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Halofantrine in the treatment of multidrug resistant malaria
Published 1989-09-01Get full text
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Cardiac effects of antimalarial treatment with halofantrine.
Published 1993“…More than 60% of the effect occurred with three doses of halofantrine (24 mg/kg). The arrhythmogenic potential of halofantrine should now be investigated.…”
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The treatment of falciparum malaria in children with halofantrine suspension
Published 1992-01-01Subjects: Get full text
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Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria.
Published 1993“…1 The pharmacokinetics, efficacy and toxicity of a new parenteral formulation of halofantrine hydrochloride were evaluated in 12 adults with acute uncomplicated falciparum malaria and nine adults who attended in convalescence. 2 Intravenous halofantrine (1 mg kg(-1) infused in 1 h) was given every 8 h for a total of three doses in the acute study. …”
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Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography.
Published 1994“…Whole blood mefloquine, halofantrine, and desbutyl-halofantrine concentrations were measured by high-performance liquid chromatography in capillary blood, venous blood, and venous plasma samples from patients along the Thai/Burmese border with falciparum malaria who were treated with either mefloquine (25 mg/kg) or halofantrine (24 mg/kg or 72 mg/kg). …”
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Halofantrine Hydrochloride (Halfan) Induced Toxicity of the Pancreas in Wistar Rats
Published 2009-10-01“…The toxicity of halofantrine hydrochloride to the pancreas of wistar rats (Rattus norvegicus) was studied using twenty five male wistar rats divided into five groups of five rats per group. …”
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Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria.
Published 1993“…We have investigated the relative efficacy of halofantrine and mefloquine in two paired randomised trials on the Thai-Burmese border, a multidrug-resistant area. …”
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Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine.
Published 1995“…Thus, chloroquine plus primaquine in combination and halofantrine alone are effective therapies for chloroquine-resistant P. vivax.…”
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Halofantrine and primaquine for radical cure of malaria in Irian Jaya, Indonesia.
Published 1997“…The combination of halofantrine and primaquine therapies was calculated as a regimen for achieving radical curve of falciparum or vivax malaria in Irian Jaya, Indonesia, and compared with combined chloroquine and primaquine therapies. …”
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Halofantrine pharmacokinetics in Kenyan children with non-severe and severe malaria.
Published 1995“…Kenyan children with uncomplicated malaria given oral halofantrine (HF; non-micronised suspension; 8 mg base kg-1 body weight 6 hourly for three doses) showed wide variation in the disposition of HF and desbutylhalofantrine (HFm). 2. …”
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Preliminary Study on the Effect of Halofantrine Hydrochloride on the Testes of Mature Wistar Rats
Published 2004-02-01“…Halofantrine hydrochloride is a phenantrine methanol antimalarial, which is schizonticidal with a high degree of activity against the asexual erythrocytic stage of malaria parasites. …”
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Other 4-methanolquinolines, amyl alcohols and phentathrenes: Mefloquine, lumefantrine and halofantrine
Published 2012“…This chapter describes mefloquine, pyronaridine, halofantrine, piperaquine and lumefantrine under the broader title of the 4-methanolquinolines, amyl alcohols and phentathrenes. …”
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The antimalarial drugs mefloquine and halofantrine inhibit ATP-sensitive potassium channels
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Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria
Published 2012“…Aims To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. …”
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Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria.
Published 2012“…AIMS: To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. …”
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Short report: in vivo sensitivity of Plasmodium falciparum to halofantrine in southern central Vietnam.
Published 2003“…We assessed the in vivo sensitivity of P. falciparum to halofantrine in two villages in the southern part of central Vietnam. …”
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Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base
Published 2009-12-01“…<p>Abstract</p> <p>Background</p> <p>Halofantrine (HF) was considered an effective and safe treatment for multi-drug resistant falciparum malaria until 1993, when the first case of drug-associated death was reported. …”
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Halofantrine Hydrochloride Acts as an Antioxidant Ability Inhibitor That Enhances Oxidative Stress Damage to <i>Candida albicans</i>
Published 2024-02-01Subjects: “…halofantrine hydrochloride…”
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Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in southern, central Vietnam using an extended 28-day in vivo test and polymerase chain reaction genotyping.
Published 2000“…We assessed the drug sensitivity of P. vivax to chloroquine or halofantrine in two villages in southern, central Vietnam. …”
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