Detection of primary and secondary brain tumours using molecularly-targeted magnetic resonance imaging by Serres, S, Kirkman, M, de Pennington, N, Bristow, C, Sibson, N

“…These findings suggest that VCAM-1-targeted MRI may enable improved detection of tumour margins, as compared to the current clinical gold standard of gadolinium-enhanced MRI, for both primary and secondary tumours in the brain. …”

Assessment of the arthritic knee by Hamilton, T

“…As stress radiographs are time and resource consuming, a novel stress device was developed in line with the IDEAL-D framework and validated against the gold standard of manual, clinician performed stress radiographs, as well as independently tested in clinical practice.…”

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-bas... by Domingo, E, Camps, C, Kaisaki, P, Parsons, M, Mouradov, D, Pentony, M, Makino, S, Palmieri, M, Ward, R, Hawkins, N, Gibbs, P, Askautrud, H, Oukrif, D, Wang, H, Wood, J, Tomlinson, E, Bark, Y, Kaur, K, Johnstone, E, Palles, C, Church, D, Novelli, M, Danielsen, H, Sherlock, J, Kerr, D, Kerr, R, Sieber, O, Taylor, J, Tomlinson, I

“…We compared a prognostic model based on the gold standard of clinicopathological variables and MSI with our new model incorporating clinicopathological variables, mutation burden, and driver mutations in KRAS, BRAF, and TP53. …”

The role of ultrasound compared to biopsy of temporal arteries in the diagnosis and treatment of giant cell arteritis (TABUL): a diagnostic accuracy and cost-effectiveness study by Luqmani, R, Lee, E, Singh, S, Gillett, M, Schmidt, W, Bradburn, M, Dasgupta, B, Diamantopoulos, A, Forrester-Barker, W, Hamilton, W, Masters, S, McDonald, B, McNally, E, Pease, C, Piper, J, Salmon, J, Wailoo, A, Wolfe, K, Hutchings, A

“…</p><p> LIMITATIONS: There is no independent gold standard diagnosis for GCA. The reference diagnosis used to determine accuracy was based on classification criteria for GCA that include clinical features at presentation and biopsy results.…”

Comparative performance of four rapid Ebola antigen-detection lateral flow immunoassays during the 2014-2016 Ebola epidemic in West Africa by Wonderly, B, Jones, S, Gatton, M, Barber, J, Killip, M, Hudson, C, Carter, L, Brooks, T, Simpson, A, Semper, A, Urassa, W, Chua, A, Perkins, M, Boehme, C

“…The non-commercial Trombley Zaire ebolavirus RT-PCR assay warrants further investigation, as it appeared more sensitive than the current gold standard, the altona Filovirus Screen RT-PCR assay.…”

Blood culture versus antibiotic use for neonatal inpatients in 61 hospitals implementing with the NEST360 Alliance in Kenya, Malawi, Nigeria, and Tanzania: a cross-sectional study by Murless-Collins, S, Kawaza, K, Salim, N, Molyneux, EM, Chiume, M, Aluvaala, J, Macharia, WM, Ezeaka, VC, Odedere, O, Shamba, D, Tillya, R, Penzias, RE, Ezenwa, BN, Ohuma, EO, Cross, JH, Lawn, JE, NEST360 Infection Group

“…Many receive antibiotics for clinically diagnosed infections without blood cultures, the current &lsquo;gold standard&rsquo; for neonatal infection detection. …”

Novel stress T1-mapping applications for the assessment of cardiovascular disease by Burrage, MK

“…However, this field has not progressed beyond original proof-of-principle studies, is limited by method sensitivity and choice of pharmacological stress agent, and has not been validated against gold standard invasive coronary physiology. This Thesis addresses these issues by performing further clinical validation and method development work towards standardising the technique across a range of T1-mapping methods and stress agents.…”

Comparing monomodality treatments of low--‐ grade intracranial arteriovenous malformation at hospital Kuala Lumpur between 2008 and 2011: a retrospective study by Rosli, Fadzlishah Johanabas

