From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients by Furong Huang, Furong Huang, Furong Huang, Bo Lyu, Bo Lyu, Fanci Xie, Fanci Xie, Fang Li, Fang Li, Fang Li, Yufeng Xing, Yufeng Xing, Zhiyi Han, Zhiyi Han, Jianping Lai, Jinmin Ma, Yuanqiang Zou, Yuanqiang Zou, Hua Zeng, Hua Zeng, Zhe Xu, Zhe Xu, Zhe Xu, Pan Gao, Pan Gao, Pan Gao, Yonglun Luo, Yonglun Luo, Yonglun Luo, Yonglun Luo, Yonglun Luo, Yonglun Luo, Lars Bolund, Lars Bolund, Lars Bolund, Lars Bolund, Lars Bolund, Guangdong Tong, Guangdong Tong, Guangdong Tong, Guangdong Tong, Xu Fengping, Xu Fengping, Xu Fengping, Xu Fengping

“…Furthermore, KEGG pathway analysis highlighted significant disturbances in various types of glucose metabolism pathways in the NASH group compared to the NAFL group, as well as notably compromised flavonoid and flavonol biosynthesis functions. …”
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The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial by Anuradhani Kasturiratne, Khadija I. Khawaja, Sajjad Ahmad, Samreen Siddiqui, Khurram Shahzad, Lathika K. Athauda, Ranil Jayawardena, Sara Mahmood, Mirthe Muilwijk, Tayyaba Batool, Saira Burney, Matthew Glover, Saranya Palaniswamy, Vodathi Bamunuarachchi, Manju Panda, Suren Madawanarachchi, Baldeesh Rai, Iqra Sattar, Wnurinham Silva, Swati Waghdhare, Marjo-Riitta Jarvelin, Ravindra P. Rannan-Eliya, Heather M. Gage, Irene G. M. van Valkengoed, Jonathan Valabhji, Gary S. Frost, Marie Loh, Ananda R. Wickremasinghe, Jaspal S. Kooner, Prasad Katulanda, Sujeet Jha, John C. Chambers

“…Secondary endpoints at 1 and 3 years are the following: (i) physical measures: waist circumference, weight and blood pressure; (ii) lifestyle measures: smoking status, alcohol intake, physical activity and dietary intake; (iii) biochemical measures: fasting glucose, insulin and lipids (total and HDL cholesterol, triglycerides); and (iv) treatment compliance. …”
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Effects of Glucocorticoids on Postoperative Neurocognitive Disorders in Adult Patients: A Systematic Review and Meta-Analysis by Xiaoyu Xie, Xiaoyu Xie, Rui Gao, Rui Gao, Hai Chen, Hai Chen, Xueying Zhang, Xueying Zhang, Xingwei Cai, Xingwei Cai, Changteng Zhang, Changteng Zhang, Changliang Liu, Changliang Liu, Tao Zhu, Tao Zhu, Chan Chen, Chan Chen

“…However, there were no significant differences between groups with regards to the incidence of postoperative infection (RR: 0.94, 95% CI: 0.84 to 1.06, P = 0.30, GRADE = moderate), blood glucose level (RR: 1.05, 95% CI: −0.09 to 2.19, P = 0.07, GRADE = low), duration of mechanical ventilation (RR: −2.44, 95% CI: −5.47 to 0.59, P = 0.14, GRADE = low), length of hospital stay (RR: −0.09, 95% CI: −0.27 to 0.09, P = 0.33, GRADE = moderate) and 30-day mortality (RR: 0.86, 95% CI: 0.70 to 1.06, P = 0.16, GRADE = moderate).ConclusionsThis meta-analysis suggests that perioperative administration of glucocorticoids may not reduce the incidence of PNDs after surgery. …”
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Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima‐Media Thickness: An Individual Participant Data Meta‐Analys... by Engelbert A. Nonterah, Nigel J. Crowther, Kerstin Klipstein‐Grobusch, Abraham R. Oduro, Maryam Kavousi, Godfred Agongo, Todd J. Anderson, Gershim Asiki, Palwendé R. Boua, Solomon S. R. Choma, David J. Couper, Gunnar Engström, Jacqueline de Graaf, Jussi Kauhanen, Eva M. Lonn, Ellisiv B. Mathiesen, Lisa K. Micklesfield, Shuhei Okazaki, Joseph F. Polak, Tatjana Rundek, Jukka T. Salonen, Stephen M. Tollman, Tomi‐Pekka Tuomainen, Diederick E. Grobbee, Michéle Ramsay, Michiel L. Bots

