Interorgan communication with the liver: novel mechanisms and therapeutic targets by Jiulu Zhao, Jiulu Zhao, Xi Zhang, Xi Zhang, Yuan Li, Yuan Li, Jizhang Yu, Jizhang Yu, Zhang Chen, Zhang Chen, Yuqing Niu, Yuqing Niu, Shuan Ran, Shuan Ran, Song Wang, Song Wang, Weicong Ye, Weicong Ye, Zilong Luo, Zilong Luo, Xiaohan Li, Xiaohan Li, Yanglin Hao, Yanglin Hao, Junjie Zong, Junjie Zong, Chengkun Xia, Jiahong Xia, Jiahong Xia, Jiahong Xia, Jie Wu, Jie Wu, Jie Wu

“…The liver is a multifunctional organ that plays crucial roles in numerous physiological processes, such as production of bile and proteins for blood plasma, regulation of blood levels of amino acids, processing of hemoglobin, clearance of metabolic waste, maintenance of glucose, etc. Therefore, the liver is essential for the homeostasis of organisms. …”
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The Benefits of a Comprehensive Cardiac Rehabilitation Program for Patients with Acute Coronary Syndrome: A Follow-Up Study by Laura Maria Craciun, Florina Buleu, Ana Maria Pah, Marius Badalica-Petrescu, Olivia Bodea, Dana Emilia Man, Oana Catalina Cosor, Stela Iurciuc, Simona Dragan, Maria Rada

“…A multivariable analysis, following GDMT, showed the actual value or information and training of patients regarding optimal cardiovascular risk factor control was independently associated with lower values of systolic blood pressure (R² = 0.48), diastolic (R² = 0.38), serum glucose (R² = 0.48), glycated hemoglobin (R² = 0.50), total cholesterol (R² = 0.31), LDL-cholesterol (R² = 0.30), HDL-cholesterol (R² = 0.19) and serum triglycerides (R² = 0.20). …”
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A pedigree-based cohort to study the genetic risk factors for cardiometabolic diseases: study design, baseline characteristics and preliminary results by Hongchen Zheng, Hongchen Zheng, Hongchen Zheng, Ying Ye, Hui Huang, Hui Huang, Chunlan Huang, Wenjing Gao, Wenjing Gao, Mengying Wang, Mengying Wang, Wenyong Li, Wenyong Li, Ren Zhou, Ren Zhou, Jin Jiang, Jin Jiang, Siyue Wang, Siyue Wang, Canqing Yu, Canqing Yu, Canqing Yu, Jun Lv, Jun Lv, Jun Lv, Xiaoling Wu, Xiaoming Huang, Weihua Cao, Weihua Cao, Yansheng Yan, Kuicheng Zheng, Tao Wu, Tao Wu, Tao Wu, Liming Li, Liming Li, Liming Li

“…Based on the pedigree structure, the heritability of systolic blood pressure, diastolic blood pressure, fast blood glucose, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein was estimated at 0.379, 0.306, 0.386, 0.452, 0.568, 0.852, and 0.387, respectively.ConclusionAs an extended pedigree cohort in China, FTPC will provide an important source to study both genetic and environmental risk factors prospectively.…”
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Doença de Moyamoya e anestesia com sevoflurano fora do centro cirúrgico: relato de caso Enfermedad de Moyamoya y anestesia con sevoflurano fuera del centro quirúrgico: relato de ca... by Sheila Braga Machado, Florentino Fernandes Mendes, Adriana de Campos Angelini

“…An intravenous catheter was inserted for 5% glucose solution infusion. Manual controlled ventilation was started and anesthesia was maintained with 4% sevoflurane in 50% oxygen/nitrous oxide. …”
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Effects of an Eight Week Very Low-Calorie Ketogenic Diet (VLCKD) on White Blood Cell and Platelet Counts in Relation to Metabolic Dysfunction-Associated Steatotic Liver Disease (MA... by Sara De Nucci, Caterina Bonfiglio, Rosanna Donvito, Martina Di Chito, Nicole Cerabino, Roberta Rinaldi, Annamaria Sila, Endrit Shahini, Vito Giannuzzi, Pasqua Letizia Pesole, Sergio Coletta, Elsa Lanzilotta, Giuseppina Piazzolla, Raffaele Cozzolongo, Gianluigi Giannelli, Giovanni De Pergola

