Target Screen of Anti-Hyperuricemia Compounds from Cortex Fraxini In Vivo Based on ABCG2 and Bioaffinity Ultrafiltration Mass Spectrometry by Xiuxiu Huang, Wenqing Dong, Xiao Luo, Lu Xu, Yinan Wang

“…The ATP-binding cassette (ABC) transporter ABCG2 is a significant urate transporter with a high capacity, and it plays a crucial role in the development of hyperuricemia and gout. Therefore, it has the potential to be targeted for therapeutic interventions. …”
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Chemical Modification of Cysteine with 3-Arylpropriolonitrile Improves the In Vivo Stability of Albumin-Conjugated Urate Oxidase Therapeutic Protein by Byungseop Yang, Inchan Kwon

“…To evaluate the in vivo stability of the thiol-APN reaction product, we prepared HSA-conjugated <i>Arthrobacter globiformis</i> urate oxidase (AgUox), a therapeutic protein for gout treatment. Site-specific HSA conjugation to AgUox was achieved by combining site-specific incorporation of tetrazine containing an amino acid (frTet) into AgUox and a crosslinker containing trans-cyclooctene and either thiol-maleimide (AgUox-MAL-HSA) or -APN chemistry (AgUox-APN-HSA). …”
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Sex-Specific Association of Uric Acid and Kidney Function Decline in Taiwan by Po-Ya Chang, Yu-Wei Chang, Yuh-Feng Lin, Hueng-Chuen Fan

“…However, postmenopausal women have a higher risk of gout than men, and comorbidities are also higher than in men. …”
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Bempedoic Acid: Safety and Efficiacy of a New Lipid-Lowering Agent by I. A. Mazerkina, T. V. Bukatina, T. V. Aleksandrova

“…In the CLEAR Outcomes trial, long-term treatment with bempedoic acid reduced the risk of major adverse cardiovascular events in patients with statin intolerance (n=13970) by 13%. A slight increase in gout attack frequency was observed, primarily in patients with pre-existing hyperuricaemia.Conclusions. …”
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Joint manifestations revealing inborn metabolic diseases in adults: a narrative review by Amaury Loret, Claire Jacob, Saloua Mammou, Adrien Bigot, Hélène Blasco, Alexandra Audemard-Verger, Ida VD Schwartz, Denis Mulleman, François Maillot

“…Some IMD may induce microcrystalline arthropathy. Beyond classical gout, there are also gouts in connection with purine metabolism disorders known as “enzymopathic gouts”. …”
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Instructions for Flow Cytometric Detection of ASC Specks as a Readout of Inflammasome Activation in Human Blood by Nico Wittmann, Ann-Kathrin Behrendt, Neha Mishra, Lukas Bossaller, Almut Meyer-Bahlburg

“…Although inflammasomes are important for many diseases such as periodic fever syndromes, COVID-19, gout, sepsis, atherosclerosis and Alzheimer’s disease, only a little knowledge exists on the precise and cell type specific occurrence of inflammasome activation in patient samples ex vivo. …”
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Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii by Kyung Hoan Im, Seung A Baek, Jaehyuk Choi, Tae Soo Lee

“…The study results demonstrated that the fruiting bodies of Ph. vaninii possessed good antioxidant, anti-xanthine oxidase, cell-free anti-tyrosinase, cellular anti-tyrosinase, anti-collagenase, and moderate anti-elastase activities, which might be used for the development of novel anti-gout, skin-whitening, and skin anti-wrinkle agents.…”
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Utility of Dual-Energy CT in Abdominal Interventions by Tara Prasad Tripathy, Ranjan Patel, Karamvir Chandel, Amar Mukund

“…Presently, DECT is widely used to evaluate pulmonary embolism, characterize abdominal masses, determine the composition of urinary calculi, and detect tophi in gout. CT angiography is an essential prerequisite for endovascular intervention. …”
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Analysis of 16 teenage patients with sickle cell anemia and musculoskeletal complications by Aref Hosseinian Amiri, Ramin Shekarriz, Maryam Yazdanian

“…The most common musculoskeletal complications were: Acute painful crisis in 10 (62.5%), osteomyelitis in 3 (18.5%), dactilitis in 4 (25%), avascular necrosis of bones in 6 (37.5%), stress fractures and vertebral collapse in 2 (12.5%), septic arthritis in 1 (0.6%) patient, and hyperuricemia/gout arthritis in 3 (18.5%) patients. Conclusion: Serious musculoskeletal complications of sickle cell anemia are very important and must be considered in these patients. …”
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α-AMYLASE, α-GLUCOSIDASE AND LIPASE INHIBITORY PROPERTIES AND PHYTOCHEMICAL ANALYSIS OF ENDEMIC PLANT Jurinea brevicaulis Boiss. by Nevin Ulaş Çolak, Ali Kandemir, Ufuk Özgen, Rezzan Aliyazıcıoğlu, Merve Badem, Şeyda Kanbolat, Sıla Sener

