Application of artificial intelligence to decode the relationships between smell, olfactory receptors and small molecules by Rayane Achebouche, Anne Tromelin, Karine Audouze, Olivier Taboureau

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Fellow of the European board of ophthalmology glaucoma examination and diploma (FEBOS-Gl): update on 8 years of experience and future perspectives by Gordana Sunaric Mégevand, Gordana Sunaric Mégevand, Alain M. Bron, Alain M. Bron, Fotis Topouzis

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Serum uric acid level as a prognostic factor in sepsis outcome by Emad El-Shebiny, Shymaa Daif, Sabry Shoeib, Yasser Fathi, Enas Zahran

“…Characteristics of the included patients were: age greater than 18 years, first time to admit to hospital, and patients who were diagnosed to have gout, chronic renal failure, malignancy, and those on diuretics were excluded. …”
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Hot spring bathing is associated with a lower prevalence of hypertension among Japanese older adults: a cross-sectional study in Beppu by Satoshi Yamasaki, Tomotake Tokunou, Toyoki Maeda, Takahiko Horiuchi

“…In multivariable logistic regression, age (≥ 85 years: OR, 1.410); history of arrythmia (OR, 1.580), stroke (OR, 1.590), gout (OR, 1.880), diabetes mellitus (OR, 1.470), hyperlipidemia (OR, 1.680), renal disease (OR, 1.520), chronic hepatitis (OR, 0.648); and hot spring bathing at 19:00 or later (OR, 0.850) were independently and significantly associated with hypertension during the lifetime. …”
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The role of NLRP3 inflammasome in the pathogenesis of rheumatic disease by Ruixue Kong, Lulu Sun, Hua Li, Dashan Wang

“…NLRP3 inflammasome plays an important role in the pathogenesis of rheumatic disease such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), Sjögren's syndrome (SS), dermatomyositis/polymyositis (DM/PM), gout, and systemic sclerosis (SSc). For example, NLRP3 inflammasome has been found highly activated in synovial tissues and peripheral blood mononuclear cells from RA patients. …”
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Odor-evoked memories: The importance of choosing the right odor by D. Lopis, D. Valentin, C. Manetta

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Metformin reduces urate nephropathy in experimental nephrolithiasis by V. Y. Perfil’ev, Y. F. Zverev, D. Y. Perfil’eva, I. V. Lysenko, A. G. Miroshnichenko

“…The relationship between metabolic syndrome, especially insulin resistance, with gout and urate nephrolithiasis, is now proven. The search for a common pathophysiological link in the development of these conditions allows us to identify insulin-dependent excessive urinary acidification due to impaired education and renal ammonium transport. …”
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Incidentally Detected Amyloid Light-Chain Amyloidosis Caused by Monoclonal Gammopathy of Undetermined Significance: Possible Time-Dependent Change in Colonic Findings by Toshiro Fukui, Yuji Tanimura, Yasushi Matsumoto, Shunsuke Horitani, Takashi Tomiyama, Kazuichi Okazaki

“…A 72-year-old male was treated for high blood pressure, diabetes, and gout at the clinic of a private physician. Due to a positive fecal occult blood test discovered during colon cancer screening, he underwent colonoscopy and was diagnosed with adenomatous polyps by biopsies. …”
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Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond by Mark F. McCarty, Simon Bernard Iloki Assanga, Lidianys Lewis Luján, James H. O’Keefe, James J. DiNicolantonio

“…The NLRP3 inflammasome has received the most study and plays an important pathogenic role in a vast range of pathologies associated with inflammation—including atherosclerosis, myocardial infarction, the complications of diabetes, neurological and autoimmune disorders, dry macular degeneration, gout, and the cytokine storm phase of COVID-19. A consideration of the molecular biology underlying inflammasome priming and activation enables the prediction that a range of nutraceuticals may have clinical potential for suppressing inflammasome activity—antioxidants including phycocyanobilin, phase 2 inducers, melatonin, and N-acetylcysteine, the AMPK activator berberine, glucosamine, zinc, and various nutraceuticals that support generation of hydrogen sulfide. …”
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Nasal gouty tophus: Report a rare case presenting as a nasal hump with nasal obstruction by John Chung-Han Wu, Pang-Yun Chou, Chih-Hao Chen

“…The case report illustrates a common illness, gout, with a rare clinical manifestation leading to a common symptom, nasal obstruction. …”
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Bilateral Avascular Necrosis of Femoral Heads Associated with Pregnancy: A Case Report and Review of Literature by Servet İğrek, Tolga Onay, Emir Kütük