“…Smoking (beta coefficient, 0.39; 95% CI, 0.09–0.70), body mass index (beta coefficient, 0.05; 95% CI, 0.01–0.08) and glucose (beta coefficient, 0.13; 95% CI, 0.06–0.19) had the strongest positive association with CIMT in the Asian population when compared with all other racial and ethnic groups. …”
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Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression o... by Tawakaltu Abdulrasheed-Adeleke, Bashir Lawal, Eyuwa Ignatius Agwupuye, Yucheng Kuo, Amarachi Mary Eni, Okwukwe Faith Ekoh, Halimat Yusuf Lukman, Amos S. Onikanni, Femi Olawale, Sani Saidu, Yunusa O. Ibrahim, Maliha Abdullah Saleh Al Ghamdi, Sarah S. Aggad, Abdulrahman A. Alsayegh, Nada H. Aljarba, Gaber El-Saber Batiha, Alexander T.H. Wu, Hsu-Shan Huang

“…Our in vitro studies revealed dose-dependent increased glucose uptake and inhibition of α-amylase (50% inhibitory concentration (IC50)= 217.19 µg/mL), antioxidant (DPPH, ferric-reducing activity of plasma (FRAP), and lipid peroxidation (LPO) [IC50 = 103.23, 58.72, and 114.16 µg/mL respectively]), and anti-inflammatory potential (stabilizes human red blood cell (HRBC) membranes, and inhibits proteinase and protein denaturation [IC50 = 143.73, 131.63, and 198.57 µg/mL]) by the PAm extract. …”
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Associations and pathways between residential greenness and metabolic syndromes in Fujian Province by Xiaoqing Li, Qinjian Wang, Chuanteng Feng, Chuanteng Feng, Bin Yu, Bin Yu, Xi Lin, Yao Fu, Shu Dong, Ge Qiu, Ge Qiu, Darren How Jin Aik, Darren How Jin Aik, Yanrong Yin, Pincang Xia, Shaofen Huang, Nian Liu, Xiuquan Lin, Yefa Zhang, Xin Fang, Wenling Zhong, Peng Jia, Peng Jia, Shujuan Yang, Shujuan Yang

“…MetS was defined as the presence of three or more of the five components: abdominal obesity, elevated triglyceride, reduced high-density lipoprotein cholesterol (HDL-C), high blood pressure, and elevated fasting glucose. The residential greenness exposure was measured as the 3-year mean values of the normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI) within the 250, 500, and 1,000 meters (m) buffer zones around the residential address of each participant. …”
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Obesity- and lipid-related indices as a predictor of obesity metabolic syndrome in a national cohort study by Jiaofeng Gui, Yuqing Li, Haiyang Liu, Lei-lei Guo, Jinlong Li, Yunxiao Lei, Xiaoping Li, Lu Sun, Liu Yang, Ting Yuan, Congzhi Wang, Dongmei Zhang, Huanhuan Wei, Jing Li, Mingming Liu, Ying Hua, Lin Zhang

“…A total of 13 obesity- and lipid-related indices, including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), conicity index (CI), visceral adiposity index (VAI), Chinese visceral adiposity index (CVAI), lipid accumulation product (LAP), a body shape index (ABSI), body roundness index (BRI), and triglyceride glucose index (TyG-index) and its correlation index (TyG-BMI, TyG-WC, and TyG-WHtR), were recorded. …”
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Clinical feasibility study of early 30-minute dynamic FDG-PET scanning protocol for patients with lung lesions by Fen Du, Xieraili Wumener, Yarong Zhang, Maoqun Zhang, Jiuhui Zhao, Jinpeng Zhou, Yiluo Li, Bin Huang, Rongliang Wu, Zeheng Xia, Zhiheng Yao, Tao Sun, Ying Liang

“…Abstract Purpose This study aimed to evaluate the clinical feasibility of early 30-minute dynamic 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) positron emission tomography (PET) scanning protocol for patients with lung lesions in comparison to the standard 65-minute dynamic FDG-PET scanning as a reference. …”
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Setanaxib mitigates oxidative damage following retinal ischemia-reperfusion via NOX1 and NOX4 inhibition in retinal ganglion cells by Jing Liao, Zhaoguang Lai, Guangyi Huang, Jiali Lin, Wei Huang, Yuanjun Qin, Qi Chen, Yaguang Hu, Qiaochu Cheng, Li Jiang, Ling Cui, Haibin Zhong, Min Li, Yantao Wei, Fan Xu