“…Seemingly, WBC (<i>p</i>-value < 0.001) and PLT (<i>p</i>-value < 0.001) counts were lowered by VLCKD in the whole group; however, the decrease in WBC and platelet counts were significant only in patients with steatosis (CAP ≥ 215 dB/m). Fasting blood glucose (<i>p</i>-value < 0.001), insulin (<i>p</i>-value < 0.001), HbA1c (<i>p</i>-value < 0.001), triglycerides (<i>p</i>-value < 0.001), total cholesterol (<i>p</i>-value < 0.001), LDL-cholesterol (<i>p</i>-value < 0.001), HDL-cholesterol (<i>p</i>-value < 0.001); γGT (<i>p</i>-value < 0.001) blood levels and insulin resistance (as measured by HOMAIR) (<i>p</i>-value < 0.001); and systolic (<i>p</i>-value < 0.001), and diastolic (<i>p</i>-value < 0.001) blood pressure levels, were all significantly lower after VLCKD. …”
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NDSP 12: Atherogenic index of plasma as a useful marker of cardiovascular disease risk among Pakistani individuals; a study from the second National Diabetes Survey of Pakistan (ND... by Asher Fawwad, Yasir Mahmood, Saima Askari, Anum Butt, Abdul Basit, Mujeeb Ur Rehman Abro, Khawaja Ishfaq Ahmed, Khurshid Ahmed, Sobia Sabir Ali, Ahmed Bilal, Anam Butt, Bikha Ram Devrajani, Ijaz Hayder, Yasir Humayun, Rabia Irshad, Riasat Ali Khan, Asima Khan, Aamir Akram Khowaja, Raheela Khowaja, Qazi Masroor, Maqsood Mehmood, Hassan Moin, Nida Mustafa, Wasif Noor, Huma Qureshi, Ibrar Rafique, Tahir Rasool, Rubina Sabir, M. Arif N. Saqib, Pir Alam Said, Abrar Shaikh, Bilal Bin Younus, Bilal Tahir, Salma Tanveer, Jamal Zafar

“…Biochemical parameters including oral glucose tolerance test, lipid profile, and various lipid-derived parameter/ratios were also analyzed via standardized methods. …”
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Data-driven clustering approach to identify novel phenotypes using multiple biomarkers in acute ischaemic stroke: A retrospective, multicentre cohort study by Lingling Ding, Ravikiran Mane, Zhenzhou Wu, Yong Jiang, Xia Meng, Jing Jing, Weike Ou, Xueyun Wang, Yu Liu, Jinxi Lin, Xingquan Zhao, Hao Li, Yongjun Wang, Zixiao Li

“…Phenotype 1 was associated with abnormal glucose and lipid metabolism. Phenotype 2 was characterized by inflammation and abnormal renal function. …”
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Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging by Letizia Vogler, Anna Ballweg, Bernd Bohr, Nils Briel, Karin Wind, Melissa Antons, Lea H. Kunze, Johannes Gnörich, Simon Lindner, Franz-Josef Gildehaus, Karlheinz Baumann, Peter Bartenstein, Guido Boening, Sibylle I. Ziegler, Johannes Levin, Andreas Zwergal, Günter U. Höglinger, Jochen Herms, Matthias Brendel

“…Objective: In preclinical research, the use of [18F]Fluorodesoxyglucose (FDG) as a biomarker for neurodegeneration may induce bias due to enhanced glucose uptake by immune cells. In this study, we sought to investigate synaptic vesicle glycoprotein 2A (SV2A) PET with [18F]UCB-H as an alternative preclinical biomarker for neurodegenerative processes in two mouse models representing the pathological hallmarks of Alzheimer’s disease (AD). …”
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Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome by Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi

“…L-phenylalanine was found to be increased and correlated with the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (r = 0.22, p = 0.050) and fasting glucose (r = 0.33, p = 0.003) for rs2994652, while arachidonic acid metabolism was found to be decreased and associated with increased anti-Müllerian hormone (AMH; r = –0.51, p = 0.01) and total testosterone (TT; r = –0.71, p = 0.02) for rs182542888. …”
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Role of Incretins in Muscle Functionality, Metabolism, and Body Composition in Breast Cancer: A Metabolic Approach to Understanding This Pathology by Brenda-Eugenia Martínez-Herrera, Michelle-Guadalupe Muñoz-García, Laura-Liliana José-Ochoa, Luis-Aarón Quiroga-Morales, Luz-María Cervántes-González, Mario-Alberto Mireles-Ramírez, Raúl Delgadillo-Cristerna, Carlos-M. Nuño-Guzmán, Caridad-Aurea Leal-Cortés, Eliseo Portilla-de-Buen, Benjamín Trujillo Hernández, Eduardo Gómez-Sánchez, Martha-Cecilia Velázquez-Flores, Mario Salazar-Páramo, Miguel-Ricardo Ochoa-Plascencia, Daniel Sat-Muñoz, Luz-Ma.-Adriana Balderas-Peña