“…The list of common causes for AVN includes alcohol consumption, gout, Caisson disease, Gaucher disease, renal osteodystrophy, hypercoagulable states, sickle cell anemia, systemic steroid use, and trauma. …”
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Dysuricemia—A New Concept Encompassing Hyperuricemia and Hypouricemia by Naoyuki Otani, Motoshi Ouchi, Einosuke Mizuta, Asuka Morita, Tomoe Fujita, Naohiko Anzai, Ichiro Hisatome

“…The importance of uric acid, the final metabolite of purines excreted by the kidneys and intestines, was not previously recognized, except for its role in forming crystals in the joints and causing gout. However, recent evidence implies that uric acid is not a biologically inactive substance and may exert a wide range of effects, including antioxidant, neurostimulatory, proinflammatory, and innate immune activities. …”
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Doppler US in rheumatic diseases with special emphasis on rheumatoid arthritis and spondyloarthritis by Hüseyin Toprak, Erkan Kılıç, Aslı Serter, Ercan Kocakoç, Salih Özgöçmen

“…US is also a good imaging modality for crystal arthropathies, including gout and pseudogout, in which synovitis, erosions, tophi, and crystal deposition within or around the joint can be visualized readily. …”
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Promoting Cultural Humility by Integrating Health Equity Literature into the Pharmacy Curriculum by Vincent J. Venditto, Kristie Colón

“…Throughout the semester, five journal articles were assigned that relate to course material and focus on one characteristic (e.g., gout—gender). Students’ evolved perceptions of SDOH were compared to baseline data and characteristics of assigned articles indicate an improved understanding of SDOH including race/ethnicity (3.0 to 4.4, <i>p</i> < 0.0001); gender (2.8 to 4.0, <i>p</i> < 0.0001); and religion (2.3 to 2.9, <i>p</i> < 0.01). …”
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Evaluation of purine-nucleoside degrading ability and in vivo uric acid lowering of Streptococcus thermophilus IDCC 2201, a novel antiuricemia strain. by Dayoung Kim, Jin Seok Moon, Ji Eun Kim, Ye-Ji Jang, Han Sol Choi, Ikhoon Oh

“…This study evaluated 15 lactic acid bacteria with a focus on their ability to degrade inosine and hypo-xanthine-which are the intermediates in purine metabolism-for the management of hyperuricemia and gout. After a preliminary screening based on HPLC, Lactiplantibacillus plantarum CR1 and Lactiplantibacillus pentosus GZ1 were found to have the highest nucleoside degrading rates, and they were therefore selected for further characterization. …”
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Efektivitas pemberian terapi kompres hangat jahe merah untuk mengurangi nyeri sendi pada lansia by Muhammad Rifai Muchlis, Ernawati Ernawati

“…Namun penyakit sendi yang paling banyak ialah osteoarthritis, remathoid arthrthis, dan gout, penyakit ini dikelompokan berdasarkan diagnose dan keluhan pasien diantaranya nyeri yang disertai dengan kemerahan, bengkak dan kekauan pada sendi. …”
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Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract by Ormjai Taejarernwiriyakul, Naohiko Anzai, Promsuk Jutabha, Wantika Kruanamkam, Suparat Chanluang

“…A previous in vitro study found that it has an inhibitory effect on xanthine oxidase (XOD) activity but its use as a traditional medicine in the treatment of hyperuricemia and gout has a lacked scientific evidence. This study aimed to investigate the effects of Adlay seed extract on the level of plasma uric acid (Pua), reduction in fractional excretion of urate (%FEua), decreasing creatinine clearance (Ccr), and increasing plasma creatinine and urea nitrogen in hyperuricemic mice. …”
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Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice by Jiayuan Cao, Qiqi Liu, Haining Hao, Yushan Bu, Xiaoying Tian, Ting Wang, Huaxi Yi

“…Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an increased risk of chronic kidney disease and gout. Probiotics have the potential effect of alleviating HUA. …”
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Association of Mutations Identified in Xanthinuria with the Function and Inhibition Mechanism of Xanthine Oxidoreductase by Mai Sekine, Ken Okamoto, Kimiyoshi Ichida

“…Three XOR inhibitors are currently used as hyperuricemia and gout therapeutics but are also expected to have potential effects other than uric acid reduction, such as suppressing XO–generating reactive oxygen species. …”
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Monitoring of exposure to toxins in raptors in Albania by K. Korro, A. Lugaj, J. Mavromati, T. Bimo, E. Xeka, U. Pantovic, J. Andevski

“…The results indicated elevated blood lead levels in 65.7% of sampled raptors, while in 17.1% there was evidence of exposure to the non-steroidal anti-inflammatory drug (NSAID) diclofenac, based on visceral gout and the presence of cases with high serum uric acid concentration. …”