Maresin1 ameliorates MSU crystal-induced inflammation by upregulating Prdx5 expression by Hui Jiang, DianZe Song, Xiaoqin Zhou, Feng Chen, Qingqing Yu, Long Ren, Qian Dai, Mei Zeng

“…Our study provides a new strategy by which Prdx5 may help prevent acute gout attacks.…”
Get full text

Cytomegalovirus-Associated Autoantibody against TAF9 Protein in Patients with Systemic Lupus Erythematosus by Yen-Fu Chen, Ao-Ho Hsieh, Lian-Chin Wang, Kuang-Hui Yu, Chang-Fu Kuo

“…<b>Methods</b>: The sera from patients with rheumatic diseases, including ankylosing spondylitis (AS), gout, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren syndrome (SS) were examined using ELISA for antibodies of CMV, CMVpp65, and TAF9. …”
Get full text

Are complications after repairing acute Achilles tendon ruptures related to the surgical approach or the patient’s comorbidities?* by Ana Cecilia Parise, Nicolás Martin Molho, Melanie Naiman, Pablo Valenti, Virginia María Cafruni, Daniel Sebastián Villena, Facundo Bilbao, María Gala Santini Araujo, Leonardo Angel Conti, Guillermo Cardone, Pablo Sotelano, Marina Carrasco

“…The following relevant comorbidities were analyzed: obesity, diabetes mellitus, smoking, dyslipidemia, gout, chronic corticosteroid use, connective tissue pathologies, transplant history, cancer treatment patients, and postoperative complications. …”
Get full text

Socioeconomic position and the influence of food portion size on daily energy intake in adult females: two randomized controlled trials by Tess Langfield, Katie Clarke, Lucile Marty, Andrew Jones, Eric Robinson

Get full text

Rapid ethnographic appraisal of community concepts of and responses to joint pain in Kilimanjaro, Tanzania by Emma McIntosh, Sally Wyke, Blandina T Mmbaga, Christopher Bunn, Elizabeth F Msoka, Perry Msoka, Nateiya M Yongolo, Emma Laurie

“…Data were analysed by constant comparison using QDA Miner software.Results Across the sample, dominant concepts of joint pain were named ugonjwa wa baridi, cold disease; ugonjwa wa uzee, old age disease; rimatizim, disease of the joints; and gauti, gout. Causes mentioned included exposure to the cold, old age, alcohol and red meat consumption, witchcraft, demons and injuries/falls. …”
Get full text

Simiao pill inhibits epithelial mesenchymal transition in a mouse model of chronic hyperuricemic nephropathy by inhibiting NLRP3 inflammasome activation by Guangxing Shui, Zheyi Cai, Feng Wang, Ting Chen, Xueyuan Huang, Yun Cai, Xiuhua Mi

“…Abstract Background Simiao pill module (SMM), a traditional Chinese medicine formula, has been widely used to treat gout and gouty arthritis. The goal of this study was to investigate the effects of SMM on epithelial-mesenchymal transition (EMT) and activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome in a mouse model of potassium oxonate (PO)-induced chronic hyperuricemic nephropathy (HN). …”
Get full text

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study by Yan-Lin Wu, Zheng-Jun Lin, Chang-Chun Li, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Fuxingzi Li, Ling-Qing Yuan, Zhi-hong Li

“…Abstract Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism and others. …”
Get full text

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives by Urszula Majcher, Greta Klejborowska, Mahshad Moshari, Ewa Maj, Joanna Wietrzyk, Franz Bartl, Jack A. Tuszynski, Adam Huczyński

“…Colchicine has been used to treat gout, but it has also been an investigational anticancer agent with a known antimitotic effect on cells. …”
Get full text

Capparis cartilaginea decne (capparaceae): isolation of flavonoids by high-speed countercurrent chromatography and their anti-inflammatory evaluation by Bashaer Alsharif, Bashaer Alsharif, Nadhim Hante, Nadhim Hante, Bruna Govoni, Hugo Verli, Wirginia Kukula-Koch, María Jose Santos-Martinez, María Jose Santos-Martinez, Fabio Boylan

“…In traditional medicine, tea of CC leaves is commonly used to treat inflammatory conditions such as rheumatism, arthritis, and gout. Due to the limited studies on the phytochemistry and biological activity of CC compared to other members of the Capparaceae family, this work aims to: 1) Identify the chemical composition of CC extract and 2) Investigate the potential anti-inflammatory effect of CC extract, tea and the isolated compounds.Methods: To guarantee aim 1, high-speed countercurrent chromatography (HSCC) method; Nuclear Magnetic Resonance (NMR) and High-Performance Liquid Chromatography coupled to Electrospray Ionisation and Quadrupole Time-of-Flight Mass Spectrometry (HPLC-ESIQTOF-MS/MS) were employed for this purpose. …”
Get full text

Effet de l’alimentation et de la race des vaches sur la fabrication de fromage d’Auvergne de Saint-Nectaire by J.P. GAREL, J.B. COULON