“…The model of retinal I/R induced by acute intraocular hypertension and the oxygen-glucose deprivation/reoxygenation (OGD/R) model of primary RGCs were established. …”
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A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells by Itziar González-Moro, Itziar González-Moro, Henar Rojas-Márquez, Henar Rojas-Márquez, Maialen Sebastian-delaCruz, Maialen Sebastian-delaCruz, Jon Mentxaka-Salgado, Jon Mentxaka-Salgado, Ane Olazagoitia-Garmendia, Ane Olazagoitia-Garmendia, Ane Olazagoitia-Garmendia, Luis Manuel Mendoza, Luis Manuel Mendoza, Aina Lluch, Aina Lluch, Federica Fantuzzi, Carmen Lambert, Carmen Lambert, Jessica Ares Blanco, Jessica Ares Blanco, Jessica Ares Blanco, Lorella Marselli, Piero Marchetti, Miriam Cnop, Miriam Cnop, Elías Delgado, Elías Delgado, Elías Delgado, Elías Delgado, José Manuel Fernández-Real, José Manuel Fernández-Real, José Manuel Fernández-Real, Francisco José Ortega, Francisco José Ortega, Ainara Castellanos-Rubio, Ainara Castellanos-Rubio, Ainara Castellanos-Rubio, Ainara Castellanos-Rubio, Izortze Santin, Izortze Santin, Izortze Santin

“…Diminished LncTGM2 in human beta cells impairs glucose-stimulated insulin release.ConclusionsThese findings provide novel information on the molecular mechanisms by which T2D-associated SNPs in lncRNAs may contribute to disease, paving the way for the development of new therapies based on the modulation of lncRNAs.…”
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Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation by Zehe Ge, Miao Xu, Yuqian Ge, Guang Huang, Dongyin Chen, Xiuquan Ye, Yibei Xiao, Hongyu Zhu, Rong Yin, Hua Shen, Gaoxiang Ma, Lianwen Qi, Guining Wei, Dongmei Li, Shaofeng Wei, Meng Zhu, Hongxia Ma, Zhumei Shi, Xiuxing Wang, Xin Ge, Xu Qian

“…In this study, we show that quercetin directly binds with glucose-6-phosphate dehydrogenase (G6PD) and inhibits its enzymatic activity through competitively abrogating NADP+ binding in the catalytic domain. …”
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The prevalence of MAFLD and its association with atrial fibrillation in a nationwide health check-up population in China by Fang Lei, Fang Lei, Juan-Juan Qin, Juan-Juan Qin, Xiaohui Song, Xiaohui Song, Ye-Mao Liu, Ye-Mao Liu, Ye-Mao Liu, Ming-Ming Chen, Ming-Ming Chen, Tao Sun, Tao Sun, Xuewei Huang, Xuewei Huang, Ke-Qiong Deng, Ke-Qiong Deng, Ke-Qiong Deng, Xiuran Zuo, Dongai Yao, Li-Juan Xu, Huiming Lu, Gang Wang, Feng Liu, Lidong Chen, Jie Luo, Jiahong Xia, Lin Wang, QiongYu Yang, Peng Zhang, Peng Zhang, Yan-Xiao Ji, Yan-Xiao Ji, Xiao-Jing Zhang, Xiao-Jing Zhang, Zhi-Gang She, Zhi-Gang She, Qiang Zeng, Hongliang Li, Hongliang Li, Hongliang Li, Hongliang Li, Jingjing Cai, Jingjing Cai

“…In addition, the coexistence of prediabetes or diabetes had the largest impact on subsequent AF.ConclusionOur findings suggested a high prevalence of MAFLD and a high prevalence of other metabolic diseases in the MAFLD population, particularly overweight and glucose dysregulation. Moreover, MAFLD was associated with a significantly higher risk for existing and subsequent subclinical AF in the Chinese population.…”
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A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en... by Laura Hernández-Montoliu, M-Mar Rodríguez-Peña, M-Mar Rodríguez-Peña, Rocío Puig, Rocío Puig, Brenno Astiarraga, Brenno Astiarraga, Fernando Guerrero-Pérez, Nuria Virgili, Rafael López-Urdiales, Javier Osorio, Rosa Monseny, Claudio Lazzara, Lucía Sobrino, Manuel Pérez-Maraver, María Pérez-Prieto, Silvia Pellitero, Sonia Fernández-Veledo, Sonia Fernández-Veledo, Joan Vendrell, Joan Vendrell, Joan Vendrell, Nuria Vilarrasa, Nuria Vilarrasa

