
Published 2024-01-01“…Results Age, neck circumference (NC), fasting blood glucose (FPG) and glycosylated hemoglobin (HbA1c) in the healthy control group were lower than those in the T2DM with non-MAFLD and T2DM with MAFLD groups, the albumin (Alb) in the healthy control group was higher than that in the T2DM with non-MAFLD and T2DM with MAFLD groups (P<0.05). …”
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51972
Dawn-to-dusk dry fasting induces anti-atherosclerotic, anti-inflammatory, and anti-tumorigenic proteome in peripheral blood mononuclear cells in subjects with metabolic syndrome
Published 2022-12-01“…Background: Metabolic syndrome characterized by abdominal obesity, high blood pressure, elevated fasting glucose and triglyceride levels and low high-density lipoprotein cholesterol level is associated with pro-inflammatory state, increased risk for atherosclerosis, and multiple cancers. …”
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51973
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCCSummary
Published 2023-01-01“…We explored the regulatory mechanism of ZEB1 in SSP flux using uniformly-labeled [13C]-glucose tracing analyses, liquid chromatography–mass spectrometry, real-time quantitative polymerase chain reaction, luciferase report assay, and chromatin immunoprecipitation assay. …”
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51974
Sex-Specific Effects of Nutritional Supplements for Infants Born Early or Small: An Individual Participant Data Meta-Analysis (ESSENCE IPD-MA) I—Cognitive Function and Metabolic Ri...
Published 2022-01-01“…Supplementation lowered triglyceride concentrations but did not affect other metabolic outcomes (high-density and low-density lipoproteins, cholesterol, fasting glucose, blood pressure, body mass index). Macronutrient supplementation for infants born small may not alter later cognitive function or metabolic risk, but may improve early motor function, especially for girls.…”
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51975
Effects of Vitamin A on Immune Responses and Vitamin A Metabolism in Broiler Chickens Challenged with Necrotic Enteritis
Published 2023-05-01“…The results showed that NE challenge increased lesion score in the jejunum and decreased serum glucose, total glyceride, calcium, phosphorus and uric acid levels (<i>p</i> < 0.05). …”
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51976
Nutrition Intervention for Reduction of Cardiovascular Risk in African Americans Using the 2019 American College of Cardiology/American Heart Association Primary Prevention Guideli...
Published 2021-09-01“…Cardiometabolic risk factors improved significantly, highlighted by a marked reduction in serum insulin (−43%, <i>p</i> = 0.000), hemoglobin A1c (6.2% to 6.0%, <i>p</i> = 0.000), weight and BMI (−10.2 lbs, 33 to 31 kg/m<sup>2</sup>, <i>p</i> = 0.000), but with small reductions of fasting glucose (−6%, <i>p</i> = 0.405) and triglyceride levels (−4%, <i>p</i> = 0.408). …”
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51977
Metabolic syndrome, adiposity, diet, and emotional eating are associated with oxidative stress in adolescents
Published 2023-09-01“…In addition, univariable analysis revealed positive significant associations between 8-isoprostane and body mass index, waist circumference, waist-to-height ratio, body fat percentage, blood lipid profile and glucose, emotional eating, and refined cereal intake. …”
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51978
Prenatal air pollution, fetal β-cell dysfunction and neurodevelopmental delay
Published 2023-12-01“…Screening and treatment of abnormal glucose metabolism in infants could benefit the prevention of air pollution-associated neurodevelopment delay.…”
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51979
Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons
Published 2022-11-01“…Methods: In this study, oxygen consumption rate, ATP production, mitochondrial biosynthesis, glucose metabolism, and SIRT1-PGC-1α pathways in untreated and GS-treated different cells, fly, and mouse models were investigated. …”
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51980
Imaging for assessment of cancer treatment response to immune checkpoint inhibitors can be complementary in identifying hypophysitis
Published 2023-11-01“…Available structural brain imaging with magnetic resonance imaging (MRI) or computed tomography (CT) of the brain and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography with computed tomography (FDG-PET/CT) were assessed retrospectively. …”
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