The effects of obesity and weight loss in heart failure: imaging the obesity paradox using magnetic resonance imaging and spectroscopy od Rayner, J

“…</p> <p>Magnetic resonance imaging is perfectly placed to interrogate this interplay in more detail, being the gold-standard technique for assessing a number of different parameters of cardiovascular structure and function, but also unveiling the potential for investigating cellular physiological parameters using non-invasive spectroscopic techniques.…”

Investigation of autoantibodies to soluble, onconeural or transmembrane autoantigens in patients with autoimmune-mediated neurological diseases od Chang, P-S

“…Modifying the target structure in any way reduces the test accuracy, hence live CBAs are the gold standard for antibody detection in patients with autoimmune antibody-associated diseases. …”

Novel applications of cardiovascular magnetic resonance in acute myocardial injury od Shanmuganathan, M

“…However, there are clinically-important limitations with this approach and it is likely that cardiovascular magnetic resonance imaging (CMR), given its status as the gold standard imaging test in the assessment of the causes and the extent of myocardial disease, can add clinical value as a non-invasive approach, either alone or in conjunction with ICA. …”

Development and validation of segmental length equations to estimate height among cerebral palsy children in southern and central regions of Peninsular Malaysia od Mokhy, Mahnon Suria

“…The standing height and recumbent length (RL) has become the gold standard for the actual height measurement. However, the current predictive equation has not been tested among the Malaysian population. …”
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Potential differentiation of human amniotic epithelial stem and mesenchymal bone marrow cells into cardiomyocytes od Motamedi, Batool

“…The characteristics and differentiation potential of the hAECs are concurrently compared with that of BM-MSCs, the gold standard in cell therapy. hAECs and BM-MSCs were isolated from the amniotic membrane and bone marrow, respectively and their cell surface antigens characterized based on flow cytometry, culture properties and colony formation. …”
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Development of a multiplex PCR-lateral flow assay for the detection of samonella typhi and salmonella paratyphi A od Zulkiply, Nor Amalina

“…Stool culture is the gold standard for the detection of typhoid and paratyphoid carriers but this method is time consuming and requires highly skilled personnel. …”
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Lab-on-chip for magnetic resonance relaxometry detection for rapid malaria diagnosis od Kong, Tian Fook

“…At present, Giemsa-stained microscopic examination of thick blood smear remains the gold standard for laboratory diagnosis of malaria. Although the procedure is labor intensive, time consuming and requires a well-trained and highly experienced personnel, Giemsa microscopic examination is still being practiced in the current clinical setting for more than a century. …”
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The effect of design on endovascular embolisation device performance od Peach, T

“…A number of inaccuracies of previous 'virtual contrast' models, as presented in the literature, are addressed and quantified by comparison to a gold-standard <em>in-vivo</em> porcine model. </p> <p><b>RESULTS</b></p> <p>In a number of aneurysm geometries, novel flow-diverter designs are shown to out-perform current commercially available devices. …”

Using multi-parametric imaging and multi-nuclear cardiac magnetic resonance to investigate novel treatment strategies for heart failure od Hundertmark, MJ

“…Firstly, CMR is the gold standard method to assess cardiac structure and function. …”

Big drug data for big drug trials: development, validation, and implementation of routinely-collected data on medications within large trials in cardiovascular disease and COVID-19... od Pessoa-Amorim, G

“…<p><strong>Background</strong></p> <p>Randomised controlled trials (RCTs) are the established gold-standard for the reliable assessment of medical interventions. …”

Growing a list od Letham, Benjamin, Rudin, Cynthia, Heller, Katherine A.

“…We use experiments with gold standards and open-ended experiments without gold standards to show that our method significantly outperforms the state of the art. …”
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Disease assessment in systemic vasculitis od Luqmani, R

“…Effective measurement of disease activity disease damage and function are the current gold standards of evaluation of patient status. In this paper, we review the evidence for the usefulness of serological markers of disease activity and discuss the role of the Birmingham Vasculitis Activity Score, the Vasculitis Damage Index and the Short Form 36 in the comprehensive evaluation of systemic vasculitis. …”

Anecdotes that provide definitive evidence od Aronson, J, Hauben, M

“…Such reactions could serve as gold standards for use, for example, when validating pharmacovigilance systems or assessing the quality of systematic reviews of adverse drug reactions and the methods used to perform them. …”

Bone quality evaluation at dental implant site using multislice CT, micro-CT and come beam CT od Parsa, A., Ibrahim, N., Hassan, B., van der Stelt, P., Wismeijer, D.

“…A strong correlation also was found between CBCT gray values and BV/TV and their gold standards, suggesting the potential of this modality in bone quality assessment at implant site.…”
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Non-invasive prenatal screening using cell-free fetal DNA : how good a screening assay is this ? od Tan, Christina En Hui

“…Karyotyping and fluorescence in situ hybridisation (FISH) following chorionic villus sampling (CVS) or amniocentesis are the gold standards in detecting genetic abnormalities. However, these procedures are invasive with up to 1% increased miscarriage risk. …”
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A comparison of Bayesian and maximum likelihood methods to determine the performance of a point of care test for Helicobacter pylori in the office setting. od Delaney, B, Holder, R, Allan, T, Kenkre, J, Hobbs, F

“… OBJECTIVE: Evaluations of point of care tests (PCT) are often hampered by a lack of appropriate gold standards. This study aimed to compare the results of a Bayesian statistical analysis and a maximum likelihood method to evaluate the performance of a PCT for Helicobacter pylori in primary care. …”

Low sensitivity of a nested polymerase chain reaction in oropharyngeal washings for the diagnosis of pneumocystis pneumonia in HIV-infected patients. od Nyamande, K, Lalloo, U, York, D, Naidoo, M, Irusen, E, Chetty, R

“… STUDY OBJECTIVE: To compare the relative yield and diagnostic utility of the polymerase chain reaction (PCR) analysis for Pneumocystis jirovecii DNA in oropharyngeal washings using transbronchial biopsy (TBBx) and BAL as "gold standards." DESIGN: Prospective study. SETTING: Academic tertiary center. …”

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence od Kelly, R. S., Giovannucci, E., Mucci, L. A., Vander Heiden, Matthew G.

“…In the subset of studies where biomarker discriminatory ability was quantified, high AUCs were reported that would potentially outperform the current gold standards in diagnosis, prognosis, and disease recurrence, including PSA testing. …”
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Classification of prostate cancer using a protease activity nanosensor library od Dudani, Jaideep S, Ibrahim, Maria, Kirkpatrick, Jesse, Warren, Andrew D, Bhatia, Sangeeta N

“…Improved biomarkers are needed for prostate cancer, as the current gold standards have poor predictive value. Tests for circulating prostate-specific antigen (PSA) levels are susceptible to various noncancer comorbidities in the prostate and do not provide prognostic information, whereas physical biopsies are invasive, must be performed repeatedly, and only sample a fraction of the prostate. …”
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HiSStology: high spectral and spatial resolution magnetic resonance imaging detection of vasculature validated by histology and micro-computed tomography. od Haney, C, Pelizzari, C, Foxley, S, Zamora, M, Mustafi, D, Tretiakova, M, Li, S, Fan, X, Karczmar, G

“…The data demonstrate a strong correlation between tumor vasculature identified using HiSS and two gold standards: histology and microCT angiography.…”