“…Species belonging to Streptococaceae, Akkermansiacea, Rickenellaceae, Sutterellaceae, Enterobacteriaceae, Oscillospiraceae, Veillonellaceae, Enterobacterales_uc, and Fusobacteriaceae families increased after intervention and correlated positively with AUC of GLP-1 and GLP-2, and negatively with glucose, HbA1c, triglycerides and adiposity markers. …”
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The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial by Kasturiratne, Anuradhani, Khawaja, Khadija I., Ahmad, Sajjad, Siddiqui, Samreen, Shahzad, Khurram, Athauda, Lathika K., Jayawardena, Ranil, Mahmood, Sara, Muilwijk, Mirthe, Batool, Tayyaba, Burney, Saira, Glover, Matthew, Palaniswamy, Saranya, Bamunuarachchi, Vodathi, Panda, Manju, Madawanarachchi, Suren, Rai, Baldeesh, Sattar, Iqra, Silva, Wnurinham, Waghdhare, Swati, Jarvelin, Marjo-Riitta, Rannan-Eliya, Ravindra P., Gage, Heather M., van Valkengoed, Irene G. M., Valabhji, Jonathan, Frost, Gary S., Loh, Marie, Wickremasinghe, Ananda R., Kooner, Jaspal S., Katulanda, Prasad, Jha, Sujeet, Chambers, John C.

“…Secondary endpoints at 1 and 3 years are the following: (i) physical measures: waist circumference, weight and blood pressure; (ii) lifestyle measures: smoking status, alcohol intake, physical activity and dietary intake; (iii) biochemical measures: fasting glucose, insulin and lipids (total and HDL cholesterol, triglycerides); and (iv) treatment compliance. …”
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Role of cell-cell signaling, differentiation and fitness in multi-species biofilms by Lee, Kelvin Kai Wei

“…The proportions and structures of the three bacterial species within the mixed species biofilms grown at the inlet end and outlet end of the continuous-culture flow cell also differed, most likely as a result of decreasing glucose concentration and associated changes in the specific growth rate for KP-1 along the channel. …”
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Interactive telemedicine: effects on professional practice and health care outcomes by Flodgren, G, Rachas, A, Farmer, A, Inzitari, M, Shepperd, S

“…Studies recruiting participants requiring mental health services and those requiring specialist consultation for a dermatological condition reported no differences between groups.The findings in our review indicate that the use of TM in the management of heart failure appears to lead to similar health outcomes as face-to-face or telephone delivery of care; there is evidence that TM can improve the control of blood glucose in those with diabetes. The cost to a health service, and acceptability by patients and healthcare professionals, is not clear due to limited data reported for these outcomes. …”

Effectiveness of practice guidelines nutritional care and basic nutritional care on anthropometric and metabolic outcomes in type 2 diabetes mellitus patients at Sultan Qaboos Univ... by Al-Shookri, Ali Obaid Salim

“…Anthropometric (weight, height, BMI and waist circumference), biochemical (fasting blood glucose, HbA1c, triglycerides, cholesterol, LDL cholesterol and HDL cholesterol), dietary intake (total energy, carbohydrate, fat, cholesterol, saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty acids) and physical activity (total physical activity MET-minutes/week, walking MET-minutes/week,moderate MET-minutes/week and vigorous MET-minutes/week) variables were measured at three time points (0, 3, 6 months). …”
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Evaluation of diabetic wound healing properties of moringa oleifera lam using in vitro and in vivo wound models by Muhammad Amali, Abubakar

“…Following induction of diabetes by STZ-NAD in Wistar rats, hyperglycemia was maintained for 21 days and the reading of blood glucose level was more significant in diabetic groups compared to normal control group (p < 0.05). …”
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Chemical profiling of Cosmos caudatus Kunth possessing antioxidant and α-glucosidase inhibitory activity by W. Ahmad, Wan Nadilah Adibah

“…It’s showed that the flavonoids glycosides were the responsible compounds that contribute to the free radical scavenging and lowering the glucose effects of C. caudatus leaves. Interestingly, in the present study, quercetin 3-O-xyloside in C. caudatus extracts was reported for the first time. …”
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Proximate composition, starch properties and functionality in selected aquatic macrophytes by Syed, Nurul Nur Farahin

“…Non-starch components like protein was high in most starches (3.06-26.47%) as well as lipid contents (0.24-5.57%) affected the starch purities, whereas phosphorus contents (0.02-0.43%) association with starch increased the starch functionality. Glucose was present in all of the samples range between 0.19 g 100 g-1 - 0.25 g 100 g-1. …”
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