Effects of intermittent preventive treatment with two doses of sulphadoxine-pyrimethamine in malaria infection and its associated adverse pregnancy outcomes: a systematic review by Balami, Ahmed Dahiru, Muhammad Said, Salmiah, Mohd Zulkefli, Nor Afiah

“…It also demonstrated non-inferiority to other anti-malarial drugs like mefloquine and proguanil which were considered as ‘gold-standards’. Only higher doses of SP and Dihydroartemisinin-piperaquine, showed clear superiority over 2-dose SP. …”
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Automated 3D Renal Segmentation Based on Image Partitioning by Voiculescu, I, Yeghiazaryan, V

“…Quantitative analysis of our automated segmentation compared against hand–segmented gold standards indicates an average Dice similarity coefficient of 90%. …”

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper by Mateescu, B, Kowal, E, van Balkom, B, Bartel, S, Bhattacharyya, S, Buzás, E, Buck, A, de Candia, P, Chow, F, Das, S, Driedonks, T, Fernández-Messina, L, Haderk, F, Hill, A, Jones, J, Van Keuren-Jensen, K, Lai, C, Lässer, C, Liegro, I, Lunavat, T, Lorenowicz, M, Maas, S, Mäger, I, Mittelbrunn, M, Momma, S, Mukherjee, K, Nawaz, M, Pegtel, D, Pfaffl, M, Schiffelers, R, Tahara, H, Théry, C, Tosar, J, Wauben, M, Witwer, K, Nolte-'t Hoen, E

“…This position paper was written by the participants of the workshop not only to give an overview of the current state of knowledge in the field, but also to clarify that our incomplete knowledge – of the nature of EV(-RNA)s and of how to effectively and reliably study them – currently prohibits the implementation of gold standards in EV-RNA research. In addition, this paper creates awareness of possibilities and limitations of currently used strategies to investigate EV-RNA and calls for caution in interpretation of the obtained data.…”

Classification of prostate cancer using a protease activity nanosensor library by Dudani, Jaideep S, Ibrahim, Maria, Kirkpatrick, Jesse, Warren, Andrew D, Bhatia, Sangeeta N

“…Improved biomarkers are needed for prostate cancer, as the current gold standards have poor predictive value. Tests for circulating prostate-specific antigen (PSA) levels are susceptible to various noncancer comorbidities in the prostate and do not provide prognostic information, whereas physical biopsies are invasive, must be performed repeatedly, and only sample a fraction of the prostate. …”
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Poor sensitivity and consistency of microscopy in the diagnosis of low grade non-gonococcal urethritis. by Smith, R, Copas, A, Prince, M, George, B, Walker, A, Sadiq, S

“…The SM's initial grading and the consensus among microscopists provide two gold standards for analysis. RESULTS: Nine low grade and five high grade slides were removed from analysis because of loss of cells. …”

A New Variational Method for Bias Correction and Its Applications to Rodent Brain Extraction by Chang, Huibin, Huang, Weimin, Wu, Chunlin, Huang, Su, Guan, Cuntai, Sekar, Sakthivel, Bhakoo, Kishore Kumar, Duan, Yuping

“…On the other hand, the results of brain extraction are compared against manually segmented gold standards, BET, BSE and 3-D PCNN based on a number of metrics. …”
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Validating the use of Hospital Episode Statistics data and comparison of costing methodologies for economic evaluation: an end-of-life case study from the Cluster randomised triAl... by Thorn, J, Turner, E, Hounsome, L, Walsh, E, Down, L, Verne, J, Donovan, J, Neal, D, Hamdy, F, Martin, R, Noble, S

“…Neither HES nor medical record review represent gold standards of data collection. Requesting cost data from finance departments is impractical for large clinical trials.…”

Economic potential of a point-of-care CD4+ T cell count diagnostic in Mexico : a case study for low-end disruption diagnostics in middle of the pyramid Latin America by Camargo Támara, Mauricio

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Predicting Asian glycemic responses in food using a physiologically-based pharmacokinetic-pharmacodynamic model by Koh, Hor Cheng

“…However, current gold standards for prediabetes detection suffer from suboptimal sensitivity and accuracy, missing out on as many as one-third of prediabetes cases. …”
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Microfluidics nucleic acid testing for point-of-care liver assessment by Lim, Geok Soon

“…The inherent complexities of current gold standards of liver assessment such as histopathology and Liver Function Tests are generally incompatible with point-of-care testing (POCT). …”
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Development of a non-invasive tool for mammalian sperm by Vilanova Perez, T

“…In vitro fertilization and intracytoplasmic sperm injection remain the gold standards for assisted reproduction; however, the manipulation of sperm, oocytes, and embryos, can induce structural and functional damage. …”

Cellular-resolution optical coherence tomography : low-cost, compact hand-held probe development and image analysis by Xie, Jun

“…The future work on the automatic detection algorithms will be focused on reduction of the computational demand for real-time diagnosis, and validation studies in larger patient populations against clinical gold standards.…”
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