“…The genus Jurinea Cass. with approximately 200 described species worldwide has been traditionally used as a therapeutic agent for colic, fever, gout and rheumatism. The aim of this study was to analyze the volatile components, to determine phenolic compounds and to evaluate α-amylase, α-glucosidase, and lipase inhibitory activities of the endemic plant species Jurinea brevicaulis Boiss. …”
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The Effect of Size of Materials Formed or Implanted In Vivo on the Macrophage Response and the Resultant Influence on Clinical Outcome by Dale Feldman

“…This will be looked at for three configurations: spherical particulate (silicone oil or gel from breast implants), elongated particulate (monosodium urate [MSU] crystals in gout or in kidney stones), and fibers (e.g., polyester used in fabric implants). …”
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Preparation and characterization of liposomes containing methanol extract of aerial parts of Platycladus orientalis (L.) Franco by Javad Asili, Navid Mosallaei, Ali Shaterzadeh, Bizhan Malaekeh-Nikouei

“…Objective:Platycladus orientalis or Thuja orientalis is a native plant of Iran different parts of which are used in the treatment of various diseases such as: gout, rheumatoid arthritis, common cold, cough, bronchitis, asthma, high blood pressure and hormonal disorders like hirsutism and baldness. …”
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Obesity and Morbidity Risk in the U.S. Veteran by Jose A. Betancourt, Paula Stigler Granados, Gerardo J. Pacheco, Ramalingam Shanmugam, C. Scott Kruse, Lawrence V. Fulton

“…Veteran population, but also a significantly higher level (higher odds ratio) of the associated co-morbidities when compared to non-Veterans, including coronary heart disease (CHD) or angina (odds ratio (OR) = 2.63); stroke (OR = 1.86); skin cancer (OR = 2.18); other cancers (OR = 1.73); chronic obstructive pulmonary disease (COPD) (OR = 1.52), emphysema, or chronic bronchitis; arthritis (OR = 1.52), rheumatoid arthritis, gout, lupus, or fibromyalgia; depressive disorders (OR = 0.84), and diabetes (OR = 1.61) at the 0.95 confidence interval level.…”
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Ultrasound-diagnosed bone and joint destruction as a typical image in advanced Charcots arthropathy – case report by Aleksandra Konarzewska, Ludomira Rzepecka-Wejs, Anna Korzon-Burakowska

“…In the acute phase the patient usually presents with edema, redness and increased temperature of the foot, which can suggest many other diagnoses including bacterial infection, gout, venous thrombosis or trauma. Because of its non specific clinical presentation and unsufficient awareness of the specificity of the diabetic foot syndrome among health professionals and the patients the diagnosis of this process is in many cases delayed. …”
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Exploring the Typicality, Sensory Space, and Chemical Composition of Swedish Solaris Wines by Gonzalo Garrido-Bañuelos, Jordi Ballester, Astrid Buica, Mihaela Mihnea

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Ten Years Milestones in Xanthine Oxidase Inhibitors Discovery: Febuxostat-Based Inhibitors Trends, Bifunctional Derivatives, and Automatized Screening Assays by Miguel F. S. de Abreu, Camila A. Wegermann, Millena S. Ceroullo, Isabella G. M. Sant’Anna, Renato C. S. Lessa

“…Both UA and ROS are dangerous for human health, and some health conditions trigger upregulation of XO activity, which results in many diseases (cancer, atherosclerosis, hepatitis, gout, and others) given the worsened scenario of ROS and UA overproduction. …”
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Association between smoking behavior and serum uric acid among the adults: Findings from a national cross-sectional study. by Yun Seo Jang, Nataliya Nerobkova, Il Yun, Hyunkyu Kim, Eun-Cheol Park

“…<h4>Background</h4>Gout incidence is increasing worldwide; appropriate management of serum uric acid levels and a healthy lifestyle may help its prevention. …”
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Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis by Choi, I, Karpus, O, Turner, J, Hardie, D, Marshall, J, de Hair, M, Maijer, K, Tak, P, Raza, K, Hamann, J, Buckley, C, Gerlag, D, Filer, A

“…Diagnostic classification (gout, psoriatic arthritis, unclassified arthritis (UA), parvovirus associated arthritis, reactive arthritis and RA), disease outcome (resolving vs persistent) and clinical variables were determined at baseline and after follow-up, and related to the expression of stromal markers. …”

Genome-wide study of familial juvenile hyperuricaemic (gouty) nephropathy (FJHN) indicates a new locus, FJHN3, linked to chromosome 2p22.1-p21. by Piret, SE, Danoy, P, Dahan, K, Reed, A, Pryce, K, Wong, W, Torres, R, Puig, J, Müller, T, Kotanko, P, Lhotta, K, Devuyst, O, Brown, M, Thakker, R

“…FJHN3 is likely located within a approximately 5.5 Mbp interval on chromosome 2p22.1-p21, and identifying the genetic abnormality will help to further elucidate mechanisms predisposing to gout and renal failure.…”

Au carrefour des cultures : Marie-Aimée Steck-Guichelin by Seth, CJ

“…Le « Fragment d'une Epître à l'Obscurité, par une jeune personne de dix-sept ans» précède une « Elégie dans le goût ancien par feu André Chénier». Le second morceau est devenu célèbre sous le titre de «La Jeune Tarentine ». …”