“…Le régime à base d’ensilage d’herbe n’a pas eu d’effets sur le goût des fromages. Il a modifié les caractéristiques des fromages affinés, en accentuant l’ouverture de la pâte et le gonflement précoce, mais en améliorant la souplesse et la couleur jaune des fromages. …”
Get full text

Soy consumption and serum uric acid levels: A systematic review and meta-analysis by Ying Duan, Qi Qi, Zihao Liu, Min Zhang, Huaqing Liu

“…Soy products like tofu, bean curd cake, and dried bean curd sticks could be high-quality protein sources for individuals with hyperuricemia or gout. It can be beneficial to nutritionists and healthcare decision-makers reconsider their conceptions about the relationship between soy and uric acid levels according to the latest and further scientific study results.Systematic review registration[www.crd.york.ac.uk/PROSPERO], identifier [CRD42022331855].…”
Get full text

Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop by Orsolya Mózner, Boglárka Zámbó, Zsuzsa Bartos, Anna Gergely, Kata Sára Szabó, Bálint Jezsó, Ágnes Telbisz, György Várady, László Homolya, Tamás Hegedűs, Balázs Sarkadi

“…The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this work, we have analyzed the effects of selected variants, residing in a structurally unresolved cytoplasmic region (a.a. 354–367) of ABCG2 on the function and trafficking of this protein. …”
Get full text

Machine Learning Prediction Models for Chronic Kidney Disease Using National Health Insurance Claim Data in Taiwan by Surya Krishnamurthy, Kapeleshh KS, Erik Dovgan, Mitja Luštrek, Barbara Gradišek Piletič, Kathiravan Srinivasan, Yu-Chuan (Jack) Li, Anton Gradišek, Shabbir Syed-Abdul

“…The most prominent predictors in the tree-based models were identified, including diabetes mellitus, age, gout, and medications such as sulfonamides and angiotensins. …”
Get full text

Comparison of Xanthine Oxidase Inhibitory Effect of Swertia chirayita and Febuxostat in Vitro by Qura-Tul-Ain, Sidra Mushtaq, Naveeda Manzoor, Mahreen Akhtar, Anila Errum, Naseem Saud Ahmad

“…6.5 to 7.0 mg/dl increases the incidence of gout, hypertension, diabetes mellitus type 2, stroke and heart failure. …”
Get full text

Validation of the Italian Version of the Educational Needs Assessment Tool in Rheumatoid Arthritis Patients and Factors Associated with Educational Needs by Marta Favero, Francesca Ometto, Fausto Salaffi, Elisa Belluzzi, Augusta Ortolan, Mariagrazia Lorenzin, Mara Felicetti, Leonardo Punzi, Mwidimi Ndosi, Roberta Ramonda

Get full text

Farinelli and the English: “One God” or the Devil? by Thomas McGeary

“…Ses contemporains l’accusent d’avoir perverti le goût esthétique. L’opéra est représenté par exemple dans les peintures de Hogarth comme un monde désordonné où tout sens du devoir est perdu au profit des caprices les plus fous. …”
Get full text

Probenecid, an Old Drug with Potential New Uses for Central Nervous System Disorders and Neuroinflammation by Claudia García-Rodríguez, Paula Mujica, Javiera Illanes-González, Araceli López, Camilo Vargas, Juan C. Sáez, Arlek González-Jamett, Álvaro O. Ardiles

“…Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal excretion of antibiotics. …”
Get full text

Debate 3: Genetically Tested Embryos Expected to Have Mild Adult Disease Should Not Be Transferred <subtitle>Motion For – Author: Junhao Yan; Motion Against – Author: Michael Gabbe... by Junhao Yan, Michael Gabbett

“…This data can used to determine the chances of an embryo developing adult-onset conditions such as cardiovascular disease, diabetes, mental illness and even gout. This presentation argues that there is a limit at which society should stop screening embryos for disease and draws upon practical observations and well-accepted ethical frameworks to support the case.…”
Get full text

O médico brasileiro José Pinto de Azeredo (1766?-1810) e o exame químico da atmosfera do Rio de Janeiro Brazilian physician José Pinto de Azeredo (1766?-1810) and the chemical exam... by Manuel Serrano Pinto, Marco Antonio G. Cecchini, Isabel Maria Malaquias, Lycia Maria Moreira-Nordemann, João Rui Pita

“…<br>José Pinto de Azeredo, of Rio de Janeiro, studied medicine and conducted notable experimental research in Edinburgh (1786-88), presenting his graduate thesis on gout in Leiden. Already appointed surgeon-general of Angola, he returned to Rio in 1789 and practiced medicine in Brazil. …”
Get full text

Les « routes du jazz », ou portrait du jazz en nomade : mémoire sonore et voyage identitaire dans Jazz from the Haiku King de James A. Emanuel (1999) by Nathalie Vincent-Arnaud

“…Poète américain contemporain, auteur de nombreux recueils dont l’éclectisme souligne son goût pour le franchissement des frontières géographiques et culturelles, James A. …”
Get full text