“…Surgical excision remains the gold standard treatment for accessible, low-grade AVM. …”
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Optimization of an elisa using a 50 kda omp antigen salmonella typhi for detection of anti-typhoid antibodies in human sera by Hoe, Lau Wai

“…Blood Culture method was used as a gold standard for diagnosis of typhoid fever. Antibody concentration in test sera was expressed as Arbitrary Antibody Units (AAU) using a reference standard serum which was assigned 100 Arbitrary units. …”
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Validation of CliEndomet as a diagnostic tool for endometriosis by Yeng, Lou Wei

“…Background: Endometriosis is one of the most common gynaecological disorders affecting the reproductive age group of women. The current gold standard in diagnosing this disease is via direct visualisation of endometriosis lesion intraoperatively and followed histological confirmation. …”
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Evaluation of genetic alterations of IDH1, TP53 and CASP9 genes as biomarkers in glioma patients by Yit, Pua Jing

“…The performance of the T-ARMS PCR assay was comparable to the gold standard and could be adapted for preoperative or intraoperative diagnosis as a sensitive and specific screening tool.…”
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Quantifying Short-Term Dynamics of Parkinson’s Disease Using Self-reported Symptom Data From an Internet Social Network by Little, Max, Wicks, Paul, Vaughan, Timothy, Pentland, Alex Paul

“…Methods: Online self-reported data was validated against the gold standard Parkinson's Disease Data and Organizing Center (PD-DOC) database, containing clinical symptom data at intervals greater than 3 months. …”
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Adaptive sampling of transient environmental phenomena with autonomous mobile platforms by Preston, Victoria Lynn.

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A novel equivalence method for high fidelity hybrid stochastic-deterministic neutron transport simulations by Giudicelli, Guillaume Louis.

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Domain decomposition for Monte Carlo particle transport simulations of nuclear reactors by Horelik, Nicholas E. (Nicholas Edward)

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Evaluation of keratin templates on dermal regeneration of full-thickness burns by Moay, Zi Kuang

“…Full-thickness burns presents themselves as damages to both epidermis and dermis, and may affect the subcutaneous tissue, muscular, neurovascular, and skeletal structures. The current gold standard for treating full-thickness burns is skin grafting. …”
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Multiorgan detection and segmentation strategies for 2D ultrasound images of the thyroid gland by Subbarao, Nikhil Narayan

“…But in a clinical setting, which is where a majority of patients are treated, ultrasound is the gold standard imaging modality used to screen the thyroid gland for disorders. …”
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Digital problem-based learning in health professions : systematic review and meta-analysis by the digital health education collaboration by Car, Lorainne Tudor, Kyaw, Bhone Myint, Dunleavy, Gerard, Smart, Neil A., Semwal, Monika, Rotgans, Jerome Ingmar, Low-Beer, Naomi, Campbell, James

“…Methods: We used the gold-standard Cochrane methods to conduct a systematic review of randomized controlled trials (RCTs). …”
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Digital education for health professions on smoking cessation management : systematic review by the digital health education collaboration by Semwal, Monika, Whiting, Penny, Bajpai, Ram, Bajpai, Shweta, Kyaw, Bhone Myint, Tudor Car, Lorainne

“…Methods: We searched 7 electronic databases and 2 trial registers for randomized controlled trials published between January 1990 and August 2017. We used gold standard Cochrane methods to select and extract data and appraise eligible studies. …”
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Benchmarking CRISPR-BP34 for point-of-care melioidosis detection in low-income and middle-income countries: a molecular diagnostics study by Pakdeerat, S, Boonklang, P, Angchagun, K, Chomkatekaew, C, Apichaidejudom, N, Dokket, Y, Faosap, A, Wongsuwan, G, Wuthiekanun, V, Aramrueung, P, Khamnoi, P, Thananchai, H, Siriboon, S, Chamnan, P, Peacock, SJ, Day, NPJ, Thomson, NR, Uttamapinant, C, Wongpalee, SP, Chewapreecha, C

“…We also performed CRISPR-BP34 detection on clinical specimens collected from 330 patients with suspected melioidosis and compared its performance with the current gold-standard culture-based method. Discordant results were validated by three independent qualitative PCR tests. …”