“…A poorly studied issue in women with breast cancer is the role of incretins (GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1)) in the quantity and quality of muscle mass in lean and obese individuals. …”
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Correlation of lncRNA NEAT1 and miRNA-182-5p with the Risk of Liver Fibrosis in Type 2 Diabetes Mellitus Patients with MAFLD by HE Jia, LI Yongping, WEI Feng, LIU Meilan, WU Yaling, SHAO Longge

“…Results Age, neck circumference (NC), fasting blood glucose (FPG) and glycosylated hemoglobin (HbA1c) in the healthy control group were lower than those in the T2DM with non-MAFLD and T2DM with MAFLD groups, the albumin (Alb) in the healthy control group was higher than that in the T2DM with non-MAFLD and T2DM with MAFLD groups (P&lt;0.05). …”
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Dawn-to-dusk dry fasting induces anti-atherosclerotic, anti-inflammatory, and anti-tumorigenic proteome in peripheral blood mononuclear cells in subjects with metabolic syndrome by Ayse L. Mindikoglu, Jihwan Park, Antone R. Opekun, Mustafa M. Abdulsada, Zoe R. Wilhelm, Prasun K. Jalal, Sridevi Devaraj, Sung Yun Jung

“…Background: Metabolic syndrome characterized by abdominal obesity, high blood pressure, elevated fasting glucose and triglyceride levels and low high-density lipoprotein cholesterol level is associated with pro-inflammatory state, increased risk for atherosclerosis, and multiple cancers. …”
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ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCCSummary by Huihui Wang, Furong Lin, Zhenzhen Xu, Shengnan Yu, Guannan Li, Shan Liao, Wentao Zhao, Fengqiong Zhang, Jinyang Wang, Shijie Wang, Cong Ouyang, Cixiong Zhang, Hailong Xia, Yufei Wu, Bin Jiang, Qinxi Li

“…We explored the regulatory mechanism of ZEB1 in SSP flux using uniformly-labeled [13C]-glucose tracing analyses, liquid chromatography–mass spectrometry, real-time quantitative polymerase chain reaction, luciferase report assay, and chromatin immunoprecipitation assay. …”
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Sex-Specific Effects of Nutritional Supplements for Infants Born Early or Small: An Individual Participant Data Meta-Analysis (ESSENCE IPD-MA) I—Cognitive Function and Metabolic Ri... by Luling Lin, Greg D. Gamble, Caroline A. Crowther, Frank H. Bloomfield, Massimo Agosti, Stephanie A. Atkinson, Augusto Biasini, Nicholas D. Embleton, Mary S. Fewtrell, Fernando Lamy-Filho, Christoph Fusch, Maria L. Gianni, H. Gozde Kanmaz Kutman, Winston Koo, Ita Litmanovitz, Colin Morgan, Kanya Mukhopadhyay, Erica Neri, Jean-Charles Picaud, Niels Rochow, Paola Roggero, Atul Singhal, Kenneth Stroemmen, Maw J. Tan, Francesco M. Tandoi, Claire L. Wood, Gitte Zachariassen, Jane E. Harding

“…Supplementation lowered triglyceride concentrations but did not affect other metabolic outcomes (high-density and low-density lipoproteins, cholesterol, fasting glucose, blood pressure, body mass index). Macronutrient supplementation for infants born small may not alter later cognitive function or metabolic risk, but may improve early motor function, especially for girls.…”
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Effects of Vitamin A on Immune Responses and Vitamin A Metabolism in Broiler Chickens Challenged with Necrotic Enteritis by Shuangshuang Guo, Lai He, Yuanke Zhang, Junlong Niu, Changwu Li, Zhengfan Zhang, Peng Li, Binying Ding

