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J. Zijlmans, Hond en baas. Een geschiedenis van haat en liefde
Published 2003-01-01Get full text
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J. Zijlmans, Hond en baas. Een geschiedenis van haat en liefde
Published 2003-01-01Get full text
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Ph.H. Breuker, A. Janse, Negen eeuwen Friesland-Holland. Geschiedenis van een haat-liefdeverhouding
Published 1999-01-01Get full text
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Ph.H. Breuker, A. Janse, Negen eeuwen Friesland-Holland. Geschiedenis van een haat-liefdeverhouding
Published 1999-01-01Get full text
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Human Alpha 1 Antitrypsin Suppresses NF-κB Activity and Extends Lifespan in Adult <i>Drosophila</i>
Published 2022-09-01Subjects: “…human alpha-1 antitrypsin (hAAT)…”
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Accelerated Wound Border Closure Using a Microemulsion Containing Non-Inhibitory Recombinant α1-Antitrypsin
Published 2022-07-01“…Here, wound healing was examined in the presence of recombinant hAAT (hAAT<sup>WT</sup>) and protease-inhibition-lacking hAAT (hAAT<sup>CP</sup>). …”
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A Novel Cellular Therapy to Treat Pancreatic Pain in Experimental Chronic Pancreatitis Using Human Alpha-1 Antitrypsin Overexpressing Mesenchymal Stromal Cells
Published 2021-11-01“…MSC or hAAT-MSC infusion reduced abdominal pain sensitivities. hAAT-MSC therapy also suppressed TRPV1 expression in DRG and reduced pancreatic mast cell density induced by TNBS. …”
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Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model
Published 2011-02-01“…These mice were pretreated either with hAAT protein or with recombinant adeno-associated virus vector expressing hAAT (rAAV-hAAT). …”
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Proteomic Analysis of Exosomes Secreted from Human Alpha-1 Antitrypsin Overexpressing Mesenchymal Stromal Cells
Published 2021-12-01“…Nanoparticle tracking analysis (NTA) showed that the particle size of the EVs from control MSCs or hAAT-MSCs ranged from 30 to 200 nm. Both MSCs and hAAT-MSCs expressed exosome-associated proteins, including CD63, CD81, and CD9. hAAT-MSCs also expressed high levels of hAAT. …”
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Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition
Published 2022-07-01“…Here, we tested whether treatment with human AAT (hAAT) would have a therapeutic effect on CMT1A in a <i>PMP22</i> transgenic mouse model. …”
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The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins
Published 2018“…We assessed whether rSIV.F/HN transduction of the lung generates therapeutically relevant levels of secreted proteins in the lung and systemic circulation using human α1-anti-trypsin (hAAT) and factor VIII (hFVIII) as exemplars. Sedated mice were transduced with rSIV.F/HN carrying either the secreted reporter gene Gaussia luciferase or the hAAT or hFVIII cDNAs by nasal sniffing. rSIV.F/HN-hAAT transduction lead to therapeutically relevant hAAT levels (70 μg/ml) in epithelial lining fluid, with stable expression persisting for at least 19 months from a single application. …”
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The Result of Vitamin C Treatment of Patients with Cancer: Conditions Influencing the Effectiveness
Published 2022-04-01“…We believe that the clinical use of HAAT in cancer treatment should be reassessed. The accumulation of more study results on HAAT is desperately needed.…”
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Human Alpha-1 Antitrypsin Attenuates ENaC and MARCKS and Lowers Blood Pressure in Hypertensive Diabetic db/db Mice
Published 2022-12-01“…First, we show hAAT administration results in reduced blood pressure in diabetic db/db mice compared to vehicle treatment in both the inactive and active cycles. …”
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The unfolded protein response to PI*Z alpha‐1 antitrypsin in human hepatocellular and murine models
Published 2022-09-01“…Additionally, novel full‐length genomic DNA PI*Z hAAT and PI*M hAAT transgenic mouse models were established. …”
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Mouse characteristics that affect establishing xenografts from hepatocellular carcinoma patient biopsies in the United States
Published 2022-02-01“…Mice with macroscopically detectable PDX showed rising human alpha1‐antitrypsin (hAAT) serum levels, and conversely, no PDX was observed in mice with undetectable hAAT. …”
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An Inclusive Workplace Approach to Disability through Assistive Technologies: A Systematic Review and Thematic Analysis of the Literature
Published 2023-10-01“…Overall, the use of the HAAT model highlighted a lack of studies on the affective and socio-cultural dimensions that characterize the use of AT in the workplace. …”
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Correction of F8 intron 1 inversion in hemophilia A patient-specific iPSCs by CRISPR/Cas9 mediated gene editing
Published 2023-03-01“…The iPSCs were differentiated into hepatocyte-like cells (HPLCs).Results: The hAAT promoter and exon one were targeted addition in HA-iPSCs with a high efficiency of 10.19% via HMEJ. …”
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