“…The results showed that NE challenge increased lesion score in the jejunum and decreased serum glucose, total glyceride, calcium, phosphorus and uric acid levels (<i>p</i> < 0.05). …”
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Nutrition Intervention for Reduction of Cardiovascular Risk in African Americans Using the 2019 American College of Cardiology/American Heart Association Primary Prevention Guideli... by Kim Allan Williams, Ibtihaj Fughhi, Setri Fugar, Monica Mazur, Sharon Gates, Stephen Sawyer, Hena Patel, Darrius Chambers, Ronald McDaniel, Jochen R. Reiser, Terry Mason

“…Cardiometabolic risk factors improved significantly, highlighted by a marked reduction in serum insulin (−43%, <i>p</i> = 0.000), hemoglobin A1c (6.2% to 6.0%, <i>p</i> = 0.000), weight and BMI (−10.2 lbs, 33 to 31 kg/m², <i>p</i> = 0.000), but with small reductions of fasting glucose (−6%, <i>p</i> = 0.405) and triglyceride levels (−4%, <i>p</i> = 0.408). …”
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Metabolic syndrome, adiposity, diet, and emotional eating are associated with oxidative stress in adolescents by Sonia L. Ramírez-Garza, Emily P. Laveriano-Santos, Emily P. Laveriano-Santos, Juan J. Moreno, Juan J. Moreno, Patricia Bodega, Patricia Bodega, Amaya de Cos-Gandoy, Amaya de Cos-Gandoy, Mercedes de Miguel, Mercedes de Miguel, Gloria Santos-Beneit, Gloria Santos-Beneit, Juan Miguel Fernández-Alvira, Rodrigo Fernández-Jiménez, Rodrigo Fernández-Jiménez, Rodrigo Fernández-Jiménez, Jesús Martínez-Gómez, Ana María Ruiz-León, Ana María Ruiz-León, Ramon Estruch, Ramon Estruch, Rosa M. Lamuela-Raventós, Rosa M. Lamuela-Raventós, Anna Tresserra-Rimbau, Anna Tresserra-Rimbau

“…In addition, univariable analysis revealed positive significant associations between 8-isoprostane and body mass index, waist circumference, waist-to-height ratio, body fat percentage, blood lipid profile and glucose, emotional eating, and refined cereal intake. …”
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Prenatal air pollution, fetal β-cell dysfunction and neurodevelopmental delay by Peng Wang, Lin Wu, Haixia Wang, Lei Zhang, Wanjun Yin, Ruixue Tao, Fangbiao Tao, Peng Zhu

“…Screening and treatment of abnormal glucose metabolism in infants could benefit the prevention of air pollution-associated neurodevelopment delay.…”
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Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons by Qingxia Huang, Tingting Lou, Jing Lu, Manying Wang, Xuenan Chen, Linyuan Xue, Xiaolei Tang, Wenxiu Qi, Zepeng Zhang, Hang Su, Wenqi Jin, Chenxu Jing, Daqing Zhao, Liwei Sun, Xiangyan Li

“…Methods: In this study, oxygen consumption rate, ATP production, mitochondrial biosynthesis, glucose metabolism, and SIRT1-PGC-1α pathways in untreated and GS-treated different cells, fly, and mouse models were investigated. …”
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Imaging for assessment of cancer treatment response to immune checkpoint inhibitors can be complementary in identifying hypophysitis by Anna Galligan, Anna Galligan, Anna Galligan, Amir Iravani, Amir Iravani, Amir Iravani, Arian Lasocki, Arian Lasocki, Roslyn Wallace, Alison M. Weppler, Nirupa Sachithanandan, Nirupa Sachithanandan, Nirupa Sachithanandan, Cherie Chiang, Cherie Chiang, Cherie Chiang, Peter G. Colman, Peter G. Colman, John Wentworth, John Wentworth, Lavinia Spain, George Au-Yeung, George Au-Yeung, Belinda Lee, Thomas W. H. Kay, Thomas W. H. Kay, Thomas W. H. Kay, Rodney J. Hicks, Shahneen Sandhu, Shahneen Sandhu, Balasubramanian Krishnamurthy, Balasubramanian Krishnamurthy, Balasubramanian Krishnamurthy

“…Available structural brain imaging with magnetic resonance imaging (MRI) or computed tomography (CT) of the brain and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography with computed tomography (FDG-PET/CT) were assessed retrospectively. …”
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